Beyond Surface-Localized Reaction Paradigm: Intramacropore-Confined Thermal-Field-Driven Photothermal Reactivity Leap.

Although photothermal reactions have gained extensive attention, their surface-localized naturewhere heat concentrates on nanoscale surfacesleads to suboptimal chemical reactivity. This study establishes an intrapore-confined thermal-field-driven reaction paradigm with unprecedented photothermal reactivity, through investigations of photothermal Congo Red (CR) pyrolysis in three-dimensional ordered macroporous carbon (OMC) versus nonmacroporous solid carbon (SC). Two model systems are constructed: (1) intrapore-confined configuration: fluorine-cerium nanodomains with ultrahigh CR adsorption capacity are anchored onto macroporous walls to achieve uniform CR distribution in OMC; (2) surface-localized pathway: CR is blended on the external surface of SC, decoupling intrapore confinement and surface localization mechanisms.

Association of Unhealthy Lifestyles with Cataract Risk, and The Mediating Role of Metabolic Signature: Analysis of the UK Biobank Prospective Cohort.

Emerging evidence has shown an association between certain unhealthy lifestyle factors and cataract risk. However, the synergistic effect of unhealthy lifestyle factors on cataract risk and their underlying mechanisms remains unknown. This study analyzed data from 199,415 baseline cataract-free participants from the UK Biobank prospective cohort study.

Associations Among Sleep Duration, Sleep Quality, and Age-Related Ocular Diseases: Insights From Longitudinal and Mediation Analyses.

Purpose: To investigate the associations among sleep duration, sleep quality, and age-related ocular diseases, accounting for interactions with systemic inflammation.

Methods: A total of 380,182 participants in the UK Biobank were included in this prospective population-based cohort study. The investigated exposures were sleep duration, sleep quality (quantified through an established algorithm comprised of five sleep traits), and traits including insomnia, daytime dozing, chronotype, and snoring.

Efficacy of image-guided accurate limbal relaxing incisions for astigmatism correction during cataract surgery.

Purpose: To investigate the efficacy of image-guided accurate limbal relaxing incisions (LRIs) for astigmatism correction during cataract surgery.

Methods: Consecutive cataract patients with regular corneal astigmatism ranging from 0.75 to 2.

The Performance of Ti/Steel Joints Welded by Resistance Spot Welding with a Nickel Interlayer.

Resistance spot welding was performed to join a 2 mm thick TA2 titanium plate and Q235 steel plate using nickel foil with thicknesses of 0.02 mm, 0.04 mm, and 0.

Effect of Sn grain orientation on microstructure and mechanical properties of pure Sn solder joints under thermoelectric coupling.

This paper investigates the microstructure and mechanical properties of Sn/Cu micro solder joints with varying β-Sn orientations under thermoelectric coupling conditions. The findings indicate that in single-crystal Sn/Cu solder joints, when the angle θ between the current direction and the c-axis of the β-Sn grain is ≤ 43.5°, significant dissolution occurs in the cathode CuSn intermetallic compound (IMC) layer and the Cu substrate; large-sized CuSn IMC forms at the anode.

Plasma Metabolic Profile with Machine Learning Reveals Distinct Diagnostic and Biological Signatures for Pathologic Myopia.

Pathologic myopia (PM), characterized by serious myopic macular degeneration (MMD), is a detrimental subtype of high myopia (HM) and has become one of the leading causes of blindness worldwide. In this concern, precise and high-throughput molecular diagnosis and further pathologic insights are urgently needed. Here, through the combined strategy of nanoparticle-enhanced laser desorption/ionization mass spectrometry-based rapid metabolic analysis (<30 s) and machine learning, a precise molecular diagnostic approach of PM (HM with MMD grade ≥ 2) is proposed, which achieves areas under the curve of 0.

Advanced maternal reproductive age elevates myopia risk in offspring.

Aims: To evaluate the associations of parental reproductive age with the risk of myopia and high myopia in adult offspring.

Methods: This cross-sectional study included 14 044 UK Biobank participants. Myopia and high myopia were defined as a mean spherical equivalent (spherical power+1/2 cylindrical power) of both eyes ≤-0.

Development of a multispectral imaging apparatus for cost-effective fundus disease detection.

Fundus spectral imaging (FSI) integrates fundus photography with spectral techniques, providing both spatial and spectral information for retinal imaging. Whereas existing FSI systems have demonstrated advantages in structural and functional imaging, their widespread adoption is hindered by high costs and complex optical designs. To address these challenges, we propose a low-cost multispectral fundus camera with a simplified optical design, built from off-the-shelf optics, 3D-printed parts, and equipped with fiber-bundle-coupled multi-wavelength LED illumination source (470-740 nm).

Radiofrequency ablation of liver metastases in a patient with pancreatic cancer and long-term survival: A case report.

Background: According to the GLOBCAN2022 database, pancreatic cancer has become the 6th leading cause of cancer-related death worldwide. The latest statistics suggest that the incidence of pancreatic cancer is increasing at a rate of 0.5% to 1.

Grip Strength and Age-Related Ocular Diseases: Insights from Observational, Mendelian Randomization, and Mediation Analyses.

Objective: We aimed to examine the cross sectional and causal associations of grip strength with cataract, glaucoma, diabetic retinopathy (DR), and age-related macular degeneration (AMD) and probe the underlying mechanisms by evaluating the mediating role of metabolomic alterations.

Design: Cross sectional study.

Subjects: A total of 307 796 UK Biobank participants with grip strength and covariates data available.

A Predictive Nomogram for Post-Cesarean Infections: Risk Factors and Clinical Implications.

BACKGROUND Postoperative infections following cesarean sections contribute to increased maternal morbidity, prolonged hospital stays, and elevated healthcare costs. Identifying risk factors and developing predictive models are essential for targeted prevention. MATERIAL AND METHODS A retrospective study of 685 cesarean section patients from January 2021 to December 2023 categorized them into infection (n=33) and non-infection (n=652) groups.

Impact of nursing based on Orem's self-care theory on self-care behaviours in older patients with heart failure: A randomised controlled trial.

Objective: This study aimed to evaluate the impact of Orem's self-care theory on self-care behaviours in older patients with chronic heart failure.

Methods: A prospective randomised controlled trial that involved 104 older patients with heart failure who were admitted to the cardiology department of our hospital between November 2021 and April 2023. Participants were randomly assigned to either the control group or the study group.

Clinical features of anti-RNP-positive primary Sjögren's syndrome.

Objective: This study sought to explore the clinical features exhibited by individuals with anti-RNP antibodies who had primary Sjögren's syndrome (pSS).

Methods: Various clinical data of 410 pSS patients from our hospital between September 2018 and August 2023 were retrospectively analysed. Each individual fulfilled the 2016 American College of Rheumatology/European League Against Rheumatism (EULAR) classification criteria for pSS.

Optimizing serum 25(OH)D levels to mitigate the risk of age-related ocular diseases: insights from a large-scale prospective cohort study.

Background: Investigations into the association between serum 25-hydroxyvitamin D (25(OH)D) levels and the risk of age-related ocular diseases have yielded inconsistent results. Thus, we aimed to provide robust longitudinal evidence, identify optimal serum thresholds, and explore the underlying mechanisms.

Methods: We analyzed data of 322,953 participants from the UK Biobank.

Nintedanib regulates miR-23b-3p/TGFBR2 axis and competitively binds to TGFBR2 protein, inhibiting EMT process in human pterygium cells.

Aim: To investigate the effects of nintedanib on epithelial-mesenchymal transition (EMT) in cells derived from pterygium, aiming to explore its potential as a pharmacological intervention for pterygium treatment.

Methods: Primary human pterygium epithelial cells (hPEC) and human conjunctival epithelial (hCJE) cells were isolated from patients, cultured, and characterized. The impact of nintedanib on transforming growth factor beta (TGF-β)-induced EMT was assessed by examining the expression of EMT markers such as vimentin and E-cadherin.

HSC70 Promotes Breast Cancer Progression via PTEN Autophagic Degradation and PI3K/AKT/mTOR Activation.

Heat shock cognate protein 70 (HSC70) functions as a molecular chaperone and plays a crucial role in the regulation of intracellular protein modifications that are involved in tumor autophagy. However, its expression and mechanism in breast cancer have not been studied. The expression of HSC70 was verified by TCGA database and breast cancer patient tissue.

The Six-Transmembrane Epithelial Antigen of the Prostate (STEAP) 3 Regulates the Myogenic Differentiation of Yunan Black Pig Muscle Satellite Cells (MuSCs) In Vitro via Iron Homeostasis and the PI3K/AKT Pathway.

The myogenic differentiation of muscle satellite cells (MuSCs) is an important biological process that plays a key role in the regeneration and repair of skeletal muscles. However, the mechanisms regulating myoblast myogenesis require further investigation. In this study, we found that STEAP3 is involved in myogenic differentiation based on the Yunan black pig MuSCs model in vitro using cell transfection and other methods.

Macrophage PKM2 depletion ameliorates hepatic inflammation and acute liver injury in mice.

Introduction: Pyruvate kinase M2 (PKM2), the rate-limiting enzyme of glycolysis, plays a critical role in macrophage activation and a broad spectrum of chronic liver diseases. However, whether PKM2 contributes to the pathogenesis of acute liver injury (ALI) remains largely unexplored.

Methods: PKM2 expression was assessed in human and mouse ALI livers.

Discovery of 3-(Fluoro-imidazolyl)pyridazine Derivatives as Potent STING Agonists with Antitumor Activity.

Stimulator of interferon genes (STING) represents a promising therapeutic target for cancer and infectious diseases due to its ability to activate innate immune responses. Herein, we describe the discovery of 3-(fluoro-imidazolyl) pyridazine derivatives as potent STING agonists. Our comprehensive investigation, including structural and functional analysis as well as molecular dynamics simulation, suggests that appropriate spatial dimensions may play a crucial role in determining agonist efficacy.

Linkage Engineering of Triazine-Based Covalent Organic Frameworks for Selective Photocatalytic Oxidation of Amines.

Covalent organic frameworks (COFs) have garnered significant attention as versatile photocatalysts due to their tunable structure and activity. In this work, linkage engineering is applied to two triazine-based COFs, yielding TFPT-spc-COF, with a C═C linkage and TFPT-IM-COF, with a C═N linkage. TFPT-spc-COF exhibits better thermal stability and a significantly higher specific surface area than TFPT-IM-COF.

Effect of Capsular Tension Ring Implantation on Postoperative Rotational Stability and Visual Performance of a Multifocal Toric Intraocular Lens.

Purpose: To investigate the effect of capsular tension ring (CTR) implantation on postoperative rotational stability and visual performance of a plate-haptic multifocal toric intraocular lens in highly and non-highly myopic eyes.

Methods: Consecutive cataract patients intended for phacoemulsification and plate-haptic multifocal toric IOL (AT LISA 909 M) implantation were enrolled and randomized to receive either co-implantation of a CTR or not. Axial length (AL) ≥ 26 mm was defined as highly myopic (HM) eyes.

TGF-β1-induced m6A modifications accelerate onset of nuclear cataract in high myopia by modulating the PCP pathway.

High myopia is an important cause of visual impairment worldwide, characterized by early-onset nuclear cataracts, whose underlying mechanisms remain largely unexplained. Here, we identify conspicuously polarized and compacted lens fiber alignment, along with a simultaneous rise in N6-methyladenosine (m6A) modifications in patients with highly myopic cataracts (HMC), which is confirmed to be induced by elevated transforming growth factor-β1 (TGF-β1) in lens. Mechanistically, methyltransferase METTL3 and m6A reader insulin-like growth factor 2 mRNA binding protein 3 synergistically enhance planar cell polarity (PCP) signaling by affecting mRNA stability of dishevelled 2.

Anlotinib for the treatment of recurrent and refractory hemangioblastomas: a case report and review of literature.

Hemangioblastomas (HBs) are rare, highly vascular tumors that present significant treatment challenges, especially in cases of multiple recurrences. Here we present our experience treating one patient with recurrent and refractory HBs, aiming to provide preliminary data on the use of anlotinib in treating this disease. An 18-year-old woman with recurrent and refractory HBs, treated at the Henan Provincial Hospital of Traditional Chinese Medicine, achieved disease remission through oral anlotinib treatment after recurrence.