Association of FOXO3 gene polymorphisms with egg-laying intervals in pigeon.

The egg-laying interval reflects the laying performance of pigeons and is affected by the mechanism of ovulation. The Forkhead box O3 (FOXO3) gene is closely associated with follicular development, playing roles in the regulation of follicular granulocyte proliferation, differentiation and periodic ovulation. The objective of this research was to analyze associations of polymorphisms of FOXO3 gene with egg-laying intervals in pigeon.

Changes in gut microbiota and physiological functions of mud crab (Scylla paramamosain) in response to Vibrio parahaemolyticus infection.

The mud crab (Scylla paramamosain) is a major aquaculture species in southeastern China. However, intensifying farming has led to disease outbreaks, with Vibrio parahaemolyticus (Vp) infections causing high mortality and economic losses. Although gut microbiota is important for host health, its response to artificial Vp challenge in mud crabs remains poorly understood.

Bclaf1 mediates super-enhancer-driven activation of POLR2A to enhance chromatin accessibility in nitrosamine-induced esophageal carcinogenesis.

Gene-environment interactions are pivotal contributors to nitrosamine-induced esophageal carcinogenesis. While genetic mechanisms in esophageal carcinoma (ESCA) are well-defined, epigenetic drivers remain elusive. This study identifies a novel mechanism of epigenetic regulation centered on B-cell lymphoma-2-associated transcription factor 1 (Bclaf1) in nitrosamine-induced (Methylnitronitrosoguanidine, MNNG) esophageal carcinogenesis.

Effects of dietary probiotic ( I9, G15, or X13) on growth, digestive enzyme activities, immunity, and intestinal microbiota of Pacific white shrimp ().

Pacific white shrimp () is one of the most productive and economically important species globally. However, the development and continuous expansion of the farming scale led to an increase in the risk of disease occurrence in shrimp farming. The application of probiotics as an effective method for controlling diseases in aquaculture has been widely considered.

Impact of Telehealth on Health Disparities Associated With Travel Time to Hospital for Patients With Recurrent Admissions: 4-Year Panel Data Analysis.

Background: Geographic, demographic, and socioeconomic differences in health outcomes persist despite the global focus on these issues by health organizations. Barriers to accessing care contribute significantly to these health disparities. Among these barriers, those related to travel time-the time required for patients to travel from their residences to health facilities-remain understudied compared with others.

Novel Circular RNA CircSLC2A13 Regulates Chicken Muscle Development by Sponging MiR-34a-3p.

The skeletal muscle is the major muscle tissue in animals, and its production is subject to a complex and strict regulation. The proliferation and differentiation of myoblasts are important factors determining chicken muscle development. Circular RNAs (circRNAs) are endogenous RNAs that are widely present in various tissues of organisms.

Prediction of Receptor Status in Radiomics: Recent Advances in Breast Cancer Research.

Breast cancer is a multifactorial heterogeneous disease and the leading cause of cancer-related deaths in women; its diagnosis and treatment require clinical sensitivity and a comprehensive disciplinary research approach. The expression of different receptors on tumor cells not only provides the basis for molecular typing of breast cancer but also has a decisive role in the diagnosis, treatment, and prognosis of breast cancer. To date, immunohistochemistry (IHC), which uses invasive histological sampling, has been extensively used in clinical practice to analyze the status of receptors and to make an accurate diagnosis of breast cancer.

Circular RNA circIGF2BP3 Promotes the Proliferation and Differentiation of Chicken Primary Myoblasts.

The quality and quantity of animal meat are closely related to the development of skeletal muscle, which, in turn, is determined by myogenic cells, including myoblasts and skeletal muscle satellite cells (SMSCs). Circular RNA, an endogenous RNA derivative formed through specific reverse splicing in mRNA precursors, has the potential to influence muscle development by binding to miRNAs or regulating gene expression involved in muscular growth at the transcriptional level. Previous high-throughput sequencing of circRNA in chicken liver tissue revealed a circular transcript, circIGF2BP3, derived from the gene encoding insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3).

Integrated ONT Full-Length Transcriptome and Metabolism Reveal the Mechanism Affecting Ovulation in Muscovy Duck ().

Ovulation is a complicated physiological process that is regulated by a multitude of different pathways. In comparison to mammalian studies, there are few reports of ovulation in Muscovy ducks, and the molecular mechanism of ovarian development remained unclear. In order to identify candidate genes and metabolites related to Muscovy duck follicular ovulation, the study combined Oxford Nanopore Technologies (ONT) full-length transcriptome and metabolomics to analyze the differences in gene expression and metabolite accumulation in the ovaries between pre-ovulation (PO) and consecutive ovulation (CO) Muscovy ducks.

[Pleurotus ferulae polysaccharide adjuvant enhances the immune infertility of CZP3DNA vaccine].

Objective To investigate the effect of Pleurotus ferulae polysaccharide (PFP) as an adjuvant on the infertility induced by canine zona pellucida 3 (CZP3) DNA vaccine (pcDNA3-CZP3). Methods Female mice were intramuscularly immunized with pcDNA3-CZP3 alone or co-immunized with pcDNA3-CZP3 and aluminum adjuvant or PFP for three times. CZP3-specific antibody titers of antiserum were determined by ELISA.