Task effectiveness, usability, and acceptability of mHealth technologies among older adults at risk for cardiovascular disease: a feasibility study.

Purpose: New research shows the benefits of mobile health (mHealth) interventions for older adults. However, older adults adopt digital technology less than younger ones. This study measures the task effectiveness, perceived usability, and acceptability of a mHealth intervention (i.

Plasma phosphorylated tau 217 and amyloid‑β 42/40 for amyloid risk in subgroups.

Background: Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β (Aβ) pathology. Recently, plasma biomarkers, particularly p-tau217, have emerged as promising tools for early diagnosis and risk stratification. In this retrospective study, we evaluated the diagnostic performance of p-tau217 combined with other plasma biomarkers in distinguishing Aβ Positron emission tomography (PET) positivity in cognitively unimpaired (CU) and cognitively impaired (CI) individuals across diverse clinical subgroups.

Association of Tooth Loss With Stress and Depressive Symptoms in Korean Adults: An Analysis Using Korean National Health and Nutrition Examination Survey (KNHANES VI) (2013, 2015).

Objective: To examine the association between tooth loss and depressive symptoms in the Korean population using nationally representative data.

Background: Tooth loss negatively impacts oral function, aesthetics, and overall quality of life. It can lead to systemic issues, such as nutritional deficiencies, and is associated with mental health problems, including depressive symptoms.

"We Should Not Call an Ambulance, Even If We are Very Sick": Ukrainian Refugee Women's Experiences in the United States Healthcare System.

As the number and diversity of refugees worldwide increases, healthcare providers working with these populations face unique challenges. Thus, healthcare providers in host countries have limited understanding of challenges refugees face when using healthcare in host countries. The goal of the study is to achieve an interpretive understanding of women refugees' perspectives on their interactions with healthcare systems and providers, as well as to identify factors and processes that women refugees view as enabling or hindering their access to healthcare.

Barriers and opportunities to bridge between hospital and community via rehabilitation exercises for people with disabilities: multi-ministerial R&D efforts in South Korea.

People with disabilities often experience limited participation in community-based exercise activities aimed at promoting health. The concept that "Exercise is Medicine" is widely acknowledged across societies and historical periods. However, there is a notable discontinuity between hospital-based and community-based health promotion efforts for people with disabilities.

Second Dialect Acquisition by North Korean Refugee Speakers: Acquiring Seoul Korean Stops.

This study examined Korean three-way stop contrasts produced by North Korean (NK) immigrant speakers now living in South Korea, from the perspective of second dialect acquisition (SDA). Their production was compared with that of South Korean (SK) speakers. SK speakers and NK refugee speakers ( = 22 each) completed three tasks designed to elicit careful and conversational speech: reading aloud lists of one-syllable words and short phrases and participating in a sociolinguistic interview.

Effects of Physical Activity on Health Among Informal Caregivers of People With Cognitive Decline: A Systematic Review and Meta-Analysis.

Background: Caregiving for people living with cognitive decline, including Alzheimer's disease and related dementias, can negatively affect informal caregivers' health.

Objective: Our review aimed to systematically evaluate the effects of physical activity on physical and psychological health and well-being among informal caregivers of people with cognitive decline because no comprehensive evidence has been drawn so far.

Methods: A literature search of 9 databases was conducted to identify appropriate randomized controlled trials.

Utilizing Conversational AI Technology for Social Connectedness Among Older Adults: A Systematic Review.

With the growing global older population and the impact of loneliness and social isolation in this group, it is imperative to study resources to improve social connectedness. Artificial Intelligence (AI)-powered platforms are an emerging technology being utilized for this purpose. This systematic review investigated the impact of AI interventions on loneliness and social isolation in older adults.

Sleep Quality of Persons with Dementia and Family Caregivers in Korean Americans: Wearable Technology to Study the Dyadic Association.

Background: Sleep disturbances, such as difficulty in falling asleep and multiple awakenings at night, are prevalent among persons with Alzheimer's disease and related dementias (hereafter dementia), resulting in advanced cognitive impairment and increased behavioral problems. Additionally, family caregivers (eg, spouses or offspring) suffer from reduced sleep quality as a result of sleep disturbances in the persons with dementia (PWDs) they care for. Relatively little is known about the interaction of sleep parameters in dyads (PWD-caregiver) as paired units among understudied immigrant minorities, particularly Korean Americans.

Beliefs and attitudes of family caregivers of People with dementia toward advance care planning: A Q methodology study.

Family caregivers' perspectives for advance care planning (ACP) are critically important to reflect the end-of-life wishes of people with dementia. Culture can influence ACP practice and people's perspectives toward it. Little is known about family caregivers' perspectives toward ACP in Asian countries, especially in Korea.

Digital Health Technologies to Promote Healthy Eating and Physical Activity and Reduce Risk Factors for Cardiovascular Disease in Older Adults: A Pilot Study.

Background: Digital health technologies can promote healthy aging, diagnosis, treatment, self-care, and prevention to reduce inequities. However, limited data exist on the feasibility and efficacy of these technologies for healthy lifestyle behaviors and clinical outcomes for older adults at risk for cardiovascular disease.

Objectives: The purpose of this pilot study was to evaluate the feasibility of the study protocol for factors impacting process, resources, and safety and compared changes in eating patterns, physical activity, and clinical outcomes in participants randomized to Get FIT vs Get FIT + at baseline and 12 weeks.

Out-of-hospital cardiac arrest event after cancer diagnosis: a korean metropolitan cohort study.

Background: The importance of assessing out-of-hospital cardiac arrest (OHCA) risk in cancer patients is increasing as cancer incidence rises in aging populations.

Objective: This study aimed to investigate the association between newly diagnosed cancer and OHCA risk using a metropolitan cohort from South Korea.

Methods: A population-based retrospective cohort study was conducted, linking the nationwide OHCA registry with the National Health Information Database.

Immunogenicity and protective efficacy of a multi-antigenic adenovirus-based vaccine candidate against .

Introduction: The inadequate efficacy of the Bacillus Calmette-Guérin (BCG) vaccine against adult pulmonary tuberculosis (TB) necessitates the development of new and effective vaccines. Human adenovirus serotype 5 (Ad5), which induces T-cell response, is a widely used viral vector. In this study, we aimed to evaluate the efficacy of a multi-antigenic recombinant Ad5 vectored vaccine and determine the optimal immunization route for enhanced immune response against .

Patient activation improves with a multi-component personalized mHealth intervention in older patients at risk of cardiovascular disease: a pilot randomized controlled trial.

Aims: This study aimed to determine the effect of a multi-component mHealth intervention on patient activation and examine its predictors among older adults at risk of cardiovascular disease (CVD).

Methods And Results: This pilot randomized controlled trial compared two groups: Get FIT (control), who received healthy lifestyle counselling from a licensed health coach, a mHealth app (MyFitnessPal) with push alerts, and an activity tracker, and Get FIT + (intervention), who received the same interventions and had personalized text messages with 3- and 6-month follow-up periods. Patient activation was measured using the 13-item Patient Activation Measure; higher scores indicated better activation.

Dual-Mechanism mRNA Delivery via Fluorinated-Sorbitol Polyplexes: Enhancing Cellular Uptake and Endosomal Escape for COVID-19 Vaccination.

Advancements in mRNA delivery nanoparticles have significantly improved the potential for treating challenging diseases. Due to the inherent immunogenicity and rapid degradation of mRNA, specialized nanoparticles are required for efficient intracellular uptake, endosomal escape, and protection from lysosomal degradation. Although current methods enable transgene expression but achieving a balance between efficiency and toxicity remains challenging.

Predicting Sleep Quality in Family Caregivers of Dementia Patients From Diverse Populations Using Wearable Sensor Data.

This study aimed to use wearable technology to predict the sleep quality of family caregivers of people with dementia among underrepresented groups. Caregivers of people with dementia often experience high levels of stress and poor sleep, and those from underrepresented communities face additional burdens, such as language barriers and cultural adaptation challenges. Participants, consisting of 29 dementia caregivers from underrepresented populations, wore smartwatches that tracked various physiological and behavioral markers, including stress level, heart rate, steps taken, sleep duration and stages, and overall daily wellness.

Community health workers supporting diverse family caregivers of persons with dementia: Preliminary qualitative results from a randomized home-based study.

Background And Objectives: Culturally diverse informal caregivers of community-dwelling persons with dementia face challenges in accessing dementia care resources due to language barriers and cultural stigmas surrounding dementia. This study presents the perceived intervention experiences of a home-based approach which considers the cultural and linguistic needs of diverse family caregivers in dementia care. The intervention model includes home visits by trained bilingual, non-licensed community health workers (CHWs) whose cultural histories and understandings reflect that of the caregivers.

Poly(β-amino ester) polymer library with monomer variation for mRNA delivery.

Non-viral vectors for mRNA delivery primarily include lipid nanoparticles (LNPs) and polymers. While LNPs are known for their high mRNA delivery efficiency, they can induce excessive immune responses and cause off-target effects, potentially leading to side effects. In this study, we aimed to explore polymer-based mRNA delivery systems as a viable alternative to LNPs, focusing on their mRNA delivery efficiency and potential application in mRNA vaccines.

Establishing the Foundations of Emotional Intelligence in Care Companion Robots to Mitigate Agitation Among High-Risk Patients With Dementia: Protocol for an Empathetic Patient-Robot Interaction Study.

Background: An estimated 6.7 million persons are living with dementia in the United States, a number expected to double by 2060. Persons experiencing moderate to severe dementia are 4 to 5 times more likely to fall than those without dementia, due to agitation and unsteady gait.

Evaluating dyadic factors associated with self-care in patients with heart failure and their family caregivers: Using an Actor-Partner Interdependence Model.

Dyadic conditions of patients with heart failure and their caregivers may affect both patient self-care and caregiver contribution to patient self-care (CCPS). The purpose of this study was to examine the relationships of patient-caregiver physical function and depressive symptoms to the patient self-care (maintenance and management) and CCPS. Data from 55 were analyzed using an Actor-Partner Interdependence Model to address the aim through AMOS.

Innate immune responses against mRNA vaccine promote cellular immunity through IFN-β at the injection site.

mRNA vaccines against SARS-CoV-2 have revolutionized vaccine development, but their immunological mechanisms are not fully understood. Here, we investigate injection site responses of mRNA vaccines by generating a comprehensive single-cell transcriptome profile upon lipid nanoparticle (LNP) or LNP-mRNA challenge in female BALB/c mice. We show that LNP-induced stromal pro-inflammatory responses and mRNA-elicited type I interferon responses dominate the initial injection site responses.

Immunogenicity and Cross-Protection Efficacy of a Genotype F-Derived Attenuated Virus Vaccine Candidate against Mumps Virus in Mice.

Mumps virus (MuV) causes an acute contagious human disease characterized by swelling of the parotid glands. Despite the near elimination of mumps in many countries, the disease has recurred, even in vaccinated populations, especially adolescents. Immunization effectivity of the genotype A vaccine strain Jeryl Lynn (JL) is declining as genotype A is no longer predominant; therefore, a new vaccine strain and booster vaccine are required.

Cognitive Impairment and Social Determinants of Health Among Indigenous Women.

Background And Objectives: Cognitive impairment and Alzheimer's disease and related dementias (ADRD) pose significant challenges for Indigenous populations, necessitating urgent research. Limited evidence suggests that high rates of ADRD among Indigenous peoples are associated with social determinants of health (SDOH), such as education, income, health literacy, religion, and social engagement.

Research Design And Methods: Collaborating with a Northern Plains tribe, participants were recruited 123 self-identified Indigenous women aged 40-70 through a comprehensive recruitment strategy.