Unveiling anaphylatoxins: Pioneering cancer therapies through complement system insights.

The complement system, a cornerstone of innate immunity, plays pivotal roles in both defense and pathology, particularly through its anaphylatoxins, C3a and C5a. These small peptides, generated during complement activation, not only mediate pro-inflammatory responses but also contribute to the progression of various cancers by modulating the tumor microenvironment (TME). Anaphylatoxins influence tumor cell proliferation, epithelial-mesenchymal transition, angiogenesis, immune suppression, and therapy resistance via key signaling pathways such as PI3K/AKT, MEK/ERK, and p38 MAPK.

Design and Parameter Optimization of Quasi-Zero-Stiffness Structures Based on Cosine-Curve Compliant Beams.

Quasi-zero-stiffness (QZS) structures can provide a near constant force output in a certain range of displacement without force sensors and controllers. Therefore, they can be used in overload protection, vibration isolation, and biomedical application. In this paper, we propose a novel QZS structure based on cosine-curve compliant beams, which have a large QZS stoke and compact layout.

Postbiotics Suppress Adhesion and Survival through a Coaggregation Mechanism.

can cause gastric ulcers, gastritis, and even gastric cancer, with increasing antibiotic resistance. Due to their safety, stability, and lack of side effects, postbiotics have become a focus in research. However, strategies for screening anti- postbiotics remain unclear.

Harnessing intratumoral microbiota: new horizons in immune microenvironment and immunotherapy.

Microorganisms are ubiquitous in the human body, including within tumor tissues. Recent studies have demonstrated that intratumoral microbiota serve as critical regulators of the tumor microenvironment (TME), promoting the progression of solid tumors (e.g.

AMPred-MFG: Investigating the Mutagenicity of Compounds Using Motif-Based Graph Combined with Molecular Fingerprints and Graph Attention Mechanism.

Accurate mutagenicity prediction is crucial in drug discovery, but evaluating the mutagenicity of drug molecules is technically challenging, and experimental mutagenicity tests are both time-consuming and costly. In this study, we introduce a new deep learning predictive model called AMPred-MFG, designed to predict the mutagenicity of drug molecules. Our approach first combines multiple molecular fingerprint features with molecular graph features to obtain a comprehensive molecular representation.

Immune-based molecular subtyping of triple-negative breast cancer via SNF-CC and functional validation of key immune-associated genes.

Triple-negative breast cancer (TNBC) presents significant therapeutic challenges due to its aggressive nature and lack of targeted treatment options. Emerging evidence highlights the critical role of immune infiltration patterns in TNBC progression and prognosis, yet a comprehensive classification system integrating immune and transcriptomic features remains elusive. In this study, we employed the xCell algorithm to characterize immune infiltration across TNBC samples and utilized the Similarity Network Fusion and Consensus Clustering (SNF-CC) method to identify molecular subtypes.

Impact of future climate trend and fluctuation on winter wheat yield in the North China Plain and adaptation strategies.

Research on the impacts of climate change on crop yield is crucial for improving agricultural management practices and enhancing climate adaptability. Although previous studies have explored the effects of climate trends and fluctuations on wheat yield, their combined impacts under future climate scenarios in the North China Plain (NCP) remain insufficiently understood. This study employs the DSSAT model to analyze the impacts of future climate trends and fluctuations on winter wheat yield.

CircMAN1A2 Levels Determine GBM Susceptibility to TMZ in a Pathway Involving TEP1- and KEAP1-Mediated NRF2 Degradation Leading to Ferroptosis.

Background: Glioblastoma (GBM) is a highly aggressive brain tumor with poor prognosis and resistance to temozolomide (TMZ). The role of downregulated circular RNAs (circRNAs) in GBM progression remains unclear.

Methods: CircRNA sequencing and public dataset analysis identified dysregulated circRNAs in GBM.

In situ self-growth nano-selenium hydrogel coating alleviates surface thrombosis of blood-contacting devices by inactivating inflammatory cells.

The formation of thrombi in blood-contacting devices is accompanied by a several risks that can be life-threatening. Specifically, the process of blood exposure immediately after implantation triggers an immune response aimed at removing foreign substances, which can lead to thrombosis, inflammation and device malfunction. To confer anticoagulant properties to the implanted devices, a nano-selenium hydrogel coating which was in-situ self-growing on implant devices had been developed that inhibited thrombosis by intervening in the inflammatory cell activation pathway, possibly by decreasing tissue factor activity and thrombin production expressed by inflammatory cells.

Selenium-enriched Kazachstania unispora KU2 ameliorates patulin-induced intestinal injury in mice by mediating the gut microbiota and selenoprotein P synthesis.

Patulin (PAT) is a foodborne mycotoxin that causes intestinal injury. Selenium (Se)-enriched Kazachstania unispora (K. unispora) KU2 is a novel dietary Se carrier, and Se exerts important roles in intestinal homeostasis.

Roles of the soil microbiome in sustaining grassland ecosystem health on the Qinghai-Tibet Plateau.

Soil microbes, as intermediaries in plant-soil interactions, are closely linked to plant health in grassland ecosystems. In recent years, varying degrees of degradation have been observed in the alpine grasslands of the Qinghai-Tibet Plateau (QTP). Addressing grassland degradation, particularly under the influence of climate change, poses a global challenge.

Metabolic profiling of abdominal subcutaneous adipose tissue reveals effects of apple polyphenols for reversing high-fat diet induced obesity in C57BL/6 J mice.

Apple polyphenols (APP) can reduce obesity. However, the effects of APP on abdominal subcutaneous adipose tissue (aSAT) at metabolic level were unclear. In this study, 5-week APP intervenes were conducted on 10-week high-fat diet (HFD) feeding mice with doses of 200 and 500 mg/kg b.

Planar Two-Dimensional Vibration Isolator Based on Compliant Mechanisms.

In practical engineering applications, the vibration is often generated in various directions and can be harmful to the engineering equipment. Thus, it is necessary to develop vibration isolators that can reduce vibration in multiple directions. In this paper, we propose a planar two-dimensional vibration isolator based on compliant mechanisms.

Ginsenoside RK3 inhibits glioblastoma by modulating macrophage M2 polarization via the PPARG/CCL2 axis.

Background: Glioblastoma is recognized as the most aggressive form of intracranial tumor, presenting significant challenges in treatment. Recent emphasis has been placed on the potential of traditional Chinese medicine (TCM) as an adjuvant treatment for cancer.

Methods: We employed a series of assays-including CCK8, EdU, Transwell, and neurosphere formation-to evaluate the impact of ginsenoside RK3 on the phenotype of GBM.

Towards precision medicine: design considerations for nanozymes in tumor treatment.

Since the discovery of Fe3O4 nanoparticles with enzyme-like activity in 2007, nanozymes have emerged as a promising class of catalysts, offering advantages such as high catalytic efficiency, low cost, mild reaction conditions, and excellent stability. These properties make nanozymes highly suitable for large-scale production. In recent years, the convergence of nanomedicine and nanocatalysis has highlighted the potential of nanozymes in diagnostic and therapeutic applications, particularly in tumor therapy.

FUS/circZEB1/miR-128-3p/LBH feedback loop contributes to the malignant phenotype of GSCs via TNF-α-mediated NF-κB signaling pathway.

Glioblastoma (GBM) is the most lethal and common primary tumor of central nervous system with a poor prognosis. Glioma stem cells (GSCs) are particularly significant in GBM proliferation, invasion, self-renewal and recurrence. Circular RNAs (circRNAs) play important roles in various physiological and pathological processes, including regulating the biological behavior of GBM.

Predicting the potential associations between circRNA and drug sensitivity using a multisource feature-based approach.

The unique non-coding RNA molecule known as circular RNA (circRNA) is distinguished from conventional linear RNA by having a longer half-life, greater degree of conservation and inherent solidity. Extensive research has demonstrated the profound impact of circRNA expression on cellular drug sensitivity and therapeutic efficacy. There is an immediate need for the creation of efficient computational techniques to anticipate the potential correlations between circRNA and drug sensitivity, as classical biological research approaches are time-consuming and costly.

Response of soil fungal-community structure and function to land conversion to agriculture in desert grassland.

Land conversion to agriculture is an important factor affecting soil ecological processes in the desert grasslands of northern China. However, soil fungal-community structure and function in response to Land conversion remain unclear. In this study, desert grassland, artificial shrubland, and land conversion were investigated in the western part of the Mu Us Sandland (Yanchi, Ningxia; Dingbian, Shaanxi).

Tailored extracellular matrix-mimetic coating facilitates reendothelialization and tissue healing of cardiac occluders.

Minimally invasive transcatheter interventional therapy utilizing cardiac occluders represents the primary approach for addressing congenital heart defects and left atrial appendage (LAA) thrombosis. However, incomplete endothelialization and delayed tissue healing after occluder implantation collectively compromise clinical efficacy. In this study, we have customized a recombinant humanized collagen type I (rhCol I) and developed an rhCol I-based extracellular matrix (ECM)-mimetic coating.

CircVPS8 promotes the malignant phenotype and inhibits ferroptosis of glioma stem cells by acting as a scaffold for MKRN1, SOX15 and HNF4A.

Exciting breakthroughs have been achieved in the field of glioblastoma with therapeutic interventions targeting specific ferroptosis targets. Nonetheless, the precise mechanisms through which circRNAs regulate the ferroptosis pathway have yet to be fully elucidated. Here we have identified a novel circRNA, circVPS8, which is highly expressed in glioblastoma.

Planting halophytes increases the rhizosphere ecosystem multifunctionality via reducing soil salinity.

Soil salinization poses a significant global challenge, exerting adverse effects on both agriculture and ecosystems. Planting halophytes has the potential ability to improve saline-alkali land and enhance ecosystem multifunctionality (EMF). However, it remains unclear which halophytes are effective in improving saline-alkali land and what impact they have on the rhizosphere microbial communities and EMF.

Clinical evaluation of resection of functional area gliomas guided by intraoperative 3.0 T MRI combined with functional MRI navigation.

Background: In assessing the clinical utility and safety of 3.0 T intraoperative magnetic resonance imaging (iMRI) combined with multimodality functional MRI (fMRI) guidance in the resection of functional area gliomas, we conducted a study.

Method: Among 120 patients with newly diagnosed functional area gliomas who underwent surgical treatment, 60 were included in each group: the integrated group with iMRI and fMRI and the conventional navigation group.

alleviates adenine-induced acute kidney injury in mice by improving intestinal barrier function.

Acute kidney injury (AKI) is a kind of critical kidney disease characterized by tubular injury, rapid decline of renal function and renal inflammation, with high clinical incidence. AKI has been shown to be associated with dysregulation of the gut microbiota and impaired intestinal barrier. has a positive impact on the treatment of many diseases.

Enhydrin suppresses the malignant phenotype of GBM via Jun/Smad7/TGF-β1 signaling pathway.

GBM is the most threatening form of brain tumor. The advancement of GBM is propelled by the growth, infiltration, and movement of cancer cells. Understanding the underlying mechanisms and identifying new therapeutic agents are crucial for effective GBM treatment.

l-Carnosine loaded on carboxymethyl cellulose hydrogels for promoting wound healing.

Wound management remains a challenge in clinical practice. Nowadays, patients have an increasing demand for wound repair with enhanced speed and quality; therefore, there is a great need to seek therapeutic strategies that can promote rapid and effective wound healing. In this study, we developed a carboxymethyl cellulose hydrogel loaded with l-carnosine (CRN@hydrogel) for potential application as a wound dressing.