Decision-making experience for second donation in unrelated hematopoietic stem cell donors: a descriptive qualitative study.

Background: A second allogeneic hematopoietic stem cell transplantation (allo-HSCT) is often the most effective treatment option for patients experiencing graft failure or disease relapse following a first round of allo-HSCT. Unfortunately, the consent rate for second donation is insufficient to meet treatment needs worldwide. The purpose of this study was to provide a comprehensive understanding of the decision-making experience of unrelated donors when considering making a second donation.

Understanding Mental Health Service Perceptions in Chinese Americans with Type 2 Diabetes and Co-Occurring Mental Health Challenges Living in New York City: A Qualitative Study.

Purpose: Chinese Americans face disproportionately higher rates of Type 2 Diabetes (T2D) and co-occurring mental health challenges. Little is known about how they perceive mental health care during their journey with diabetes. This study aimed to provide an in-depth exploration of mental health care perceptions in this population.

Stigma experienced by adolescents with type 1 diabetes: A systematic review and meta-synthesis.

Aim: To identify and synthesize qualitative evidence on the stigma experiences of adolescents with type 1 diabetes.

Methods: Six databases were searched from inception to February 2024: PubMed, Cochrane Library, CINAHL, MEDLINE, Embase, and PsycINFO. This meta-synthesis followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement.

A translation and validation study of the traditional Chinese version of RU-SATED scale in Chinese Hong Kong residents.

Objective: The Regularity, Satisfaction, Alertness, Timing, Efficiency, and Duration (RU-SATED) version 4.0 is a 6-item tool designed to evaluate sleep health. This study examined the psychometric properties of the traditional Chinese version of RU-SATED (RU-SATED-TC) scale.

The effectiveness of a mindfulness-based stress reduction (MBSR) programme for parents of children with attention deficit hyperactivity disorder (ADHD): a pilot randomized controlled trial.

Background: Parents of children with attention deficit hyperactivity disorder (ADHD) often experience high levels of parental stress. This has exacerbated during the coronavirus disease 2019 (COVID-19) pandemic. The aim of this study was to examine the effectiveness of mindfulness-based stress reduction (MBSR) programme in the Chinese population, which is feasible among Chinese parents during the COVID-19 pandemic period in reducing the parental stress of parents compared with the usual care group.

Association Between Maternal Sleep Health and Mental Health: Moderating Role of Family Function.

Objective: Pregnancy, as a complex physiological process, significantly alters maternal sleep patterns, which are closely associated with various maternal health outcomes. This study explored the association between maternal sleep health and anxiety/depression symptoms and whether this association differed by family function.

Methods: A cross-sectional survey was conducted among pregnant women attending obstetrics departments at two hospitals in Nanjing, China.

Communication Patterns and Influencing Factors Between Chronically Ill Adolescents and Their Parents: A Scoping Review.

Aims: Parent-adolescent communication is vital for the self-management of chronically ill adolescents. However, evidence regarding communication patterns and influencing factors between adolescents with chronic diseases and their parents remains limited. This study aims to synthesise and summarise these patterns and factors.

Acceptability of self-administered acupressure for knee osteoarthritis in middle-aged and older adults: A mixed-method secondary analysis.

Objectives: To evaluate the acceptability of self-administered acupressure for Knee osteoarthritis (KOA) among middle-aged and older adults.

Methods: This is a mixed-method acceptability evaluation was embedded in a randomized controlled trial on self-administered acupressure for KOA. Participants received two 2-h training sessions on self-administered acupressure and were instructed to practice twice daily for 12 weeks.

Symptom experience of unrelated haematopoietic stem cell donors: A descriptive qualitative study.

Purpose: Unrelated haematopoietic stem cell donors face physical and psychological discomforts, which aggravate their fear and hesitation and reduce their consent rate and donation efficiency. However, the available experience in the management of these symptoms is insufficient, and strong evidence and guidance are lacking. The symptom experiences of Chinese unrelated haematopoietic stem cell donors were explored.

Effects of a flexibly delivered group-based acceptance and commitment therapy on reducing stress and enhancing psychological wellbeing in parents of school-age children during the COVID-19 pandemic: a quasi-experimental study.

Introduction: COVID-19 has increased parental stress and significantly impacted the psychological well-being of individuals, especially parents of school-age children. Acceptance and Commitment Therapy posits that individuals can accept their unchangeable inner experiences (thoughts and feelings) while acting in ways aligned with their personal values, demonstrating effectiveness in reducing stress and improving psychological well-being, especially among parents of children with chronic illness. This study aimed to test the effectiveness of a group-based ACT, delivered flexibly, in improving stress and psychological well-being in parents with school-age children, regardless of their children's chronic conditions, within a real-world context.

Traditional Chinese medicine interventions based on meridian theory for pain relief in patients with primary dysmenorrhea: a systematic review and network meta-analysis.

Objective: To determine the comparative effects and safety of traditional Chinese medicine (TCM) interventions based on meridian theory for pain relief in patients with primary dysmenorrhea (PD).

Methods: This is a systematic review with network meta-analysis. Randomized controlled trials (RCTs) comparing meridian-based TCM interventions with waitlist, placebo, western medicine, and conventional therapies for PD pain.

DNA damage induced by CDK4 and CDK6 blockade triggers anti-tumor immune responses through cGAS-STING pathway.

CDK4/6 are important regulators of cell cycle and their inhibitors have been approved as anti-cancer drugs. Here, we report a STING-dependent anti-tumor immune mechanism responsible for tumor suppression by CDK4/6 blockade. Clinical datasets show that in human tissues, CDK4 and CDK6 are over-expressed and their expressions are negatively correlated with patients' overall survival and T cell infiltration.

Everyday life experiences of Chinese community-dwelling oldest old who live alone at home.

Purpose: Older adults aged ≥ 80 years living alone at home are more likely to experience challenges. Daily life experiences regarding living alone are still limited in the Asian context. This study explored the everyday life experiences of older Chinese residents living alone at home.

Factors associated with severe depressive symptoms among Chinese secondary school students in Hong Kong: a large cross-sectional survey.

Background: Many adolescents were reported to have severe depressive symptoms, and a careful assessment of its correlates is essential for prevention and intervention programs. This study aimed to gain insight into the prevalence of severe depressive symptoms and its association with factors at four levels (individual, relationship, school and society) in a large sample of Hong Kong Chinese secondary school students.

Methods: Secondary school students from Secondary 1 through 7 were selected as participants using a cluster random sampling method.

Traditional Chinese medicine-based integrated health interventions for depression: A systematic review and meta-analysis.

Background: Some traditional Chinese medicine (TCM)-based integrated health interventions have been used for depression, but pooled efficacy remains unknown.

Aims And Objectives: This study aimed to systematically evaluate the efficacy of TCM-based integrated health interventions for relieving depression.

Design: Systematic review and meta-analysis.

Survivorship Experiences of Chinese Hematopoietic Stem Cell Transplantation Survivors: A Qualitative Study.

Background: The number of global hematopoietic stem cell transplantation (HSCT) survivors is increasing rapidly. Survivors encounter many challenges, but studies regarding survivorship experiences in China are scarce.

Objectives: This study aimed to explore the survivorship experiences of Chinese patients with hematological cancers after HSCT and to describe the impact of HSCT on the survivors' lives.

Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription.

It is well known that interferon (IFN)-α/-β activates the JAK/STAT signaling pathway and suppresses viral replication through the induction of IFN stimulated genes (ISGs). Here, we report that knockout of HDAC3 from macrophages results in the decreased expression of STAT1 and STAT2, leading to defective antiviral immunity in cells and mice. Further studies show that HDAC3 interacts with a conserved transcription factor Forkhead Box K1 (FOXK1), co-localizes with FOXK1 at the promoter of STAT1 and STAT2, and is required for protecting FOXK1 from lysosomal system-mediated degradation.

Experiences of Body Image Changes in Chinese Patients Living with Inflammatory Bowel Disease: A Descriptive Qualitative Study.

Purpose: Body image changes are common among patients living with inflammatory bowel disease (IBD) because of the illness and related treatments. Currently, there is little known about how those patients experience and perceive their altered body image in the literature. The aim of this study was to explore the experiences of body image changes in patients with IBD in China and to describe how those changes influence patients' perception of body and self.

Prognostic Value of the Combination of CEA and Fibrinogen/Albumin Ratio in Resectable Gastric Cancer.

Purpose: To investigate the prognostic value of combined serum carcinoembryonic antigen (CEA) levels and fibrinogen/albumin ratio (FAR) in patients with resectable gastric cancer (GC).

Introduction: This retrospective study evaluated the CEA, fibrinogen, and albumin levels and other clinicopathological features of GC patients. The prognostic significance of these factors for overall survival (OS) was assessed using Kaplan-Meier curves and univariate and multivariate Cox proportional models.

The Illness Experiences of Chinese Patients Living With Lymphoma: A Qualitative Study.

Background: Lymphoma patients encounter many problems. Studies investigating the illness experiences of Chinese patients with lymphoma are limited.

Objective: The objectives of this study were to explore the illness experiences of lymphoma patients in China and describe the impacts of this disease on the everyday lives of these individuals.

Regaining normality: A grounded theory study of the illness experiences of Chinese patients living with Crohn's disease.

Background: Crohn's disease is a chronic condition causing inflammation of the lining of the digestive system. Individuals suffering from this illness encounter various challenges and problems, but studies investigating the illness experiences of patients with Crohn's disease in East Asian countries are scarce.

Objectives: The objective of this study was to explore the illness experiences of patients with Crohn's disease in China and construct an interpretive understanding of these experiences from the perspective of the patients.