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Background: Parents of children with attention deficit hyperactivity disorder (ADHD) often experience high levels of parental stress. This has exacerbated during the coronavirus disease 2019 (COVID-19) pandemic. The aim of this study was to examine the effectiveness of mindfulness-based stress reduction (MBSR) programme in the Chinese population, which is feasible among Chinese parents during the COVID-19 pandemic period in reducing the parental stress of parents compared with the usual care group.
Methods: This study was designed as a pilot randomized controlled trial with single-blind repeated measures. Parents of children aged 3-12 years with a diagnosis of ADHD were recruited from the parent resource center (PRC) of a local nongovernmental organization between June and August 2022. The participants were randomly assigned to the MBSR intervention group (n = 18) or usual care group (n = 18).
Results: With respect to the feasibility of the study, all 36 participants who were randomized fully completed the MBSR programme and assessments, resulting in a 100% attendance rate. 66% of the participants in the intervention group reported satisfaction with the intervention, which was helpful in reducing stress. They were willing to stay on this mindfulness-based programme in the future. The results of the repeated-measures ANOVA revealed a significant difference in self-perceived stress reduction between the groups (p < 0.001, ES = 0.192). The of within-group results revealed that the mean score of the intervention group decreased from 29.44 before the intervention to 25.50 (p < 0.001) immediately after intervention, and further decreased to 24.72 (p < 0.05) at one month after the intervention. By using the parental stress scale, the interaction effects also revealed significant differences between groups (p < 0.001, ES = 0.599). The stress level of the intervention group decreased from 74.50 before intervention, to 68.94 (p < 0.001) immediately after intervention, and further decreased to 67.50 (p < 0.05) at one month after intervention. These reports revealed statistically significant improvements in stress reduction and parental stress reduction in the intervention group.
Conclusion: The pilot study revealed that MBSR is feasible and acceptable for parents of children with ADHD in Chinese culture. The findings also suggested that the MBSR programme was effective in reducing parental stress and enhancing mental well-being. This study was registered in the National Library of Medicine, National Center for Biotechnology Information Clinical Trials Registry as Version 1, and the trial registration data are available as NCT06210113, 28/2/2024.
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http://dx.doi.org/10.1186/s40359-025-02747-4 | DOI Listing |
J Med Internet Res
September 2025
Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Leipzig, Germany.
Background: The loss of a loved one is a common yet stressful event in later life. Internet- and mobile-based interventions have been proposed as an effective treatment approach for individuals with prolonged grief.
Objective: The AgE-health study aimed to investigate the efficacy of an eHealth intervention, trauer@ktiv, in reducing prolonged grief symptoms in a sample of older adults.
JAMA Netw Open
September 2025
Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Lübeck, Lübeck, Germany.
Importance: Patients with inflammatory rheumatic diseases (IRDs) frequently experience psychological distress; however, access to psychological support remains limited.
Objective: To investigate the effectiveness of a digital psychological intervention for individuals with IRDs.
Design, Setting, And Participants: Participants aged 18 years or older were recruited across Germany between February 22 and June 4, 2024, if they had been diagnosed with rheumatoid arthritis, psoriatic arthritis, or systemic lupus erythematosus and reported psychological distress and reduced quality of life.
Cancer Immunol Res
September 2025
The Wistar Institute, Philadelphia, PA, United States.
Ovarian cancer remains a major health threat with limited treatment options available. It is characterized by immunosuppressive tumor microenvironment (TME) maintained by tumor-associated macrophages (TAMs) hindering anti-tumor responses and immunotherapy efficacy. Here we show that targeting retinoblastoma protein (Rb) by disruption of its LxCxE cleft pocket causes preferential cell death in Rbhigh M2 polarized or M2-like Rbhigh immunosuppressive TAMs by induction of ER stress, p53 and mitochondria-related cell death pathways.
View Article and Find Full Text PDFInt J Phytoremediation
September 2025
Innovative Food Technologies Development Application and Research Center, Gölköy Campus Bolu, Bioenvironment and Green Synthesis Research Group, Bolu Abant İzzet Baysal University, Bolu, Türkiye.
This study presents an eco-friendly approach for the green synthesis of manganese oxide nanoparticles (MnONPs) using () (einkorn wheat) seed extract as a reducing and stabilizing agent. The synthesized MnONPs were characterized by UV-Vis, XRD, FTIR, SEM-EDX, BET, and zeta potential analyses, which confirmed their crystalline nature, spherical morphology, and mesoporous structure with a surface area of 41.50 m/g.
View Article and Find Full Text PDFAlcohol Clin Exp Res (Hoboken)
September 2025
Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA.
Background: This study examined motivational pathways between internalizing symptoms (i.e., depression, anxiety, stress) and simultaneous alcohol and cannabis use among young adults.
View Article and Find Full Text PDF