Confirmation and Full-Length Sequence of the HLA-DQB1*05:305 Allele by Next-Generation Sequencing.

We report the confirmation and extension of the HLA-DQB1*05:305 allele detected in a Chinese individual.

Characterisation of the Novel HLA-DPB1*1763:01 Allele by Next-Generation Sequencing.

HLA-DPB1*1763:01 differs from DPB1*02:01:64 by a single nucleotide substitution in codon-14 of exon 1.

Telomere Shortening in Interstitial Lung Disease: Challenges and Promises.

Interstitial lung disease (ILD) is a group of diseases involving diffuse pulmonary parenchymal lesions and alveolar inflammation and interstitial fibrosis. Telomeres are repetitive DNA sequences at the end of chromosomes to maintain structural integrity and telomerase can prevent telomere shortening. Telomerase abnormalities such as related gene mutations lead to decrease in telomerase activity and telomere shortening.

Dynamics of serum tumor markers may indicate the progression of interstitial lung disease in Sjögren's syndrome patients: new roles for old friends.

A retrospective case-control study was designed to identify the characteristics and predictors of primary Sjögren's syndrome (pSS)-associated progressive fibrosing interstitial lung disease (ILD). Patients who diagnosed pSS-ILD were enrolled from Shanghai Tongji Hospital between January 1, 2015, and September 30, 2023. Relevant clinical data, including medical history, laboratory test results, and imaging findings, were collected at baseline.

Transcriptomic Changes and Pathological Mechanisms in Familial and Sporadic Idiopathic Restless Legs Syndrome: Implications for Inflammation and Cell Adhesion Molecules.

Purpose: Individuals affected by restless legs syndrome (RLS) tend to have familial predispositions without fully explained by genetic variants, and transcriptomic analysis may help elucidate the pathogenic mechanisms of RLS. The study aims to investigate transcriptomic changes and underlying pathological mechanisms in familial and sporadic idiopathic RLS to uncover potential contributors to its pathogenesis.

Patients And Methods: This study included 37 RLS patients, 39 unrelated healthy controls and 19 healthy relatives of RLS patients with a positive family history.

Confirmation and Full-Length Sequence of the HLA-DQA1*05:82 Allele Using Next-Generation Sequencing.

We report a confirmatory HLA-DQA1*05:82 allele detected in a Chinese individual.

A high FT3 level might protect bone mineral density among euthyroid type 2 diabetes mellitus patients.

Objectives: This research was to investigate the relationship among thyroid function, sensitivity to thyroid hormone indices, and bone mineral density (BMD) in euthyroid individuals with type 2 diabetes mellitus (T2DM).

Methods: A total of 536 euthyroid patients with T2DM were included. The subjects were measured for anthropometric parameters, biochemical indicators, and clinical characteristics.

Allele and Haplotype Frequencies of 17 HLA-Related Loci in Shenzhen Chinese Population by Next-Generation Sequencing.

Although the allele and haplotype frequencies of 11 HLA loci (HLA-A, B, C, DRB1, DRB3/4/5, DQA1, DQB1, DPA1 and DPB1) have been reported in different populations, rare studies have simultaneously assessed the allele distributions of non-classical HLA class I genes (HLA-E/F/G/H) and MICA/MICB together with the 11 classical HLA loci, or further analysed the haplotype frequencies covering the 17 loci. The present study aims to investigate the allele diversity and haplotype frequencies of 17 HLA-related loci including HLA genes and MICA/MICB simultaneously using a hybrid capture (HC)-based NGS method. A total of 358 HLA alleles including 177 class I and 137 class II alleles, as well as 29 MICA and 15 MICB alleles were identified in this project.

Risk factors and prognosis of acute ischemic stroke related restless legs syndrome.

Background: Recent studies suggest that stroke may be associated with an increased prevalence of restless legs syndrome (RLS) as a comorbidity or a risk factor. We aimed to explore the association between acute ischemic stroke (AIS) and RLS, and the possible pathogenesis of acute ischemic stroke related restless legs syndrome (AIS-RLS), for guiding its diagnosis and treatment.

Methods: In this single-center, prospective study, we identified consecutive AIS patients and segregated into AIS-RLS group and non-AIS-RLS group based on the diagnostic criteria of RLS.

Mechanistic insights into GLP-1 receptor agonist-induced weight loss through ceRNA network analysis.

Background: GLP-1 receptor agonists (GLP-1RA) have been extensively utilized in the management of body weight in individuals with obesity. Circular RNA (circRNA), a class of covalently closed RNA molecules, has garnered increasing attention for its potential role in the pathogenesis of obesity. However, the specific mechanisms through which circRNA contributes to GLP-1RA-induced weight loss remains elusive.

Identification of the Novel HLA-DQA1*05:01:16 Allele by Next Generation Sequencing in a Chinese Individual.

HLA-DQA1*05:01:16 differs from DQA1*05:01:01:01 by two nucleotide substitutions, one in exon 4 and one in intron 1.

Connecting the Dots: Telomere Shortening and Rheumatic Diseases.

Telomeres, repetitive sequences located at the extremities of chromosomes, play a pivotal role in sustaining chromosomal stability. Telomerase is a complex enzyme that can elongate telomeres by appending telomeric repeats to chromosome ends and acts as a critical factor in telomere dynamics. The gradual shortening of telomeres over time is a hallmark of cellular senescence and cellular death.

Breast cancer-targeted therapy and doxorubicin multidrug resistance are reversed via macrophage membrane-camouflaged liposomes.

Medication therapy is the primary treatment for breast cancer. However, many patients develop multidrug resistance (MDR), which complicates treatment and reduces its effectiveness. To address this, a novel approach was developed by combining the chemotherapeutic drug, doxorubicin (DOX), and the MDR reversal agent, tetrandrine (Tet), within degradable liposomes covered with macrophage membranes to create MM@DOX-Tet nanoparticles (NPs).

The novel non-classical HLA-G*01:55 identified in a Chinese individual.

The non-classical HLA-G*01:55 allele differs from G*01:01:12 at one position in exon 4.

MICB*002:06, a novel exonic variant of MICB (MHC class I chain-related gene B).

MICB*002:06 differs from MICB*002:01:01 by one nucleotide change at nucleotide 33 in exon 1 from C to T.

Integrated serum proteomic and N-glycoproteomic characterization of dengue patients.

Dengue fever is a mosquito-borne viral disease caused by the dengue virus (DENV). It poses a public health threat globally and, while most people with dengue have mild symptoms or are asymptomatic, approximately 5% of affected individuals develop severe disease and need hospital care. However, knowledge of the molecular mechanisms underlying dengue infection and the interaction between the virus and its host remains limited.

Functional significance of DNA methylation: epigenetic insights into Sjögren's syndrome.

Sjögren's syndrome (SjS) is a systemic, highly diverse, and chronic autoimmune disease with a significant global prevalence. It is a complex condition that requires careful management and monitoring. Recent research indicates that epigenetic mechanisms contribute to the pathophysiology of SjS by modulating gene expression and genome stability.

Tofacitinib in the treatment of primary Sjögren's syndrome-associated interstitial lung disease: study protocol for a prospective, randomized, controlled and open-label trial.

Introduction: Tofacitinib, a selective inhibitor of JAK1 and/or JAK3, is considered to alleviate the pulmonary condition of primary Sjögren's syndrome (pSS)-associated interstitial lung disease (ILD) through its anti-inflammatory and antifibrotic effects.

Methods And Analysis: This is a single-center, prospective, randomized, open-label trial. The trial will compare a 52-week course of oral tofacitinib with traditional therapy cyclophosphamide (CYC) combined with azathioprine (AZA) in the treatment of pSS-ILD.

Predicting cardiovascular risk in a Chinese primary Sjögren's syndrome population: development and assessment of a predictive nomogram.

Background: Patients with primary Sjögren's syndrome (pSS) are at increased risk of cardiovascular morbidity as compared with the general population.

Objectives: A retrospective study on 349 Chinese patients with pSS was conducted to identify potential risk factors for cardiovascular events and develop a cardiovascular risk nomogram.

Design: This is a retrospective observational study.

Chronic Epstein-Barr virus infection: A potential junction between primary Sjögren's syndrome and lymphoma.

Primary Sjögren's syndrome (pSS) is an autoimmune disease that targets exocrine glands, leading to exocrine dysfunction. Due to its propensity to infect epithelial and B cells, Epstein-Barr virus (EBV) is hypothesized to be related with pSS. Through molecular mimicry, the synthesis of specific antigens, and the release of inflammatory cytokines, EBV contributes to the development of pSS.

Predictors of poor prognosis in ANCA-associated vasculitis (AAV): a single-center prospective study of inpatients in China.

To identify potential predictors by assessing adverse outcomes in ANCA-associated vasculitis (AAV) patients. Eighty-nine untreated AAV patients were followed up to January 31, 2022, death, or loss of follow-up. Clinical characteristics, laboratory tests, treatment, and progress were collected, and disease activity was evaluated via Birmingham Vasculitis Activity Score (BVAS).

Potential Mechanisms of White Peony against Primary Sjögren's Syndrome Based on Network Pharmacology and Molecular Docking.

Background: Multiple system and organ damage occurs with the continuous progression of primary Sjögren's syndrome (pSS), and the lack of specific drugs against this disease is a huge challenge. White peony (WP), a widely used traditional Chinese herb, has been confirmed to have a therapeutic value in pSS. However, the specific mechanisms of WP in the treatment of pSS are unknown.

The Efficiency of Hydroxychloroquine for the Treatment of Primary Sjögren's Syndrome: A Systematic Review and Meta-Analysis.

This meta-analysis was conducted to evaluate the effects of hydroxychloroquine (HCQ) in the treatment of primary Sjögren's syndrome (pSS). Nine databases were searched for data collection. We used clinical features, including involvement in superficial tissues and visceral systems, and experimental findings, including Schirmer's test, unstimulated salivary flow rate (uSFR), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and immunoglobulins (IgG, IgM and IgA) as major outcome measures.