Transition Shock Among Nursing Interns: Roles of Achievement Motivation and Clinical Practice Environment-A Cross-Sectional Study.

Aims: To examine the relationships between achievement motivation, clinical practice environment and nursing interns' transition shock.

Design: A descriptive cross-sectional study with an online survey.

Methods: This study included 343 nursing interns from practice hospitals across six Chinese provinces.

Integration of Multi-Rotor and Multi-Conjugation: Ultrahigh Absorption Coefficient Dye Enables NIR-II Fluorescence Imaging-guided Photothermal Immunotherapy.

The progressive accumulation of mutated genes in cancer cells facilitates tumor immune escape. Photothermal immunotherapy addresses this problem by triggering immunogenic cell death (ICD) through photothermal treatment, releasing endogenous immunogenic neoantigens. Herein, guided by the "multi-rotor & multi-conjugation" concept, near-infrared region II (NIR-II) cyanine molecules are designed with varying numbers of benzene rotors.

CDC25A Alleviates Obstructive Sleep Apnea-Hypopnea Syndrome With Hypertension and Inhibits Ferroptosis.

Obstructive sleep apnea-hypopnea syndrome (OSAHS) is significantly correlated with hypertension. This investigation aimed to explore the effect of ferroptosis on OSAHS-hypertension. Ferroptosis-associated genes were screened based on the GSE205050 dataset and FerrDb database.

Comparative study of electrocardiogram-gated computed tomography (CT) and respiratory four-dimensional CT for radiotherapy in breast cancer patients.

Background: Theoretically, electrocardiogram-gated computed tomography (ECG-CT) can more precisely characterize the motion of a beating heart. However, cardiac motion involves both pulsatile cardiac activity and respiratory-induced movement. ECG-CT has high temporal resolution and fast scanning speed, requiring image acquisition to be completed within a single cardiac cycle.

Incidence and Risk Factors of Platinum-Based Chemotherapy-Induced Nausea and Vomiting: A Systematic Review and Meta-Analysis.

Background: Platinum-based chemotherapy significantly increases the risk of nausea and vomiting, which can impair the treatment's efficacy and the patient's quality of life. This meta-analysis examines the incidence and risk factors of platinum-based chemotherapy-induced nausea and vomiting (PINV) in patients treated with this chemotherapy.

Methods: This systematic review and meta-analysis were conducted in accordance with the PRISMA 2020 guidelines.

Artesunate carbon dots for attenuating periodontal inflammation and promoting bone regenerationviaactivation of AMPK.

Periodontitis, recognized as a chronic inflammatory condition, manifests through sustained gingival inflammation and gradual degradation of alveolar bone tissue. Without proper intervention, this pathological process may culminate in permanent tooth detachment. Consequently, therapeutic strategies for periodontitis primarily focus on mitigating inflammatory reactions and stimulating osseous tissue regeneration.

Assessing treatment accuracy of image-guided liver stereotactic body radiotherapy: a quantitative analysis based on 4D CT through post-therapeutic MRI-morphologic alterations.

Background: Stereotactic body radiotherapy (SBRT) has become a promising alternative for patients with inoperable liver cancer. However, the accurate delivery of high doses to moving liver tumors remains challenging. Treatment accuracy can be quantified by comparing post-radiotherapeutic magnetic resonance imaging (MRI)-morphologic alterations (MMA) and corresponding isodose-structure cropped to the liver (ISL) upon planning computed tomography (CT).

Prevalence of food and inhalant allergies in infants and children from the Nanhai area of Foshan city.

Background: The aim of our research was to explore the distribution characteristics of the most common food and inhalant allergens in children from Foshan city in Southwest China to provide evidence for the development of prevention and treatment strategies for allergic diseases in children.

Methods: A total of 635 children who attended the Sixth Affiliated Hospital, South China University of Technology, were included in our retrospective study from February 2013 to October 2019. The sensitivity of immunoglobulin E (IgE) for 20 allergens (10 inhalant allergens and 10 food allergens) was determined.

The combination of CA125, CA199, CEA, and AFP is an effective diagnostic biomarker for gastric cancer in elderly individuals.

Background: Serum tumour markers (TMs) such as alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), carbohydrate antigen 199 (CA199) and CA125 have been established as prognostic indicators for gastric cancer (GC); however, the diagnostic value of these markers for GC in older adults has yet to be examined. Therefore, this study aimed to explore the diagnostic and prognostic significance of AFP, CEA, CA199 and CA125 for GC in elderly individuals.

Methods: A total of 188 patients who visited The Sixth Affiliated Hospital, School of Medicine, South China University of Technology, from May 2021 to March 2024 were selected for this study.

Chondroitin sulfate-based dissolvable microneedles loaded with NIR-II photothermal and natural anticancer agents for synergistic melanoma therapy.

Melanoma is characterized by its aggressiveness, high metastatic potential, and numerous mutations, which limit the effectiveness of current treatments. To address this issue, we developed a dissolvable microneedle (MN) system composed of poly(2-ethyl-2-oxazoline) (PEtOz) and chondroitin sulfate (CS). This MN system was loaded with liposomes containing both a NIR-II photothermal small molecule (IRLy) and the natural anticancer agent Gambogic acid (GA), forming Lip(IRLy + GA) MNs.

Tellurium nanoparticles and Fucoidan-loaded dissolvable microneedles for combined photothermal therapy and anti-angiogenesis in melanoma treatment.

Melanoma, an aggressive skin tumor, is prone to metastasis, significantly reducing patient survival rates once it occurs. Tumor microvascularity is a key factor in metastasis, making the inhibition of microvascular formation crucial. Emerging photothermal therapy (PTT) and microneedles (MNs) have garnered attention due to their non-invasive and controllable nature.

ECG changes following balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension: a retrospective study.

Purpose: This research evaluates the effect of balloon pulmonary angioplasty (BPA) on cardiac electrophysiological changes in patients with chronic thromboembolic pulmonary hypertension (CTEPH).

Methods: Involving a retrospective analysis of 39 CTEPH patients (average age 61 ± 11), who had at least two BPAs and paired ECGs pre- and post-surgery, we examined changes in ECG indicators of right ventricular hypertrophy and their correlation with hemodynamic results.

Results: BPA yielded marked improvements in cardiac function and hemodynamics.

Downregulation of lncRNA XLOC_032768 in diabetic patients predicts the occurrence of diabetic nephropathy.

LncRNA XLOC_032768 is reported to prevent renal tubular epithelial cells from cisplatin-induced apoptosis, suggesting its involvement in the development of kidney injury. The present study aimed to explore the role of XLOC_032768 in diabetic nephropathy (DN). The present study enrolled a total of 140 healthy controls (Control group) and 140 patients with type 2 diabetes (Diabetes group).

External Stimuli-Responsive Strategies for Surface Modification of Orthopedic Implants: Killing Bacteria and Enhancing Osteogenesis.

Bacterial infection and insufficient osteogenic activity are the main causes of orthopedic implant failure. Conventional surface modification methods are difficult to meet the requirements for long-term implant placement. In order to better regulate the function of implant surfaces, especially to improve both the antibacterial and osteogenic activity, external stimuli-responsive (ESR) strategies have been employed for the surface modification of orthopedic implants.

Chitosan/NH-MIL-125 (Ti) scaffold loaded with doxorubicin for postoperative bone tumor clearance and osteogenesis: An in vitro study.

Surgical resection remains the primary treatment modality for bone tumors. However, it is prone to local bone defects and tumor recurrence. Therefore, there is an urgent need for multifunctional biomaterials that combine tumor treatment and bone repair after bone tumor surgery.

Efficacy and Cost-Effectiveness Analysis of Internet-Based Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder: Randomized Controlled Trial.

Background: Obsessive-compulsive disorder (OCD) is a common and chronic mental illness with a high rate of disability. Internet-based cognitive behavioral therapy (ICBT) makes online treatment available to patients and has been shown to be effective. However, 3-arm trials on ICBT, face-to-face cognitive behavioral group therapy (CBGT), and only medication are still lacking.

Inhibiting Osteolytic Breast Cancer Bone Metastasis by Bone-Targeted Nanoagent via Remodeling the Bone Tumor Microenvironment Combined with NIR-II Photothermal Therapy.

Bone is one of the prone metastatic sites of patients with advanced breast cancer. The "vicious cycle" between osteoclasts and breast cancer cells plays an essential role in osteolytic bone metastasis from breast cancer. In order to inhibit bone metastasis from breast cancer, NIR-II photoresponsive bone-targeting nanosystems (CuP@PPy-ZOL NPs) are designed and synthesized.

Successful chemotherapy with continuous immunotherapy for primary pulmonary endovascular epithelioid hemangioendothelioma: A case report.

Rationale: Epithelioid hemangioendothelioma (EHE) is a rare, low to moderate-grade malignancy, even less in pulmonary endovascular neoplasm. Patients with pulmonary EHE have no optimal treatment, resulting in poor prognoses.

Patient Concerns: We reported a 42-year-old man with multiple mild metabolic uptakes in pulmonary endovascular filling defect with a maximum standardized uptake value of 4.

Aloe polymeric acemannan inhibits the cytokine storm in mouse pneumonia models by modulating macrophage metabolism.

The cytokine storm is highly associated with inflammatory-type disease severity and patients' survival. Plant polysaccharides, the main natural phytomedicine source, have a great potential to be an effective drug to treat cytokine storm. Herein we found that a polymeric acemannan (ABPA1) isolated from Aloe Vera Barbadensis extract C (AVBEC) exerted prominent inhibitory effects on inflammation-induced cytokine storm.

Ag nanoparticles/PbTiO with in-situ photocatalytic process and its application in an ultra-sensitive molecularly imprinted hemoglobin detection.

An electrochemical sensor based on loading molecularly imprinted polymers (MIP) on the material surface can improve the specificity towards the object. In this work, a T-shaped PbTiO with a high active-exposed (110) facet was prepared by a hydrothermal process. Then, Ag nanoparticles (Ag NPs) modified T-shaped PbTiO was obtained by in-situ photocatalytic reduced method under UV irradiation, where a hetero-junction was formed with a well lattice matching between the (111) facet of Ag and the (110) facet of PbTiO.

An acetylated mannan isolated from Aloe vera induce colorectal cancer cells apoptosis via mitochondrial pathway.

The anti-cancer effects of Aloe vera barbadensis extract C (AVBEC) have been demonstrated in a previous study. However, the specific functional ingredient and mechanism remain undefined. This study aimed to evaluate the function and associated mechanisms of purified polysaccharide (ABPA1) from AVBEC on colorectal cancer.

Development and validation of a novel mitophagy-related gene prognostic signature for glioblastoma multiforme.

Background: Glioblastoma multiforme (GBM) is one of the most malignant tumors in brain with high morbidity and mortality. Mitophagy plays a significant role in carcinogenesis, metastasis, and invasion. In our study, we aim to construct a mitophagy-related risk model to predict prognosis in GBM.

Copper fumarate with high-bifunctional nanozyme activities at different pH values for glucose and epinephrine colorimetric detection in human serum.

Metal-organic frameworks (MOFs) have attracted extensive attention for the development of colorimetric detection methods due to their ease of modification and high density of active sites. However, most of the reported colorimetric sensors based on MOFs show only a single nanozyme activity. Herein, the bifunctional enzyme activities of a hexagonal prism Cu MOF with fumaric acid as the ligand (Cu FMA), namely laccase-like activity under alkaline conditions (pH = 8) and peroxidase-like activity under acidic conditions (pH = 4), were verified.

Study of differences between patients with schizophrenia and healthy people in semantic processing.

Semantic processing is important in language comprehension and production, and context can facilitate understanding and accelerate processing speed by pre-activating semantically related words. There are many studies suggesting that patients with schizophrenia have inferior language ability. This study was aimed to examine the differences between patients with schizophrenia and healthy people in semantic processing with Chinese classifier-noun pairs rating tasks.

Meso-tetra(4-sulfonatophenyl)porphyrin silver/Ag nanoparticles/graphene-phase CN with a sandwich-like structure and double-faced active centers two-step room-temperature photocatalytic synthesis for ractopamine detection.

Photochemical synthesis under visible light irradiation is a novel approach in the field of green chemistry, and composites with abundant active centers for electrochemical detection are highly attractive. Herein, a meso-tetra(4-sulfonatophenyl)porphyrin silver/Ag nanoparticles/graphene phase CN nanosheets (AgTPPS/AgNPs/ng-CN) material with a sandwich-like structure was synthesized using a two-step photocatalytic reaction at room temperature (25 °C). In the first visible light irradiation step and in the presence of a hole capture agent, Ag ions were photocatalytically reduced onto the surface of ng-CN that was used as a photocatalyst.