How parents of children with musculoskeletal disorder use short videos for seeking health information and support: A qualitative study.

Background: Short videos are a way that parents get health information. It is unclear how people seek health information in short videos on musculoskeletal conditions in children.

Objective: To investigate the health information needs of parents of children with musculoskeletal disorders and to examine the factors that influence their perceptions of that information.

Applications and Assessment of Social Media in Pediatric Orthopedics: Scoping Review.

Background: With the continuous advancement of science and technology, the demand for health knowledge about pediatric orthopedics is also gradually growing. The traditional paper-based and multimedia health education models can no longer fully meet the needs of society. Fortunately, the emergence of social media has mitigated the problem of insufficient medical education resources.

Sex disparities in papillary thyroid cancer survival: Divergent patterns of relative and absolute effects across the age spectrum.

Purpose: This retrospective cohort study aimed to reevaluate the prognostic impact of sex and determine whether age modifies the effect of sex on cancer-specific survival (CSS) in PTC patients.

Methods: Data for PTC patients diagnosed between 2004 and 2015 were retrieved from the SEER database. The primary outcome was CSS.

Survey on the current status of statistical cognition and teaching needs of Chinese medical students.

Purpose: To assess medical students' needs regarding statistics education and inform potential reforms in medical statistics teaching.

Method: A self-administered questionnaire survey was conducted among 274 medical students from five Chinese institutions. The survey evaluated students' attitudes toward statistics, their perceived mastery of statistical knowledge, and their perspectives on current teaching methods and desired improvements.

Rubia cordifolia L. extract ameliorates vitiligo by inhibiting the CXCL10/CXCL9/STAT1 signaling pathway.

Ethnopharmacological Relevance: Rubia cordifolia L. (RCL) is a traditional herbal medicine with a long history of use. It has been employed to treat conditions such as abnormal uterine bleeding, primary dysmenorrhea, allergic purpura, eczema, and psoriasis.

promotes liver regeneration by increasing -hydroxybutyric acid (BHB) production and BHB-driven STAT3 signals.

The liver regenerative capacity is crucial for patients with end-stage liver disease following partial hepatectomy (PHx). The specific bacteria and mechanisms regulating liver regeneration post-PHx remain unclear. This study demonstrated dynamic changes in the abundance of () post-PHx, correlating with hepatocyte proliferation.

Integrated widely targeted metabolomics and flavoromics reveal processing-driven dynamic changes in functional metabolites of leaf tea.

This study employed a widely targeted metabolomics approach combined with flavoromics evaluation to systematically analyze dynamic metabolic variations under four processing techniques: fresh EUL (XY), traditionally dried EUL (HG), green tea processed EUL (GT), and black tea processed EUL (BT). A total of 1839 non-volatile metabolites and 289 volatile metabolites were identified. Key affected metabolites included amino acids (e.

Interictal suppression in patients with mesial temporal lobe epilepsy: A simultaneous PET/fMRI study.

Previous stereotactic-electroencephalography (SEEG) results have suggested that seizure-onset zones (SOZs) could be suppressed by strengthened inward connectivity from the rest of the brain during interictal periods, which might explain why people with epilepsy did not have seizures continuously. However, the limited coverage of SEEG contacts and allocation bias hindered a more comprehensive survey of interictal suppression at the whole-brain level. Previous studies also lacked a direct comparison between patients and healthy controls due to the invasive nature of SEEG.

Evaluation of the measurement properties of online health information quality assessment tools: A systematic review.

Objectives: This study aimed to evaluate the measurement properties and methodological quality of instruments developed to evaluate the quality of online health information.

Methods: In this study, a systematic search was conducted across a range of databases, including the China National Knowledge Infrastructure (CNKI), Wanfang, China Science and Technology Journal (VIP), SinoMed, PubMed, Web of Science, CINAHL, Embase, the Cochrane Library, PsycINFO, and Scopus. The search period spanned from the inception of the databases to October 2023.

Pregnane X receptor alleviates sepsis-induced liver injury through activation of yes-associated protein in mice.

The severity of sepsis is attributed to excessive inflammatory responses leading to liver injury. Pregnane X receptor (PXR), a nuclear receptor that controls xenobiotic and endobiotic metabolism, has been implicated in regulating inflammation and liver regeneration. This study aimed to investigate the role of PXR in sepsis-induced liver injury and the underlying mechanisms.

Direct and Indirect Effects of Risk Perception and Risk Information on PTSD in Frontline Healthcare Workers.

Background: The COVID-19 Delta variant caused an outbreak in Guangdong in mid-May 2021. The risk information and risk perception of COVID-19 have been considered factors associated with mental health statuses, especially posttraumatic stress disorder (PTSD), in frontline healthcare workers.

Objective: The aim of this study is to investigate the interactive relationship in risk information and risk perception of COVID-19 and PTSD in healthcare personnel from the emergency department.

Clinical validation and optimization of machine learning models for early prediction of sepsis.

Introduction: Sepsis is a global health threat that has a high incidence and mortality rate. Early prediction of sepsis onset can drive effective interventions and improve patients' outcome.

Methods: Data were collected retrospectively from a cohort of 2,329 adult patients with positive bacteria cultures from a tertiary hospital in China between October 1, 2019 and September 30, 2020.

Development and validation of an explainable machine learning model for mortality prediction among patients with infected pancreatic necrosis.

Background: Infected pancreatic necrosis (IPN) represents a severe complication of acute pancreatitis, commonly linked with mortality rates ranging from 15% to 35%. However, the present mortality prediction tools for IPN are limited and lack sufficient sensitivity and specificity. This study aims to develop and validate an explainable machine learning (ML) model for death prediction among patients with IPN.

Utilizing explainable machine learning for progression-free survival prediction in high-grade serous ovarian cancer: insights from a prospective cohort study.

Background: High-grade serous ovarian cancer (HGSOC) remains one of the most challenging gynecological malignancies, with over 70% of ovarian cancer patients ultimately experiencing disease progression. The current prognostic tools for progression-free survival (PFS) in HGSOC patients have limitations. This study aims to develop an explainable machine learning (ML) model for predicting PFS in HGSOC patients.

Screening, identification, and mechanism of novel antioxidant peptides in walnut meal under aerobic stress.

Walnut (Juglans regia L.) meal, being the primary by-product of walnut oil processing, is rich in high-quality proteins and of significant potential for development and utilization. The study used multi-stage gradient purification, liquid-quantity chromatography, and computerized virtual screening to isolate and characterize antioxidant peptides from walnut meal.

The status of China's international division of labour from Marx's theory of international value.

Based on Marx's theory of international value, this paper analyzes the carrier of unequal exchange and the path of international transfer of surplus value, constructs an international division of labour status index by comprehensively observing the organic composition of capital in the export and import sectors, and tries to accurately grasp the characteristics of the current international division of labour pattern coexisting between horizontal products and vertical products. At the same time, based on the data of all available HS92 six-digit code categories in various countries in the world from 1993 to 2016, the level of international division of labour in China is empirically analysed. The results show that: (1) there is no breakthrough in the situation of China's low status of international division of labour; (2) the high capital-organic composition of the import sector is the main reason for the low status of international division of labour; (3) the continuous decline in the absolute value of captured surplus is a global phenomenon; (4) WTO accession has not significantly improved the status of international division of labour.

Schisandrol B alleviates depression-like behavior in mice by regulating bile acid homeostasis in the brain-liver-gut axis via the pregnane X receptor.

Background: Depression is a widely recognized neuropsychiatric disorder. Recent studies have shown a potential correlation between bile acid disorders and depression, highlighting the importance of maintaining bile acid balance for effective antidepressant treatment. Schisandrol B (SolB), a primary bioactive compound from Schisandra chinensis (Turcz.

Chiral Cobalt Nanocluster-Driven Chemiluminescent System for the Facile Discrimination of Carnitine Enantiomers with a Hydrogel-Assisted Strategy.

Facile chiral discrimination without relying on chromatographic techniques has long been a huge challenge due to the minimal differences in the physicochemical properties of enantiomers. Polysaccharide hydrogels with natural chiral selectivity can be promising materials for constructing chiral discrimination platforms. In this study, l-cysteine-induced cobalt nanoclusters (LC-CoNCs) were prepared and utilized as chiral nanozymes for promoting the chemiluminescent (CL) signal of a luminol-HO system.

Pregnane X receptor activation promotes hematopoiesis during liver regeneration by inducing proliferation of hematopoietic stem and progenitor cells in mice.

Liver regeneration is a complex process that involves the recruitment of bone marrow (BM)-derived hematopoietic stem and progenitor cells (HSPCs). Pregnane X receptor (PXR), also known as NR1I2, is an important regulator for liver enlargement and regeneration. However, the role of PXR activation in hematopoiesis during liver regeneration remains unclear.

BRAF V600E mutation in thyroid carcinoma: a large-scale study in Han Chinese population.

Background: The prevalence of genetic mutations in thyroid cancer varies significantly among different ethnic backgrounds. The present study aimed to investigate the clinical potential of BRAF V600E in a large group of homogenous Han Chinese patients.

Methods: From 2018 to 2021, 6232 thyroid disease patients who underwent thyroidectomy at our hospital were enrolled.

Receivers' responses are integrated into costly third-party punishment in a way that interacts with the unfairness of allocations.

Costly third-party punishment (TPP) is an effective way to enforce fairness norms and promote cooperation. Recent studies have shown that the third party considers not only the proposer's suggested allocation but also the receiver's response to the allocation, which was typically ignored in traditional TPP studies when making punishment decisions. However, it remains unclear whether and how the varying unfair allocations and receivers' responses are integrated into third-party punishment.

Robust Luminescent Pyrene-Based Metal-Organic Framework Hydrogel as a pH-Responsive Fluorescence Emitter for Sensitive Immunoassay of Cardiac Troponin I.

Despite many luminescent advantages including outstanding absorption coefficient and high quantum yield, pyrene and its derivatives have been suffering from a dramatic aggregation-caused quenching (ACQ) effect. Although the dramatic ACQ effect of pyrene-based fluorophores has been restrained in pyrene-doped metal-organic frameworks (MOFs), the low loading of fluorescent (FL) units substantially impedes the improved luminescent behaviors. Herein, pyrene-based MOFs hydrogel was synthesized with a high loading of pyrene as the unique organic linker blocks instead of a dopant in MOFs.