Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Ethnopharmacological Relevance: Rubia cordifolia L. (RCL) is a traditional herbal medicine with a long history of use. It has been employed to treat conditions such as abnormal uterine bleeding, primary dysmenorrhea, allergic purpura, eczema, and psoriasis. In Uyghur traditional medicine, it is also utilized to manage vitiligo, tinea, skin scars, and inflammatory wounds. However, the precise mechanism through which RCL improves vitiligo is still not fully understood.
Aim Of The Study: This research sought to examine the therapeutic impacts of RCL on vitiligo, determine whether its effects on the progression of vitiligo are facilitated via the CXCL10/CXCL9/STAT1 pathway, and perform an analysis of the chemical composition along with the identification of RCL.
Materials And Methods: Chemical composition identification of RCL extract was performed using UHPLC-QTOF-MS/MS. A mouse model of vitiligo was created to assess the therapeutic effectiveness of RCL by analyzing the expression of CD8 T cells, performing HE staining, conducting melanin staining, evaluating TYR activity, and measuring the levels of inflammatory cytokines. Transcriptomic and metabolomic analyses were conducted to explore the mechanisms underlying RCL-mediated improvement of vitiligo.
Results: A total of 156 compounds were identified in RCL, predominantly including anthraquinones, naphthoquinones, and terpenoids. RCL treatment significantly reduced CD8 T cell expression, downregulated expression of cytokines that promote inflammation, and upregulated TYR activity and melanin production. Transcriptomic and metabolomic analyses identified the CXCL10/CXCL9/STAT1 signaling pathway and the metabolism of lysophosphatidylcholine and leukotriene B4 as key mechanisms underlying RCL's therapeutic effects on vitiligo, indicating that RCL ameliorates vitiligo by modulating autoimmunity and attenuating inflammatory responses. Western blotting and qPCR further validated that RCL inhibits the production of proteins linked to the CXCL10/CXCL9/STAT1 axis, including CXCL10, CXCL9, STAT1, and CXCR3. Additionally, RCL reduced the expression of inflammatory markers such as IL-1RAP, IL-6, IL-17A, KNG1, and PLA2G4E, further supporting its anti-inflammatory and immunoregulatory properties.
Conclusions: Our study demonstrates that RCL ameliorates the progression of vitiligo by modulating autoimmunity and attenuating inflammatory responses. The underlying mechanisms may involve mediating the CXCL10/CXCL9/STAT1 axis and regulating lysophosphatidylcholine and leukotriene B4 metabolism.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jep.2025.120027 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The complex role of financial hardship in understanding depression among youth in Uganda.
J Affect Disord
September 2025
California State University, San Bernardino, United States of America.
Background: Financial stability plays a crucial role in individuals' mental well-being, with emerging evidence suggesting a complex relationship between financial factors and depression. This study addresses three fundamental questions: (1) what is the relationship between financial stability and depression? and (2) To what extent is the relationship mediated by financial hardship? and (3) do these possible relationships differ by adolescents' age and gender?
Methods: A structural equation modeling (SEM) was conducted to examine the relationship between finance and depression using four variables: family income, diversified savings, financial hardship, and depression. The measurement of variables and structural models χ/df ratio < 1; root mean square error of approximation (RMSEA) ≤ 0.
Collectin-11 promotes fibroblast proliferation and modulates their activation status and extracellular matrix synthesis.
Front Immunol
September 2025
Department of Critical Care Medicine, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Introduction: Collectin-11 (CL-11), a recently described soluble C-type lectin, has been shown to stimulate cell proliferation in fibroblasts and melanoma cells. However, its broader influence on fibroblast functions and the specific receptors mediating CL-11's effects remain to be elucidated.
Methods: The EDU proliferation assay and WB detection of PCNA protein levels were used to evaluate the fibroblast proliferative effect after CL-11 stimulated.
Pepscan and bioinformatic strategies for identification of potential B-cell epitopes for a peptide-based vaccine for tick control.
Mol Biochem Parasitol
September 2025
Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul (UFRGS), RS, Brazil; Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular (INCT-EM), Rio de Janeiro, RJ, Brazil; Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS), RS, Brazil. Electronic add
The cattle tick Rhipicephalus microplus poses a major problem to the livestock industry worldwide, with acaricides resistance presenting an increasing challenge. On other hand, vaccination has been suggested as a better strategy for tick control, and peptide-based vaccines could be developed to target multiple tick antigens. Nevertheless, there are still limitations to the identification of epitopes in tick candidate antigens, as the bioinformatics tools currently available were developed almost exclusively based on mammalian genomes.
View Article and Find Full Text PDFAssociations between recreational cannabis legalization and cannabis use disorder treatment outcomes in California, 2010-2021.
J Cannabis Res
August 2025
Department of Addiction Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, 10911 Weyburn Avenue, Suite 200, Los Angeles, CA, 90024, USA.
Background: Despite extensive research on the broader effects of recreational cannabis legalization (RCL), limited attention has been given to its impact on cannabis use disorder (CUD) treatment outcomes. This study addresses this gap by analyzing CUD treatment outcomes, including 90-day treatment retention and successful discharge.
Methods: Data were collected from a dataset of all publicly funded cannabis use disorder treatment delivered in California between January 2010 and December 2021 ( = 192,580).
Less is more: Improving cell-type identification with augmentation-free single-cell RNA-Seq contrastive learning.
Bioinformatics
August 2025
School of Computing and Mathematical Sciences, Birkbeck, University of London, London, WC1E 7HX, United Kingdom.
Motivation: Cell-type identification is one of the most important tasks in single-cell RNA-Seq analysis. Recent research has revealed contrastive learning's great potential in handling multiple cell-type identification tasks.
Results: In this work, we proposed a novel augmentation-free single-cell RNA-Seq contrastive learning (AF-RCL) algorithm, which simplifies the conventional data augmentation operation and adopts a new contrastive learning loss function.