A Bivalent mRNA Vaccine Efficiently Prevents Gammaherpesvirus Latent Infection.

: It is still challenging to develop effective vaccines against tumorigenic human gammaherpesviruses such as Epstein-Barr virus (EBV). A major obstacle is the lack of a small animal model that reproduces the natural infection course of human gammaherpesviruses to allow for proper assessment of vaccine efficacy. Murine gammaherpesvirus 68 (MHV68) is a natural pathogen of wild rodents and laboratory mice and therefore can be used as a surrogate for human gammaherpesviruses to evaluate vaccination strategies.

Coordinated Dual-Fin Actuation of Bionic Ocean Sunfish Robot for Multi-Modal Locomotion.

This paper presents a bionic dual-fin underwater robot, inspired by the ocean sunfish, that achieves multiple swimming motions using only two vertically arranged fins. This work demonstrates that a mechanically simple platform can execute complex 2-D and 3-D motions through advanced control strategies, eliminating the need for auxiliary actuators. We control the two fins independently so that they can perform cooperative actions in the water, enabling the robot to perform various motions, including high-speed cruising, agile turning, controlled descents, proactive ascents, and continuous spiraling.

Results of the ACCOuNT Trial: A Multi-Institutional Prospective Pharmacogenomics Implementation Trial for African American Inpatients.

Pharmacogenomics implementation efforts have increased over the last decade, but no published prospective pharmacogenomics trials have formally evaluated utility in underrepresented populations. We present final results from the ACCOuNT trial, a multi-institutional prospective study [NCT03225820] in which African American inpatients were genotyped and pharmacogenomic results made available via an integrated, scalable pharmacogenomics clinical decision support (PGx CDS) system to guide prescribing. We hypothesized that PGx CDS utilization would improve genomically concordant prescribing during inpatient admissions.

Unraveling the role of discoidin domain receptors as an anti-fibrotic target in various organs: A comprehensive review.

Discoidin domain receptors (DDRs) are a family of tyrosine kinase transmembrane receptors composed of discoidin domain receptor 1 (DDR1) and discoidin domain receptor 2 (DDR2) that interact with components of the extracellular matrix. They are involved in a broad range of important physiological processes, such as extracellular matrix signaling, cell adhesion, cell migration, and tissue fibrosis. DDR1 and DDR2 are expressed in a variety of cell and tissue types, but their expression patterns are variable and dependent on receptor type and physiological environment.

[Retracted] miR-372 promotes breast cancer cell proliferation by directly targeting LATS2.

[This retracts the article DOI: 10.3892/etm.2018.

A new species of karst-adapted gecko (Squamata, Gekkonidae, ) from Guangxi, southern China.

A new species of the genus Laurenti, 1768, , is described based on six specimens from Fengshan County, Hechi City, Guangxi Zhuang Autonomous Region, China. It is placed into the subgenus Japonigekko based on morphological and molecular phylogenetic analyses, and distinguished from consubgeners of by a combination of morphological characters in body size, cephalic proportions, and pholidosis features. Molecular phylogenetic analyses using mitochondrial 16S and ND2 sequences reveal that sp.

Prediction of the efficacy and clinical prognosis of first-line EGFR-tyrosine kinase inhibitors in non-small cell lung cancer patients based on ΔCt values derived from the super-amplification refractory mutation system (ARMS): a real-world retrospective study.

Background: Lung cancer, especially non-small cell lung cancer (NSCLC), is a leading cause of cancer mortality. Epidermal growth factor receptor (EGFR) mutations drive NSCLC progression but also sensitize tumors to EGFR-tyrosine kinase inhibitors (TKIs). However, the response rate to targeted therapy is only 70%, and most patients experience disease progression 9 to 14 months after first- or second-generation EGFR-TKI treatment.

Knockdown of MIR205HG prevents cell proliferation, migration and invasion through autophagy and ferroptosis pathways in lung adenocarcinoma.

Background: The MIR205 host gene (MIR205HG) has been reported to play important roles in various cancers. However, its role in the occurrence and development of lung cancer remains to be clarified. This study aimed to analyze the function and molecular mechanisms of MIR205HG in lung adenocarcinoma (LUAD).

A case of intestinal MALT lymphoma characterized by diffuse capillary hyperplasia nodules with hemorrhage.

A 52-year-old man presented to our department, complaining of recurrent episodes of hematochezia for half a month. Colonoscopy showed diffuse nodular mucosal eminences of approximately 2-3 mm in size in the colorectum and terminal ileum, presenting a "cobblestone" appearance, with visible capillary hyperplasia that are prone to rupture and bleeding upon light touch. Narrow-band imaging (NBI) showed that the hyperplastic capillaries presented "root-like" branching.

Peanut 9--epoxycarotenoid Dioxygenase Enhances Salt and Drought Stress Tolerance by Regulating ROS Homeostasis.

Peanut ( L.), a vital oilseed and cash crop, faces yield limitations due to abiotic stresses. The 9--epoxycarotenoid dioxygenase (NCED) enzyme, a key enzyme in abscisic acid (ABA) biosynthesis regulating plant development and stress responses, remains mechanistically uncharacterized in peanut abiotic stress tolerance.

Integration of Transcriptomics and Metabolomics Reveals Mechanisms of High-Temperature Stress Tolerance in the Hepatopancreas of .

High temperatures in summer often trigger disease outbreaks in shrimp, resulting in significant economic losses. To investigate the heat tolerance mechanisms of , juvenile tiger shrimp were subjected to a high-temperature stress of 38 °C for 144 h. The cumulative survival rate of shrimp sharply decreased to 5.

LncRNA ZFAS1 Combined with SRSF1 Regulate CNPY2 Expression and Leads to Microglia Endoplasmic Reticulum Stress-Induced Spinal Cord Injury.

Spinal cord injury (SCI) has a high mortality and disability rate. Endoplasmic reticulum (ER) stress induces neuronal apoptosis and participates in the regulation of SCI. LncRNA ZFAS1 can participate in the regulation of SCI by influencing ER stress; however, its mechanism is worth further exploring.

A Novel Rail Damage Fault Detection Method for High-Speed Railway.

With the vigorous development of speedy railway technology, steel rails, as an important structural infrastructure in speedy railways, play a crucial role in ensuring the safety of the entire speedy railway operation. A brand-new type of speedy rail inspection robot and its fault detection method are proposed to solve a number of problems, such as the difficulty and low accuracy of real-time online detection of rail defects and damage in speedy railways. The brand-new rail inspection robot is driven by two drive wheels and adopts a standard rail gauge of 1435 mm, which ensures its speedy and smooth operation on the track as well as accurate motion posture information.

Biomimetic Hydrofoil Propulsion: Harnessing the Propulsive Capabilities of Sea Turtles and Penguins for Robotics.

This review synthesizes current research on hydrofoil-propelled robots inspired by the swimming mechanisms of sea turtles and penguins. It begins by summarizing the swimming kinematics of these organisms, highlighting their superior aquatic performance as the primary motivation for biomimetic design. Next, established analytical methods for characterizing hydrofoil locomotion patterns are presented, along with a clear delineation of the decoupled motion components exhibited by sea turtle flippers and penguin wings.

IGF2BP3-regulated circPLEKHH2 promotes autophagy via AKT/mTOR signaling pathway to suppress lung adenocarcinoma progression.

Lung adenocarcinoma (LUAD) is the most common malignant tumor in the lung. Circular RNAs (circRNAs) play critical roles in cancer progression. However, the functions and mechanisms of circPLEKHH2 in regulating cancer progression and autophagy in LUAD are largely unknown.

Alcids-like flapping wing for exploring the role of wing folding in underwater locomotion.

Alcids showcase excellent aerial-aquatic locomotion abilities benefitting from the morphing wing. In the aerial environment, alcids fully extend their wings, while underwater, they partly fold the wings. In this article, we mimicked the wing morphology of the alcids family to explore the hydrodynamic advantage of the folded configuration in the aquatic environment and four three-dimensional-printed wings including any combination of with feather or without feather, and extended or folded were created.

Correction: Silencing of the long non-coding RNA LINC00265 triggers autophagy and apoptosis in lung cancer by reducing protein stability of SIN3A oncogene.

[This corrects the article DOI: 10.32604/or.2023.

Endoscopic misdiagnosis of a polypoid gastric neuroendocrine neoplasm: literature review.

A 75-year-old man presented to our department, complaining of recurrent abdominal pain for the past month. Esophagogastroduodenoscopy (EGD) revealed a single 0.6 cm polypoid lesion, classified as Yamada Type II, at the lesser curvature of the lower body of the stomach.

Care Team Attributes Predict Likelihood of Utilizing Pharmacogenomic Information During Inpatient Prescribing.

Medication prescribing is imperfect, and unintended side effects complicate patient care. Pharmacogenomics (PGx) is an emerging solution that associates genotypes with personalized drug-related outcomes, but it has not been widely adopted. We hypothesize that patient and provider attributes may predict and promote PGx utilization.

Human regulatory B cells suppress autoimmune disease primarily via interleukin-37.

Regulatory B cells (Bregs) are crucial for maintaining homeostasis and controlling inflammation. Although interleukin (IL)-10 has been traditionally suggested as the primary suppressive mechanism of Bregs in both mice and humans, the key functional differences between Bregs in these two species, particularly in the context of disease, is still largely unresolved. IL-37, the latest described immunosuppressive cytokine, is produced in humans but not in mice.

CT manifestations of primary esophageal tuberculosis.

Background: Primary esophageal tuberculosis is an uncommon manifestation of Mycobacterium tuberculosis infection in Asian adults, often presenting with nonspecific symptoms that can complicate diagnosis. This report details a case of primary esophageal tuberculosis in middle age female, emphasizing the diagnostic value of computed tomography (CT) imaging.

Case Presentation: The patient, a 46-year-old female from Sichuan Province, China, experienced recurrent choking and mild retrosternal pain postprandially.

Polarization-independent dual-band quasi-bound states in the continuum based on graphene metasurface for tunable THz sensing application.

To catch high quality (Q) factors is always pursued for optical resonators. In this study, polarization-independent dual-band quasi-bound states in the continuum (quasi-BIC) in a graphene-based metasurface is proposed for the first time in the terahertz regime. The quasi-BIC resonance modes with a Q factor of 176 is achieved by introducing symmetry breaking into the unit structure.

Growth arrest and DNA damage-inducible 45: a new player on inflammatory diseases.

Growth arrest and DNA damage-inducible 45 (GADD45) proteins are critical stress sensors rapidly induced in response to genotoxic/physiological stress and regulate many cellular functions. Even though the primary function of the proteins is to block the cell cycle, inhibit cell proliferation, promote cell apoptosis, and repair DNA damage to cope with the damage caused by internal and external stress on the body, evidence has shown that GADD45 also has the function to modulate innate and adaptive immunity and plays a broader role in inflammatory and autoimmune diseases. In this review, we focus on the immunomodulatory role of GADD45 in inflammatory and autoimmune diseases.

Gadd45γ alleviates collagen-induced arthritis by increasing IL-10 level and suppressing JNK activity.

It has been shown that Gadd45β alleviated K/BxN serum-induced arthritis, but in collagen-induced arthritis (CIA), it exacerbated joint inflammatory response, clinical signs, and symptoms. So far, the function of Gadd45γ in arthritis remains to be explored. This study aimed to investigate the role and immune regulatory mechanism of Gadd45γ in arthritis by intra-articular injection of a lentiviral vector encoding the Gadd45γ gene (LV-Gadd45γ) or lentiviral vectors (LV).

Predicting Chern numbers in photonic crystals using generative adversarial network-based data augmentation.

The Chern number is the core of topological photonics, which is used to describe the topological properties of photonic crystals and other optical systems to realize the functional transmission and the control of photons within materials. However, the calculation process of Chern numbers is complex and time-consuming. To address this issue, we use the deep learning accompanied with Maxwell's equations to predict the Chern number of a two-dimensional photonic crystal with a square lattice in this paper.