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[This corrects the article DOI: 10.32604/or.2023.030771.].
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http://dx.doi.org/10.32604/or.2024.061822 | DOI Listing |
Crit Rev Oncol Hematol
September 2025
Student Research Committee, Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.. Electronic address:
Epigenetic regulation is fundamental to hematopoiesis, influencing stem cell fate, lineage commitment, and the development of hematologic diseases. Recent technological innovations have transitioned from traditional genetic editing towards programmable, reversible epigenetic modulation without altering the DNA sequence. This review explores the evolution of epigenetic editing platforms, from zinc finger proteins and TALEs to the transformative CRISPR-dCas9 system, and introduces next-generation technologies leveraging dCas12, dCas13, and modular RNA-guided systems.
View Article and Find Full Text PDFVestn Otorinolaringol
September 2025
Sverzhevsky Research Clinical Institute of Otorhinolaryngology, Moscow, Russia.
Hearing plays a key role not only in the perception of information from the environment and the formation of speech, but also in social construction, communication and the maintenance of important cognitive functions. At the same time, persistent hearing loss can lead to cognitive disorders and dementia, as well as central auditory dysfunction. Subjective methods of hearing research were used - pure tone threshold audiometry (PTA), speech audiometry in silence and noise; and objective diagnostics - recording of long-latency auditory evoked potentials (LLAEP).
View Article and Find Full Text PDFJ Am Coll Cardiol
August 2025
Department of Cardiology, University of California-San Francisco, San Francisco, California, USA.
Background: Symptomatic nonobstructive hypertrophic cardiomyopathy (nHCM) lacks approved therapies. The ODYSSEY-HCM trial (A Study of Mavacamten in Non-Obstructive Hypertrophic Cardiomyopathy; NCT05582395), the largest to date in HCM patients, evaluating the efficacy of mavacamten in symptomatic adults with nHCM, did not demonstrate improvements in its primary endpoints (functional capacity and patient-reported health status).
Objectives: This exploratory analysis of the phase 3, randomized, placebo-controlled trial evaluated echocardiographic changes in nHCM patients from baseline to week 48.
ACS Nanosci Au
August 2025
Center for Nanomedicine and Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.
Cancer is commonly caused by a gain of function in proto-oncogenes and a simultaneous loss of function in tumor suppressor genes. Advanced prostate cancer (PCa) is often linked with changes in the activity or expression of phosphatase and tensin homologue deleted on chromosome 10 (PTEN), a well-known tumor suppressor, and androgen receptor (AR), a pro-tumorigenic transcription factor. However, no therapies exist for the simultaneous correction of tumorigenic promotion and suppressor depletion.
View Article and Find Full Text PDF