Oncostatin M Drives Th2 Polarized Allergic Airway Inflammation Through Fibroblast Reprogramming and Endoplasmic Reticulum Stress.

Background: Allergic airway inflammation, characterized by Th2 cytokine production and eosinophilic infiltration, is a hallmark of asthma. The airway epithelium plays a pivotal role in orchestrating allergic responses by releasing cytokines such as oncostatin M (OSM). This study investigates the role of OSM in dust mite extract (DME)-induced allergic airway inflammation and identifies a novel mechanism by which OSM drives Th2-polarized inflammation.

TRIM28 mediates Mettl5 ubiquitination to promotes Th2 polarization.

Background: Th2 polarization is the primary characteristic of airway allergy (AA) and many other immune disorders. Further elucidation of its mechanism is necessary. The immune cells of patients with immune diseases have been found to have abnormal epigenetic status.

Quercetin improves macrophage immune regulatory functions to alleviate airway Th2 polarization.

Background: Th2 polarization is a central driver of allergic airway inflammation, yet the epigenetic mechanisms underlying its dysregulation remain poorly defined. Quercetin is a bioactive flavonoid with immunomodulatory properties. This study investigates whether quercetin alleviates Th2-driven pathology in allergic airway inflammation by targeting IL-10 promoter hypermethylation in airway M2 macrophages.

Pickering emulsions stabilized by protein/polysaccharide polyelectrolyte complexes for lipase catalysis.

The Pickering emulsion stabilized by ovalbumin/pectin polyelectrolyte complex with porcine pancreatic lipase (PPL) dissolved in the aqueous phase was investigated for its feasibility in biphasic catalysis. CLSM and QCM-D analysis revealed that PPL discretely adsorbed to emulsion interface, though they were both negatively charged. The hydrolysis of p-NPP was favored in low stabilizer concentrations and could be saturated by PPL, and the optimum conditions were pH 6.

Modulation of Mettl5 alleviates airway allergy by regulating the epigenetic profile of M2 macrophages.

M2 macrophages (M2 cells) are known to be involved in both Th2 responses and immune regulation. However, the underlying mechanisms remain unclear. Functional abnormalities in macrophages are associated with airway allergy (AA).

Intermittent Fasting Reduces Intestinal Inflammation in Dextran Sulfate Sodium-Induced Colitis of Mice.

Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), is a chronic condition impacting both the gastrointestinal tract and the immune system. Intestinal inflammation and epithelial injury are the pathological features of IBD. Recent studies have reported that some strategies of dietary restriction (DR) can regulate immune system, correct the immune disorders, and improve some immune-associated diseases such as IBD.

Dust mite antigens endow dendritic cells with the capacity to induce a Th2 response by regulating their methylation profiles.

Background: It is well-known that Dendritic cells (DCs) are essential in the development of airway Th2 polarization and airway allergy (AA). The underlying mechanism is still not fully understood. The objective of this study is to examine the role of methyltransferase-like protein-5 (Mettl5), a methyltransferase involved in N6-methyladenosine (m6A) methylation, in altering DC's properties to facilitate the development of Th2 polarization and AA.

Integrative Analysis of Transcriptome and Metabolome Reveals the Pivotal Role of the NAM Family Genes in Lodd. Pseudobulb Growth.

Lodd. is an important ornamental flower that is used as both a cut flower and a potted plant around the world; additionally, its pseudobulbs serve as essential carriers for floral organs and flower development. The NAM gene family is crucial for managing responses to various stresses as well as regulating growth in plants.

Combined Analysis of Transcriptome and Metabolome Provides Insights in Response Mechanism under Heat Stress in Avocado ( Mill.).

Plants generate a range of physiological and molecular responses to sustain their growth and development when suffering heat stress. Avocado is a type of tropical fruit tree with high economic value. Most avocado cultivars delete, wither, or even die when exposed to heat stress for a long time, which seriously restricts the introduction and cultivation of avocados.

In vivo edited eosinophils reconcile antigen specific Th2 response and mitigate airway allergy.

Background: Improvement is needed in the remedies used to control Th2 polarization. Bioengineering approaches have modified immune cells that have immunosuppressive functions. This study aims to generate modified eosinophils (Meos) in vivo and use Meos to balance Th2 polarization and reduce airway allergy.

Nemo mRNA vaccination improves airway barrier function in mice with airway allergy.

Epithelial barrier dysfunction plays an important role in the pathogenesis of Th2 bias. The mechanism requires further clarification. NEMO is associated with regulating apoptotic activities in the cell.

Multi-scale perceptual YOLO for automatic detection of clue cells and trichomonas in fluorescence microscopic images.

Vaginitis is a common disease among women and has a high recurrence rate. The primary diagnosis method is fluorescence microscopic inspection, but manual inspection is inefficient and can lead to false detection or missed detection. Automatic cell identification and localization in microscopic images are necessary.

The association between CD46 expression in B cells and the pathogenesis of airway allergy.

CD46 can facilitate the production of IgE. Activation of CD46 may contribute to the pathogenesis of allergic diseases. The aim of this study is to elucidate the association between CD46 expression in B cells and the pathogenesis of airway allergy.

Comparative Analysis of Codon Usage Patterns in Nuclear and Chloroplast Genome of (Fabaceae).

The plants are widely distributed across more than 130 tropical and subtropical countries and have significant economic and medicinal value. Codon usage bias (CUB) is a critical feature for studying gene function and evolution, which can provide a better understanding of biological gene regulation. In this study, we comprehensively analyzed the CUB patterns of the nuclear genome, chloroplast genome, and gene expression, as well as systematic evolution of species.

The Role of Leukotriene B in Cow Metritis.

Introduction: Metritis is a common postpartum disease in dairy cows. As a mast cell (MC) mediator, leukotriene B (LTB) is the strongest phagocyte chemokine. It is important in inflammation for the recruitment of immune cells to resist infection.

Academic achievement is more closely associated with student-peer relationships than with student-parent relationships or student-teacher relationships.

Introduction: Personal relationships have long been a concern in education. Most studies indicate that good personal relationships are generally positively correlated with academic performance. However, few studies have compared how different types of personal relationships correlate with academic performance, and the conclusions of existing studies are inconsistent.

Multicolor ultralong phosphorescence from perovskite-like octahedral α-AlF.

Designing organic fluorescent and phosphorescent materials based on various core fluorophore has gained great attention, but it is unclear whether similar luminescent units exist for inorganic materials. Inspired by the BX octahedral structure of luminescent metal halide perovskites (MHP), here we propose that the BX octahedron may be a core structure for luminescent inorganic materials. In this regard, excitation-dependent color-tunable phosphorescence is discovered from α-AlF featuring AlF octahedron.

Color-tunable ultralong room temperature phosphorescence from EDTA.

Unexpected color-tunable ultralong room-temperature phosphorescence (RTP, τ∼0.5 s) was observed from EDTA (and also EDTA salts, chelates, and structural analogues). Through both experimental and theoretical investigations, the through-space conjugation of the lone pair n electrons of N/O atoms in EDTA was identified as the origin of RTP.

Ultralong Room-Temperature Phosphorescence from Boric Acid.

For a long time, phosphors with long-lived emission are dominated by rare earth/transition metal ion-doped sulfides and oxides. Recently, organic materials capable of emitting long-lived room-temperature phosphorescence (RTP) are reported, carbon skeletons are almost the exclusive structural feature of the conjugated luminophores. Herein, we reported that boric acid, a non-metal and C-free material, could emit RTP with lifetime up to 0.