Effect of R-18 on Maize Growth Promotion Under Salt Stress.

Soil salinization poses a significant constraint to agricultural productivity. However, certain plant growth-promoting bacteria (PGPB) can mitigate salinity stress and enhance crop performance. In this study, a bacterial isolate, R-18, isolated from saline-alkali soil in Ningxia, China, was identified as based on 16S rRNA gene sequencing.

Screening and Application of Highly Efficient Rhizobia for Leguminous Green Manure in Lyophilized Inoculants and Seed Coating.

, a key leguminous green manure widely cultivated in Southern China's rice-based cropping systems, plays a pivotal role in sustainable agriculture by enhancing soil organic matter sequestration, improving rice yield, and elevating grain quality. The symbiotic nitrogen-fixing association between and its matching rhizobia is fundamental to its agronomic value; however, suboptimal inoculant efficiency and field application methodologies constrain its full potential. To address these limitations, we conducted a multi-phase study involving (1) rhizobial strain screening under controlled greenhouse conditions, (2) an optimized lyophilization protocol evaluating cryoprotectant (trehalose, skimmed milk powder and others), and (3) seed pelleting trails with rhizobial viability and nodulation assessments over different storage periods.

Population Pharmacokinetics and Limited Sampling Strategy of Mycophenolate Mofetil for Patients in Early Period After Kidney Transplantation.

Background: Mycophenolate mofetil (MMF) is widely used as an immunosuppressant in kidney transplantation. The pharmacokinetics (PK) of its active metabolite, mycophenolic acid (MPA), exhibit significant inter- and intra-individual variability. The early post-operative period is crucial for renal function recovery, and MPA exposure is linked to acute rejection.

FMRP silencing via siRNA lipid nanoparticles to reprogram the tumor microenvironment and enhance anti-PD-1 efficacy in triple-negative breast cancer.

Fragile X mental retardation protein (FMRP), encoded by the Fmr1 gene, is notably upregulated in various malignancies, including triple-negative breast cancer, pancreatic ductal adenocarcinoma, and colon carcinoma, and potentially mediates immune evasion through multiple mechanisms. Here a small interfering RNA (siRNA) targeting Fmr1 is designed for tumor site delivery to suppress FMRP expression and enhance immune activation. Lipid nanoparticles loaded with siFmr1 (LNP@siFmr1) are prepared using a microfluidic-based electrospray method, achieving optimal particle size, encapsulation efficiency, and stability.

Dual-Ligand-Regulated Tb-Containing Antimonotungstate for the Heterogeneous Catalytic Synthesis of N-Heterocycles in Ethanol.

A novel Tb-containing antimonotungstate, [(CH)NH]Na[Tb(mal)(OAc)(WO)(SbWO)(HO)]·47HO, regulated by dl-malic acid and acetic acid (, Hmal = malic acid; HOAc = acetic acid), has been successfully synthesized. The structural analysis reveals that the polyanion of consists of four {B-α-SbWO} units interconnected by a decanuclear metal cluster {TbW(mal)(OAc)}. The flexible malic acid ligands involved in the coordinating process create a certain torsion angle, resulting in a twisted rectangular structure of polyanion .

A Giant Ce-Bridged Selenotungstate Containing Three Different Building Blocks for Photocatalyzed C-N Bonds Formation.

The quest to delve into high-nuclearity molecular metal-oxo clusters and unravel their reactivity presents a significant challenge in chemistry and materials science. In this work, we synthesized an unprecedented bowknot-like selenotungstates, [CeSeWO(OH)(HO)(mal)] (, Hmal = dl-malic acid) via an assembly strategy. The three building units, including tetravacant Keggin-{SeW}, bivacant Dawson-{SeW}, and trivacant Keggin-{SeW}, were self-assembled by the connection of {W}, independent {SeO} fragments, and seven mutually isolated Ce ions to form the unique asymmetric structure, which was further extended to the bowknot-like dimeric structure and the 1D chain structure by symmetry.

A tetranuclear Pr-W heterometal cluster-imbedded antimotungstate for the catalytic synthesis of benzimidazoles.

A novel organic-inorganic Pr-W heterometal cluster-imbedded antimotungstate, [(CH)NH]Na{[(OAc)PrWO(tar)](SbWO)(HO)}Cl· 40.3HO (Pr-1), was synthesized a one-step assembly strategy. Pr-1 features a distinctive tetranuclear Pr-based organic-inorganic hybrid structure stabilized by polycarboxylic acid ligands, which efficiently regulate the hydrolysis of Pr to facilitate the assembly of Pr-W heterometallic clusters.

A phase 1, randomized, double-blind, placebo-controlled trial investigating the safety, tolerability, pharmacokinetics, and pharmacodynamics of KN056 (a recombinant human GLP-1 variant Fc fusion protein) in healthy Chinese participants.

Background: This randomized clinical pharmacology trial investigated the pharmacokinetics (PK), pharmacodynamics (PD), safety, and tolerability of KN056 following single-dose subcutaneous administration in healthy Chinese participants.

Methods: Thirty healthy male subjects were randomized to receive a single dose of KN056 (0.5, 1.

Physiologically-based pharmacokinetic modeling to predict the exposure and provide dosage regimens of adalimumab in patients with juvenile idiopathic arthritis.

Background: Adalimumab has been approved for treating juvenile idiopathic arthritis (JIA). This study aimed to develop a physiologically-based pharmacokinetic (PBPK) model for adalimumab in JIA patients to optimize personalized treatment.

Methods: A comprehensive literature search identified 13 clinical studies as the dataset for constructing and validating a PBPK model of adalimumab.

Vitamin D deficiency enhances platelet activation and thrombosis by regulating VDR/Akt pathway based on platelet proteomics.

Scope: Vitamin D deficiency (VDD) is a worldwide pandemic. Pleiotropic effects of vitamin D beyond calcium homeostasis have been shown. However, the direct impact of VDD on platelet reactivity and thrombus formation, as well as the underlying mechanisms, remain vague.

Association of antibiotics with Stevens-Johnson syndrome and toxic epidermal necrolysis: A real-world pharmacovigilance study.

Background: Recent reports suggest antibiotics may cause severe allergic reactions, such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), exacerbating concerns about antibiotic safety.

Objective: Given the limited real-world evidence, this study aims to analyse the FDA Adverse Event Reporting System to investigate the association between various antibiotics and SJS/TEN risk.

Methods: Reports from infected patients (Q1 2014-Q4 2023) were extracted from the FDA Adverse Event Reporting System.

Engineering Solvent-Coordinated Heterometallic-Organic Frameworks for Wide-Range Tuning of Ultralong Room Temperature Phosphorescence toward Time-Resolved Anticounterfeiting.

Metal-organic frameworks (MOFs) have been proven promising ultralong room temperature phosphorescence (RTP) materials for anticounterfeit due to their unique optical properties. However, it remains a major challenge to achieve the desired phosphorescent properties due to the limited regulatory methods and indistinct mechanism. Herein, the coordination solvent and second metal ion costrategy is firstly proposed to prepare seven robust heterometallic-organic frameworks (HMOFs) with two configurations, ZnMg/Ca-sol [sol = HO, dimethylformamide (DMF), dimethylacetamide (DMA), and formyldiethylamine (DEF)] and ZnSr/Ba-HO, exhibiting different ultralong RTP.

Machine Learning for Prediction of Drug Concentrations: Application and Challenges.

With the advancements in algorithms and increased accessibility of multi-source data, machine learning in pharmacokinetics is gaining interest. This review summarizes studies on machine learning-based pharmacokinetics analysis up to September 2024, identified from the PubMed and IEEE Xplore databases. The main focus of this review is on the use of machine learning in predicting drug concentration.

Initial treatment with a single capsule containing half-dose quadruple therapy vs standard-dose dual therapy in hypertensive patients (QUADUAL): a randomized, blinded, crossover trial.

Background: Guidelines recognized dual combination in initial antihypertensive therapy. Studies found that low-dose quadruple combination were superior to monotherapy. However, whether low-dose quadruple therapy is better than dual combination is unknown.

Photochromic Metal-Organic Frameworks Based on Host-Guest Strategy and Different Viologen Derivatives for Organic Amines Sensing and Information Anticounterfeiting.

The encapsulation of viologen derivatives in metal-organic frameworks (MOFs) to construct host-guest materials has been widely discussed owing to their distinctive spatial arrangement and physical/chemical properties. Herein, three new photochromic MOFs (NWM-1-3) have been successfully synthesized by 1,1,2,2-Tetra(4-carboxylphenyl)ethylene (HTCPE) ligand as well as three different viologen derivatives based on host-guest strategy. Remarkably, NWM-1-3 exhibit a notable reversible photochromism change from yellow to green under 365 nm UV irradiation.

CPhaMAS: The first pharmacokinetic analysis cloud platform developed by China.

Objectives: Software for pharmacological modeling and statistical analysis is essential for drug development and individualized treatment modeling. This study aims to develop a pharmacokinetic analysis cloud platform that leverages cloud-based benefits, offering a user-friendly interface with a smoother learning curve.

Methods: The platform was built using Rails as the framework, developed in Julia language, and employs PostgreSQL 14 database, Redis cache, and Sidekiq for asynchronous task management.

A Wavy Multiple Tm(III)-Containing Open Wells-Dawson Silicotungstate: Synthesis, Structure, and Catalytic Application.

A Tm(III)-rich silicotungstate Na{Tm(HO)[Tm(HO)(SiWO)]}·35HO () based on the open Wells-Dawson-type [SiWO] building unit was synthesized by the reaction of Na[α-SiWO]·18HO, itaconic acid, and TmCl in a HAc/NaAc buffer solution. Five kinds of Tm(III) ions were found in this compound and further linked the {TmSiW} subunit to form an interesting wavy 1D chain structure, which achieved the introduction of more lanthanide (Ln) ions into the [SiWO] unit for the first time. contains multiple exposed Tm-metal active sites, making it an efficient catalyst for the acetalization of 2-aminobenzamides/2-aminobenzenesulphonamides with aldehydes.

Efficient analysis of drug interactions in liver injury: a retrospective study leveraging natural language processing and machine learning.

Background: Liver injury from drug-drug interactions (DDIs), notably with anti-tuberculosis drugs such as isoniazid, poses a significant safety concern. Electronic medical records contain comprehensive clinical information and have gained increasing attention as a potential resource for DDI detection. However, a substantial portion of adverse drug reaction (ADR) information is hidden in unstructured narrative text, which has yet to be efficiently harnessed, thereby introducing bias into the research.

Pharmacokinetic-pharmacodynamic Modelling of NH600001 in Healthy Subjects and Patients Undergoing Gastroscopy.

NH600001 is a new general anaesthetic drug with a structure similar to etomidate. The objective of this study was to investigate the relationship between concentrations of NH600001 and sedation efficacy based on data from phase I-II studies and factors influencing the pharmacokinetics and pharmacodynamics of NH600001. The dataset consisted of 2 phase I studies in healthy subjects and 1 phase II study in patients undergoing gastroscopy.

Tolerability, safety, and pharmacokinetics of GR1603 injection in healthy subjects: a randomized, double-blind, placebo-controlled single-dose escalation clinical trial.

Background: GR1603 is a monoclonal antibody targeting the type I interferon receptor. The aim of this study was to evaluate the safety, tolerability, pharmacokinetics, immunogenicity and pharmacodynamics of GR1603 in healthy volunteers.

Methods: Healthy adults (≥18 years old) were enrolled in a placebo control, dose-escalation Phase I clinical trial receiving a single injectable dose of GR1603.

The pharmacokinetics, pharmacodynamics and tolerability of SHR6508 in chinese healthy subjects: a randomized, placebo-controlled, double-blind, single-dose and dose-escalation phase I trial.

This study aimed to evaluate the pharmacokinetics (PK), pharmacodynamics (PD), safety, and tolerability of SHR6508 injection, a new calcimimetic agent, in healthy Chinese subjects following single dose. This study utilized a placebo-controlled, single-dose, and dose-escalation design with four dose groups (0.5 mg, 2.

Impact of white blood cell count on the development of contrast-induced acute kidney injury in patients receiving percutaneous coronary intervention.

This study aimed to investigate the efficacy of a pre-procedural white blood cell (WBC) count in the prediction of contrast-induced acute kidney injury (CI-AKI) risk in coronary artery disease patients receiving a percutaneous coronary intervention (PCI). This observational study comprises a sample of 1,013 coronary artery disease patients (including ACS and stable angina) receiving PCI, gathered from September 2015 to July 2017. CI-AKI incidence in the study population was 4.

A Scalable Pore-space-partitioned Metal-organic Framework Powered by Polycatenation Strategy for Efficient Acetylene Purification.

Efficient separation of acetylene (CH) from carbon dioxide (CO) and ethylene (CH) is a significant challenge in the petrochemical industry due to their similar physicochemical properties. Pore space partition (PSP) has shown promise in enhancing gas adsorption capacity and selectivity by reducing pore size and increasing the density of guest binding sites. Herein, we firstly employ the 2D→3D polycatenation strategy to construct a PSP metal-organic framework (MOF) Ni-dcpp-bpy, incorporating functional N/O sites to enhance CH purification.

Advanced AI-Driven Prediction of Pregnancy-Related Adverse Drug Reactions.

Ensuring drug safety during pregnancy is critical due to the potential risks to both the mother and fetus. However, the exclusion of pregnant women from clinical trials complicates the assessment of adverse drug reactions (ADRs) in this population. This study aimed to develop and validate risk prediction models for pregnancy-related ADRs of drugs using advanced Machine Learning (ML) and Deep Learning (DL) techniques, leveraging real-world data from the FDA Adverse Event Reporting System.