Enhanced Photo-Fenton Removal of Oxytetracycline Hydrochloride via BP/BiMoO Z-Scheme Heterojunction Photocatalyst.

Fenton oxidation technology utilizing hydrogen peroxide is recognized as an effective method for producing reactive oxygen species (ROS) to facilitate the degradation of antibiotics. However, the requirement for strongly acidic conditions during this process significantly restricts its broader applicability. In this study, we synthesized black phosphorus (BP) nanosheets by exposing the {010} crystal planes and then constructed a 0D/2D BP/BiMoO (PBMO) heterojunction to function as a Fenton catalyst.

Immune persistence of a single dose of 23-valent pneumococcal polysaccharide vaccine: A 6-year follow-up.

In a previous phase 3 clinical trial, a 23-valent pneumococcal polysaccharide vaccine (PPV23) induced robust immune responses in participants aged 2 years and older. We conducted this study to evaluate the immune persistence of a single dose of PPV23 6 years after vaccination. In this follow-up study, 600 participants aged 2 years and older (referred to the age of vaccination) who had received a single dose of either test vaccine or control vaccine in the previous clinical trial were enrolled in a 3:1 ratio.

Safety and Immunogenicity of a New Rotavirus-Inactivated Vaccine in the Chinese Adolescent Population: A Randomized, Double-Blind, Placebo-Controlled Phase I Clinical Trial.

Background: We performed a phase I experiment in a healthy teenage population in Sui County, Henan Province, China. The trial was randomized, double-blind, and placebo-controlled.

Methods: Ninety-six adolescents were randomly assigned in three groups (high-dose, medium-dose, and low-dose) to receive a dose of the vaccine or the placebo.

Effectively Enhanced Photocatalytic Performance of BP/BiOBr 2D/2D Z-Scheme Heterojunction.

Black phosphorus (BP) is a novel two-dimensional (2D) material with remarkable potential for use in environmental remediation and energy conversion. However, the practical application of BP is significantly limited by its low catalytic efficiency and poor structural stability. In this study, a Z-scheme BP/BiOBr 2D/2D heterojunction was fabricated using a simple solution reaction method at room temperature.

Tetramethyl Cucurbit[6]uril-Porphyrin Supramolecular Polymer Enhances Photosensitization.

Porphyrins serve as photosensitizers (PS) in the realm of cancer photodynamic therapy (PDT). Upon excitation by laser light, porphyrins are capable of converting molecular oxygen into highly cytotoxic singlet oxygen (O). However, the rigid π-conjugated structure of porphyrins frequently results in the formation of aggregates in aqueous solutions, which leads to the self-quenching of the excited state.

A randomized, double-blind, placebo-controlled phase I clinical trial of rotavirus inactivated vaccine (Vero cell) in a healthy adult population aged 18-49 years to assess safety and preliminary observation of immunogenicity.

We conducted a phase I, randomized, double-blind, placebo-controlled trial including healthy adults in Sui County, Henan Province, China. Ninety-six adults were randomly assigned to one of three groups (high-dose, medium-dose, and low-dose) at a 3:1 ratio to receive one vaccine dose or placebo. Adverse events up to 28 days after each dose and serious adverse events up to 6 months after all doses were reported.

Immune Persistence following Primary Immunization and the Immunogenicity and Safety of a Booster Dose of a Multidose Sabin Strain-Based Inactivated Polio Vaccine in Infants Aged 18 Months.

Background: The multidose Sabin-strain inactivated poliovirus vaccine (sIPV) has the potential to significantly aid in the eradication of poliomyelitis, particularly in low- and middle-income countries. As part of a phase III clinical trial in which infants were given three doses of primary immunization at 2, 3, and 4 months of age, this study aimed to evaluate immune persistence following primary immunization, as well as the safety and immunogenicity of a booster of the 5-dose sIPV in infants aged 18 months.

Methods: Infants aged 18 months were given one booster dose of 5-dose sIPV in stage one, which was open-label.

Construction of a g-CN/Bi(OH) Heterojunction for the Enhancement of Visible Light Photocatalytic Antibacterial Activity.

Photocatalytic technology has been recently conducted to remove microbial contamination due to its unique features of nontoxic by-products, low cost, negligible microbial resistance and broad-spectrum elimination capacity. Herein, a novel two dimensional (2D) g-CN/Bi(OH) (CNB) heterojunction was fabricated byincorporating Bi(OH) (BOH) nanoparticles with g-CN (CN) nanosheets. This CNB heterojunction exhibited high photocatalytic antibacterial efficiency (99.

A cross-sectional study of appropriateness evaluation of anticoagulation therapy for inpatients with nonvalvular atrial fibrillation.

Oral anticoagulants (OACs) are essential for stroke prevention in patients with nonvalvular atrial fibrillation (NVAF). However, the appropriateness of anticoagulation treatment in locally practice remains unclear. This study evaluated compliance with anticoagulation therapy concerning the guidelines and drug labels in patients with NVAF.

Immunogenicity and safety of a live-attenuated varicella vaccine in a healthy population aged 13 years and older: A randomized, double-blind, controlled study.

Objectives: Vaccines for prevention against varicella are important for adolescents and adults, who have an increased risk of severe varicella. This study aimed to evaluate the immunogenicity and safety of a two-dose immunization schedule of a live-attenuated varicella vaccine (VarV) manufactured by Sinovac (Dalian) in healthy adolescents and adults.

Methods: A randomized, double-blind, controlled clinical trial was conducted in healthy population aged ≥ 13 years old in China.

Safety, tolerability, and immunogenicity of a CpG/Alum adjuvanted SARS-CoV-2 recombinant protein vaccine (ZR202-CoV) in healthy adults: Preliminary report of a phase 1, randomized, double-blind, placebo-controlled, dose-escalation trial.

This was a phase 1 dose-escalation study of ZR202-CoV, a recombinant protein vaccine candidate containing a pre-fusion format of the spike (S)-protein (S-trimer) combined with the dual-adjuvant system of Alum/CpG. A total of 230 participants were screened and 72 healthy adults aged 18-59 years were enrolled and randomized to receive two doses at a 28-day interval of three different ZR202-CoV formulations or normal saline. We assessed the safety for 28 days after each vaccination and collected blood samples for immunogenicity evaluation.

Self-assembled, hemin-functionalized peptide nanotubes: an innovative strategy for detecting glutathione and glucose molecules with peroxidase-like activity.

Accurately detecting dynamic changes in bioactive small molecules in real-time is very challenging. In this study, a hemin-based peptide assembly was rationally designed for the colorimetric detection of active small molecules. Hemin-functionalized peptide nanotubes were obtained through the direct incubation of hemin (hemin@PNTs) and peptide nanotubes (PNTs) or were coassembled with the heptapeptide Ac-KLVFFAL-NH via electrostatic, π-π stacking, and hydrophobic interactions (hemin-PNTs).

Safety, immunogenicity, and lot-to-lot consistency of a multidose Sabin strain-based inactivated polio vaccine: a phase III, randomized, blinded, positive-control clinical trial in infants aged 2 months.

Objectives: To evaluate the safety, immunogenicity, and lot-to-lot consistency of Sabin strain-based inactivated polio vaccine (sIPV) in a five-dose vial presentation.

Methods: Stage I was an open-label safety observation, in which 72 healthy subjects (including 24 adults, children, and infants each) were given one or three doses of the five-dose vial sIPV; stage II was a randomized, blinded, and positive-control study, in which 1500 infants were randomized at the ratio of 1: 1: 1: 1: 1 into five groups to receive either three doses of the five-dose sIPV three lots, a conventional inactivated poliovirus vaccine, or a single-dose sIPV as controls, for primary immunization. Safety, immunogenicity, and lot-to-lot consistency were assessed.

The Synergistic Effect of Adsorption-Photocatalysis for Removal of Organic Pollutants on Mesoporous CuVO/CuVO/g-CN Heterojunction.

CuVO/CuVO/g-CN heterojunctions (CVCs) were prepared successfully by the reheating synthesis method. The thermal etching process increased the specific surface area. The formation of heterojunctions enhanced the visible light absorption and improved the separation efficiency of photoinduced charge carriers.

Effective Removal of Methylene Blue on EuVO/g-CN Mesoporous Nanosheets via Coupling Adsorption and Photocatalysis.

In this study, we first manufactured ultrathin g-CN (CN) nanosheets by thermal etching and ultrasonic techniques. Then, EuVO (EV) nanoparticles were loaded onto CN nanosheets to form EuVO/g-CN heterojunctions (EVCs). The ultrathin and porous structure of the EVCs increased the specific surface area and reaction active sites.

[Dynamic change in the gene expression profile of rat benign prostate hyperplasia tissue after complete denervation].

Objective: To investigate the dynamic change in the gene expression profile of the rat BPH tissue with progressive atrophy after complete denervation.

Methods: Twelve 29-week-old male rats with spontaneous hypertension and spontaneously developed BPH were used for this study, of which 3 were included in the control (C) group and the other 9 underwent complete denervation of the prostate. At 3, 7 and 11 days after operation (the D3, D7 and D11 groups), all the rats were sacrificed and their ventral prostatic lobes harvested for histopathological examination and RNA extraction, and the RNA samples were subjected to whole genome microarray of the expression profile, followed by real-time RT-PCR validation and bioinformatics analysis.

Qizhufang (ZSF) Ameliorates Hepatic Iron Overload via Signal Transducer and Activator of Transcription 3 (STAT3) Pathway.

BACKGROUND Iron overload is a prominent characteristic of liver injury, but there is no effective treatment at present. Qizhufang (ZSF) is a Chinese herbal formula showed anti-HBV activities, improved liver function, and anti-fibrosis effect. ZSF showed a series of liver-protection functions, but whether ZSF can relieve hepatic iron overload is still unclear.

New Protocol of Intermittent Androgen Deprivation Therapy for Patients With Metastatic Prostate Cancer: A Retrospective Study.

Background: The optimal points for halting and resuming treatment in intermittent androgen deprivation therapy (IADT) for metastatic prostate cancer patients are controversial.

Patients And Methods: In the 65 metastatic prostate cancer patients in group 1, androgen deprivation therapy was stopped when prostate-specific antigen (PSA) levels reached a nadir and was resumed when PSA levels doubled and ≥ 1.0 ng/mL (new protocol).

The Composition-Dependent Photoluminescence Properties of Non-Stoichiometric ZnAgInS Nanocrystals.

A facile hot injection approach to synthesize high-quality non-stoichiometric ZnAgInS nanocrystals (NCs) in the size range of 2.8-3.1 nm was presented.

Species of Neoperla (Plecoptera: Perlidae) from Henan Province, China.

A new species, Neoperla jigongshana Li & Li, sp. nov., is proposed from Henan Province, China and compared with related congeners.