Investigating the mechanical behavior of anti-impact airbag fabrics: a structural design approach.

. This study introduces a cutting-edge approach to enhance safety protection through the innovative structural design of anti-impact cushion airbag fabrics, with significant implications for the clothing industry and sports safety. .

Isoliensinine inhibits mitophagy and sensitizes T cell malignancies for STING-mediated NK clearance.

Mitochondrial DNA (mtDNA) damage and accumulation activate the cGAS-STING DNA-sensing pathway, which promotes immune clearance of tumor cells. Maintenance of the cytosolic level of mtDNA is key to sustain immune activation. T cell malignancies (T-CMs) are a general name of diseases with abnormal clonal proliferation of T lymphocytes at various stages.

Antegrade insertion of full-length ramus screws for the treatment of pelvic and/or acetabular fracture.

Introduction: The success rate of antegrade insertion of a full-length ramus osseous fixation pathway (OFP) screw remains unreported. The objective of this study was to assess the safety, feasibility, and effectiveness of a novel antegrade technique for inserting full-length ramus screws, as well as to determine the parameters of the ramus OFP based on screw placement.

Patients And Methods: From January 2022 to September 2024, patients with fractures of the superior pubic ramus or the anterior acetabular column treated with a novel technique of an antegrade insertion of a superior ramus OFP screw were recruited into this study.

Development and validation of a modified SOFA score for mortality prediction in candidemia patients.

Candidemia is a life-threatening bloodstream infection associated with high mortality rates, particularly in critically ill patients. Accurate risk stratification is crucial for timely intervention and could improve patient outcomes. This study aimed to enhance the predictive performance of the sequential organ failure assessment (SOFA) score by developing a modified SOFA (mSOFA) score, which is specifically designed for candidemia patients.

The Efficacy of Combined Use of Huaier Granules in the Treatment of Primary Liver Cancer: An Updated Systematic Review and Meta-Analysis.

Existing clinical data suggest that Huaier granules effectively improve the condition of PLC patients. However, their specific efficacy and safety in PLC patients remain unclear. This study aimed to investigate the effects of Huaier granules as an adjunctive therapy for PLC patients.

Comprehensive examination of resting state fMRI connectomics yields new insights into brain function deficits in Gulf War illness after accounting for heterogeneity in brain impairment across the ill veteran population.

An estimated 200,000 veterans (up to 32% of those deployed) of the 1991 Gulf War (GW) suffer from GW illness (GWI), an incompletely understood chronic medical condition, characterized by multiple symptoms indicative of brain function deficits in various domains. Epidemiologic and animal studies have associated GWI with exposure to neurotoxic chemicals such as nerve agents, organophosphate pesticides and pyridostigmine bromide. One factor that hampers mechanistic investigations into GWI is that there is considerable heterogeneity in brain impairments across the ill GW veteran population.

miR-142-5p Affects Oral Squamous Cell Carcinoma by Regulating PIAS3/pSTAT3.

Objective: miR-142-5p's role in tumors is inconsistent. The PIAS3/pSTAT3 signaling is an important regulator of the tumor microenvironment. Our study assessed whether miR-142-5p and PIAS3/pSTAT3 affect oral squamous cell carcinoma (OSCC).

Toward the Ideal Alkaline Hydrogen Evolution Electrocatalyst: a Noble Metal-Free Antiperovskite Optimized with A-Site Tuning.

To achieve the ideal non-noble-metal HER electrocatalyst in alkaline media, developing conductive systems with multiple active sites targeting every elementary step in the alkaline HER, is highly desirable but remains a great challenge. Herein, a conductive noble metal-free antiperovskite CdNNi is reported with intrinsic metallic characteristics as a highly efficient alkaline HER electrocatalyst, which is designed by the facile A-site tuning strategy with the modulation the electronic structures and interfacial water configurations of antiperovskites. Impressively, the HER performance of CdNNi antiperovskite is superior to various state-of-the-art non-noble metal catalysts ever reported, and also outperforms the commercial Raney Ni catalyst when assemble as the cathode in the practical anion exchange membrane water electrolyzer (AEMWE) device.

Injury of sonic weapons to human body: A narrative review.

Sonic weapons are non-lethal weapons that some countries around the world are actively developing and equipping in their troop. Its injury to the human body is increasingly valued. Given that previous research on the injury, prevention, and treatment of sonic weapons to the human body has not been systematic and comprehensive, after explaining certain acoustic concepts, these authors introduce infrasonic and intense sound weapons from aspects of weapon types and applications, injury mechanisms and characteristics, injury thresholds, biological effects, injury diagnosis, and injury prevention and treatment.

Corrigendum: Mitochondrial-derived vesicles protect cardiomyocytes against hypoxic damage.

[This corrects the article DOI: 10.3389/fcell.2020.

A Case Report of Pulmonary Malignant Melanoma with Multiple Intracranial Hemorrhagic Metastases.

Primary pulmonary malignant melanoma is a very rare non-epithelial tumour with a high degree of malignancy, susceptibility to early haematogenous metastasis and poor prognosis. Lung malignant melanoma with multiple intracranial metastases is highly susceptible to misdiagnosis or underdiagnosis in clinical practice. This article reports a case of pulmonary malignant melanoma with multiple intracranial hemorrhagic metastases, aiming to improve clinicians' understanding of this disease through this case analysis.

A novel ionic-liquid-supported polythieno[3,2-b]thiophene coating for headspace solid-phase microextraction of phenolic compounds from environmental water via gas chromatography-mass spectrometry.

A novel thieno[3,2-b]thiophene (TT) was utilized for the first time to electrochemically fabricate an ionic liquid (IL)-supported polythieno[3,2-b]thiophene (PTT) coating. This innovative coating serves as a new headspace solid-phase microextraction (HS-SPME) material for the extraction of five phenolic compounds, which were subsequently determined via gas chromatography-mass spectrometry (GC-MS). The coating was characterized using Fourier-transform infrared spectroscopy, scanning electron microscopy, and energy-dispersive X-ray spectroscopy.

Automobile Accident Injury Leading to Cryptic Bowel Perforation.

Background: Blunt abdominal trauma poses diagnostic challenges, particularly in identifying cryptic gastrointestinal perforations. This case report highlights the critical role of meticulous imaging analysis and timely surgical intervention in managing occult bowel injuries following automobile accidents.

Case Presentation: A 48-year-old male presented with acute abdominal discomfort, muscular rigidity, and peritoneal signs 12 hours after a nighttime traffic collision.

Co-expression of multi-genes for polynary perovskite electrocatalysts for reversible solid oxide cells.

High-entropy LnBaCoO perovskites are explored as rSOC air electrodes, though high configuration entropy (S) alone poorly correlates with performance due to multifactorial interactions. We systematically engineer LnBaCoO perovskites (Ln = lanthanides) with tunable S and 20 consistent parameters, employing Bayesian-optimized symbolic regression to decode activity descriptors. The model identifies synergistic contributions from S, ionic radius, and electronegativity, enabling screening of 177,100 compositions.

Insect metamorphosis and chitin metabolism under miRNA regulation: a review with current advances.

Insect metamorphosis is a complex developmental process regulated by microRNAs (miRNAs) and hormonal signaling pathways. Key genes driving insect ontogenic changes are precisely modulated by miRNAs, which interact with 20-hydroxyecdysone (20E) and juvenile hormone (JH) to coordinate developmental transitions. Over the past decade, significant progress has been made in understanding miRNA biogenesis, their regulatory roles in gene expression, and their involvement in critical biological processes, including metamorphosis and chitin metabolism.

Kinetic energy evolution and injury assessment of high-speed tear jets.

High-speed tear liquid ejectors, as novel less-lethal weapons, demonstrate significant potential in public security, counter-terrorism, and riot control applications. However, critical gaps persist in understanding their kinetic energy dissipation dynamics and associated injury risks, particularly when using traditional specific kinetic energy methods. Therefore, this study establishes an integrated experimental framework combining transient trajectory acquisition systems, ballistic gelatin targets, and dynamic impact force measurements.

Identification and functional analyses of the CmdsRNase5 and CmdsRNase6 genes in rice leaffolder Cnaphalocrocis medinalis.

RNA interference (RNAi) is a promising method for pest control; however, some studies have showed that the degradation of double-stranded RNA (dsRNA) by dsRNA-degrading nucleases (dsRNases) is one of the factors that may reduce RNAi efficiency in lepidopteran insects. In this study, we cloned two dsRNase genes named CmdsRNase5 and CmdsRNase6 from rice leaffolder Cnaphalocrocis medinalis, a notorious insect pest of rice. Open reading frames (ORFs) of CmdsRNase5 and CmdsRNase6 are 1317 and 1185 bp in length, encoding 438 and 394 amino acids, respectively.

SQSTM1/P62 Mediates the Effects of CPNE3 on the Epithelialmesenchymal Transition and Migratory Inhibition of Lung Adenocarcinoma Cells.

Introduction: Copine-3 (CPNE3) is a conservative calcium-dependent phospholipid-binding protein belonging to the copines protein family. CPNE3 has been implicated in the development and progression of several diseases, including cancer.

Method: Herein, we investigated the molecular mechanisms through which CPNE3 regulates the migration of lung adenocarcinoma (LUAD) cells in vitro.

Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice.

While previous research has demonstrated the therapeutic efficacy of telomerase reverse transcriptase (TERT) overexpression using adeno-associated virus and cytomegalovirus vectors to combat aging, the broader implications of TERT germline gene editing on the mammalian genome, proteomic composition, phenotypes, lifespan extension, and damage repair remain largely unexplored. In this study, we elucidate the functional properties of transgenic mice carrying the Tert transgene, guided by precise gene targeting into the Rosa26 locus via embryonic stem (ES) cells under the control of the elongation factor 1α (EF1α) promoter. The Tert knock-in (TertKI) mice harboring the EF1α-Tert gene displayed elevated telomerase activity, elongated telomeres, and extended lifespan, with no spontaneous genotoxicity or carcinogenicity.

Therapeutic Effect of Targeted Deployment Filling Coils in the Treatment of Intracranial Aneurysms.

Endovascular coil embolization is the primary therapeutic modality for intracranial aneurysms. Substantial reports have been found regarding the coil packing density and inflow jet. However, the hemodynamic effect of increasing the rate of tamponade in the inflow jet area within the aneurysm remains unclear.

Knockdown of the glucosamine-6-phosphate N-acetyltransferase gene by RNA interference enhances the virulence of entomopathogenic fungi against rice leaffolder Cnaphalocrocis medinalis.

Insect cuticle acts as a first line of defense and a physical protective barrier against entomopathogens. Chitin biosynthesis pathway plays a crucial role in chitin formation in the cuticle of insects. Glucosamine-6-phosphate N-acetyltransferase (GNA) is a key enzyme in insect chitin biosynthesis that regulate the chitin formation.

A Case Report of Frontal Sinus Abscess Complicated by Epidural Abscess with a Literature Review.

Inflammation of the frontal sinus is a relatively common clinical condition among paranasal sinusitis and is curable through anti-infection treatments, with a rare progression to frontal sinus abscess. An even rarer complication is the development of intracranial epidural empyema secondary to frontal sinus abscess. In this report, we describe a case of a 14-year-old male with a frontal sinus abscess that led to intracranial infection and was complicated by an epidural abscess misdiagnosed as an epidural hematoma.

The Effects of Combined Treatments of Laser Engraving, Plasma Spraying and Resin Pre-Coating on Improving the Bonding Strength of Titanium Alloy and Carbon Fiber-Reinforced Polymer.

This study focused on effective methods of laser engraving treatment (LET), plasma spraying, and resin pre-coating (RPC) to manufacture the reinforced adhesive joints of titanium alloy and carbon fiber-reinforced polymer (TA-CFRP) composites. The combined treatments contributed to the creation of a better adhesive bonding condition and offer a vertical gap between circular protrusions to form epoxy pins and carbon nanotube (CNT)-reinforced epoxy pins. The bonding strength of the TA-CFRP composite was reinforced by 130.

Advancements and prospects of perovskite-based fuel electrodes in solid oxide cells for CO electrolysis to CO.

Carbon dioxide (CO) electrolysis to carbon monoxide (CO) is a very promising strategy for economically converting CO, with high-temperature solid oxide electrolysis cells (SOECs) being regarded as the most suitable technology due to their high electrode reaction kinetics and nearly 100% faradaic efficiency, while their practical application is highly dependent on the performance of their fuel electrode (cathode), which significantly determines the cell activity, selectivity, and durability. In this review, we provide a timely overview of the recent progress in the understanding and development of fuel electrodes, predominantly based on perovskite oxides, for CO electrochemical reduction to CO (CORR) in SOECs. Initially, the current understanding of the reaction mechanisms over the perovskite electrocatalyst for CO synthesis from CO electrolysis in SOECs is provided.