[Integration and innovation of wet granulation and continuous manufacturing technology: a review of on-line detection, modeling, and process scale-up].

Continuous manufacturing, as an innovative pharmaceutical production model, offers advantages such as high production efficiency and ease of control compared to traditional batch production, aligning with the future trend of drug production moving toward greater efficiency and intelligence. However, the development of continuous manufacturing technology in wet granulation has been slow. On one hand, this is closely related to its high technical complexity, substantial equipment investment costs, and stringent process control requirements.

The association between the microbes in the tracheobronchial aspirate fluid and bronchopulmonary dysplasia in preterm infants.

Objective: The study aimed to evaluate the association between microbes in the lower respiratory tract (LRT) and the srisk for severe bronchopulmonary dysplasia (sBPD) in premature infants.

Methods: We conducted a retrospective, single-center study of preterm infants who were admitted to the neonatal intensive care unit (NICU) of Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, China, between January 2015 and December 2017. The microbes in the LRT were screened by using tracheobronchial aspirate fluid (TAF) culture.

Synthesis and characterization of a novel POM compound containing two different layers stacked alternately.

A novel POM compound containing the first Sb bicapped Keggin anion {SiMo(12)O(40)Sb(2)} and two different layers constructed from these anions stacked alternately has already been hydrothermally synthesized.

First examples of extended structures based on {PMo(12)Sb(2)O(40)} polyoxoanions.

Three novel heteropolyanions [PMo(12)Sb(2)O(40)][Cu(enMe)(2)].4H(2)O (), [PMo(12)Sb(2)O(40)][Ni(enMe)(2)].4H(2)O (2) and [PMo(12)Sb(2)O(40)][Cu(en)(2)].

[hVEGF siRNA inhibits initial growth of A549 tumor cells in nude mice and angiogenesis on CAM assay].

Objective: To investigate the effect of small interfering RNA (siRNA) targeting human vascular endothelial growth factor (hVEGF) on A549 cell growth in nude mice and angiogenesis on chorioallantoic membrane (CAM) assay.

Methods: Three pairs of hVEGF siRNA-plasmid and non-silencing-plasmid were constructed, and transfected into A549 cells through lipofectamine 2000, respectively. The most effective pair of hVEGF siRNA-plasmid was selected by ELISA and real-time RT-PCR.

[Crystal structures and luminescence property of d10 transition metal complexes].

Five Zn( [II)) and Cd(II) coordination complexes, [Zn(NA)2 (H2O)4](1), [Zn(INA)2 (H2O)4](2), [Zn(2,2'-bi-py)2 (SCN)2](3), [Cd(INA)2 (H2O)4](4) and [Cd(phen)2(NO3)](5) (HNA=nicotinic acid, HINA=isonicotinic acid, 2, 2'-bipy=2,2'-bipyridine, phen=1,10-phenanthroline), were synthesized through constant temperature magnetic stirrer or hydrothermal method, and their single-crystal structures were determined by X-ray diffraction. The authors measured the IR, UV-Vis-NIR and fluorescence spectra of the complexes and analyzed their photophysical properties. At room temperature in the solid state the five complexes can show strong fluorescence, i.

{Bis[2-(diphenyl-phosphino)phen-yl] ether-κP:P'}(dimethyl 2,2'-biphenyl-4,4'-dicarboxyl-ate-κN:N')copper(I) hexa-fluorido-phosphate acetonitrile solvate.

In the title compound, [Cu(C(14)H(12)N(2)O(4))(C(36)H(28)OP(2))]PF(6)·CH(3)CN, the Cu(I) ion is coordinated by two N atoms from the dimethyl 2,2'-biphenyl-4,4'-dicarboxyl-ate ligand and two P atoms from the bis-[2-(diphenyl-phosphino)phen-yl] ether ligand in a distorted tetra-hedral environment. In the cation, the short distance of 3.870 (4) Å between the centroids of the benzene and phenyl rings suggests the existence of intra-molecular π-π inter-actions.

3,9-Dibromo-5,7-dihydro-dibenzo[c,e]oxepine.

The title compound, C(14)H(10)Br(2)O, is a biphenyl derivative containing a -CH(2)-O-CH(2)- bridge in the 2,2'-position. The compound displays a twisted conformation with the two benzene rings making a dihedral angle of 45.02 (5)°, while the central seven-membered ring is in a boat conformation.

3,9-Dibromo-6,7-dihydro-5H-dibenzo[c,e]thiepine.

In the title mol-ecule, C(14)H(10)Br(2)S, the two benzene rings form a dihedral angle of 48.35 (14)°. The seven-membered ring adopts a boat conformation.

2,10-Dibromo-6-isobutyl-6-methyl-dibenzo[d,f][1,3]dioxepine.

In the crystal structure of the title compound, C(18)H(18)Br(2)O(2), the two benzene rings of the bridged biphenyl unit are twisted by 38.0 (1)°.

2,2'-Bi[6,6'-dimethyl-dibenzo[d,f][1,3]dioxepine].

The title compound, C(30)H(26)O(4), is a dimer of 6,6'-dimethyl-dibenzo[d,f][1,3]dioxepine linked by formation of a C-C bond in the para position with respect to one O atom. The dimer is arranged around an inversion centre. As is usually observed in related compounds, the dibenzo group is twisted, the two benzene rings making a dihedral angle of 41.

2,10-Dibromo-6,6-dimethyl-dibenzo[d,f][1,3]dioxepine.

In the crystal structure of the title compound, C(15)H(12)Br(2)O(2), which was synthesized from 2,10-dibromo-2,2'-dihydroxy-biphenyl and 2,2-dimethoxy-propane, the aromatic rings are twisted by 35 (1)°. The heterocyclic ring exhibits a twisted conformation.

Hydrothermal syntheses and structural characterizations of organic-inorganic hybrid materials of the M(II)-ligand/vanadium oxide system (M(II) = Mn(II), Cu(II) and Zn(II); ligand = 2,2'-bipyridine and 1,10-phenanthroline).

Three organic-inorganic hybrid compounds [Mn(bpy)V(bpy)V(3)O(11)] (bpy = 2,2'-bipyridine) (1), [Cu(bpy)V(2)O(6)] (2) and [Zn(phen)3][V(2)O(6)].10H(2)O (phen = 1,10-phenanthroline) (3) have been synthesized hydrothermally. Single crystal X-ray diffraction analyses revealed that compound 1 is the first example of bpy units coordinating to different transition metals in one molecule.

Synthesis and characterization of binuclear molybdenum-polycarboxylate complexes with sulfur bridges.

A group of four binuclear sulfur-bridged molybdenum-polycarboxylato complexes with homocitrate, citrate, cysteine, ethylenediaminetetraacetate ligands, respectively, have been synthesized and characterized. These complexes were prepared in order to study the interaction of Mo and homocitrate in the FeMo-co of nitrogenases. In the structures of K4(NH4)2[Mo2O2S2(C6H4O7)2].

A new route for preparing coordination polymers from hydrothermal reactions involving in situ ligand synthesis.

The coordination chemistry of inorganic cobalt salt and the organic ligands H(4)bbh (=benzene-1,2,4,5-bihydrazide) and H(3)bcbh (=benzene-4-carboxylate-1,2-bihydrazide) generated through the in situ hydrothermal acylate reaction of H(4)bta (=benzene-1,2,4,5-tetracarboxylic acid) and H(3)btc (=benzene-1,2,4-tricarboxylic acid) with hydrazine hydrate, respectively, has been investigated. Three new coordination polymers were prepared and fully characterized by infrared spectroscopy, elemental analysis, and single-crystal X-ray diffraction. The compound [Co(micro(3)-H(2)bbh)(phen)](n)() (1) (triclinic space group P with a = 9.

Two- and three-dimensional molecular organization of Schiff-base derivatives.

We have designed and synthesized a series of Schiff base derivatives, and studied their structural features in two-dimensional (2D) and three-dimensional (3D) states by combining scanning tunneling microscopy (STM) and X-ray diffraction experiments. The Schiff-base derivatives with short alkyl chains crystallize easily, which allows a detailed structural analysis by X-ray diffraction. Due to the strong adsorbate-substrate interactions, those bases with long alkyl chains easily form 2D assemblies on highly oriented pyrolytic graphite (HOPG).