Global Invasion Potential of Black-Headed and Red-Headed Webworm, (Drury) (Lepidoptera: Erebidae: Arctiidae) Following Climatic Niche Simulations.

The fall webworm, (Drury) (Lepidoptera: Erebidae: Arctiidae), is a highly dangerous global invasive pest. It exhibits two races: the "red-headed" and "black-headed," each with distinct ecological traits. However, much remains unknown regarding the climatic niche and potential global distribution suitability of these two races.

Cross-cohort microbiome-wide study reveals consistent alterations in the gut bacteriome, but not the gut mycobiome, in patients with hypertension.

Unlabelled: Hypertension, one of the most prevalent cardiovascular diseases, has been linked to the gut microbiota. However, there is a lack of well-defined, cross-population validated gut microbial signatures associated with hypertension, particularly at both the bacterial and fungal levels. To address this gap, we conducted a metagenome-wide analysis of fecal samples from 159 hypertensive patients and 101 healthy controls, using two publicly available data sets from the Beijing and Dalian regions.

Correlation between CBC-derived inflammatory indicators and all-cause mortality with rheumatoid arthritis: a population-based study.

Objectives: We investigated the relationship between inflammatory indicators derived from complete blood cell (CBC) counts and all-cause mortality in individuals with rheumatoid arthritis (RA).

Methods: Data were collected from the National Health and Nutrition Examination Survey (NHANES) database from 2007 to 2018, with a median follow-up duration of 78 months. The inflammatory indicators derived from CBC included several types: the systemic inflammatory response index (SIRI), the systemic immune-inflammation index (SII), the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), and the monocyte-to-lymphocyte ratio (MLR).

A temporal and spatial dual-dimension fusion spectra mapping method for rapid detection of coal quality in laser-induced breakdown spectroscopy.

Coal analysis is essential in mitigating pollutant emissions and optimizing energy efficiency. Laser-induced breakdown spectroscopy (LIBS) has been a promising candidate for coal analysis because of its uniquely fast, minimally destructive, and online capabilities. However, the complex composition of coal leads to matrix effect, which poses a significant challenge to precise quantification by conventional LIBS.

The Chinese gut virus catalogue reveals gut virome diversity and disease-related viral signatures.

Background: The gut viral community has been increasingly recognized for its role in human physiology and health; however, our understanding of its genetic makeup, functional potential, and disease associations remains incomplete.

Methods: In this study, we collected 11,286 bulk or viral metagenomes from fecal samples across large-scale Chinese populations to establish a Chinese Gut Virus Catalogue (cnGVC) using a de novo virus identification approach. We then examined the diversity and compositional patterns of the gut virome in relation to common diseases by analyzing 6311 bulk metagenomes representing 28 disease or unhealthy states.

A metagenome-wide study of the gut virome in chronic kidney disease.

Chronic kidney disease (CKD) is a progressively debilitating condition leading to kidney dysfunction and severe complications. While dysbiosis of the gut bacteriome has been linked to CKD, the alteration in the gut viral community and its role in CKD remain poorly understood. Here, we characterize the gut virome in CKD using metagenome-wide analyses of faecal samples from 425 patients and 290 healthy individuals.

Irx1 mechanisms for oral epithelial basal stem cell plasticity during reepithelialization after injury.

The oral mucosa undergoes daily insults, and stem cells in the epithelial basal cell layer regenerate gingiva tissue to maintain oral health. The Iroquois Homeobox 1 (IRX1) protein is expressed in the stem cell niches in human/mouse oral epithelium and mesenchyme under homeostasis. We found that Irx1+/- heterozygous (Het) mice have delayed wound closure, delayed morphological changes of regenerated epithelium, and defective keratinocyte proliferation and differentiation during wound healing.

Gut mycobiome alterations and network interactions with the bacteriome in patients with atherosclerotic cardiovascular disease.

The connection between the gut mycobiome and atherosclerotic cardiovascular disease (ACVD) is largely uncharted. In our study, we compared the gut fungal communities of 214 ACVD patients with those of 171 healthy controls using shotgun metagenomic sequencing and examined their interactions with gut bacterial communities and network key taxa. The gut mycobiome composition in ACVD patients is significantly different, showing a rise in opportunistic pathogens like , , and , with and showing the most significant changes (Wilcoxon rank-sum test, < 0.

Transcriptional programs of Pitx2 and Tfap2a/Tfap2b controlling lineage specification of mandibular epithelium during tooth initiation.

How the dorsal-ventral axis of the vertebrate jaw, particularly the position of tooth initiation site, is established remains a critical and unresolved question. Tooth development starts with the formation of the dental lamina, a localized thickened strip within the maxillary and mandibular epithelium. To identify transcriptional regulatory networks (TRN) controlling the specification of dental lamina from the naïve mandibular epithelium, we utilized Laser Microdissection coupled low-input RNA-seq (LMD-RNA-seq) to profile gene expression of different domains of the mandibular epithelium along the dorsal-ventral axis.

Exploring the Dynamic Invasion Pattern of the Black-Headed Fall Webworm in China: Susceptibility to Topography, Vegetation, and Human Activities.

The fall webworm (FWW), (Drury) (Lepidoptera: Erebidae: Arctiidae), is an extremely high-risk globally invasive pest. Understanding the invasion dynamics of invasive pests and identifying the critical factors that promote their spread is essential for devising practical and efficient strategies for their control and management. The invasion dynamics of the FWW and its influencing factors were analyzed using standard deviation ellipse and spatial autocorrelation methods.

Dopamine promotes proliferation and inflammatory response in the presence of macrophages.

Background: Dopamine, a frequently used therapeutic agent for critically ill patients, has been shown to be implicated in clinical infections recently, however, the precise mechanisms underlying this association remain elusive. , a novel strain belonging to the species, exhibits potential pathogenic attributes. The impact of dopamine on infection has aroused our interest.

Computational identification of key transcription factors for embryonic and postnatal dental epithelial stem cell.

While many reptiles can replace their tooth throughout life, human loss the tooth replacement capability after formation of the permanent teeth. It was thought that the difference in tooth regeneration capability depends on the persistence of a specialized dental epithelial structure, the dental lamina that contains dental epithelial stem cells (DESC). Currently, we know very little about DESC such as what genes are expressed or its chromatin accessibility profile.

Exploring the Close-Range Detection of UAV-Based Images on Pine Wilt Disease by an Improved Deep Learning Method.

Pine wilt disease (PWD) is a significantly destructive forest disease. To control the spread of PWD, an urgent need exists for a real-time and efficient method to detect infected trees. However, existing object detection models have often faced challenges in balancing lightweight design and accuracy, particularly in complex mixed forests.

Wolf-Hirschhorn syndrome candidate 1 (Whsc1) methyltransferase signals via a Pitx2-miR-23/24 axis to effect tooth development.

Wolf-Hirschhorn syndrome (WHS) is a developmental disorder attributed to a partial deletion on the short arm of chromosome 4. WHS patients suffer from oral manifestations including cleft lip and palate, hypodontia, and taurodontism. WHS candidate 1 (WHSC1) gene is a H3K36-specific methyltransferase that is deleted in every reported case of WHS.

A Novel Joint Adversarial Domain Adaptation Method for Rotary Machine Fault Diagnosis under Different Working Conditions.

In real-world applications of detecting faults, many factors-such as changes in working conditions, equipment wear, and environmental causes-can cause a significant mismatch between the source domain on which classifiers are trained and the target domain to which those classifiers are applied. As such, existing deep network algorithms perform poorly under different working conditions. To solve this problem, we propose a novel fault diagnosis method named Joint Adversarial Domain Adaptation (JADA) for fault detection under different working conditions.

acts as a tumor suppressor by negatively regulating the cluster.

Anaplastic thyroid cancer (ATC) is an aggressive, highly metastatic cancer that expresses high levels of the microRNA ( cluster. We employ an miR inhibitor system to study the function of the different miRs within the cluster based on seed sequence homology in the ATC SW579 cell line. While three of the four families were oncogenic, we uncovered a novel role for as a tumor suppressor and .

A putative long noncoding RNA-encoded micropeptide maintains cellular homeostasis in pancreatic β cells.

Micropeptides (microproteins) encoded by transcripts previously annotated as long noncoding RNAs (lncRNAs) are emerging as important mediators of fundamental biological processes in health and disease. Here, we applied two computational tools to identify putative micropeptides encoded by lncRNAs that are expressed in the human pancreas. We experimentally verified one such micropeptide encoded by a β cell- and neural cell-enriched lncRNA TCL1 Upstream Neural Differentiation-Associated RNA (, also known as , , or ).

The unfolded protein response regulates hepatic autophagy by sXBP1-mediated activation of TFEB.

Defective macroautophagy/autophagy and a failure to initiate the adaptive unfolded protein response (UPR) in response to the endoplasmic reticulum (ER) stress contributes to obesity-associated metabolic dysfunction. However, whether and how unresolved ER stress leads to defects in the autophagy pathway and to the progression of obesity-associated hepatic pathologies remains unclear. Obesity suppresses the expression of hepatic spliced XBP1 (X-box binding protein 1; sXBP1), the key transcription factor that promotes the adaptive UPR.

Ovary removal modifies liver message RNA profiles in single Comb White Leghorn chickens.

Ovaries produce sex hormones, and ovariectomized animals are often used as models for ovarian dysfunction. The liver is a vital organ involved in metabolism and immunity. In the present study, we conducted experiments to investigate the effects of ovariectomy on transcription and metabolic processes in the liver in chicken.

Intraoperative localization of small pulmonary nodules to assist surgical resection: A novel approach using a surgical navigation puncture robot system.

Background: Localization and resection of nonvisible, nonpalpable pulmonary nodules during video-assisted thoracoscopic surgery is challenging. In this study we developed a surgical navigation puncture robot system in order to locate small pulmonary nodules before thoracoscopic surgery.

Methods: Four pigs were divided into group A and group B and underwent positioning puncture with the aid of the robotic system.

Identification of Loci Controlling the Dwarfism Trait in the White Sailfin Molly () Using Genome-Wide Association Studies Based on Genotyping-By-Sequencing.

Dwarfism is a condition defined by low harvest weight in fish, but also results in strange body figures which may have potential for the selective breeding of new ornamental fish strains. The objectives of this study are to reveal the physiological causes of dwarfism and identify the genetic loci controlling this trait in the white sailfin molly. Skeletons of dwarf and normal sailfin mollies were observed by X-ray radioscopy and skeletal staining.