High-Resolution Measurements of Multi-Isotopic Signatures (δN, δO, and ΔO) of Winter NO in a Megacity in Central China.

Isotopic compositions (δN, δO, and ΔO) of nitrogen dioxide (NO) are crucial proxies for elucidating the sources and transformations of atmospheric NO, yet observations remain scarce. Here, we reported high-resolution (2 h interval) measurements of NO isotopic compositions in a megacity in Central China. ΔO(NO) exhibited a clear diurnal cycle with elevated values during the day versus night.

Gut mycobiome alterations and network interactions with the bacteriome in patients with atherosclerotic cardiovascular disease.

The connection between the gut mycobiome and atherosclerotic cardiovascular disease (ACVD) is largely uncharted. In our study, we compared the gut fungal communities of 214 ACVD patients with those of 171 healthy controls using shotgun metagenomic sequencing and examined their interactions with gut bacterial communities and network key taxa. The gut mycobiome composition in ACVD patients is significantly different, showing a rise in opportunistic pathogens like , , and , with and showing the most significant changes (Wilcoxon rank-sum test, < 0.

Reduction of misdiagnosis in urinary tract infections during pregnancy: The role of adjusted urine flow cytometry parameters.

Introduction: Urinary tract infections (UTIs) pose a significant health concern, particularly among pregnant women, for whom accurate diagnosis is essential. However, the use of Urine flow cytometry (UF) for detecting UTIs in this demographic often results in misdiagnosis. The objective of this study was to explore the reasons behind these diagnostic errors and to develop a strategy to minimize the rate of UTI misdiagnosis in pregnant women.

SIRT1-autophagy axis inhibits excess iron-induced ferroptosis of foam cells and subsequently increases IL-1Β and IL-18.

Objective: Ferroptosis is a new form of programmed cell death characterized by an iron-dependent increase in lipid ROS. It has recently been reported that elevated iron levels in macrophages in plaques are associated with atherosclerosis(AS). However, it is not clear whether iron induces ferroptosis and the mechanism of ferroptosis induced by iron in macrophages in plaque.

Establishment of Reference Intervals for Blood Cell Analysis of Adult Tibetan Farmers and Herdsmen Over 4100 Meters Above Sea Level in Tibet Based on a Health Survey.

Yang, Wei, Song Zhao, Dan Liu, Guangming Su, Dongwei Zhang, Gui La, Yu Deng, Pian Ni, and Xiuru Guan. Establishment of reference intervals for blood cell analysis of adult Tibetan farmers and herdsmen over 4100 meters above sea level in Tibet based on a health survey. .

Aquaporin 1 alleviates acute kidney injury via PI3K-mediated macrophage M2 polarization.

Background: Lipopolysaccharide (LPS)-induced acute kidney injury (AKI) is associated with an abnormal immune response. Accumulating evidence has demonstrated that aquaporin 1 (AQP1) prevents kidney tissue injury in LPS-induced AKI by mediating immune response. However, the underlying mechanisms remain obscure.

Aquaporin-1 attenuates macrophage-mediated inflammatory responses by inhibiting p38 mitogen-activated protein kinase activation in lipopolysaccharide-induced acute kidney injury.

Objective: This study was designed to investigate the role of AQP1 in the development of LPS-induced AKI and its potential regulatory mechanisms in the inflammatory responses of macrophages.

Methods: Male Wistar rats were injected intraperitoneally with LPS, and biochemical and histological renal damage was assessed. The levels of inflammatory mediators, macrophage markers and AQP1 in blood and kidney tissues were assessed by ELISA.

[Assessment of Heavy Metal Pollution and Tracing Sources by Pb & Sr Isotope in the Soil Profile of Woodland in Quanzhou].

The contents of 8 heavy metal elements (Sr, Ni, Fe, Cr, Cu, Mn, Pb, Zn) and the lead & strontium isotope composition of soil profile of woodland in Quanzhou city were analyzed by AAS and ICP-MS, respectively. A modified BCR four-step sequential extraction procedure was carried out to obtain the speciation fractionation of heavy metals in the soil profile from 4 stations. The results of the heavy metal elements and the speciation fractionation of heavy metals in the soil profile showed that the heavy metal pollution in the woodland in Quanzhou was relatively light, and the main pollution factor was Sr.

[Tracing Sources of Heavy Metals in the Soil Profiles of Drylands by Multivariate Statistical Analysis and Lead Isotope].

Two profile soils in drylands of Xiamen City were collected and 26 kinds of heavy metals were determined by ICP-MS. The distribution characteristics, environmental risk and pollution sources of heavy metals in soil profiles were studied. The results of Nemero comprehensive pollution index method, the geological accumulation index method and potential ecological hazard index method indicated that Cd was the main pollution factor in the drylands of Xiamen City; the soil pollution was serious in 50-60 cm depth.

Stem cell-based therapies for age-related macular degeneration: current status and prospects.

Age-related macular degeneration (AMD) is one of the major causes of irreversible blindness both in developed and developing countries. During the past decades, the managements of neovascular AMD (wet AMD) have dramatically progressed. However, still no effective treatment for non-neovascular AMD (dry AMD) which was characterized by geographic macular atrophy.

[Effects of allelochemicals ethyl cinnamate on the growth and physiological characteristics of Chlorella pyrenoidosa].

The effects of ethyl cinnamate on the growth and physiological characteristics of Chlorella pyrenoidosa were studied. The allelopathic mechanisms were explored, from views of chlorophyll a content, antioxidant enzyme activities, reactive oxygen species (ROS) level, malondialdehyde (MDA) content and photosynthetic activity. The results revealed that ethyl cinnamate had acute inhibitory effects on the growth of Chlorella pyrenoidosa, and the inhibited degree tended to increase with increased concentrations.