Causal Relationship Between Serum Zinc Levels and Diabetic Kidney Disease (DKD): A Plasma Proteomics Mediation Study.

The association between serum zinc levels and diabetic kidney disease (DKD) has been a focus of considerable scientific interest. Lower serum zinc has been observed to be involved in the progression of DKD, and zinc supplementation can improve the kidney damage of DKD. However, the causal link and the underlying mechanisms driving this association remain poorly understood.

Recurrent immunotactoid glomerulopathy in a kidney transplant recipient: Case report.

Rationale: Immunotactoid glomerulopathy (ITG) is a rare glomerular disease characterized by protein deposition in hollow microtubules on electron microscopy. Patients may present with proteinuria, hematuria, hypertension, and renal insufficiency, and some patients even progress to end-stage renal disease (ESRD). In patients with ESRD, ITG recurs in more than 50% of patients after kidney transplantation; however, there is no clear treatment plan for these patients owing to the limited number of reported cases.

Perioperative sildenafil citrate administration in hepatectomy: a study protocol of randomized controlled trial.

Background: Intraoperative blood loss (IBL) is the major concern in hepatectomy, which was closely relating to the central venous pressure (CVP). The controlled low central venous pressure (CLCVP) technique is moderately required for minimizing hemorrhage during hepatectomy nowadays. Nevertheless, an excessive reduction in CVP might give rise to the jeopardy of inadequate perfusion of vital organs.

Effects of bacterial fertilizer and soil amendment on (Kom.) Kitag. growth and soil microbiota.

Introduction: (Kom.) Kitag. is a nutritious wild vegetable, but its quality deteriorates during artificial cultivation due to soil condition alterations.

Evaluation of Different Drying Methods on the Quality Parameters of Fruits.

(Rupr. and Maxim.; AS) fruit, an underutilized byproduct, possesses significant bioactive potential, yet its quality is highly influenced by drying methods.

ADHDP-based robust self-learning 3D trajectory tracking control for underactuated UUVs.

In this work, we propose a robust self-learning control scheme based on action-dependent heuristic dynamic programming (ADHDP) to tackle the 3D trajectory tracking control problem of underactuated uncrewed underwater vehicles (UUVs) with uncertain dynamics and time-varying ocean disturbances. Initially, the radial basis function neural network is introduced to convert the compound uncertain element, comprising uncertain dynamics and time-varying ocean disturbances, into a linear parametric form with just one unknown parameter. Then, to improve the tracking performance of the UUVs trajectory tracking closed-loop control system, an actor-critic neural network structure based on ADHDP technology is introduced to adaptively adjust the weights of the action-critic network, optimizing the performance index function.

Proximate Composition and In Vitro Bioactive Properties of Leaf Extracts from Seven Species.

, an edible wild plant, is valued for its distinctive flavor and health-promoting properties. This study examines the proximate composition, bioactive compounds, and in vitro biological activities of seven leaves (, , , , var. , and ).

LHPP-P38 MAPK/ERK-ETS1 Axis Negative Feedback Signaling Restrains Progression in Breast Cancer.

Invasion and metastasis are major causes of mortality in breast cancer (BRCA) patients. LHPP, known for its tumor-suppressive effects, has an undefined role in BRCA. We found reduced LHPP protein in BRCA tissues, with lower levels correlating with poor patient outcomes.

Prognostic value of in pan-cancer analysis.

Background: Transmembrane and tetratricopeptide repeat containing 1 () is a recently discovered enzyme involved in the O-mannosylation of cadherins and protocadherins. It has been implicated in various types of cancer, but the overall prognostic significance of in pan-cancer and its potential as an immunotherapeutic target remain unclear.

Methods: We applied various bioinformatics methods to investigate the potential oncogenic roles of using public databases.

Unraveling the Genetic Control of Pigment Accumulation in Physalis Fruits.

and , members of the Physalis genus, are valued for their delicious and medicinal fruits as well as their different ripened fruit colors-golden for and scarlet for . This study aimed to elucidate the pigment composition and genetic mechanisms during fruit maturation in these species. Fruit samples were collected at four development stages, analyzed using spectrophotometry and high-performance liquid chromatography (HPLC), and complemented with transcriptome sequencing to assess gene expression related to pigment biosynthesis.

Colorectal cancer-specific microbiome in peripheral circulation and cancer tissues.

Introduction: Accumulating evidence has supported that gut microbiota and metabolite profiles play indispensable roles in the pathogenesis of colorectal cancer (CRC), which ranks as the third most common cancer and the second leading cause of cancer-related deaths worldwide. However, alterations in tumoral or circulating microbiomes in CRC remain incompletely understood. It has been well-documented that tissue or serum microbiomes with low microbial biomass could be screened by use of 2bRAD sequencing for microbiome (2bRAD-M) at the species resolution.

Radiotherapy combined with anti-PD-1 and TKI for primary cardiac angiosarcoma considering the joint assessment of TLSs and PD-L1: a case report.

Background: Primary cardiac angiosarcoma(PCA) has a low incidence rate and poor prognosis. Currently, no unified clinical treatment standards are available.

Case Presentation: We report the case of a 48-year-old man presenting chest tightness, breathlessness, and dyspnea.

Salicylic acid had the potential to enhance tolerance in horticultural crops against abiotic stress.

Horticultural crops are greatly disturbed by severe abiotic stress conditions. This is considered one of the major threats to the healthy lives of the human population. Salicylic acid (SA) is famous as one of the multifunctional phytohormones that are widely found in plants.

HNF4G stimulates the development of pancreatic cancer by promoting IGF2BP2 transcription.

Objective: Pancreatic cancer is a devastating and lethal malignancy. Our study investigated the effective mechanism of HNF4G on pancreatic cancer cell functions through the IGF2BP2 transcription.

Methods: HNF4G and IGF2BP2 expressions in pancreatic cancer were examined.

Regeneratively mode-locked optoelectronic oscillator.

A regeneratively mode-locked optoelectronic oscillator is proposed to realize multi-mode phase locking in optoelectronic oscillators by coupling a modulating signal generation loop. To verify the feasibility of the scheme, a numerical simulation model is established. In addition, a proof-of-concept experiment is demonstrated in a single-loop optoelectronic oscillator with a 2.

Online recorded data-based finite-time composite neural trajectory tracking control for underactuated MSVs.

This paper presents an online recorded data-based composite neural finite-time control scheme for underactuated marine surface vessels (MSVs) subject to uncertain dynamics and time-varying external disturbances. The underactuation problem of the MSVs was solved by introducing the line-of-sight (LOS) method. The uncertain dynamics of MSVs are approximated by the composite neural networks (NNs).

A bioinformatics framework to identify the biomarkers and potential drugs for the treatment of colorectal cancer.

Colorectal cancer (CRC), a common malignant tumor, is one of the main causes of death in cancer patients in the world. Therefore, it is critical to understand the molecular mechanism of CRC and identify its diagnostic and prognostic biomarkers. The purpose of this study is to reveal the genes involved in the development of CRC and to predict drug candidates that may help treat CRC through bioinformatics analyses.

Green walnut husk extracts Proliferation and Migration in Gastric Cancer.

In the past few decades, natural products have become an increasingly important source of potential anti-cancer agents. The green walnut husk(GWH) extracts have been reported to inhibit multiple tumor cells and might be a promising chemopreventive agent in human neoplasia. However, it is not clear whether GWH extracts inhibit gastric cancer.

Long Noncoding RNA HCG18 Promotes Malignant Phenotypes of Breast Cancer Cells the HCG18/miR-103a-3p/UBE2O/mTORC1/HIF-1α-Positive Feedback Loop.

In recent years, an increasing number of studies have reported that long noncoding RNAs (lncRNAs) play crucial roles in breast cancer (BC) progression and metastasis. Another study group of our research center reported that lncRNA HCG18 was one of the 30 upregulated lncRNAs in BC tissues compared with normal tissues in The Cancer Genome Atlas database. However, the exact biological roles of HCG18 in BC remain unclear.

Stereoselective Synthesis of -Decalin-Based Spirocarbocycles via Photocyclization of 1,2-Diketones.

Diastereoselective synthesis of the -decalin-based α-hydroxyl butanone spirocarbocycles bearing all-carbon quaternary stereogenic centers has been achieved via Norrish-Yang photocyclization of -decalin-substituted-2,3-butanediones using daylight. Density functional theory (DFT) calculations suggest that this diastereoselective reaction is affected by both substrate conformation and intramolecular hydrogen bonds. The developed chemistry could be applied to synthesizing the derivatives of the -decalin-based biologically important natural products.

Silencing of FTX suppresses pancreatic cancer cell proliferation and invasion by upregulating miR-513b-5p.

Background: Abnormal expression of long non-coding RNA (lncRNA) FTX (five prime to Xist), which is involved in X chromosome inactivation, has been reported in various tumors. However, the effect of FTX on the development of pancreatic cancer (PC) has not been elucidated. The purpose of this study was to explore the possible molecular mechanism of FTX in PC.

MicroRNA-15a Carried by Mesenchymal Stem Cell-Derived Extracellular Vesicles Inhibits the Immune Evasion of Colorectal Cancer Cells by Regulating the KDM4B/HOXC4/PD-L1 Axis.

The relevance of microRNA-15a (miR-15a) to autoimmunity has been reported. Herein, we intended to probe the potential roles of miR-15a shuttled by adipose-derived mesenchymal stem cells (adMSCs)-derived extracellular vesicles (Evs) in colorectal cancer (CRC). Initially, CRC cells were treated with interferon gamma (IFN-γ) to screen out differentially expressed genes by transcriptome sequencing.

Stereoselective Synthesis of Cyclohepta[b]indoles by Visible-Light-Induced [2+2]-Cycloaddition/retro-Mannich-type Reactions.

A novel method for the concise synthesis of cyclohepta[b]indoles in high yields was developed. The method involves a visible-light-induced, photocatalyzed [2+2]-cycloaddition/ retro-Mannich-type reaction of enaminones. Experimental and computational studies suggested that the reaction is a photoredox process initiated by single-electron oxidation of an enaminone moiety, which undergoes subsequent cyclobutane formation and rapidly fragmentation in a radical-cation state to form cyclohepta[b]indoles.