Novel near-infrared solid-state probe for monitoring carbon monoxide in cholestatic liver injury and toxic hepatitis.

Carbon monoxide (CO) is an important gas transporter and is closely related to a variety of physiological and pathological processes. Many fluorescent probes have been prepared for detecting CO, but most of them suffer from water-soluble fluorophores, which diffuse easily and are limited for application . Herein, a new solid-state fluorophore (HPQ-IM-OH) is prepared by introducing isophorone to HPQ, which has a long emission wavelength (680 nm) and good diffusion-resistance ability.

Lacticaseibacillus suihuaensis sp. nov., Isolated from Traditional Chinese Pickle.

A novel bacterium of the genus Lacticaseibacillus (designated as N149-9) was isolated from traditional Chinese pickle ('Suan cai'), and was identified by a polyphasic taxonomic approach. Phylogenies based on 16S rRNA, pheS, rpoA, concatenated pheS and rpoA, and whole genome sequences indicated that strain N149-9 was related to the type strains of Lacticaseibacillus parakribbianus, Lacticaseibacillus kribbianus, Lacticaseibacillus absianus and Lacticaseibacillus daqingensis. Strain N149-9 was most closely related to L.

Emphysema: an ignored radiologic sign of diffuse alveolar hemorrhage.

Background: Diffuse alveolar hemorrhage (DAH) is characterized by the presence of diffuse ground glass opacities and/or consolidation on chest CT. Emphysema has been reported occasionally. Nevertheless, the pathogenesis, incidence, imaging subtypes, and clinical impact of emphysema in patients with DAH are still unclear.

Pay attention to the value of liver regeneration in the re-compensation of decompensated cirrhosis.

Conventional wisdom holds that progression from compensated cirrhosis to decompensated cirrhosis is irreversible in the natural history of the disease. However, in recent years, more and more clinical evidence suggests that liver cirrhosis can achieve re-compensation, that is, after effective etiological treatment and complication management, the liver function of partially decompensated patients with cirrhosis has improved and gradually stabilized, and decompensation no longer occurs for a long time. Liver regeneration, as one of the powerful intrinsic abilities of the liver, is the key to the restoration of the structure and complex physiological functions of the damaged liver.

ATP-responsive nanoparticles for improved chemodynamic therapy and dual starvation therapy.

Cancer has become a serious threat to human health and the search for a safe and effective treatment method is particularly urgent. Chemodynamic therapy (CDT) is a non-invasive therapeutic method, but CDT still has certain disadvantages such as its limited therapeutic efficacy through overexpression of GSH and single treatment mode. In this paper, ZIF-based nanoparticles called Cu-SK-GOD@ZIF-90 are constructed for improved chemodynamic therapy and dual starvation therapy (ST).

Specific imaging of hydrogen sulfide in paw edema mice via a novel near-infrared fluorescent probe with large stokes shift.

Paw edema is a classic acute inflammation model, which is often used in clinical screening and evaluation of anti-inflammatory effects of drugs. As an endogenous gas signaling molecule, hydrogen sulfide (HS) is closely related to the progression of paw edema inflammation. However, no fluorescent probes have been reported to visualize HS levels in paw edema mice.

Hydrophilic/Hydrophobic Composite Catalysts to Enhance Contact-Electro-Catalytic Performance of Polytetrafluoroethylene.

The strong hydrophobicity of polytetrafluoroethylene (PTFE) restricts its effective interaction with aqueous media, thereby hindering its contact-electro-catalytic (CEC) performance. Herein, an effective strategy is proposed to enhance CEC efficiency by developing hydrophobic/hydrophilic composites. This approach not only improves hydrophilicity to facilitate solid-liquid contact-electrification (CE) but also leverages solid-solid CE, significantly boosting the CEC activity of PTFE.

Highly Durable Antifouling Performance of Amphiphobic and Slippery Coatings with PFPE-Stored POTS-MSNs@PVDF.

Although the slippery liquid-infused porous surfaces (SLIPSs) exhibit highly antifouling performance against various working liquids, the loss of lubricant always deteriorates their long-term durability. Herein, a spongy composite of polyvinylidene difluoride (PVDF) and hydrangea-type perfluorooctyltrimethoxysilane (POTS)-modified mesoporous silica nanoparticles (MSNs) has been successfully prepared via the spraying method and used as the substrate for SLIPSs, which exhibits satisfactory storage and lock capacities for lubricant to enhance its durable antifouling performances. After infusing perfluoropolyether (PFPE) into the spongy substrate, a stable POTS-MSNs@PVDF@PFPE is prepared, which exhibits high amphiphobic performances (WSA of 1.

Smart Antibacterial Fabric Response to Sweat: Constructing Reversibly Switchable Surface by Zwitterionic Block Copolymers.

Although various antibacterial fabrics have been extensively developed, smart antibacterial fabrics that can achieve stimulus responses have not been developed under high humidity conditions. In this study, a smart sweat-responsive antibacterial fabric has been designed by grafting zwitterionic PTMSPMA--PTMAO copolymer on cotton fabric (CF) to achieve "active attack" and "passive defense" against bacteria. It exhibits desirable antibacterial properties in both HO and dry environments with the killing rates against and reaching over 99.

Monitoring the level of hydrogen sulfide in arthritis and its treatment with a novel near-infrared fluorescent probe.

Hydrogen sulfide (HS) is a physiological gaseous transmitter that plays a crucial role in maintaining the cellular redox state. Arthritis is usually accompanied by redness, swelling, pain, dysfunction and deformity of the joints, and in severe cases can lead to joint disability. Disorders of HS level are associated with the pathological process of arthritis.

VRd vs. VPd as induction therapy in high risk newly diagnosed multiple myeloma.

In high-risk newly diagnosed multiple myeloma (HRNDMM), two different induction regimens were evaluated for safety and efficacy: Bortezomib-Pomalidomide-Dexamethasone (VPd) and Bortezomib-Lenalidomide-Dexamethasone (VRd). Newly diagnosed high-risk MM patients(age > 18) were included in this retrospective study, who received VRd and VPd induction therapy between January 2021 and November 2023. All methods of this experiment were performed in accordance with relevant guidelines and regulations.

OxDc-A0: an oral gastro-tolerant oxalate decarboxylase for treating secondary hyperoxaluria.

Secondary hyperoxaluria is an acquired oxalate metabolic disorder characterized by increased urinary oxalate excretion. Reducing exogenous oxalate absorption through enzyme therapy represents a promising therapeutic strategy. However, the extremely acidic pH and protease-rich environment of the upper gastrointestinal tract pose major obstacles for the oral administration of protein therapeutics.

Hypochlorous Acid-Activatable NIR Fluorescence/Photoacoustic Dual-Modal Probe with High Signal-to-Background Ratios for Imaging of Liver Injury and Plasma Diagnosis of Sepsis.

Hypochlorous acid can be employed as a biomarker for blood infection (such as sepsis) and tissue damage (such as drug-induced liver injury, DILI), and the diagnosis of tissue damage or blood infection can be achieved through the detection of hypochlorous acid in relevant biological samples. Considering the complex environment and the diverse interferences in living organisms and blood plasma, developing new detection methods for HClO with high signal-to-background ratios is particularly important, and it can improve the accuracy of detection and quality of imaging based on a higher contrast, which makes the detection of HClO clearer and more accurate. Here, based on the advantages of the NIR fluorescence/photoacoustic dual-modal probe, we reported a hypochlorous acid-activatable NIR fluorescence/photoacoustic dual-modal probe (NIRF-PA-HClO) based on the spirolactam ring-opening strategy in this paper.

The complete chloroplast genome of Thunb. 1784 (Asteraceae).

Thunb. (1784) is primarily distributed in eastern Asia,  has a total length of 152,778 bp and consists of a large single copy (LSC) region of 84,517 bp, a small single copy (SSC) region of 18,277 bp, and two inverted repeat (IRs) regions of 24,992 bp . The GC content is 37.

The complete chloroplast genome of (Bunge) Fisch. & C. A. Mey. 1836 (Asteraceae) and its phylogenetic analysis.

, widely distributed in China, has a 152,467 bp chloroplast genome with a large single-copy (LSC) region of 83,473 bp, a small single-copy (SSC) region of 18,594 bp, a pair of inverted repeat regions (IRs) of 25,194 bp in length. The GC content is 36.46%.

A Novel Colon-Targeting Ratiometric Probe with Large Emission Shift for Imaging Peroxynitrite in Ulcerative Colitis.

Ulcerative colitis (UC) is an inflammatory disease that leads to the overexpression of peroxynitrite (ONOO). Up to now, it has been a challenge to design a colon-targeted fluorescent probe with a large emission shift that can detect and image ONOO in UC mice. Here, a fluorophore (pyran-coumarin) is linked with cholic acid to develop a colon-targeted fluorescent probe () for the detection of ONOO.

Machine learning applications in breast cancer survival and therapeutic outcome prediction based on multi-omic analysis.

The high heterogeneity within and between breast cancer patients complicates treatment determination and prognosis assessment. Treatment decision-making is influenced by various factors, such as tumor subtype, histological grade, and genotype, necessitating personalized treatment strategies. Prognostic outcomes vary significantly depending on patient-specific conditions.

An ATP-responsive ZIF-based NIR fluorescence nanosystem for enhanced chemo-photodynamic therapy of tumors.

The combination of chemotherapy and photodynamic therapy holds immense potential for achieving synergistic anti-tumor efficacy. However, challenges such as poor stability and premature drug release prior to reaching tumor sites impede the widespread application of this synergistic therapeutic approach. In this study, a novel ATP-responsive NIR fluorescence nanosystem (CDZ) for imaging-guided chemotherapy and PDT has been developed.

ATP-responsive copper(II)-doped ZIF-nanoparticles for synergistic cancer therapy: combining cuproptosis and chemo/chemodynamic therapy.

Cancer, a pressing global health challenge, is characterized by its rapid onset and high mortality rates. Conventional treatment methods prove insufficient in achieving the desired therapeutic outcomes, underscoring the critical need to identify an effective and safe approach for cancer treatment. In this study, a copper-doped nanoparticle known as Cu-DOX@ZIF-90 is designed by incorporating copper(II) (Cu(II)) and encapsulating doxorubicin (DOX) within ZIF-90.