Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Hydrogen sulfide (HS) is a physiological gaseous transmitter that plays a crucial role in maintaining the cellular redox state. Arthritis is usually accompanied by redness, swelling, pain, dysfunction and deformity of the joints, and in severe cases can lead to joint disability. Disorders of HS level are associated with the pathological process of arthritis. In this paper, a near-infrared fluorescent probe (TX-HS) was developed to detect the alterations in HS levels of arthritis. TX-HS has excellent response performance to HS such as near-infrared emission (725 nm), large Stokes shift (125 nm) and high fluorescence enhancement (72-fold). Owing to low cytotoxicity, the probe can be employed to observe the alterations of exogenous and endogenous HS level in HeLa and HepG2 cells. By making full use of near-infrared emission and good biocompatibility, the probe can be employed for exogenous HS imaging in mice, and is able to track the fluctuation of HS level during arthritis and its treatment. These make the probe have the potential to invent an efficient tool for the diagnosis of arthritic disease and its treatment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.aca.2025.343898 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A multifunctional hydrogen sulfide-releasing microparticle/hydrogel hybrid for biomedical applications.
Int J Pharm
September 2025
Department of Biomedical Engineering, Amirkabir University of Technology (Tehran polytechnic), Iran. Electronic address:
Hydrogen sulfide (HS) has been recognized as one of the three main gasotransmitters found extensively in tissues, regulating functions crucial for survival. In many pathological cases, its concentration drops from the intrinsic level, impairing healing and leading to unmet regeneration outcomes. A hybrid microparticle/hydrogel system was developed to sustainably release HS and regulate its level in deprived tissues.
View Article and Find Full Text PDFHydrogen sulfide inhibits recruitment of monocyte-derived tumor associated macrophages in glioblastoma by downregulating CXCL12.
Redox Biol
September 2025
Department of Neurosurgery, LSU Health Shreveport, Shreveport, LA, 71103, United States. Electronic address:
Tumor associated macrophages (TAMs) directly contribute to the dismal prognosis of glioblastoma by preventing anti-tumor immunity and promoting tumor invasion and angiogenesis. Inhibiting TAM infiltration is a potential therapeutic strategy in glioblastoma, with several chemokine antagonists in early clinical development. Hydrogen sulfide, a gasotransmitter that regulates microglial accumulation in a wide range of CNS diseases, may be a novel therapeutic target to prevent TAM recruitment in glioblastoma.
View Article and Find Full Text PDFPrimary production by the purple nonsulfur bacterium in an acidic, moderately sulfidic warm spring.
Appl Environ Microbiol
September 2025
School of Earth and Space Exploration, Arizona State University, Tempe, Arizona, USA.
Populations of the acidophilic purple nonsulfur bacterium were identified in two geographically distinct thermal areas in Yellowstone National Park (Wyoming, USA), as confirmed by 16S rRNA gene sequencing and detection of characteristic methoxylated ketocarotenoids. Microcosm-based carbon uptake assays where oxygenic photosynthesis was excluded via addition of 3-(3,4-dichlorophenyl)-1,1-dimethylurea yielded a light-driven dissolved inorganic carbon (DIC) assimilation rate (7 ± 2 mg C g C h) comparable to those of highly productive algal mats in acidic hot springs, suggesting that may be performing photoautotrophy at the time of the assay. Rates of acetate assimilation were more than two orders of magnitude lower than DIC assimilation and did not differ between light and dark treatments, indicating photoheterotrophic use of acetate was not occurring, though photoheterotrophic assimilation of other organic compounds cannot be excluded.
View Article and Find Full Text PDFDevelopment of collagen-based hydrogel derived from allicin-silver nanoparticles for wound healing.
Naturwissenschaften
September 2025
Department of Biomedical Engineering, Sri Sivasubramaniya Nadar College of Engineering, Kalavakkam, 603110, Tamil Nadu, India.
Wounds with extensive tissue damage are highly susceptible for microbial infections delaying the process of wound healing. Currently, biomaterials with therapeutic molecules emerged as key players in wound repairing. This work developed a novel collagen-based hydrogel loaded with allicin and silver nanoparticles.
View Article and Find Full Text PDFThe multidrug resistance protein inhibitor, MK571 inhibits the hypercontractility state in prostate from obese mice.
World J Urol
September 2025
Department of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Sao Paulo, Brazil.
Purpose: To evaluate the impact of MRP inhibition by MK571 on prostate hypercontractility in diet-induced obesity, based on the hypothesis that this intervention enhances intracellular cAMP and cGMP signaling.
Methods: Adult C57BL/6 mice were divided into three groups: (i) lean, (ii) obese, and (iii) obese + MK571 (5 mg/kg/day, 14 days). The prostate was isolated for immunohistochemistry, biochemistry and functional assays.