Physical function evaluation in volleyball training based on intelligent GRNN.

This study aims to improve both the evaluation accuracy and the real-time feedback capability in monitoring athletes' physical function changes during volleyball training. Firstly, based on the framework of the generalized regression neural network, a variable-structure generalized regression neural network (VSGRNN) is proposed and developed. Three heterogeneous kernel functions, namely Gaussian kernel, radial basis kernel, and Matern kernel, are introduced, and a local weighted response mechanism is constructed to enhance the expression ability of nonlinear physiological signals.

YY1-induced Long non-coding RNA HOXA11-AS activates oxidative stress and inflammation by epigenetic modification of Nrf2 pathway to promote keloid formation.

Background: Long non-coding RNAs (lncRNAs) are increasingly recognized in keloid pathogenesis. This study investigates the role and mechanisms of HOXA11-AS in keloid formation.

Methods: Expression levels of HOXA11-AS and related proteins were measured in keloid tissues and fibroblasts using qRT-PCR, Western blot, and ELISA.

Laser modulation transfer phenomenon in a four-level heterodyne Rydberg atom system.

This paper investigates the transfer of probe or coupling light modulation interference to density matrix elements in a four-level heterodyne Rydberg system. By combining the density matrix dynamical equations with power spectral density (PSD) analysis, we derive analytical solutions to describe this phenomenon. Our results demonstrate that coherence in multi-level systems fundamentally enables this transfer mechanism, thereby increasing the system's noise floor and degrading microwave detection sensitivity.

Laser frequency stabilization method based on a ladder-type Rydberg atom electromagnetically induced transparency.

We established a theoretical model for the ladder-type EIT laser frequency stabilization method based on the analysis of the system response. By using the method of deriving the density matrix equations, we obtained the density matrix elements of the three-level system and subsequently derived the system's response function. Based on this, we revealed the complex interference mechanism of the modulated probe light in the atomic medium.

Loofah Fiber Fabric-Based Piezoresistive Pressure Sensor with Wide-Linear-Range High Sensitivity.

Flexible pressure sensors are indispensable components of artificial tactile perception, whereas it remains a great challenge to possess high sensitivity and a wide linear response range simultaneously. Here, a plant fabric made of loofah fibers with excellent mechanical properties and intricate hierarchical porous structures is designed to replace the conventional soft materials as the sensing layer matrix, promoting structural compressibility while simultaneously providing enough conductive path with increasing pressure. Therefore, the loofah fiber fabric (LFF)-based piezoresistive pressure sensor exhibits high sensitivity (30.

Biotransformation of Phenolic Acids in Foods: Pathways, Key Enzymes, and Technological Applications.

Phenolic acids, as widely distributed secondary metabolites in plants, possess significant biological activities, such as antioxidant and anti-inflammatory effects. However, their practical applications are limited by low absorption rates and poor bioavailability. Biotransformation technology, with its advantages of strong substrate specificity and mild reaction conditions, has become an effective strategy for the directional modification of phenolic acid molecular structures and the preparation of high-value-added derivatives.

High-sensitivity and low-harmonic microwave detection using Rydberg atoms based on a loop-level structure.

We propose and investigate a Rydberg atom sensor based on a loop-level structure, which utilizes the eigenfrequencies of the energy levels as a reference. This design eliminates the need for the local oscillator (LO) electric field required in the traditional superheterodyne structure while maintaining a linear relationship between the readout signal and the microwave (MW) electric field to be measured, along with exhibiting significantly lower harmonic distortion. For experimental validation, we implemented a cesium atomic system based on the loop five-level structure.

p38 protein as a therapeutic target for sepsis-induced organ dysfunction.

Sepsis is a systemic disorder with a dysregulated host response caused by infection and is associated with multiple organ dysfunction and a high risk of mortality. Several factors are involved in the complex pathophysiological process of sepsis, including the inflammatory response, immune response, mitochondrial dysfunction, and coagulation cascade. p38 proteins, a class of mitogen-activated protein kinases, play key roles in inflammatory/immune responses and are involved in essential cellular processes.

The causal relationships between body composition and heart failure: A two-sample mendelian randomization study.

The objective of this study was to assess the causal relationships between various body composition indicators, including body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and specific measures of fat mass (right arm, right leg, trunk, and whole-body fat mass) and fat-free mass, and the risk of heart failure (HF) using a two-sample Mendelian randomization (MR) approach. We used genome-wide significant single nucleotide polymorphisms (SNPs) related to body composition from the UK Biobank, GIANT, and FinnGen as instrumental variables. To estimate causal associations, we applied multiple methods, including inverse variance weighted (IVW), IVW with multiplicative random effects (IVW_mre), MR-PRESSO, and maximum likelihood.

Study on the Molecular Mechanism of XiaoXianXiong Decoction in the Treatment of Atherosclerosis Based on UHPLC-Q Exactive Focus MS/MS, Network Pharmacology, and Experimental Validation.

Atherosclerosis (AS), a leading pathological basis of severe cardiovascular diseases, poses a significant threat to human health. XiaoXianXiong Decoction (XXXD), a classical traditional Chinese medicine (TCM) prescription, has demonstrated promising effects in the treatment of AS. To investigate the underlying mechanism of XXXD in treatment with AS, we used UHPLC-Q Focus MS/MS, network pharmacology and in vivo validation methods.

CD13 as a potential theranostic target for prostate-specific membrane antigen-negative prostate cancer and first-in-human study of [F]AlF-CD13-L1 PET/CT imaging.

Purpose: Approximately 10% of prostate cancer (PCa) are prostate-specific membrane antigen (PSMA)-negative, leading to blind spots in PSMA-based diagnosis. This study aimed to identify a potential target for PSMA-negative PCa and preliminarily evaluate the feasibility of using radionuclide probe targeting the identified target for PCa diagnosis.

Methods: Quantitative protein analysis was performed on eight PSMA-negative PCa and eleven controls to identify a potential molecular target, followed by validation with an expanded cohort using immunohistochemistry.

New Rat Model Mimicking Sacrocolpopexy for POP Treatment and Biomaterials Testing via Unilateral Presacral Suspension.

Introduction And Hypothesis: Pelvic organ prolapse (POP) impacts women's health and quality of life. Post-surgery complications can be severe. This study uses rat models to replicate sacrocolpopexy and test materials for pelvic support, verifying the 4-week postoperative mortality rate, the mechanical properties of the mesh tissue, and the collagen content.

Turnover intention among healthcare workers in Shenzhen, China: the mediating effect of job satisfaction and work engagement.

Background: To ensure workforce stability in China's healthcare system and maintain high-quality care, it is essential to comprehensively understand the interplay of factors contributing to turnover intention of healthcare workers. This study aims to examine the associations between potential factors and turnover intention in healthcare workers and explore the mediating effect of job satisfaction and work engagement in the association between them.

Methods: In this cross-sectional study, a random sample of 1060 healthcare workers working in 98 public medical institutions were recruited to rate their turnover intention in 2018 in Shenzhen, China.

NEDD4L Inhibits the Proliferation and Migration of Keloid Fibroblasts by Regulating YY1 Ubiquitination-Mediated Glycolytic Metabolic Reprogramming.

Keloid scarring is a complex fibroproliferative disorder characterised by excessive fibroblast proliferation. Inhibition of cellular glycolysis effectively suppresses the proliferation of keloid fibroblasts (KFs). Neural precursor cell-expressed developmentally downregulated gene 4-like (NEDD4L), a ubiquitin ligase, regulates cell proliferation in different diseases.

Pleiotropic role of CCR9/CCL25 signaling in adriamycin-induced cardiomyopathy.

Introduction: Adriamycin (ADR)-induced cardiomyopathy is a common problem in many cancer survivors. Recently, specific chemokine receptors have garnered interest as therapeutic targets in cardiovascular diseases.

Objectives: This study aim to report the role of C-C chemokine receptor 9 (CCR9)/C-C chemokine ligand 25 (CCL25) and its therapeutic potential in ADR-induced cardiomyopathy.

HO-1: An emerging target in fibrosis.

Fibrosis, an aberrant reparative response to tissue injury, involves a disruption in the equilibrium between the synthesis and degradation of the extracellular matrix, leading to its excessive accumulation within normal tissues, and culminating in organ dysfunction. Manifesting in the terminal stages of nearly all chronic ailments, fibrosis carries a high mortality rate and poses a significant threat to human health. Heme oxygenase-1 (HO-1) emerges as an endogenous protective agent, mitigating tissue damage through its antioxidant, anti-inflammatory, and antiapoptotic properties.

Development of an integrated online deposition and corrosion monitoring system in a full-scale solid waste CFB boiler.

Solid waste incineration is a clean and sustainable approach for solid waste management. However, ash deposition and corrosion remain a critical issue due to fuel's inherent enrichment of alkali chlorine. This study develops an integrated online deposition and corrosion monitoring system to enhance the operational safety and efficiency of solid waste incineration boilers.

Overlooked interconversion between tetracyclines and their 4-epimers in soil and effects on soil resistome and bacterial community.

With the widespread use of tetracycline antibiotics (TCs) and the application of manure fertilizer in farmland, TCs and their metabolites especially 4-epimers have been heavily detected in agricultural soil. However, existing studies have focused on the residual and environmental behavior of maternal TCs, and few studies have looked at the ecotoxicity of their 4-epimers in soil. In this study, the degradation and interconversion of tetracycline (TC), oxytetracycline (OTC) and their 4-epimers (4-epitetracycline, ETC; 4-epioxytetracycline, OTC) were revealed.

ImmunoPET imaging of LAG-3 expression in tumor microenvironment with Ga-labelled cyclic peptides tracers: from bench to bedside.

Background: Lymphocyte activation gene 3 (LAG-3) has been considered as the next generation of immune checkpoint and a promising prognostic biomarker of immunotherapy. As with programmed cell death protein-1/programmed death-ligand 1 and cytotoxic T-lymphocyte antigen-4 inhibitors, positron emission tomography (PET) imaging strategies could benefit the development of clinical decision-making of LAG-3-related therapy. In this study, we developed and validated Ga-labeled cyclic peptides tracers for PET imaging of LAG-3 expression in bench-to-bedside studies.

Pleiotropic role of GAS6 in cardioprotection against ischemia-reperfusion injury.

Introduction: Myocardial ischemia-reperfusion (IR) injury is a common medical issue contributing to the onset and progression of ischemic heart diseases (IHD). Growth arrest-specific gene 6 (GAS6), a vitamin K-dependent secretory protein, promotes cell proliferation and inhibits inflammation and apoptosis through binding with Tyro3, Axl, and Mertk (TAM) receptors.

Objectives: Our study aimed to examine the effect of GAS6 pathways activation as a potential new treatment in myocardial IR injury.

Free-Water Imaging of the Nucleus Basalis of Meynert in Patients With Idiopathic REM Sleep Behavior Disorder and Parkinson Disease.

Background And Objectives: Cognitive impairments are common in idiopathic REM sleep behavior disorder (iRBD), in which the cholinergic degeneration of nucleus basalis of Meynert (NBM) may play an important role. However, the progressive changes of NBM, the relationship between progressive NBM degeneration and progression of cognitive impairments, and whether degeneration of the NBM can predict cognitive decline in patients with iRBD remain unclear. This study aimed to investigate the cross-sectional and longitudinal microstructural alterations in the NBM of patients with iRBD using free-water imaging and whether free water in the NBM is related to cognitive, mood, and autonomic function.

Isopropyl 3-(3,4-dihydroxyphenyl) 2-hydroxypropanoate protects septic myocardial injury via regulating GAS6/Axl-AMPK signaling pathway.

In a previous study, we used metabolomic techniques to identify a new metabolite of Danshen Dripping Pills called isopropyl 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate (IDHP), which has potential as a drug candidate for cardiovascular diseases. This study aimed to explore the protective effects of IDHP against septic myocardial injury, as well as its molecular mechanism. Wild type or GAS6 knockout mice injured by cecal ligation and puncture (CLP) were used to observe the effect of IDHP.

Establishing a Rat Model of Pelvic Organ Prolapse with All Compartment Defects by Persistent Cervical Tension.

Introduction And Hypothesis: We hypothesized that applying cervical suction and persistent tension can develop a novel and efficient rat model of pelvic organ prolapse.

Methods: Fifteen rats underwent pilot testing to optimize the protocol. Sixteen rats were subjected to pelvic organ prolapse induction by cervical suction and constant traction, while five rats served as controls.