New point mutations in osmosensing two-component histidine kinase gene associated with iprodione resistance in Monilinia fructicola field isolates from China.

Monilinia fructicola is one of main pathogens causing brown rot in peach. Fungicide applications are the most practical way to manage this disease still now, however, overuse of fungicide has led to pathogen resistance. In this study, the susceptibility of 87 field strains of M.

Boron Cluster Functionalization: From Vertex-Specific Modifications to Boron Cage Extension.

Polycyclic molecular systems, which play a crucial role in the fields of materials science and pharmacology, typically consist of 2D extended organic aromatic rings. Extensive research has been conducted on conjugates formed through π-extension, leading to substantial advancements in the field. However, further exploration of novel conjugate systems is essential.

Precise Distal B-H Bond Activation of -Carboranes by Copper Catalysis: Synthesis of Benzene Bioisosteres from Boron Clusters.

The exploration of innovative molecular scaffolds offers an exciting opportunity to venture into a previously unexplored chemical space. Boron clusters, such as carboranes, exhibit three-dimensional (3D) cage structures for exopolyhedral derivatization along multiple directions. This makes carboranes hold great potential as bioisosteric mimetics of benzene.

Taming Inert B-H Bond with Low Energy Light: A Near-Infrared Light-Induced Approach to Facile Carborane Cluster-Amino Acid Coupling.

The selective functionalization of inert B-H bonds in carborane clusters has been a formidable challenge. Recent advances have witnessed such reactions through photoredox methods utilizing ultraviolet or visible light irradiation. However, high-energy light sources often suffer from poor energy efficiency, a limited substrate scope, undesired side reactions, and low scalability.

Meso Hybridized Silk Fibroin Watchband for Wearable Biopotential Sensing and AI Gesture Signaling.

Human biopotential signals, such as electrocardiography, are closely linked to health and chronic conditions. Electromyography, corresponds to muscle actions and is pertinent to human-machine interactions. Here, we present a type of smart and flexible watchband that includes a mini flexible electrode array based on Mo-Au filament mesh, combined with mesoscopic hybridized silk fibroin films.

Silk fibroin microspheres with photothermal nanocarrier encapsulation for anticancer drug delivery.

Controlled drug release systems are pivotal in optimizing therapeutic outcomes and mitigating side effects in treatment protocols. While traditional delivery vectors such as liposomes, micro/nanoparticles, and microspheres are effective, they often struggle with consistency in drug release rates. This study addresses these issues by integrating stimuli-responsive elements specifically magnetic, thermal, and pH-responsive components into drug delivery systems for precise control.

Dative Bonding Activation Enables Precise Functionalization of the Remote B-H Bond of -Carborane Clusters.

The innovation of synthetic strategies for selective B-H functionalization is a pivotal objective in the realm of boron cluster chemistry. However, the precise, efficient, and rapid functionalization of a B-H bond of carboranes that is distant from the existing functional groups remains intractable owing to the limited approaches for site-selective control from the established methods. Herein, we report a dative bonding activation strategy for the selective functionalization of a nonclassical remote B-H site of -carboranes.

Flexible Meso Electronics and Photonics Based on Cocoon Silk and Applications.

Flexible electronics, applicable to enlarged health, AI big data medications, etc., have been one of the most important technologies of this century. Due to its particular mechanical properties, biocompatibility, and biodegradability, cocoon silk (or SF, silk fibroin) plays a key role in flexible electronics/photonics.

Uncovering Novel QTLs and Candidate Genes for Salt Tolerance at the Bud Burst Stage in Rice through Genome-Wide Association Study.

Salt stress is one of the most important factors limiting rice growth and yield increase. Salt tolerance of rice at the bud burst (STB) stage determines whether germinated seeds can grow normally under salt stress, which is very important for direct seeding. However, reports on quantitative trait loci (QTLs) and candidate genes for STB in rice are very limited.

Direct B-H Functionalization of Icosahedral Carboranes Hydrogen Atom Transfer.

The efficient and selective functionalization of icosahedral carboranes (CBH) at the boron vertexes is a long-standing challenge owing to the presence of 10 inert B-H bonds in a similar chemical environment. Herein, we report a new reaction paradigm for direct B-H functionalization of icosahedral carboranes B-H homolysis enabled by a nitrogen-centered radical-mediated hydrogen atom transfer (HAT) strategy. Both the HAT process of the carborane B-H bond and the resulting boron-centered carboranyl radical intermediate have been confirmed experimentally.

Facile Construction of New Hybrid Conjugation via Boron Cage Extension.

Aromatic polycyclic systems have been extensively utilized as structural subunits for the preparation of various functional molecules. Currently, aromatics-based polycyclic systems are predominantly generated from the extension of two-dimensional (2D) aromatic rings. In contrast, polycyclic compounds based on the extension of three-dimensional (3D) aromatics such as boron clusters are less studied.

A switchable redox annulation of 2-nitroarylethanols affording -heterocycles: photoexcited nitro as a multifunctional handle.

The efficient transformation of nitroaromatics to functional molecules such as -heterocycles has been an attractive and significant topic in synthesis chemistry. Herein, a photoexcited nitro-induced strategy for switchable annulations of 2-nitroarylethanols was developed to construct -heterocycles including indoles, -hydroxyl oxindoles and -H oxindoles. The metal- and photocatalyst-free reaction proceeds through intramolecular redox C-N coupling of branched hydroxyalkyl and nitro units, which is initiated by a double hydrogen atom abstraction (-HAA) process.

Genome-Wide Association Study Reveals a Genetic Mechanism of Salt Tolerance Germinability in Rice ( L.).

Salt stress is one of the factors that limits rice production, and an important task for researchers is to cultivate rice with strong salt tolerance. In this study, 211 rice accessions were used to determine salt tolerance germinability (STG) indices and conduct a genome-wide association study (GWAS) using 36,727 SNPs. The relative germination energy (RGE), relative germination index (RGI), relative vigor index (RVI), relative mean germination time (RMGT), relative shoot length (RSL), and relative root length (RRL) were used to determine the STG indices in rice.

Site-Selective Functionalization of Carboranes at the Electron-Rich Boron Vertex: Photocatalytic B-C Coupling via a Carboranyl Cage Radical.

Functionalization of carboranes in a vertex-specific manner is a perennial challenge. Here, we report a photocatalytic B-C coupling for the selective functionalization of carboranes at the boron site which is most distal to carbon. This reaction was achieved by the photo-induced decarboxylation of carborane carboxylic acids to generate boron vertex-centered carboranyl radicals.

Palladium-Catalyzed Hydroboration of Alkynes with Carboranes: Facile Construction of a Library of Boron Cluster-Based AIE-Active Luminogens.

The classical aggregation-induced emission (AIE)-active luminogens (AIEgens) usually include two-dimensional aromatic systems such as tetraphenylethenes, which are synthesized in several steps by using toxic additives. Here, we proposed a new molecular design strategy for the realization of AIE properties by combining three-dimensional aromatic boron clusters of carboranes with vinyl group(s). To obtain a library of the boron cluster-based AIEgens, a Pd-catalyzed hydroboration of alkynes with carboranes is reported.

Remote Effect from Boron Cluster: Tunable Photophysical Properties of o-Carborane-Based Luminogens.

We proposed a new molecular design strategy that the o-carboranyl group is attached as "an innocent unit" to the remote side of luminogens to tune photophysical properties. To verify this strategy, two o-carborane-based compounds with asymmetric molecular geometry were designed and synthesized. Photophysical properties of o-carborane-based luminogens were investigated on the basis of UV-Vis spectra, photoluminescence spectra, crystal structure analysis and theoretical calculations.

Mask removal : Face inpainting via attributes.

Due to the outbreak of the COVID-19 pandemic, wearing masks in public areas has become an effective way to slow the spread of disease. However, it also brings some challenges to applications in daily life as half of the face is occluded. Therefore, the idea of removing masks by face inpainting appeared.

Metal-catalyzed B-H acylmethylation of pyridylcarboranes: access to carborane-fused indoliziniums and quinoliziniums.

Metal-catalyzed mono-acylmethylation of pyridylcarboranes has been realized using α-carbonyl sulfoxonium ylides as a coupling partner. The reaction features high efficiency, excellent site-selectivity and good functional group tolerance. In the presence of pyridyl and enolizable acylmethyl groups, a post-coordination mode has been proposed and validated by high resolution mass spectroscopy (HRMS) to rationalize the unique mono-substitution.

Photoredox B-H functionalization to selective B-N(sp) coupling of nido-carborane with primary and secondary amines.

Access to nido-carborane site-selective B-N(sp) coupling by photoredox catalysed B-H activation has been achieved for the first time, which leads to the synthesis of a series of nitrogen-containing nido-carboranes with moderate to good yields. This protocol is applicable to primary and secondary amines containing alkyl, or heteroaryl groups as well as sulfonamides. Furthermore, the open to air and metal-free conditions with excellent site-selectivity represent a significant improvement for B-H functionalization of nido-carboranes with organic functionalities.

A "flexible" carborane-cored luminogen: variable emission behaviours in aggregates.

The performance of tunable emissions in aggregates is highly desirable but challenging owing to the restricted molecular conformations of luminogens. Herein, we designed and synthesized a new "flexible" luminogen, a carborane-cored compound NAPH, which exhibits variable photophysical behaviours in aggregates, such as aggregation-induced emission, crystallization-induced emission, polymorph-dependent emission, and mechanochromic luminescence. Moreover, the two polymorphs with different emission colors show opposite mechano-responsive luminescence, which is rarely observed for single-component luminescent materials.

Electrooxidative B-H Functionalization of nido-Carboranes.

An atom-economical method for the direct B-H functionalization of nido-carboranes (7,8-nido-C B H ) has been developed under electrochemical reaction conditions. In this reaction system, anodic oxidation serves as a green alternative for traditional chemical oxidants in the oxidation of nido-carboranes. No transition-metal catalyst is required and different heteroatoms bearing a lone pair are reactive in this transformation.

Rh-Catalyzed Decarbonylative Cross-Coupling between o-Carboranes and Twisted Amides: A Regioselective, Additive-Free, and Concise Late-Stage Carboranylation.

The convenient cross-coupling of sp or sp carbons with a specific boron vertex on carborane cage represents significant synthetic values and insurmountable challenges. In this work, we report an Rh-catalyzed reaction between o-carborane and N-acyl-glutarimides to construct various B -C bonds. Under the optimized condition, the removable imine directing group (DG) leads to B(3)- or B(3,6)-C couplings, while the pyridyl DG leads to B(3,5)-Ar coupling.