Double Effects of Oxidative Aging on Carbon Nanotube-Asphalt Nanocomposite Interfaces: Enhancement and Deterioration.

Understanding the mechanisms of oxidative aging effects on the carbon nanotube (CNT)-asphalt nanocomposite interface has long been a challenge, as there are two opposing effects: enhancement and deterioration. In this study, a multiscale coupling method is proposed to analyze the dual effect of oxidative aging on the CNT-asphalt nanocomposite. The method is based on density functional theory (DFT) and molecular dynamics (MD) simulations, supported by microscopic interface observation and macroscopic property testing with a focus on the composite interface.

Deterioration Effects of Oxidative Aging on Graphene-Asphalt Nanocomposite Interfaces: Multiscale Modeling.

The purpose of this study is to explore the mechanism of interfacial degradation of graphene-asphalt nanocomposites by oxidative aging and to explain the principle of reduced cracking resistance. In this study, density functional theory (DFT), molecular dynamics (MD) simulation, atomic force microscopy (AFM), Fourier transform infrared (FTIR) spectroscopy, and linear amplitude scanning test (LAS) were used to quantify the effect of oxidative aging on the interfacial degradation of graphene-asphalt nanocomposites with different scales, and the coupling mechanism between scales was systematically analyzed. The results show that interfacial degradation is a complex multiscale coupling behavior.

Mining of risk perception dimensions of Chinese tourists' outbound tourism based on word vector method.

Introduction: Safety is the lifeline of tourism development. The article's goal is to examin how Chinese tourists perceive risk when travelling aboard.

Methods: In order to create the initial corpus, this study first uses "outbound tourism"as the key word to crawl the question and answer (hereinafter referred to as "Q & A") data from 4 Chinese online travel operator platforms, then preprocesses the "Q & A" data in Python.

Study of the Microscopic Mechanism of Natural Rubber (Cis-1, 4-Polyisoprene, NR)/Polyethylene (PE) Modified Asphalt from the Perspective of Simulation.

This paper aims to study the interaction mechanism of waste tire/plastic modified asphalt from the microscopic perspective of molecules. Based on BIOVIA Materials Studio, a classic four-component asphalt model consisting of asphaltene (CHNOS), resin (CHNOS), aromatic (C46H50S), and saturate (CH) was constructed. Waste tires are represented by natural rubber (NR), which uses cis-1, 4-polyisoprene as a repeating unit.

Thoracoscopic Segmentectomy for Right Upper Lobe With Unique Anatomic Variation.

Combined variation of bronchus and pulmonary vein is rare. We report the case of a 32-year-old man with lung adenocarcinoma in whom three-dimensional computed tomography bronchography and angiography displayed a unique anatomic variation in the right upper lobe. The posterior subsegmental bronchi originated from the apical segmental bronchus and the anterior segmental bronchus, respectively; the apical subsegmental vein shared a trunk with the posterior subsegmental vein.

A Quasi-Experimental Study on the Effectiveness of Compulsory and Voluntary Treatment Settings for 1,299 Drug Abusers in Hunan, China.

Although the type and structure of substance abuse treatment have changed, the overall approaches of drug rehabilitation in China has remained largely unchanged. Evidence of effectiveness for compulsory drug rehabilitation centers (CRCs) and voluntary drug rehabilitation centers (VRCs) remains mixed. The main objective of our study is to reveal the outcomes of CRCs and VRCs and examine the factors associated with relapse in these two centers.

Analysis of the Storage Stability Property of Carbon Nanotube/Recycled Polyethylene-Modified Asphalt Using Molecular Dynamics Simulations.

Carbon nanotubes (CNTs) can improve the storage properties of modified asphalt by enhancing the interfacial adhesion of recycled polyethylene (RPE) and base asphalt. In this study, the interaction of CNT/RPE asphalt was investigated using molecular dynamics simulation. The base asphalt was examined using a 12-component molecular model and verified by assessing the following properties: its four-component content, elemental contents, radial distribution function (RDF) and glass transition temperature.

Multiscale mechanisms of asphalt performance enhancement by crumbed waste tire rubber: insight from molecular dynamics simulation.

The recycling of waste tires is a major environmental problem facing mankind, and the addition of crumbed waste tire rubber (CWTB) to the base asphalt is an extremely promising recycling method. However, the modification mechanism of CWTB to asphalt is not well understood, which restricts the development of CWTB modified asphalt. In this study, the mechanism of CWTB modification of asphalt was explored by dynamic mechanical analysis (DMA), fluorescence microscopy, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and molecular dynamic (MD) simulations.

VATS right posterior segmentectomy with anomalous bronchi and pulmonary vessels: a case report and literature review.

Background: Anatomic variation may increase the difficulty and risk of anatomic segmentectomy. The preoperative three-dimensional computed tomography bronchography and angiography (3D-CTBA) can provide a detailed model of the segmental structure, and contribute to precise and safe segmentectomy.

Case Presentation: This is a case of anomalous bronchi and pulmonary vessels in the right upper posterior segment (RS).

Upgrading the Quality of Recycled Aggregates from Construction and Demolition Waste by Using a Novel Brick Separation and Surface Treatment Method.

Mixed recycled aggregates (MRA) from construction and demolition waste (CDW) with high-purity and environmental performance are required for highway construction application in base layer and precast concrete curbs. The main problematic constituents that reduce the quality level of the recycled aggregates applications are brick components, flaky particles, and attached mortar, which make up a large proportion of CDW in some countries. This paper studies the potential of brick separation technology based on shape characteristics in order to increase the recycled concrete aggregates (RCA) purity for MRA quality improvement.

FAM134B promotes adipogenesis by increasing vesicular activity in porcine and 3T3-L1 adipocytes.

Family with sequence similarity 134, Member B (FAM134B), is a cis-Golgi transmembrane protein that is known to be necessary for the long-term survival of nociceptive and autonomic ganglion neurons. Recent work has shown that FAM134B plays a pivotal role in autophagy-mediated turnover of endoplasmic reticulum (ER) membranes, tumor inhibition and lipid homeostasis. In this study, we provide mechanistic links between FAM134B and ARF-related protein 1 (ARFRP1) and further show that FAM134B resides in the Golgi apparatus.

Retrospective study on video-assisted open mediastinal lymphadenectomy for non-small cell lung cancer: a propensity-matched analysis.

Background: This retrospective study is designed to compare the surgical outcomes of mediastinal lymph node (MLN) dissection between the two groups of non-small cell lung cancer (NSCLC) patients underwent lung cancer surgery through video-assisted thoracoscopic surgery (VATS) or thoracotomy, as well as classify the differences and identify the safer method between two groups.

Methods: A total of 497 patients underwent pulmonary lobectomy and systemic MLN dissection were enrolled in this study. They were divided into VATS group (n=242) and traditional thoracotomy (TT) group (n=255).

MiR-1260b promotes the migration and invasion in non-small cell lung cancer via targeting PTPRK.

Objective: Non-small cell lung cancer (NSCLC) accounts for 80-85% of lung cancer cases which cause most of cancer-related deaths globally. As our previous study discovered miR-1260b can be regarded as a specific signature for metastasis in NSCLC patients. However, the molecular mechanisms of miR-1260b underlying NSCLC progression and metastasis remain dismal.

PAM, OLA, and LNA are Differentially Taken Up and Trafficked Via Different Metabolic Pathways in Porcine Adipocytes.

Dietary fatty acids have different effects on fat deposition in pigs. To clarify the underlying mechanisms of this difference, we compared the metabolism of palmitic (PAM, saturated), oleic (OLA, monounsaturated) and linoleic acid (LNA, polyunsaturated) in porcine adipocytes treated with 100 μM PAM, OLA or LNA. We observed that the adipocytes incubated with LNA accumulated more lipids compared with those treated with PAM and OLA.

Astrocyte elevated gene-1 is overexpressed in non-small-cell lung cancer and associated with increased tumour angiogenesis.

Objectives: Astrocyte elevated gene-1 (AEG-1) functions to mediate angiogenesis, and its upregulation is responsible for tumour angiogenesis during cancer development. This study analysed AEG-1 expression in non-small-cell lung cancer (NSCLC) for association with NSCLC clinicopathological features and tumour angiogenesis.

Methods: The expression of AEG-1, vascular endothelial growth factor and intratumoural microvessel density (assessed using the expression of CD105) was detected by immunohistochemistry in 88 paired tumour tissue and adjacent normal tissue specimens obtained from NSCLC patients.

AEG-1 mRNA expression in non-small cell lung cancer is associated with increased tumor angiogenesis.

Astrocyte-elevated gene-1 (AEG-1) is implicated in the oncogenesis and angiogenesis of various types of human malignant disease. However, the angiogenesis roles of AEG-1 in non-small cell lung cancer (NSCLC) remain to be further elucidated. In the present study, the expression level of AEG-1 mRNA in seven human lung cell lines and 89 paired tissue samples (tumor tissues (TTs) and pair-matched normal adjacent tissues (PMNATs)) from NSCLC patients was detected by real-time PCR.

Depot-specific differences in fat mass expansion in WT and ob/ob mice.

The study was designed to investigate the cellular mechanisms underlying the differential fat expansion in different fat depots in wild type (WT) and ob/ob (OB) mice. At 6 weeks old, no differences in fat mass were found between SAT and VAT in WT mice, while O-SAT showed significantly higher weight than that of O-VAT. The average adipocyte size of SAT (~ 4133.

High therapeutic efficacy of Cathelicidin-WA against postweaning diarrhea via inhibiting inflammation and enhancing epithelial barrier in the intestine.

Diarrhea is a leading cause of death among young mammals, especially during weaning. Here, we investigated the effects of Cathelicidin-WA (CWA) on diarrhea, intestinal morphology, inflammatory responses, epithelial barrier and microbiota in the intestine of young mammals during weaning. Piglets with clinical diarrhea were selected and treated with saline (control), CWA or enrofloxacin (Enro) for 4 days.

Long non-coding RNA PVT1 as a novel biomarker for diagnosis and prognosis of non-small cell lung cancer.

Accumulating evidence has indicated that long non-coding RNA PVT1 is upregulated in various human cancers. However, it remains unclear whether PVT1 is involved in the development and progression of non-small cell lung cancer (NSCLC). The present study was designed to investigate the expression, biological role, and clinical significance of PVT1 in NSCLC.

Cathelicidin-BF suppresses intestinal inflammation by inhibiting the nuclear factor-κB signaling pathway and enhancing the phagocytosis of immune cells via STAT-1 in weanling piglets.

The severity of intestinal inflammation in mammals can be profoundly impacted by weaning stress. Cathelicidins protect intestinal homeostasis by not only directly killing bacteria but also immune regulators. Here, we investigated the effects of cathelicidin-BF (C-BF) derived from the snake venoms of Bungarus fasciatus on weaning stress and intestinal inflammation and examined the mechanisms by which C-BF modulates intestinal immune responses in weanling piglets.

Alterations in oral [1-(14)C] 18:1n-9 distribution in lean wild-type and genetically obese (ob/ob) mice.

Obesity may result from altered fatty acid (FA) disposal. Altered FA distribution in obese individuals is poorly understood. Lean wild-type C57BL/6J and obese C57BL/6Job/ob mice received an oral dose of [1-(14)C]18:1n-9 (oleic acid), and the radioactivity in tissues was evaluated at various time points.