Comparative Metabolomics Reveals Phosphine-Induced Metabolic Disruptions in (Risso).

Phosphine (PH) is a fumigant often used to control insect pests, but its metabolic effects on insect physiology remain unclear. In this study, a comparative metabolomics analysis was performed to elucidate the physiological metabolic pathways affected by PH exposure in , and significant changes in the metabolic profiles induced by PH treatment were identified. Principal component analysis and correlation analysis revealed different metabolic changes, and a total of 45 metabolites were identified and mapped to metabolic pathways using the KEGG database.

Metabolomic and partial proteomic analyses of phosphine resistance in Sitophilus oryzae adults: Significant reduction in body weight after acquiring resistance.

Fumigation with phosphine (PH), the toxicity of which is related to reactive oxygen species (ROS) generation, is widely used to control insect pests such as Sitophilus oryzae in stored commodities. However, overuse and misuse of PH fumigation have led to severe resistance in the targeted insect pests, including S. oryzae.

Integrated Approaches to Invasive Fruit Fly Disinfestation: Ethyl Formate Fumigation and Cold Treatment for as a Surrogate in Korea.

The oriental fruit fly () poses a critical threat to domestic mandarin trade, necessitating effective phytosanitary measures. This study evaluated ethyl formate (EF) and phosphine (PH) fumigation as alternative disinfestation methods, either alone or in combination with cold treatment, using , pumpkin fruit fly, as a surrogate species. Eggs and third-instar larvae were tested under both naked and inoculated conditions.

Primary Investigation on the Synergistic Effects of Methyl Bromide and 1 °C Cold Treatment for Two-Spotted Spider Mite () and the Citrus Mealybug ().

Since the use of methyl bromide has been prohibited globally because of environmental concerns, several alternative fumigants have been newly developed and applied to fresh products. However, single treatment with a methyl bromide alternative fumigant cannot completely replace methyl bromide treatment for some products because of issues associated with long treatment times and phytotoxicity. In this study, we compared the mortality of two agricultural pests, and , after single treatment with methyl bromide and combined application of methyl bromide and cold treatment to confirm the synergistic effects of chemical and physical treatments.

Novel dual-targeting PROTAC degraders of GSK-3β and CDK5: A promising approach for pancreatic cancer treatment.

Pancreatic cancer remains one of the most lethal malignancies, characterized by limited therapeutic options and poor prognoses. Here, we report the development of novel dual-targeting PROTAC (proteolysis-targeting chimera) compounds designed to concurrently degrade GSK-3β and CDK5. These bifunctional molecules were systematically designed by integrating three critical components: (1) a ligand that selectively binds GSK-3β and CDK5, (2) an E3 ligase-recruiting motif, and (3) an optimized linker to facilitate target engagement and proteasomal degradation.

Dual Chalcogen-Bonding Interaction for High-Performance Filterless Narrowband Organic Photodetectors.

A novel green-absorbing organic molecule featuring dual intramolecular chalcogen bonds is synthesized and characterized. This molecule incorporates two such bonds: one between a tellurium atom and the oxygen atom of a carbonyl moiety, and the other between the tellurium atom and the adjacent nitrogen atom within a pyridine moiety. The molecule, featuring dual intramolecular chalcogen bonds exhibits a narrow absorption spectrum and elevated absorption coefficients, closely aligned with a resonance parameter of approximately 0.

Development of a Concurrent Treatment Technique of Ethyl Formate and Mixtures (Nitrogen, Phosphine) to Control Citrus Mealybug ().

Currently, the fumigant ethyl formate (EF) is stored as a liquified gas in metal cylinders mixed with carbon dioxide (CO), but this product type is expensive to manufacture, transport, and maintain in cylinders. To address these problems, we developed a new EF fumigation technique with a nitrogen (N) carrier. In this report, the susceptibility of citrus mealybugs, one of the most resistant mealybugs to fumigants, to EF was assessed; the phytotoxicity of an EF + N concurrent treatment applied to banana fruit was examined to evaluate the efficacy compared to the current EF + CO product; and the increased efficacy with a phosphine (PH) addition to EF + N was also assessed.

Synergistic Effect of Cold Treatment Combined with Ethyl Formate Fumigation against (Diptera: Drosophilidae).

Drosophila suzukii is a quarantine pest that is rapidly spreading in berries. This study evaluated the synergistic effect of combination treatment with ethyl formate (EF) and cold temperature for D. suzukii control on imported grapes.

Efficacy and Phytotoxicity Assessment of Successive Application of Methyl Bromide and Cold Treatment on Export Strawberry Fruits.

Recently, spotted wing Drosophila, , is globally prevalent and causes agricultural losses to many fruits. To export Korean strawberry, methyl bromide fumigation is required to remove infestations, but Korean strawberry farmers are worried about fruit damage because methyl bromide can cause phytotoxicity on fresh commodities. In this report, we assessed the efficacy and phytotoxicity of single and successive application of methyl bromide and cold treatment on an export variety of strawberry to reduce fruit damage.

Fumigation Activity against Phosphine-Resistant (Coleoptera: Tenebrionidae) Using Carbonyl Sulfide.

Phosphine resistance is occurring among stored-grain pests worldwide. This study investigated the fumigation activity of phosphine (PH) and carbonyl sulfide (COS) against domestic strain (d-strain) , resistance strain (r-strain) . and .

Histone acetylation together with DNA demethylation empowers higher plasticity in adipocytes to differentiate into osteoblasts.

Bone regeneration has been a challenge for both researchers and clinicians. In the field of tissue engineering, much effort has been made to identify cell sources including stem cells. The present study aimed to induce trans-differentiation from adipocytes to osteoblasts using epigenetic modifiers; 5-aza-dC and/or trichostatin-A (TSA).

Insecticidal Effects of Fumigants (EF, MB, and PH) towards Phosphine-Susceptible and -Resistant (Coleoptera: Curculionidae).

This study was conducted to evaluate the insecticidal effects of ethyl formate (EF), methyl bromide (MB), and phosphine (PH) fumigants against PH-susceptible and -resistant strains of the rice weevil (), a major rice pest. The highest lethal concentration time 50 (LCt) values of the PH-susceptible strains were 255.797, 21.

Dynamic Responses of Electrically Driven Quartz Tuning Fork and qPlus Sensor: A Comprehensive Electromechanical Model for Quartz Tuning Fork.

A quartz tuning fork and its qPlus configuration show different characteristics in their dynamic features, including peak amplitude, resonance frequency, and quality factor. Here, we present an electromechanical model that comprehensively describes the dynamic responses of an electrically driven tuning fork and its qPlus configuration. Based on the model, we theoretically derive and experimentally validate how the peak amplitude, resonance frequency, quality factor, and normalized capacitance are changed when transforming a tuning fork to its qPlus configuration.

Oral Selumetinib Does Not Negatively Impact Photoreceptor Survival in Murine Experimental Retinal Detachment.

Purpose: Mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling is neuroprotective in some retinal damage models but its role in neuronal survival during retinal detachment (RD) is unclear. In addition, serous RDs are a prevalent side effect of MEK inhibitors (MEKi), blocking MAPK/ERK signaling for treatment of certain cancers. We tested the hypothesis that MEKi treatment in experimental RD would increase photoreceptor death.

Efficacy and Phytotoxicity of Phosphine as Fumigants for Frankliniella occidentalis (Thysanoptera: Thripidae) on Asparagus.

The insecticidal activity of phosphine (PH3) and ethyl formate (EF) toward Frankliniella occidentalis (Pergande) (Thysanoptera: Thripidae) and their phytotoxicity to asparagus were evaluated. Both the PH3 and EF fumigants showed higher lethal concentration and time (LCT) values at lower temperatures. The LCT99 values of PH3 and EF at 5°C in a 12 liters desiccator for 4 h showed the following ranking: eggs (64.

Buckling-Based Non-Linear Mechanical Sensor.

Mechanical sensors provide core keys for high-end research in quantitative understanding of fundamental phenomena and practical applications such as the force or pressure sensor, accelerometer and gyroscope. In particular, in situ sensitive and reliable detection is essential for measurements of the mechanical vibration and displacement forces in inertial sensors or seismometers. However, enhancing sensitivity, reducing response time and equipping sensors with a measurement capability of bidirectional mechanical perturbations remains challenging.

Adhesive force measurement of steady-state water nano-meniscus: Effective surface tension at nanoscale.

When the surface of water is curved at nanoscale as a bubble, droplet and meniscus, its surface tension is expected to be smaller than that of planar interface, which still awaits experimental studies. Here, we report static and dynamic force spectroscopy that measures the capillary force of a single nanoscale water meniscus at constant curvature condition. Based on the Young-Laplace equation, the results are used to obtain the effective surface tension (ST) of the meniscus, which decreases to less than 20% of the bulk value at the radius-of-curvature (ROC) below 25 nm, while indicating the bulk behaviour above ~130 nm ROC.