Identifying factors related to sertraline concentrations in child/adolescent and adult patients: insights from a therapeutic drug monitoring service.

Introduction: Sertraline, a widely prescribed antidepressant, has considerable variability in serum concentrations. This retrospective study aimed to identify key determinants influencing sertraline concentrations, with a special focus on age-related differences.

Methods: We conducted a retrospective analysis of TDM data from 1076 patients (474 children/adolescents and 602 adults) collected between 2018 and 2024.

Cardiovascular comorbidities in Chinese inpatients with schizophrenia spectrum disorders.

Cardiovascular diseases (CVDs) are the leading cause of premature mortality in patients with schizophrenia spectrum disorders (SSDs). However, the detailed categorization of these conditions remains insufficiently explored. This study aims to identify CVDs comorbidity patterns among inpatients with SSDs and to investigate associated factors.

Delineating specific structural and functional patterns for neurophysiological biotypes of childhood maltreatment.

Childhood maltreatment (CM) is a major risk factor for numerous mental disorders. The long-term consequences of CM on brain structural and functional plasticity have been well documented. However, the neurophysiological biotypes of CM remain unclear although the childhood trauma questionnaire uses different dimensions to assess trauma types.

The application of artificial intelligence in diagnosis of Alzheimer's disease: a bibliometric analysis.

Alzheimer's disease (AD) is a neurodegenerative disorder that severely impacts cognitive function, posing significant physical and psychological burdens on patients and substantial economic challenges to families and society, particularly in aging populations where its prevalence is rising. Current diagnostic and therapeutic strategies, including pharmacological treatments and non-pharmacological interventions, exhibit considerable limitations in early diagnosis, etiological treatment, and disease management. This study aims to investigate the application of artificial intelligence (AI) in the early diagnosis and progression monitoring of AD through a bibliometric analysis of relevant literature.

The role of astrocytes in Alzheimer's disease: a bibliometric analysis.

Background: Alzheimer's disease (AD) is a neurodegenerative disorder marked by cognitive decline and memory loss. Recent research underscores the crucial role of astrocytes in AD. This study reviews research trends and contributions on astrocytes in AD from 2000 to 2024, shedding light on the evolving research landscape.

Aberrant individual large-scale functional network connectivity and topology in chronic insomnia disorder with and without depression.

Insomnia is increasingly prevalent with significant associations with depression. Delineating specific neural circuits for chronic insomnia disorder (CID) with and without depressive symptoms is fundamental to develop precision diagnosis and treatment. In this study, we examine static, dynamic and network topology changes of individual large-scale functional network for CID with (CID-D) and without depression to reveal their specific neural underpinnings.

LncRNA NPTN-IT1-201 Ameliorates Depressive-like Behavior by Targeting miR-142-5p and Regulating Inflammation and Apoptosis via BDNF.

Objective: Long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) are widely expressed in the brain and are associated with the development of neurological and neurodegenerative diseases. However, their roles and molecular mechanisms in major depressive disorder (MDD) remain largely unknown. This study aimed to identify lncRNAs and miRNAs involved in the development of MDD and elucidate their molecular mechanisms.

Performance of wetland applied to ecological remediation of abandoned fish ponds: A case study in Gonghu Bay, Tai lake.

To restore the abandoned fish ponds to "near natural" state, the wetland restoration was carried out in Gonghu Bay lakeside, and its long-term performance of controlling external load was studied for 5 years. The findings showed that water quality and biodiversity had been improved dramatically after the preliminary transformation. The concentrations of permanganate index (COD), total nitrogen (TN), and total phosphorus (TP) obviously decreased from 12.

Identification of key genes and crucial pathways for major depressive disorder using peripheral blood samples and chronic unpredictable mild stress rat models.

Background: Accurate diagnosis of major depressive disorder (MDD) remains difficult, and one of the key challenges in diagnosing MDD is the lack of reliable diagnostic biomarkers. The objective of this study was to explore gene networks and identify potential biomarkers for MDD.

Methods: In the present study, we performed a comprehensive analysis of the mRNA expression profiles using blood samples of four patients with MDD and four controls by RNA sequencing.

A review on removing antibiotics and antibiotic resistance genes from wastewater by constructed wetlands: Performance and microbial response.

Pollution caused by antibiotics has been highlighted in recent decades as a worldwide environmental and health concern. Compared to traditional physical, chemical and biological treatments, constructed wetlands (CWs) have been suggested to be a cost-efficient and ecological technology for the remediation of various kinds of contaminated waters. In this review, 39 antibiotics removal-related studies conducted on 106 treatment systems from China, Spain, Canada, Portugal, etc.

Occurrence and health risk assessment of volatile organic compounds in the surface water of Poyang Lake in March 2017.

An investigation into the occurrence of volatile organic compounds (VOCs) in the surface water of Poyang Lake was conducted. The determination of 54 different kinds of VOCs was performed with a purge and trap-gas chromatography-mass spectrometry method at 28 sampling points. Twenty-two types of VOCs were detected; methylene chloride had the highest mean concentration of 708.

Occurrence and fate of antibiotics and antibiotic resistance genes in typical urban water of Beijing, China.

The pollution of antibiotics and antibiotic resistance genes (ARGs) has been highlighted on a global scale because of their serious threats to the environment and human health. Typical urban water in cities with high population density are ideal mediums for the acquisition and spread of antibiotics and ARGs. The pollution level of a broad range of antibiotics and ARGs in hospital wastewater, groundwater and the Wenyu River, and their fates through three sewage treatment plants (STPs) were investigated in this study.

A review on removal of organophosphorus pesticides in constructed wetland: Performance, mechanism and influencing factors.

The residues of organophosphorus pesticides (OPPs) have been widely detected in rivers, the gulf, and even groundwater and drinking water, which may pose a serious threat to aquatic ecosystems and human health. Compared to other treatments, constructed wetlands (CWs) have been demonstrated to be a cost-effective alternative risk mitigation strategy for non-point-source pesticide pollution. This review summarizes 32 studies related to the remediation of OPPs in 117 CWs during 2001-2017 worldwide.

Occurrence and risk assessment of heavy metals in water, sediment, and fish from Dongting Lake, China.

In this study, 15 representative surface waters and sediments and seven typical fish were collected during the wet season in 2016 to explore the occurrence, chemical fractionation, and ecological risk of heavy metals (Cu, Zn, Pb, Cd, Cr, Hg, As, and Ni) in aquatic ecosystems of Dongting Lake in China. In surface water, the concentrations of all elements were lower than the third grade of the surface water quality standards (GB3838-2002). The highest concentrations of Zn, Pb, Cd, Ni, and Cu were found in the outlet of Dongting Lake, whereas As and Cr were highest in the Xiangjiang River Delta area.

Occurrence of typical antibiotics and source analysis based on PCA-MLR model in the East Dongting Lake, China.

The antibiotics residues in freshwater lakes are being highlighted around the world because of high potential threat to environment and human health. Understanding the current state of antibiotics and potential sources in lakes are important. The potential sources of antibiotics (Sewage treatment plants (STPs)), livestock and poultry farms and fishponds in the East Dongting was studied.

Equilibrium adsorption study of the adsorptive removal of Cd and Cr using activated carbon.

The performance of activated carbon (AC) with respect to characterization, adsorption kinetics, thermodynamics, and isotherms was addressed in this study. The effects of initial concentration, pH, contact time, ion strength, and temperature on removal efficiency were also studied. The adsorption isotherms of Cd and Cr on activated carbon can fit the Langmuir model well, and correlation coefficients were above 0.

Life review therapy enhances mental time travel in patients with schizophrenia.

Mental Time Travel (MTT) is the ability of individuals to project themselves to the past or to the future. Studies have shown that schizophrenia (SZ) patients are impaired in MTT. The present study aimed to examine whether MTT in patients with SZ can be improved through Life Review Therapy.

[Survey on Toxoplasma gondii Infection in Depressed Patients and Genotype Identification in Guizhou Province].

Objective: To survey on Toxoplasma gondii infection in depressed patients in Guizhou Province and identify the genotype of T. gondii.

Methods: Enzyme-linked immunosorbent assay (ELISA) was applied to detect the T.