Integrative analysis identifies FERMT3 as a key regulator of metabolic reprogramming in keloid scarring and metabolic syndrome.

 Keloid scarring and Metabolic Syndrome (MS) are distinct conditions marked by chronic inflammation and tissue dysregulation, suggesting shared pathogenic mechanisms. Identifying common regulatory genes could unveil novel therapeutic targets. Methods.

Proteomic profiling and scRNA sequencing identify signatures associated with infection and risk of developing gastric cancer.

Objective: The key molecular events signifying the -induced gastric carcinogenesis process are largely unknown.

Methods: Bulk tissue-proteomics profiling were leveraged across multi-stage gastric lesions from Linqu ( = 166) and Beijing sets ( = 99) and single-cell transcriptomic profiling ( = 18) to decipher key molecular signatures of -related gastric lesion progression and gastric cancer (GC) development. The association of key proteins association with gastric lesion progression and GC development were prospectively studied building on follow-up of the Linqu set and UK Biobank ( = 48,529).

S1P/S1PR4 Promotes the Differentiation of CD8 tissue-resident memory T Cells Aggravating Bile Duct Injury in Biliary Atresia.

Background And Aims: Biliary atresia (BA) is a severe neonatal cholangiopathy characterized by progressive inflammation and fibrosis. We aimed to systematically investigate BA pathology using integrated multi-omics.

Methods: Multi-omics integration of BA and control livers revealed sphingolipid dysregulation.

Mapping Research Trends in Traditional Chinese Medicine Exercises for Anxiety Intervention Using a Knowledge Approach.

Objective: This study aims to analyze the current status of Traditional Chinese Medicine (TCM) exercises in the intervention of anxiety, identifying research hotspots and future development trends.

Methods: The Web of Science database was utilized to conduct a literature review, focusing on studies related to TCM exercises and anxiety from 1991 to 2024. Data analysis was performed using bibliometric software, including CiteSpace, VOSviewer, and R, to visualize insights from selected publications, countries, institutions, as well as highly cited and co-cited references.

Coffee-Ring Suppression in Inkjet-Printed Perovskite Films Enabled by a Shape-Anisotropic Nanorod Solute Strategy.

Achieving uniform perovskite thin films via inkjet printing remains a significant challenge due to the pervasive coffee-ring effect. Here, we present a solute engineering strategy that incorporates shape-anisotropic perovskite nanorods into a single-solvent ink formulation, effectively suppressing coffee-ring formation and yielding ultraflat films with an average roughness (Ra) as low as 0.226 nm.