Fusobacterium nucleatum as an Emerging Culprit in Brain Abscesses: A Narrative Synthesis of 25 Years of Clinical and Diagnostic Data.

Brain abscesses are life-threatening infections, predominantly caused by anaerobic organisms. The role of oropharyngeal microbiota, presence in dental plaque biofilms, and hematogenous spread is established in the literature. However, due to its rare occurrence, limited literature is available on its management.

Stem cell therapy: a promising frontier in modern medicine with a comprehensive overview of their biology and potential therapeutic applications in chronic non-healing cutaneous injuries.

Chronic wounds represent significant challenges to the healthcare system. Their incidence increases with increase in age, especially in individuals suffering from chronic disorders like diabetes. The process of wound healing consists of a series of coordinated biological events triggered by tissue damage, ultimately leading to the repair and restoration of damaged tissues.

A comprehensive water buffalo pangenome reveals extensive structural variation linked to population-specific signatures of selection.

Background: Water buffalo is a cornerstone livestock species in many low- and middle-income countries, yet major gaps persist in its genomic characterization-complicated by the divergent karyotypes of its two subspecies (swamp and river). Such genomic complexity makes water buffalo a particularly good candidate for the use of graph genomics, which can capture variation missed by linear reference approaches. However, the utility of this approach to improve water buffalo has been largely unexplored.

FinTech adoption for ESG integration through robo advisors, personalization, and perceived trust.

In the context of China's growing emphasis on digital finance and sustainable investing, this study investigates the factors influencing investors' behavioral intentions to adopt FinTech solutions, specifically robo-advisors, for green investments. Drawing on responses from 393 investors and employing PLS-SEM analysis through SmartPLS-4, we examine the effects of robo-advisor usage, awareness of ESG factors, and personalization of ESG portfolios on perceived usefulness, perceived ease of use, and behavioral intention, with perceived trust as a moderator. The results reveal that robo-advisor usage and awareness of ESG factors significantly influence perceived usefulness and perceived ease of use, though not intention directly.

Novel insights into the genetic basis and transcriptomic elucidation of virulence attenuation in pv. variants.

pv. (Psa) is the causal agent of kiwifruit bacterial canker, but the factors affecting its pathogenicity in natural settings remain poorly explored. In this study, we isolated two Psa strains, G126 and G282, from infected kiwifruit orchards in Guizhou Province of China.

L. extract Attenuates Angiogenesis Through HIF-1α and WNT Mediated Blockage of VEGF/Angiopoietin Axis.

Objectives: The current study investigated angiogenesis-arresting attributes of oleo-gum resin extract and its underlying molecular mechanisms.

Methods: Series of , and models were used to assess anti-angiogenic properties.

Results: MTT cell viability experiments showed that oleo-gum resin extract induced moderate cytotoxicity towards EA.

Understanding Photocatalytic Degradation of RB5 Dye under Salts Using Nickel Sulfide Nanoparticles: Insights from Dynamic Light Scattering and Theoretical Investigations.

This study reports the photocatalytic degradation of the RB5 dye by nickel sulfide nanoparticles (NiS NPs) in the presence of salts. Dynamic light scattering has rarely been used to study dye photocatalytic degradation. However, hydrodynamic size ( ) and zeta potential measurements offer insights into RB5 photocatalytic degradation.

Probiotics and functional foods in metabolic disease: emerging solutions for obesity and diabetes.

Global epidemics of obesity and type 2 diabetes (T2D) call for innovative solutions apart from conventional treatments. New research shows that probiotics and functional foods are crucial for controlling metabolic health by reducing inflammation, preserving glucose levels, and adjusting the gut flora. This review investigates the complicated link between gut flora and metabolic illnesses and how functional diets and probiotics help.

Exome sequencing reveals broad genetic heterogeneity for neuromuscular disorders in consanguineous Pakistani Families.

Neuromuscular disorders comprise the majority of neurogenetic conditions, generally characterized by overlapping clinical symptoms, such as spastic paraplegia, muscular abnormalities, and ataxia. In low- and middle-income countries (LMICs), many patients remain undiagnosed or are misdiagnosed. For many NMDs, early diagnosis helps reduce the impact and mortality of the disorder, particularly in LMICs such as Pakistan, and reduces the burden on the healthcare system.

Real-World Practice in the Management of Transplant-Eligible Newly Diagnosed Multiple Myeloma: A US-Based Cross-Sectional National Survey.

Background: Transplant-eligible newly diagnosed multiple myeloma (TE-NDMM) is typically managed with induction therapy, high-dose chemotherapy consolidation, and subsequent maintenance therapy. This survey-based study explored real-world practices by evaluating how a patient's cytogenetic risk stratification, physician's institutional affiliation, sub-specialty, and years of experience influence the choice of regimens.

Methods: From May to July 2024, a cross-sectional survey was conducted among US-based hematologists and oncologists, including plasma cell disorder specialists.

A Case of Thiazide-Induced Hyponatremia in an Elderly Patient.

In the dawn of the modern era, hypertension is still prevalent globally. Regardless of age and gender, thiazide diuretics, calcium channel blockers, and renin-angiotensin inhibitors remain the first line of treatment. Drug-induced hyponatremia is a side effect of thiazide diuretics.

Critical success factors for implementing robotic process automation in the hotel industry.

This qualitative study aims to investigate the critical success factors (CSFs) driving the adoption of robotic process automation (RPA) in the hotel industry, uncovering the essential drivers behind effective implementation. Based on interviews conducted in Pakistan and China, thematic analysis was performed with the support of NVivo 14 software to systematically identify and categorize the main facilitators and barriers of RPA adoption in the hotel industry within these two national contexts. Pre-implementation highlights defined goals, process identification, and stakeholder alignment; implementation emphasizes a dedicated project team, process standardization, and a detailed project plan; post-implementation stresses continuous monitoring, performance metrics, and ongoing training.

Comparison of Intravesical Bacillus Calmette-Guérin (BCG) and Mitomycin C for the Treatment of Non-Muscle-Invasive Bladder Cancer.

Background Bacillus Calmette-Guérin (BCG) and mitomycin C (MMC) are the two most commonly used intravesical therapies for non-muscle-invasive bladder cancer (NMIBC), yet variability in treatment outcomes and tolerability continues to challenge clinical decision-making. Updated comparisons reflecting current treatment protocols and adherence patterns are needed to inform practice. Objective The objective of this study is to evaluate and compare the efficacy and safety of intravesical BCG versus MMC in the contemporary treatment of NMIBC, focusing on recurrence, progression, and adverse effects over a 24-month follow-up.

Role of interleukins in the pathogenesis of cholangiocarcinoma: A literature review.

This article summarized the role of interleukins (ILs) in the pathogenesis of cholangiocarcinoma (CCA). It discovered a negative feedback mechanism wherein alternative splicing led to the upregulation of the IL 1 receptor antagonist (IL1RN) isoforms IL1RN-201 and IL1RN-203, which play a crucial anti-inflammatory role in -mutant intrahepatic CCA (iCCA). Higher levels of IL-4 receptor were associated with a worse survival rate in patients with CCA.

The effect of cone beam computed tomography voxel size on age estimation: A three-dimensional surface area analysis study.

Accurate three-dimensional (3D) age estimation relies on cone beam computed tomography (CBCT) image quality. This study investigated the effect of voxel size on age estimation using 3D surface area analysis (3D SAA) of developing tooth apices from different CBCT systems. CBCT scans of 128 developing maxillary second premolars from children aged 7-14 years of Malay and Chinese ethnicities were retrospectively collected using a voxel size of 76 μm.

Advancing environmental sustainability through enhanced enterprise resource planning and green supply chain integration: Evidence from the manufacturing sector.

Through Green Supply Chain Management (GSCM), supplier integration, internal integration, procurement planning, and production planning, this research explores the influence of better enterprise resource planning (ERP) on firm performance. Employees and supervisors of a manufacturing company that has adopted ERP and been accredited by the International Organization for Standardization (ISO) in its environmental management system make up the population. A questionnaire on a five-point Likert scale was utilized to collect data.

Dental age estimation of northern Pakistani children using 3D surface area analyses of canine apices.

Northern Pakistani population specific dental age estimation regression model was developed for children based on the 3D surface area analysis of maxillary canine root apices. Regression model was also compared with the Malaysian population specific formula. Three-dimensional models of 237 permanent maxillary canines belonging to northern Pakistani children aged 7 to 14 years old were analysed using MIMICS and 3-Matics software.

Revitalizing cadmium-stressed sunflower: co-composted biochar improves growth, antioxidant responses, and soil remediation efficiency.

Background: Heavy metals especially cadmium (Cd), has become a matter of concern for environmentalists due to extensive industrialization and poor management of industrial waste. As a toxic pollutant, Cd has ability to deteriorate soil quality and hence disturbs the plant growth and yield. Co-composted biochar (COMBI) has been reported as an excellent organic amendment for improving soil quality, crop productivity and amelioration of heavy metals polluted soil.

Kronecker convolutional feature pyramid for fault diagnosis in rolling bearings.

Rolling bearings play a significant role in rotating machinery. Due to the failure of these components, the operations of the whole machinery are compromised and get out of service, which ultimately causes significant workload overhead and monetary loss. Many techniques are proposed for the diagnosis of faults in the rolling bearing; these techniques are manual and require a large amount of time for identification and correction of faults, which is not suitable for routine maintenance and operability of this rotating machinery.

WG-Storm: a resource-aware scheduler for distributed stream processing engines.

Stream processing engines (SPEs) allow applications to process a large amount of data in real-time. However, to schedule big data applications; the SPEs create several challenges regarding resource utilisation, dynamic configurations, heterogeneous environment, resource awareness, load balancing, As the volume of data increases over time, it also poses a challenge to predict the resource and application requirements for processing. All these factors play an important role, they can cause problems in achieving maximum throughput due to inefficiency in any of them.

Modeling and Exploring Stillbirth Risks in Northern Pakistan.

The World Health Organization (WHO) defines stillbirth as the loss of a fetus after 28 weeks of gestation. Annually, approximately 2 million stillbirths occur worldwide. Projections indicate that by 2030, this figure could rise to nearly 15.

Mixed-Potential-Driven Catalysis: An Electrochemical Mechanism for Room-Temperature CO Oxidation on Gold Catalysts.

Gold is an effective catalyst for low-temperature CO oxidation, yet its mechanism remains debated. Among the various proposed mechanisms, increasing attention has been given to a possible electrochemical pathway in recent studies. Here, experimental evidence is reported that CO oxidation at room temperature in electrolytes proceeds via coupled electrochemical CO oxidation and oxygen reduction half-reactions, i.

Dual fluorophores embedded into zeolitic imidazolate framework-8 for ratiometric fluorescence monitoring of pH and histamine in seafood samples and bioimaging.

The accurate and dynamic monitoring of pH and histamine is essential for the assessment of the freshness of seafood and the diagnosis of early diseases. A ratiometric fluorescence nanoprobe GQDs/AuNCs@ZIF-8 is constructed via embedding gold nanoclusters (AuNCs) and adsorbing graphene quantum dots (GQDs) on zeolitic imidazolate framework-8 (ZIF-8) for detecting pH and histamine. Given the enrichment characteristics of ZIF-8, intramolecular movements of embedded AuNCs are limited and yield aggregation-induced emission, increasing the fluorescence by 5-fold compared to AuNCs.