Comparative Evaluation of Behavioral and Physiological Outcomes on Dental Anxiety of Children Undergoing Dental Treatment: A Randomized Clinical Trial.

Aim: To compare and assess the efficacy of behavior management methods in reducing dental anxiety by using different facial scales and measuring the hemodynamic parameters before, during, and after the dental procedure.

Settings And Designs: The present research work was conducted in the Department of Pedodontics and Preventive Dentistry at Sardar Patel Post Graduate Institute of Dental and Medical Sciences, well equipped with the facilities required to assess and compare the level of anxiety in 180 children aged 4-8 years coming for the first time to the dental clinic for restorative dental procedures using three nonpharmacological behavior management techniques in reducing dental anxiety.

Materials And Methods: By chit method, the equal sample was subdivided into group I as tell-show-do (TSD), group II as tell-play-do (TPD), group III as tell-read-do (TRD), and group IV as Control (no intervention).

ILAM: Cross-Fusion of Latent and Attention Features for Explainable Medical Image Classification.

Accurate and interpretable AI models play a critical role in medical image analysis. However, despite advancements in explainable AI (XAI), existing methods struggle with inconsistent interpretability. To overcome this limitation, we introduce the Integrated Latent and Attention Mapping (ILAM) framework, which enhances both classification accuracy and explainability by fusing local and global feature representations.

Enhancing therapeutic efficacy of fingolimod via intranasal delivery in an ethidium bromide-induced model of multiple sclerosis.

Background: Multiple sclerosis (MS) is a chronic inflammatory autoimmune neurological characterized by muscle weakness, numbness, tingling, vision problems, and difficulty in coordination and balance caused by the damage of myelin content around the nerve fibres. The recent literature is evident that along with their lymphocyte attack prevention mechanism, fingolimod (FNG) can serve as neuroprotective also by ensuring their improved brain availability. Therefore, in this project brain availability of FNG was enhanced by delivering the FNG in the form of nanoparticles.

Tumor-Associated Macrophages Write the Script of Cancer Obesity Paradox.

Obesity paradoxically advances cancer progression while enhancing certain immunotherapies, like anti-PD-1/PD-L1. Bader et al. discovered that obesity-driven factors increase PD-1 on tumor-associated macrophages (TAMs), suppressing anti-tumor responses.

Antimicrobial Activity of Probiotic Bacteria Isolated from Plants: A Review.

Lactic acid bacteria (LAB) constitute a heterogeneous group of bacteria isolated from fermented foods, animals, plants, and mammalian guts, with many health-promoting properties. Probiotics with antagonistic properties against human pathogens and foodborne bacteria have garnered significant attention from the scientific fraternity. A dedicated review focusing on plant-derived probiotic bacteria and their antagonistic properties has not been comprehensively reviewed.

Cortical hypometabolism as a predictor of intermittent theta burst stimulation response in treatment-resistant depression patients: An open-label study.

Background: Intermittent theta burst stimulation (iTBS) is an accepted and approved brain stimulation technique to treat patients with treatment-resistant depression.

Aim: Using neuroimaging, this open-label study aimed to predict the response by observing glucose metabolism with the help of 18-FDG PET scan.

Methods: A total of 25 treatment-resistant depression patients received 15 sessions of iTBS on the left dorsolateral prefrontal cortex.

The Relationship of Pork Meat Consumption with Nutrient Intakes, Diet Quality, and Biomarkers of Health Status in Korean Older Adults.

Background: Pork meat is a widely consumed protein food with the potential to differentially affect health and nutritional status across social and cultural contexts.

Objectives: We evaluated the association between pork meat consumption and nutrient intake, diet quality, and biomarkers of health among older adults (age ≥ 65 years) in Korea.

Methods: Our analyses utilized dietary and health examination data from the 2016-2020 Korean National Health and Nutrition Examination Survey ( = 2068).

A Review on the Protecting Effects and Molecular Mechanisms of Berries Against a Silent Public Health Concern: Non-Alcoholic Fatty Liver Disease.

Non-alcoholic fatty liver disease (NAFLD) poses a silent threat to human health, with prevalence rising at an alarming rate. The treatment and prevention of NAFLD depend on novel approaches as no effective treatment options are currently available. Berries are unique sources of phenolic compounds that have proven roles in disease prevention and health promotion.

Comparative Evaluation of Microbial Reduction Using Silver Diamine Fluoride, (Neem) and Sodium Hypochlorite as Root Canal Irrigants after Biomechanical Preparation in Uniradicular Canals: An Study.

Background: It is difficult to completely eradicate microorganisms from the infected root canal system. Intracanal irrigants seem necessary for eradication of infected tissues and microorganisms in addition to mechanical debridement. Continuous use of chemical antimicrobial agents leads to serious side effects.

A Comparative Evaluation of the Acidogenic Potential of Lactose-based, Soy-based, Protein Hydrolysate-based, and Iron-based Milk Formulas Based on Dental Plaque pH, Salivary pH, and Buffering Capacity: An Study.

Aims And Background: Breastfeeding is the gold standard nutrition for infants. However, the inability of infants to latch on, maternal complaints of sore or painful nipples, and insufficient milk supply frequently result in early breastfeeding cessation. Hence, milk has subsequently been replaced by infant formula milks of high quality, which serve as an alternate source of nutrition for infants.

Mouth Breathing Habit and Their Effects on Dentofacial Growth in Children in the Age Range of 6-14 Years: A Cephalometric Study.

Unlabelled: Nasal breathing protects the upper airway and is responsible for adequate craniofacial development. It is believed that long-standing obstruction causes mouth breathing, which has a negative impact on the craniofacial complex.

Aim: The study aimed to verify the effects of mouth breathing on the dentofacial structure by employing cephalometric analysis.

Antioxidant potential of exopolysaccharides from lactic acid bacteria: A comprehensive review.

Exopolysaccharides (EPSs) from lactic acid bacteria (LAB) have multifunctional capabilities owing to their diverse structural conformations, monosaccharide compositions, functional groups, and molecular weights. A review paper on EPS production and antioxidant potential of different LAB genera has not been thoroughly reviewed. Therefore, the current review provides comprehensive information on the biosynthesis of EPSs, including the isolation source, type, characterization techniques, and application, with a primary focus on their antioxidant potential.

Nanoparticles encapsulated in polysaccharide-based pellets as colon targeting approach.

Aim(s): This article explores the application of mesalazine-loaded nanoparticles (MLZ-NPs) encapsulated in plant polysaccharide-based pellets (MLZ-NPs-Pellets) for ulcerative colitis.

Methods: MLZ-NPs were prepared and evaluated for diameter, PDI, and entrapment efficiency. efficacy study was conducted on Caco-2 cells.

Silkworm-derived carbon nano rods (swCNR) for detection of bismuth ions (Bi) in aquatic medium and their antiradical properties.

The extensive utilization of bismuth and its derivatives in many industries, such as chemical, semiconductor, pharmaceutical, and cosmetics, leads to their accumulation in wastewater, posing a risk to both human health and the environment. Carbon nanorods (CNR) are fluorescent nanoparticles with an ability to detect various analytes as sensing probes. This study focuses on the production, structure, and chemical composition characterization of silkworm-derived CNR (swCNR) and their ability to detect bismuth ions (Bi) and inhibit radicals.

Novel Grading System Based on Nasal Endoscopy: Our Experience with 650 Mucormycosis Cases.

Rhinocerebralmucormycosis, is a progressive fungal invasion of a hard palate, paranasal sinuses, orbit, and brain. Post covid the huge number of mucor cases reported in our institute. To combat them a uniform assessment scale was needed as multiple healthcare workers were involved.

To Analyze the Efficacy of Platelet-rich Plasma in Contrast to Platelet-rich Fibrin along with Synthetic Nanocrystalline Hydroxyapatite and β-tricalcium Phosphate Bone Graft in Regeneration of Bony Defects in Children.

Aim: To analyze the efficacy of platelet-rich plasma (PRP) in contrast to platelet-rich fibrin (PRF) along with synthetic nanocrystalline hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) bone graft in the regeneration of bone defects in children.

Materials And Methods: A total of 20 children in whom bone defect was present were selected and divided into two groups of 10. In group I, the bone defect was filled with PRP + nanocrystalline HA with β-TCP and group II, with PRF + nanocrystalline HA with β-TCP.

Metabolic imaging in recurrent gliomas: comparative performance of 18F-FDOPA, 18F-fluorocholine and 18F-FDG PET/CT.

Purpose: The aim of this study was to directly evaluate glucose, amino-acid and membrane metabolism in tumor cells for diagnosis and prognostication of recurrent gliomas.

Methods: Fifty-five patients (median age = 36 years; 33 men) with histologically proven gliomas and suspected recurrence were prospectively recruited and underwent 18F-FDG (Fluorodeoxyglucose), 18F-FDOPA (fluorodopa) and 18F-Fluorocholine-PET/CT. Images were evaluated by two physicians visually and quantitatively [lesion-SUVmax, tumor (T) to gray-matter (G) and metabolically-active tumor volumes (MTV)].

Extracellular Vesicles in Triple-Negative Breast Cancer: Immune Regulation, Biomarkers, and Immunotherapeutic Potential.

Triple-negative breast cancer (TNBC) is an aggressive subtype accounting for ~10-20% of all human BC and is characterized by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) amplification. Owing to its unique molecular profile and limited targeted therapies, TNBC treatment poses significant challenges. Unlike other BC subtypes, TNBC lacks specific molecular targets, rendering endocrine therapies and HER2-targeted treatments ineffective.

Impact of forced diuresis at two different time points on pelvic imaging in prostatic carcinoma with 68 Ga-PSMA PET/CT.

Objective: We compared diagnostic quality of 68 Ga-PSMA PET/CT imaging focused on the pelvic structures using two furosemide protocols in two different groups of patients.

Material And Methods: A total of 55 patients with prostate cancer were retrospectively enrolled in the study. Out of 55, 31 patients were in group 1 (median age: 66 years, Range 44-78 years) in which furosemide injection was given after completion of whole-body 68 Ga-PSMA PET/CT scan and 24 patients were in group 2 (median age: 63.

An eight-week randomized intervention study on Korean adults to evaluate the effect of milk intake on obesity.

The anti-obesity effect of milk intake has been suggested via a variety of designed studies, but findings of obesity interventions for Korean adults are scarcely reported. The study aimed to investigate the anti-obesity effect of cow milk in Korean adults with an 8-wk randomized intervention. A total of 121 adults overweight aged 19 to 60 yr old were randomly assigned to 1 of the 2 groups: milk or control.