Targeting the Hippo/YAP Pathway: A Promising Approach for Cancer Therapy and Beyond.

Cancer represents a growing cause of death and a threat to public health worldwide; thus, there is an urgent need to understand its pathological mechanism and design effective therapies. The Hippo pathway regulates diverse cellular processes under physiological conditions; however, its dysregulation is associated with several types of cancer, including lung, pancreatic, colorectal, breast, and prostate cancer. Consequently, compounds targeting deregulated Hippo components represent potential treatments for a broad spectrum of cancers.

A cross-sectional study on gender & sports specific biomechanical analysis of countermovement jump force, velocity, power and time parameters in Indian players.

Unlabelled: Kinetic variables are important to measure during countermovement jumps (CMJs) because it enables players to maximize performance and minimize injuries while also customizing their programs to the specific requirements of each gender and sport.

Aim: To assess the kinetic parameters like force, velocity, power, and time during CMJs in male and female players & sports like football, athletics, volleyball, and cricket players.

Method: In this cross-sectional study design, a total of 96 male and female players were divided into four groups-group A: football (n = 24), group B: athletics(n = 24), C: volleyball(n = 24) & group D: cricket (n = 24; batsman &bowlers).

On design, fabrication, and pre-clinical validation of customized 3D-printed dental implant assembly.

In the past few decades, 3D-printed dental implants have been manufactured, and significant studies have demonstrated the pre-clinical validation of such systems. However, studies have yet to tackle the ever-present issue of preventing the jumping gap to enhance overall outcomes. The present study details the utilization of patient computed tomography (CT) data to design and subsequently fabricate a multi-component customized dental implant assembly and customized instruments using direct metal laser sintering (DMLS) technology.

QbD assisted development of hyaluronic acid and TPGS incorporated DOX liposome(s): in vitro assessment of cytotoxicity, uptake, ROS, and NF-κB potential on MDA-MB-231 cells.

This work aimed to develop Doxorubicin (DOX), D‑alpha‑tocopheryl polyethylene glycol 1000 succinate (TPGS), and hyaluronic acid (HA) liposomal delivery system using the Quality by Design (QbD) methodology. Developed liposomal formulations show sustained release behaviour as compared to free DOX (96.7 ± 1.

Carboplatin Co-loaded 5-Fluorouracil Nanoparticles Conjugated with Trastuzumab for Targeted Therapy in HER2 Heterogeneity Breast Cancer.

Breast cancer, the second-most common cause of cancer-related deaths among women, remains a significant global health challenge. This study focuses on developing trastuzumab (TmAb)-functionalized chitosan nanoparticles (CS-NPs) co-loaded with carboplatin and 5-fluorouracil (5-FU) for targeted treatment of HER2-positive breast cancer. The NPs were prepared via the ionic gelation method, optimized using Design of Experimentation (DoE), and characterized for particle size, zeta potential, PDI, and entrapment efficiency.

A review on recent advances and challenges of microneedle technology for enhanced topical treatment of skin disorders.

Microneedles are tiny, minimally invasive needles that are made to create microchannels over a subcutaneous layer of the skin. These micro-injuries encourage the secretion of growth factors and prompt collagen synthesis. The reasons for using microneedling therapy have increased significantly, leading to its widespread adoption in dermatology.

Effectiveness of dry needling on pain & disability in athletes with iliotibial band tightness- a clinical trial.

Introduction: Dry needling (DN) for Myofascial trigger points (MTrP's) can be done on superficial or deep tissue levels for the management of a range of neuromusculoskeletal pain disorders. There is still much to learn about dry needling, despite the fact that it has been demonstrated to be useful for a variety of illnesses. The aim of the current study was to determine the effectiveness of DN with stretching on pain and disability in the treatment of athletes with iliotibial band (ITB) tightness.

Odontogenic Keratocyst of the Maxilla With Fungal Sinusitis: A Rare Case.

Odontogenic keratocysts (OKCs) in the maxilla are rare. Although destructive, their clinical presentation can mimic inflammatory conditions like radicular cysts and osteomyelitis. OKCs originate primarily from odontogenic sources.

Nanoparticles encapsulated in polysaccharide-based pellets as colon targeting approach.

Aim(s): This article explores the application of mesalazine-loaded nanoparticles (MLZ-NPs) encapsulated in plant polysaccharide-based pellets (MLZ-NPs-Pellets) for ulcerative colitis.

Methods: MLZ-NPs were prepared and evaluated for diameter, PDI, and entrapment efficiency. efficacy study was conducted on Caco-2 cells.

Effect of Forearm Supination and Pronation on Median & Ulnar Nerve Conduction Velocity Among Throwers, Archers, and Non-Athletes.

The distinct and specialized movements performed in different sports disciplines may significantly influence nerve performance, potentially affecting nerve responses and the overall function within the respective athletic activities. The purpose of this study is to find the effect of forearm supination and pronation across the elbow joint on ulnar and median nerve conduction velocity (NCV) in throwers, archers, and non-athletes. A total of 34 participants both male and females were recruited with a body mass index (BMI) between 18.

Graphene Oxide, a Prominent Nanocarrier to Reduce the Toxicity of Alzheimer's Proteins: A Revolution in Treatment.

Graphene oxide, a derivative of graphene, has recently emerged as a promising nanomaterial in the biomedical field due to its unique properties. Its potential as a nanocarrier in the treatment of Alzheimer's disease represents a significant advancement. This abstract outlines a study focused on utilizing graphene oxide to reduce the toxicity of Alzheimer's proteins, marking a revolutionary approach in treatment strategies.

Guanidinium-based Integrated Peptide Dendrimers: Pioneer Nanocarrier in Cancer Therapy.

The landscape of cancer therapy has witnessed a paradigm shift with the emergence of innovative delivery systems, and Guanidinium-based Peptide Dendrimers have emerged as a vanguard in this transformative journey. With their unique molecular architecture and intrinsic biocompatibility, these dendrimers offer a promising avenue for the targeted delivery of therapeutic cargo in cancer treatment. This comprehensive review delves into the intricate world of Guanidinium- based Peptide Dendrimers, unraveling their structural intricacies, mechanisms of action, and advancements that have propelled them from laboratory curiosities to potential clinical champions.

Pre-clinical and cellular safety assessment of oral administered DHA rich microalgae oil from sp. (Strain ATCC-20889): acute, sub-chronic and genotoxicity.

The lack of toxicity data for DHA-rich oil from sp. (Strain ATCC-20889) leads to its exclusion from the Qualified Presumption of Safety list. Therefore, present study addresses toxicity evaluation of DHA-rich microalgae oil using (cytotoxicity assay) and methods (acute (OECD 423 guidelines), sub-chronic (OECD 452 guidelines), and genotoxicity assay).

QbD-assisted optimisation of liposomes in chitosan gel for dermal delivery of aceclofenac as synergistic approach to combat pain and inflammation.

Aceclofenac (ACE) is a drug that was precisely devised to circumvent the shortcomings associated with diclofenac. However, ACE too corresponds to nonsteroidal anti-inflammatory drug (NSAID)-related adverse effects, but with a lower amplitude. The present investigation seeks to develop liposomes loaded with ACE adopting a central composite design (CCD) and formulate a chitosan-based hydrogel for synergistic anti-inflammatory efficacy and improved ACE dermal administration.

Quality-by-Design Approach for Investigating the Efficacy of Tacrolimus and Hyaluronic Acid-Loaded Ethosomal Gel in Dermal Management of Psoriasis: In Vitro, Ex Vivo, and In Vivo Evaluation.

Psoriasis is an auto-immune condition with high keratinocyte hyperproliferation due to lower p53 and p22 levels. Tacrolimus, an immune suppressor, is considered one of the most effective drugs in suppressing psoriasis. Systematic administration of tacrolimus often leads to challenging side effects, namely increased infection risk, renal toxicity, neurological symptoms such as tremors and headaches, gastrointestinal disturbances, hypertension, skin-related problems, etc.

Atypical Cervical Potts Spine with Multiple Level Epidural Collection: A Case Series of Three Patients.

Introduction: Cervical Pott's constitutes about 10% of all Pott's spine cases. In tuberculous spondylitis, initially there occurs destruction of vertebral bodies and further progression may result in adjacent abscesses, leading to cord compression. Objective is to excise the diseased focus and to provide spinal stability.

The smallest functional antibody fragment: Ultralong CDR H3 antibody knob regions potently neutralize SARS-CoV-2.

Cows produce antibodies with a disulfide-bonded antigen-binding domain embedded within ultralong heavy chain third complementarity determining regions. This "knob" domain is analogous to natural cysteine-rich peptides such as knottins in that it is small and stable but can accommodate diverse loops and disulfide bonding patterns. We immunized cattle with SARS-CoV-2 spike and found ultralong CDR H3 antibodies that could neutralize several viral variants at picomolar IC potencies in vitro and could protect from disease in vivo.

The Role of Adjunctive Chemical Solutions in the Treatment of Odontogenic Keratocysts: A Scoping Review.

Odontogenic keratocysts (OKC) are aggressive cysts with a high recurrence potential. Treating them with surgical enucleation procedures alone is associated with high recurrence rates; therefore, additional or supportive treatment approaches, such as peripheral osteotomy, cryotherapy, and chemical solutions, are warranted. The objective of the present review was to evaluate the existing literature on the efficacy of chemical approaches, such as Carnoy's solution (CS), in preventing recurrence after the enucleation of OKC.

A short appraisal of polylactic-co-glycolic acid based polymer nanotechnology for colon cancer: recent advances and literature evidences.

The currently available formulations provided non-targeted treatment of colon cancer, the deadliest cancer variant. Due to biopharmaceutical hindrances, the majority of the drugs are unable to reach the target site. Polylactic-co-glycolic acid (PLGA) is one of the versatile polymers in cancer treatment, diagnostics and theranostics.

Effect of Forearm and Elbow Joint Positions on Ulnar Nerve Conduction Velocity: A Study of Throwers, Archers, and Non-Athletes.

The intensive physical regimen followed by throwers and archers can impose stress on the elbow and hand in particular positions, which may increase the risk of developing peripheral nerve disorders and symptoms like pain and numbness. The purpose of the study is to investigate the effect of forearm and elbow joint positions on ulnar nerve conduction velocity in throwers, archers, and non-athletes. Total 34 subjects both males and females were included with body mass index (BMI) between 18.

Recent Progression in Nanocarrier based Techniques to Address Fungal Infections and Patent Status in Drug Development Process.

Fungal infections are becoming one of the most common diseases in recent years, especially when it comes about dealing skin infections. Different drugs are available commercially with antifungal activity for topical application and are effective for treatment of mild to moderate fungal infections. However they lack dermal bioavailability due to their poor penetrability, and less retention at the site thereby resulting in poor efficacy.

A Novel Case of Deep Temporal Artery (DTA) Embolization for Recurrent Subacute-Chronic Subdural Hematoma.

Subdural hemorrhage (SDH) is a common neurological disease. In past, SDHs were managed either conservatively (non-surgically) or with surgical evacuation (burr hole versus craniotomy) depending on the severity. Surgical evacuation has major challenges including high recurrence rate, stoppage and reversal of antiplatelet or anticoagulation agents, risk of general anesthesia and surgery in elderly patients with multiple comorbidities.