Effectiveness of Mini-screw and Nance palatal arch for anchorage control following segmental maxillary canine retraction in adolescents with angle Class I crowding using 3D digital models: A randomized clinical trial.

Objectives: To compare anchorage control and treatment duration between Mini-screws and the Nance palatal arch during segmental canine retraction in adolescents.

Trial Design: Two-arm, parallel-group randomized controlled trial.

Methodology: Fifty patients (11-18 years) requiring first premolar extraction were randomly assigned to Group 1 (Nance palatal arch) or Group 2 (Mini-screw) in the ratio of 1:1.

On design, fabrication, and pre-clinical validation of customized 3D-printed dental implant assembly.

In the past few decades, 3D-printed dental implants have been manufactured, and significant studies have demonstrated the pre-clinical validation of such systems. However, studies have yet to tackle the ever-present issue of preventing the jumping gap to enhance overall outcomes. The present study details the utilization of patient computed tomography (CT) data to design and subsequently fabricate a multi-component customized dental implant assembly and customized instruments using direct metal laser sintering (DMLS) technology.

Volumetric pulpal changes in permanent first molars following AdvanSyncTM and Twin Block functional appliance: A CBCT study.

Introduction: Dental pulp may respond differently to adverse orthodontic forces. Major physiological effects of optimum orthodontic force application on dental pulp are vascular pulpal changes, pulpal calcification, and fibrosis. Functional appliances taking anchorage from the dentition tend to exert reciprocal higher orthodontic forces.

Impact of Individual and Cassette Administration on Pharmacokinetics of Prednisolone, Diclofenac, and Methotrexate in a Rodent Model of Rheumatoid Arthritis.

Objectives: To find out how arthritic diseases affect the pharmacokinetics of prednisolone, diclofenac, and methotrexate when given individually and as a cassette in male Sprague- Dawley rats, the study's main goal was to look into drug-drug interactions (DDI). For the treatment of moderate to severe arthritis, doctors commonly prescribe all three drugs alone or in combination.

Methodology: Pharmacokinetics (PK) was evaluated using individual and cassette dosing in male Sprague-Dawley rats in a fasting state.

Right Atrial Mass Presenting With Pulmonary Thromboembolic Disease: An Unexpected Hepatic Tissue.

We report a rare case of a 53-year-old woman presenting with pulmonary thromboembolic disease and a right atrial mass initially suspected to be myxoma. Imaging and surgical exploration revealed the mass to be accessory hepatic tissue extending into the inferior vena cava, a highly unusual finding. Histopathologic examination confirmed the diagnosis.

Effect of age on the treatment duration and proposed "impacted incisor severity score" of impacted maxillary incisor: A retrospective study.

Background: Absence of anterior maxillary teeth has a significantly impact on esthetics, speech, mastication, and psychosocial well-being in young patients.

Materials And Methods: A retrospective study was conducted from January 2012 to January 2022, the data include children (8-15 years) with maxillary impacted incisors. After initial screening of the digital records, 75 cases with 80 impacted maxillary central incisors were recruited; 9 cases were excluded due to incomplete records.

Management of facial asymmetry assisted with digitally designed surgical guide for 3-dimensional maxillary repositioning: A case report.

Orthodontists play a pivotal role in diagnosing, planning, and preparing patients for orthognathic surgeries. Digital technologies like cephalometry, intraoral scans, CBCT scans, CAD-CAM-assisted 3-D planning, and printed surgical splints, have largely replaced conventional techniques. The automated software produces surgical splints with a design similar to conventional which may not address complex scenarios, involving symmetric and asymmetric maxillary impaction.

Management of Midface Deficiency in Syndromic Craniosynostosis with Lefort III Distraction Osteogenesis, Outcomes, and Pitfalls.

Background: Syndromic craniosynostosis is characterized by premature fusion of cranial sutures resulting in midface deficiency. Lefort III Distraction Osteogenesis (DO) has emerged as an effective surgical intervention for addressing this complex condition. This case series outlines the outcomes, encountered difficulties, and insights gained through the utilization of Lefort III Distraction Osteogenesis (DO).

Mini-implant assisted orthodontic correction of lip and occlusal cant of a young adult: A case report.

Patients seek orthodontic treatment to correct unesthetic and asymmetric smiles because even a minimal cant of 4 is well perceived by a layperson. This case report describes a nonsurgical orthodontic management of iatrogenic occlusal canting in a 22-year-old female, who developed it during a previous orthodontic treatment for an impacted canine. The iatrogenic cant was corrected by the intrusion of the left mandibular segment followed by extrusion of left maxillary segment using mini-implants.

A randomized, open-label two-period crossover pilot study to evaluate the relative bioavailability in the fed state of atovaquone-proguanil (Atoguanil™) versus atovaquone-proguanil hydrochloride (Malarone®) in healthy adult participants.

Atoguanil™ is a novel complex of atovaquone (ATV) and proguanil (PG) with enhanced ATV bioavailability compared to Malarone®. This pilot study assessed whether the relative bioavailability (F) of ATV, PG, and the primary PG metabolite cycloguanil (CG) following a single oral dose in the fed state of Atoguanil was similar to Malarone despite a 50% lower ATV dose. This open-label, single-dose, randomized 2-period, 2-treatment, balanced crossover study was conducted between 17th November 2021 and 18th March 2022.

Stress adaptive plasticity from introgression lines improves drought and heat stress tolerance in bread wheat ( L.).

is a D-genome donor of hexaploid wheat and is a potential source of genes for various biotic and abiotic stresses including heat and drought. In the present study, we used multi-stage evaluation technique to understand the effects of heat and drought stresses on derived introgression lines (ILs). Preliminary evaluation (during stage-I) of 369 ILs for various agronomic traits identified 59 agronomically superior ILs.

The impact of orthognathic surgery on articulation proficiency and speech intelligibility in skeletal Class III malocclusion: 18 months follow up.

Introduction: Orthognathic surgery results in the positional change of the maxilla and mandible that may affect speech. The present study evaluated the effect of combined maxillary advancement and mandibular setback surgery on articulation proficiency and speech intelligibility in patients with non-syndromic skeletal Class III malocclusion.

Methods: In this prospective study, twenty-five patients with skeletal class III malocclusion and consecutively treated with Lefort-1 maxillary advancement and mandibular setback (BSSO) orthognathic surgery were included in this study.

Isotopic evidence of autochthonous organic matter acting as a major sink of anthropogenic heavy metals in modern lacustrine sediments.

The knowledge of major sources, sinks, and the burial fate of various pollutants added to modern aquatic ecosystems under changing environmental conditions is limited but crucial for our sustainability. In this context, the spatial distributions and causative factors of organic matter (OM) and heavy metal accumulations have been explored in modern lacustrine sediments of a large urbanized and protected wetland (ULB: Upper Lake Bhopal) in Central India. For this purpose, geochemical properties, in particular, stable isotopes (δC and δN) were measured in the ULB surficial sediments (core depth ∼0-1 cm; n = 19), and additionally collected riverbed sediments (n = 2) and atmospheric free-fall dust samples (n = 3) from the lake periphery.

Deciphering the genetic landscape of seedling drought stress tolerance in wheat ( L.) through genome-wide association studies.

Wheat is an important cereal crop constrained by several biotic and abiotic stresses including drought stress. Understating the effect of drought stress and the genetic basis of stress tolerance is important to develop drought resilient, high-yielding wheat cultivars. In this study, we investigated the effects of drought stress on seedling characteristics in an association panel consisting of 198 germplasm lines.

The Lingering Effects of COVID-19: The Psychological State and Quality of Life of Patients with Persistent Loss of Smell and Taste.

The COVID-19 pandemic has resulted in a significant number of individuals experiencing the loss of smell and taste, medically known as anosmia and ageusia, respectively. While many patients recover these senses during the post-acute phase of the illness, a subset of individuals continues to suffer from anosmia and ageusia even after recovering from COVID-19. This article aims to explore the psychological state of COVID patients who have not regained their sense of smell and taste post-recovery, highlighting the potential impact on their mental health and overall well-being.

Two- and Three-Dimensional Transesophageal Echocardiographic Detection of Aortic Dissection Rupture With Extension of Dissection Into the Pulmonary Artery.

• AO dissections may rupture into the PA, and a linear dissection may be seen with TEE. • 3D TEE is a useful supplement to 2D TEE and helps in making a comprehensive assessment. • 3D TEE en face view helps in differentiating a linear dissection from a linear artifact.

Targeted Protein Degraders- The Druggability Perspective.

Targeted Protein degraders (TPDs) show promise in harnessing cellular machinery to eliminate disease-causing proteins, even those previously considered undruggable. Especially if protein turnover is low, targeted protein removal bestows lasting therapeutic effect over typical inhibition. The demonstrated safety and efficacy profile of clinical candidates has fueled the surge in the number of potential candidates across different therapeutic areas.

Insights into nanomechanical behavior of B. mori silk fibroin-hydroxyapatite bio-nanocomposite using MD simulations: Role of varying hydroxyapatite content.

Nanocomposite material composed of Bombyx mori Silk Fibroin and hydroxyapatite (B. mori SF-HA) is a potential biomaterial for bone tissue engineering. Here, Bombyx mori Silk Fibroin (B.

Prospective Evaluation of AI Triage of Pulmonary Emboli on CT Pulmonary Angiograms.

Background Artificial intelligence (AI) algorithms have shown high accuracy for detection of pulmonary embolism (PE) on CT pulmonary angiography (CTPA) studies in academic studies. Purpose To determine whether use of an AI triage system to detect PE on CTPA studies improves radiologist performance or examination and report turnaround times in a clinical setting. Materials and Methods This prospective single-center study included adult participants who underwent CTPA for suspected PE in a clinical practice setting.

Marker trait association for biological nitrogen fixation traits in an interspecific cross of chickpea ().

Unlabelled: A set of 165 Recombinant inbred lines (RILs) derived from an interspecific cross of chickpea was used to identify QTLs for key biological nitrogen fixation (BNF) traits. The phenotyping of BNF and related traits was done at two different agroclimatic zones viz., Central plain zone (Ludhiana) and Sub-Mountainous undulating zone (Gurdaspur) for 2 consecutive seasons (2018-2020).

Application of potassium nitrate and salicylic acid improves grain yield and related traits by delaying leaf senescence in carrying advanced wheat genotypes.

Grain protein content (GPC) is an important quality trait that effectively modulates end-use quality and nutritional characteristics of wheat flour-based food products. The gene is responsible for the higher protein content in wheat grain. In addition to higher GPC, the is also generally associated with reduced grain filling period which eventually causes the yield penalty in wheat.

Coronary allograft vasculopathy in post-heart transplant patients: pathogenesis and role of cardiac computed tomography in diagnosis-a comprehensive review.

Coronary allograft vasculopathy, often known as cardiac allograft vasculopathy (CAV), is a substantial source of morbidity and mortality in people who have had heart transplants. Early detection and monitoring of CAV are crucial for improving outcomes in this population. Although cardiac computed tomography (CT) has emerged as a possible method for finding and evaluating CAV, invasive coronary angiography has long been thought of as the gold standard for recognizing CAV.