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Introduction: Dental pulp may respond differently to adverse orthodontic forces. Major physiological effects of optimum orthodontic force application on dental pulp are vascular pulpal changes, pulpal calcification, and fibrosis. Functional appliances taking anchorage from the dentition tend to exert reciprocal higher orthodontic forces.
Objective: To evaluate the 3D volumetric changes of the dental coronal pulp of maxillary and mandibular permanent first molars 6 months after AdvanSync fixed functional and Twin Block removable functional appliance therapy and followed at 18 months of treatment (T2).
Materials And Methods: This retrospective study was performed on CBCT records obtained from a previous prospective study (Randomized Clinical Trial) comprising 32 patients [females: 17 (9.0-14.5 years), males: 15 (10.5-15.0 years)] who underwent functional mandibular advancement with Twin Block (group 1) and AdvanSync (group 2). Pretreatment (T0), 6 months (T1), and 18 months (T2) follow-up CBCT were assessed for dental pulp volume by using ITK-SNAP software version 3.2.
Results: Intragroup volumetric pulpal changes showed a significant decrease in #16, #26, and #36 at time intervals T0-T1, T0-T2, and T1-T2 in groups 1 and 2. Intergroup comparison of pulpal volume for #16 and #26 was statistically significant at T1. A statistically significant decrease in pulpal volume for #46 was observed at time intervals T0-T1, T0-T2, and T1-T2 in both groups.
Conclusion: Functional appliance therapy with both Twin Block and AdvanSync functional appliance tends to decrease the first molar pulpal volume.
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http://dx.doi.org/10.4103/jos.jos_68_24 | DOI Listing |
Commun Med (Lond)
August 2025
School of Medical Technology, Beijing Institute of Technology, Beijing, China.
Background: In percutaneous coronary intervention (PCI), the ability to predict post-PCI fractional flow reserve (FFR) and stented vessel informs procedural planning. However, highly precise and effective methods to quantitatively simulate coronary intervention are lacking. This study developed and validated a virtual coronary intervention (VCI) technique for non-invasive physiological and anatomical assessment of PCI.
View Article and Find Full Text PDFShanghai Kou Qiang Yi Xue
June 2025
Hefei Stomatology Hospital and Anhui Medical University Hefei School of Stomatology. Hefei 230001, China. E-mail:
Purpose: To evaluate the clinical effect of a new fixed Twin-block on adolescent patients with skeletal ClassⅡ malocclusion.
Methods: Twenty-one patients aged 10-13 years with skeletal ClassⅡ malocclusion with mandibular retrusion were chosen for functional treatment using a new fixed Twin-block. Before and after treatment, panoramic and cephalometric films were taken, and the observation indexes were measured and recorded.
J Conserv Dent Endod
August 2025
Department of Conservative Dentistry and Endodontics, Al-Badar Rural Dental College and Hospital, Kalaburagi, Karnataka, India.
Background: All-in-one irrigants introduced recently claim to impart added benefits for endodontic disinfection; however, their effects on root dentin need to be evaluated.
Aims: The aim of the study was to evaluate the dentinal wettability and surface roughness of Triton and Twin Kleen irrigating solutions on root dentin.
Materials And Methods: Eighty dentin blocks (6 mm × 6 mm) were prepared using middle root portion obtained by horizontal sectioning of forty single-rooted extracted human mandibular premolar teeth which were further mounted in acrylic blocks (4 cm × 4 cm) and were randomly allotted into four groups (n = 20) and subjected to 10 ml of experimental irrigating solutions for 5 min as follows, group 1: normal saline (Control), group 2: 5.
Comput Biol Med
September 2025
Mathematical Oncology Laboratory (MOLAB), Department of Mathematics, University of Castilla-La Mancha, Spain; Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), Spain. Electronic address:
Recent biological research has highlighted the relevance of myeloid-cell populations in glioma growth, with a particular role played by tumor-associated macrophages (TAMs), which comprise resident microglia and monocyte-derived macrophages. Additionally, radiation therapy, the most common treatment for gliomas, significantly alters the tumor microenvironment, affecting TAMs and contributing to tumor recurrence. Promising preclinical studies have identified and developed drugs targeting TAMs.
View Article and Find Full Text PDFAging Clin Exp Res
August 2025
Department of Twin Research & Genetic Epidemiology, King's College London, 3rd Floor D Block South Wing, St Thomas' Campus, London, SE1 7EH, UK.
Background: The ageing population has led to more cancer cases among older adults, who face higher risks of treatment-related adverse events, functional decline, and unplanned healthcare use. Traditional assessments like Eastern Cooperative Oncology Group and Karnofsky Performance Status lack sensitivity for this group, highlighting the need for new methods to monitor symptoms and functional changes in cancer care. This review examines remote monitoring technologies for older adults with cancer, focusing on their potential and challenges.
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