Advances and Prospects in Using Induced Pluripotent Stem Cells for 3D Bioprinting in Cardiac Tissue Engineering.

Background: Cardiovascular diseases remain one of the leading causes of death worldwide. Given the limited self-repair capacity of cardiac tissue, cardiac tissue engineering (CTE) aims to develop strategies and materials for repairing or replacing damaged cardiac tissue by combining biology, medicine, and engineering. Indeed, CTE has made significant strides since the discovery of induced pluripotent stem cells (iPSCs) in 2006, including creating cardiac patches, organoids, and chip models derived from iPSCs, thus offering new strategies for treating cardiac diseases.

A Feasibility Study on Using Hanging Arm Test to Assess Elbow Stability During Surgical Treatment for Varus Posteromedial Rotatory Instability.

Objectives: The aim of this study to investigate the safety and effectiveness of performing the hanging arm test during surgical treatment for elbow varus posteromedial rotatory instability (VPMRI) to assess elbow stability and determine whether to repair the lateral ulnar collateral ligament (LUCL).

Methods: In a retrospective study from August 2014 to March 2019, 27 patients with VPMRI who had a negative result in the hanging arm test after fixation of coronoid fracture were selected. Intraoperative bleeding, operative time, elbow range of motion (ROM), and complications were recorded.

Assisted-GNSS positioning algorithm based on one-way fuzzy time information.

In order to solve the problem that the accuracy of approximate position and approximate time information is limited by the traditional auxiliary positioning algorithm, this paper analyzes the problem that the calculation amount may increase and fail when these auxiliary information exceeds the precision requirement range and puts forward a positioning algorithm based on one-way fuzzy time assistance that is suitable for the positioning solution of GNSS satellite navigation receivers under the condition of fuzzy time information, such as the rotation condition. Methods using the reference information in the ephemeris information, the relatively accurate approximate time information can be reasonably searched and verified so as to achieve the effect of obtaining the positioning result with less calculation. The experimental results show that this method can accurately calculate the exact position even if there is an error in the approximate position information under the condition of one-way time assistance, which not only solves the problem that it cannot be positioned under the conditions of rotation but also does not increase the additional calculation amount and has practical engineering value.

Selective photocatalytic semihydrogenation of alkynols to alkenols on Pd-CN nanosheets under ambient conditions.

Selective hydrogenation of alkynols to alkenols is an essential process for producing fine and intermediate chemicals. Currently, thermocatalytic alkynol hydrogenation faces several challenges, e.g.

Overexpression of Confers Freezing Tolerance in .

Freezing stress is one of the main factors limiting the growth and yield of wheat. In this study, we found that expression was significantly upregulated in the tillering nodes of the strong cold-resistant winter wheat variety Dongnongdongmai1 (Dn1) under freezing stress. Weighted gene co-expression network analysis, qRT-PCR and protein-DNA interaction experiments demonstrated that monodehydroascorbate reductase () is a direct target of TaMYB4.

Identification of novel prognostic model based on homologous recombination deficiency associated lncRNAs in lung adenocarcinoma.

Background: Non-small cell lung cancer with homologous recombination deficiency (HRD) was revealed to have better response to immunotherapy. Long non-coding RNAs (lncRNAs) modulate multiple processes including HRD acting as potential biomarkers in tumors. The function of HRD-associated lncRNAs in lung cancer arouses our interests.

Advances in Selective Electrocatalytic Hydrogenation of Alkynes to Alkenes.

Selective electrochemical hydrogenation of alkynes to alkenes under ambient conditions is a promising alternative to the traditional energy-intensive and high-cost thermocatalytic hydrogenation. However, the systematic summary on the electrocatalysts and electrolyzers remains lacked. Herein, we demonstrate a comprehensive review about recent achievements in the electrocatalysts including noble metal and non-noble-metal materials.

Long-term results of postoperative unsuspected small cell lung cancer on real-world data.

Background: In traditional opinion, solid pulmonary nodule suspected lung cancer should be confirmed by pathology before the operation to exclude small cell lung cancer (SCLC), considering SCLC tends to be aggressive and surgical effect in the management of SCLC remains controversial. The aim of this study was to evaluate the survival result and risk factors of postoperative unsuspected SCLC.

Methods: A total of 120 patients with postoperative unsuspected SCLC who were confirmed by pathology and referred to Chinese PLA General Hospital between 2000 and 2021 were retrospectively analyzed (surgery group).

Aptamer-siRNA chimera and gold nanoparticle modified collagen membrane for the treatment of malignant pleural effusion.

Malignant pleural effusion is one of the most common complications of advanced lung cancer and there is no effective clinical treatment at present. Here, we constructed an aptamer-siRNA chimeras/PEI/PEG/gold nanoparticle (AuNP)/collagen membrane that can progressively activate T cells by layer by layer assembly. Electron microscope showed this collagen membrane could be divided into 10 layers with a total thickness of 50-80μm, and AuNPs could be observed.

The Inhibitory Effect of Regulatory T Cells on the Intimal Hyperplasia of Tissue-Engineered Blood Vessels in Diabetic Pigs.

Severe inflammatory response and functional impairment of endothelial progenitor cells (EPCs) often lead to the implantation failure of EPC-captured tissue-engineered blood vessels (TEBVs) in diabetes. Regulatory T cells (Treg cells) are the most important inhibitory immune cells, but their effects in angiogenesis remain undefined, and the differences in the microenvironment may be an important reason. Here, we constructed a TEBV coated with an anti-CD34 antibody-functionalized heparin-collagen multilayer (anti-CD34 antibody-modified TEBV) using layer-by-layer self-assembly.

Efficacy and safety of combined treatment with pembrolizumab in patients with locally advanced or metastatic esophageal squamous cell carcinoma in the real world.

Background: Treatments for patients with advanced esophageal cancer are still limited. Pembrolizumab has demonstrated antitumor activity in patients with advanced esophageal cancer in previous studies. Few studies have assessed safety and efficacy in routine clinical practice.

Transcriptome analysis of the winter wheat Dn1 in response to cold stress.

Background: Heilongjiang Province has a long and cold winter season (the minimum temperature can reach -30 ℃), and few winter wheat varieties can safely overwinter. Dongnongdongmai1 (Dn1) is the first winter wheat variety that can safely overwinter in Heilongjiang Province. This variety fills the gap for winter wheat cultivation in the frigid region of China and greatly increases the land utilization rate.

Deep Scale-Variant Network for Femur Trochanteric Fracture Classification with HP Loss.

Achieving automatic classification of femur trochanteric fracture from the edge computing device is of great importance and value for remote diagnosis and treatment. Nevertheless, designing a highly accurate classification model on 31A1/31A2/31A3 fractures from the X-ray is still limited due to the failure of capturing the scale-variant and contextual information. As a result, this paper proposes a deep scale-variant (DSV) network with a hybrid and progressive (HP) loss function to aggregate more influential representations of the fracture regions.

tae-miR399- Module Enhances Freezing Tolerance in Winter Wheat via a CBF Signaling Pathway.

Although the regulation of Pi homeostasis by miR399 has been studied in various plant species, its underlying molecular mechanism in response to freezing stress is still poorly understood. In this work, we found that the expression of tae-miR399 and its target gene in the tillering nodes of the strong cold-resistant winter wheat cultivar Dongnongdongmai1 (Dn1) was not only significantly altered after severe winters but also responsive to short-term freezing stress. TaUBC24 physically interacted with TaICE1.

The relationship between the number of circulating tumor cells and the prognosis in patients with esophageal squamous cell carcinoma.

Background: Esophageal cancer (EC) is one of the most common malignancies worldwide, with high morbidity and mortality rates. Circulating tumor cell (CTC) detection has become a novel approach in clinical study of EC. In this study, the relationship between CTCs/c-Kit expression of CTCs and the prognosis of EC patients was analyzed in EC.

Screening and diagnosis of colorectal cancer and advanced adenoma by Bionic Glycome method and machine learning.

Colorectal cancer (CRC), one of the major health problems worldwide, mostly develops from colorectal adenomas. Advanced adenomas are generally considered as precancerous lesions and patients are recommended to remove the adenomas. Screening for colorectal cancer is usually performed by fecal tests (FOBT or FIT) and colonoscopy, however, their benefits are limited by uptake and adherence.

Controllable Synthesis of Biocompatible Fluorescent Carbon Dots From Cellulose Hydrogel for the Specific Detection of Hg.

Heavy metal ions overload can seriously harm human health. Simple and effective strategies for the specific detection of heavy metal ions are of great important. In this work, using different pretreatment methods, a series of carbon dots (CDs) with different particle sizes and doped with varying amounts of elements (O, N, S) were prepared based on the natural polymer, cellulose hydrogel.

Comparative assessment of biomechanics induced by hinge knee prostheses with two different motion axial system.

We aimed to evaluate the biomechanical contact characteristics of rotating hinge knee (RHK) prostheses with different motion axial systems. We performed finite element (FE) analyses to investigate and compare the peak contact stress and contact location on tibial insert and bushing during a gait cycle. The biaxial (BA) system and spherical center axial (SA) system RHK prostheses were included in this study.

Identification of Abnormal Spindle Microtubule Assembly as a Promising Therapeutic Target for Osteosarcoma.

Objective: To demonstrate the expression of abnormal spindle microtubule assembly (ASPM) in clinical osteosarcoma tissue specimens collected in our hospital, and to explore the function of ASPM in osteosarcoma in vitro and in vivo.

Methods: Tissue specimens from 82 cases of osteosarcoma were collected and analyzed by immunohistochemistry assay. We also investigated the relationship between ASPM expression and clinicopathological characteristics in the patients.

Clear cell tumor of the lung could be aggressive: a case report and review of the literature.

Background: Clear cell tumors of the lung (CCTLs) are rare and mostly benign pulmonary neoplasms arising from perivascular epithelioid cells. Only approximately 100 cases have been reported, and half of them were in China. Limited details about CCTLs often cause diagnostic or therapeutic problems.