Probing the pH-Induced Spectral Modifications of NSAIDs for Designing Molecular Logic Gates and Combinational Logic Circuits.

The current paper investigates the absorption and emission spectra of two non-steroidal anti-inflammatory drugs (NSAIDs), acetaminophen (N4HPA) and diclofenac (2DAPA), in aqueous solutions across different pH values. Both molecules exhibit significant changes in absorption and fluorescence spectra as a function of pH, which are attributed to the existence of these molecules in different forms (uncharged, anionic, and cationic) based on pH. The interpretation of these pH-dependent spectral behaviors in the presence or absence of the chemical inputs offers the possibility for the realization of a variety of unimolecular logic circuits, which are able to perform combinational logic operations.

Engineering of abundant metal complexes for electrochemical water splitting.

Advancements in water splitting technologies are crucial for achieving sustainable hydrogen production. Development of highly efficient and economically viable catalysts is essential for commercialization of water electrolysers. While precious metals like platinum and iridium are renowned for their catalytic capabilities in the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER), their high cost and scarcity present significant challenges.

Design of Molecular Logic Gates Via pH-dependent Absorption and Fluorescence Transitions in Drug Molecules.

In this manuscript, we have explored the absorption and fluorescence properties of Sulfamethoxazole (SMX) and Trimethoprim (TMP) in the pH range 1-14. The absorption and fluorescence properties of SMX and TMP exhibit significant variations with changes in pH. These variations in absorption and fluorescence characteristics have been analyzed based on the existence of different species of these molecules in different pH ranges.

Bacterial meningitis is a significant catalyst for neuroinflammation.

Bacterial meningitis is a severe infection that can lead to neuroinflammation, posing risks to the central nervous system (CNS). This inflammation, if uncontrolled, can cause long-term neurological damage, cognitive decline, and neuron injury. Management strategies include telemedicine and remote monitoring, enabling continuous observation and timely adjustments in treatment.

Impact of Oxidative Stress on Reproductive Toxicity Induced by Alpha-Terpineol in Male Sprague-Dawley Rats.

α-Terpineol, a monoterpene found in essential oils and fragrances, has been reported to exhibit reproductive toxicity. The present study investigates the impact of oxidative stress on reproductive toxicity induced by α-Terpineol in male rats. α-Terpineol was administered to rats at various doses (0, 75, 150, and 300 mg/kg/day) via oral gavage for 28 days.

Honey-Mediated CeO Nanoparticles: A Cost-Effective Approach for Electrochemical Biosensing of Human Serum Albumin.

Human serum albumin (HSA), the most abundant blood plasma protein, is a vital biomarker for diagnosing various health conditions. This study introduces a green and innovative approach for synthesizing CeO nanoparticles (NPs) using natural honey as a reducing and stabilizing agent. Comprehensive spectroscopic characterization revealed that the synthesized CeO NPs possess a spongy cobblestone morphology (∼13 nm) and an optical bandgap of 3.

A bio-mimicking cobalt tetramenthol-substituted phthalocyanine-based electrochemical sensor for selective and sensitive detection of -butylhydroquinone.

Healthy eating choices and adequate nutritional foods are the most important factors in extending a person's life expectancy. Synthetic antioxidants are frequently used in the food industry as preservatives despite their toxicity and hence have drawn much attention for their accurate monitoring. This study explores the newly designed cobalt tetramenthol substituted phthalocyanine (CoTMPc) for the electrocatalytic detection of an artificial food preservative, , tertiary butylhydroquinone (TBHQ).

Synthesis of SrAlO and MgCoO bimetallic inorganic nanomaterials for thermal and electrochemical applications.

Bimetallic inorganic nanoparticles are vital due to their high biocompatibility, stability and comparatively less toxicity. Nanosized bimetallic oxide materials have been extensively studied worldwide due to their unique properties such as electrical, magnetic and mechanical properties. Present work is reporting the size-controlled synthesis of strontium aluminate and magnesium cobaltate nanoparticles (SrAlO and MgCoO) by self-propagating combustion reaction using polymer fuel.

Catalytic Reinforcement in Hybrid Imidazole Functionalized Cobalt Phthalocyanine and Ketjenblack for Boosted Hydrogen Evolution.

Hydrogen energy is widely regarded as one of the cleanest forms of green energy due to its bio-friendly nature. However, its commercialization is restricted by many issues. One of the major issues is related to high production cost, which can be overcome by designing of effective catalysts through simple, innovative and cost-effective approach for efficient green hydrogen production.

Molecular docking, ADME properties and synthesis of thiophene sulfonamide derivatives.

This study investigates the drug-like properties of target molecules containing thiophene sulfonamide groups using computational molecular docking techniques. The binding interactions of these derivatives were assessed using protein 2NSD (Enoyl acyl carrier protein reductase InhA, complexed with N-(4-methylbenzoyl)-4-benzylpiperidine, PDB DOI: 10.2210/pdb2NSD/pdb) as the receptor.

Synthesis and characterization of aniline-based azo molecules: In vitro pharmacological and emission studies.

The present work involves the synthesis of novel dispersed mono-azo dyes using different coupling components and 2-methoxy-5-nitro aniline as amine through a simple and convenient diazo-coupling method. The structures of the newly synthesized mono azo dyes were confirmed by using various spectral techniques such as H NMR, Fourier transform infrared, and high-resolution mass spectrometry. At room temperature, the electronic absorption spectra and fluorescence spectra of the synthesized mono azo dyes were recorded with different solvents.

Azoospermia and multi-organ damage in juvenile rats exposed to α-Terpineol from weaning to sexual maturity.

This study aimed to evaluate the repeated oral administration of α-terpineol in juvenile Wistar rats over a 70-day period. The objective was to assess the potential systemic and reproductive toxicity of α-terpineol when administered by gavage at doses of 75, 150, and 300 mg/kg/day to juvenile Wistar rats for 70 days from postnatal day 24. The control group received corn oil for 70 days.

Utilizing sulfa drugs' pH-dependent spectral modifications for designing molecular logic gates.

In this study, the absorption and fluorescence characteristics of sulfa drugs, specifically Sulfadiazine (SDZ), Sulfamerazine (SMZ), and Sulfamethazine (STZ), were examined across a pH range of 1-14. The absorption and fluorescence spectra of these sulfa drugs showed significant changes depending on the pH value. Analysis of their pH-dependent absorption and fluorescence properties indicated that these sulfa drugs could used to design molecular logic gates.

Elevating Oxygen Evolution using Iron Phthalocyanine Infused Vanillic acid Electrocatalyst.

Oxygen evolution reaction (OER) is the bottle neck step in water splitting reaction towards the realization of hydrogen based clean energy production and storage. Metal air batteries and polymer electrolyte membrane fuel cells (PEMFC) are the alternative green energy systems that utilise O and H in the production of continuous and high energy output without the utilization of carbon based fuels which are the major sources of pollution. Transition metal based N organics are explored extensively as oxygen electrocatalysts i.

Macromolecule-Nanoparticle-Based Hybrid Materials for Biosensor Applications.

Biosensors function as sophisticated devices, converting biochemical reactions into electrical signals. Contemporary emphasis on developing biosensor devices with refined sensitivity and selectivity is critical due to their extensive functional capabilities. However, a significant challenge lies in the binding affinity of biosensors to biomolecules, requiring adept conversion and amplification of interactions into various signal modalities like electrical, optical, gravimetric, and electrochemical outputs.

Dataset of chilli and onion plant leaf images for classification and detection.

This article presents the chili and onion leaf (COLD) dataset, which focuses on the leaves of chili and onion plants, scientifically known as Allium cepa and capsicum. The presence of various diseases such as Purple blotch, Stemphylium leaf blight, Colletotrichum leaf blight, and Iris yellow spot virus in onions, as well as Cercospora leaf spot, powdery mildew, Murda complex syndrome, and nutrition deficiency in chili, have had a significant negative effect on onion and chili production. As a consequence, farmers have incurred financial losses.

Investigation of bisindole-linked pyrimidine moieties: synthesis using strantium-aluminum supported strontium aluminate nanophosphors catalyst, DNA reactivity, and molecular docking studies.

In this communication, an innovative and straightforward protocol for the one-pot catalytic synthesis of bis(indolyl)pyrimidine derivatives and their DNA binding abilities is presented. The synthesis involves the condensation of indole with diverse substituted pyrimidine-5-carbaldehydes, employing cost-effective and reusable Sr-Al supported nanophosphors, specifically strontium aluminate (SrAlO), as a catalyst. In particular, this method does not require the use of toxic solvents.

Multiclass classification of diseased grape leaf identification using deep convolutional neural network(DCNN) classifier.

The cultivation of grapes encounters various challenges, such as the presence of pests and diseases, which have the potential to considerably diminish agricultural productivity. Plant diseases pose a significant impediment, resulting in diminished agricultural productivity and economic setbacks, thereby affecting the quality of crop yields. Hence, the precise and timely identification of plant diseases holds significant importance.

Enhanced O/N separation by QuaternizedMatrimid/Multiwalled carbon nanotube mixed-matrix membrane.

The air separation (O/N) based on polymeric membranes is critical because it is more energy efficient than traditional methods. Dense polymeric membranes are now the main stay of industrial processes that generate oxygen and nitrogen enriched gas. Though, regular polymeric membranes often fall short of selective pressure demands because O and N gases have such comparable equivalent diameters.

Novel decorated aluminium(iii) phthalocyanine complex with the application of MWCNTs on electrodes: electrochemical non-enzymatic oxidation and reduction of glucose and hydrogen peroxide.

In this study, we performed the physicochemical and electrochemical characterization of a decorated macrocyclic aluminium(iii) phthalocyanine complex (AlTMQNCAPc). Subsequently, the AlTMQNCAPc@MWCNT/GC electrode was used for the electrochemical detection of glucose and hydrogen peroxide (HO) by cyclic voltammetry (CV), differential pulse voltammetry (DPV), and chronoamperometry (CA). Moreover, the limit of detection, linear range, and sensitivity for glucose and HO were investigated (CV: 2.

Promising bioactive metabolites of mangrove inhabitant and prostate cancer PC3 cell inhibition by antimicrobial peptides.

is a group of microbes known for antibiotic production and has contributed to more than 70% of present commercially available antibiotics. These antibiotics are important in the management, protection, and treatment of chronic illnesses. In the present study, the isolated strain from mangrove soil in Mangalore, India (GenBank accession number: MW785875) was subjected for differential cultural characterization, phenotype involving brown pigmentation, filamentous mycelia, and ash-colored spore production was observed using field emission scanning electron microscopy (FESEM) analysis revealing filamentous mycelia possessing a straight spore chain.

Dataset of groundnut plant leaf images for classification and detection.

The use of machine learning is rapidly expanding across many industries, including agriculture and the IT sector. However, data is essential for machine learning models, and a substantial amount of data is required prior to training a model. We have collected data of groundnut plant leaves in the form of digital photographs taken in the Koppal (Karnataka, India) area with the assistance of a pathologist in natural settings.

Antiproliferative activity of antimicrobial peptides and bioactive compounds from the mangrove .

The group of microbes is known for antibiotic and enzyme production. Antibiotics and enzymes produced by them are important in the control, protection, and treatment of chronic human diseases. In this study, the () strain MW647910.

Electrochemical, Ultrasensitive, and Selective Detection of Nitrite and HO: Novel Macrostructured Phthalocyanine with Composite MWCNTs on a Modified GCE.

In the current study, the synthesis of tetra-4-(2-methoxyphenoxy) carboxamide cobalt(II) amide-bridged phthalocyanine (CoTMePhCAPc) is described, as well as its characterization by Fourier transform infrared (FT-IR), UV-visible, and mass spectroscopy; powder X-ray diffraction (PXRD); thermogravimetric analysis (TGA); scanning electron microscopy (SEM); and electrochemistry. Sensing of nitrite (NO) and hydrogen peroxide (HO) simultaneously was done on CoTMePhCAPc with the composite multiwalled carbon nanotube (MWCNT)-modified glassy carbon electrode (CoTMePhCAPc/MWCNT/GCE) in the range of linear absorption (NO and HO: CV 50-750, differential pulse voltammetry (DPV) 50-750, CA 50-500 nmol L), lower detection limit (NO and HO: CV 10.5 and 12.