Impact of Oxidative Stress on Reproductive Toxicity Induced by Alpha-Terpineol in Male Sprague-Dawley Rats.

α-Terpineol, a monoterpene found in essential oils and fragrances, has been reported to exhibit reproductive toxicity. The present study investigates the impact of oxidative stress on reproductive toxicity induced by α-Terpineol in male rats. α-Terpineol was administered to rats at various doses (0, 75, 150, and 300 mg/kg/day) via oral gavage for 28 days.

Azoospermia and multi-organ damage in juvenile rats exposed to α-Terpineol from weaning to sexual maturity.

This study aimed to evaluate the repeated oral administration of α-terpineol in juvenile Wistar rats over a 70-day period. The objective was to assess the potential systemic and reproductive toxicity of α-terpineol when administered by gavage at doses of 75, 150, and 300 mg/kg/day to juvenile Wistar rats for 70 days from postnatal day 24. The control group received corn oil for 70 days.

Pharmacokinetics of Bio-shell-silver-core Nanoparticles (AgNP) in Sprague-Dawley Rats - In Vivo Study.

Background: Silver nanoparticles have been widely used in the field of nanomedicine. A comprehensive understanding of their pharmacokinetics is crucial for proper risk assessment and safe biomedical applications.

Objectives: The purpose of this study was to investigate the safety of silver nanoparticles by determining their potential toxicity following 28 days of administration in Sprague-Dawley rats.

Bio-functionalized gold nanoparticles: Benign effect in Sprague-Dawley rats by intravenous administration.

Gold nanoparticles offer a great promise in clinical research. Despite various applications of the metal nanoparticles it is challenging to implement in clinical applications This aspect is deprived of understanding the biological mechanisms that occurs in the cells. In this report we have evaluated application of AuNP on the safety profile at different doses (100, 200, and 500 μg/kg Bwt/day) on intravenous administration in rats regularly for 28 days.