The Role of Human Papillomavirus Genotypes on Anal Squamous Intraepithelial Lesions Among Gay, Bisexual and Other Men Who Have Sex With Men Living With HIV: Beyond HPV-16.

Persistent high-risk human papillomavirus (hHPV) infection, especially HPV-16, plays a central role in the development of high-grade squamous intraepithelial lesions (HSIL). This study aimed to evaluate the performance of co-testing (cytology and hHPV detection) in a real-world cohort of men who have sex with men (MSM) and transgender women (TW) living with HIV. We conducted a prospective study (2017-2023) at a tertiary care center in Spain.

Succession-driven potential functional shifts in microbial communities in the tire-plastisphere: Comparison of pristine and scrap tire.

Tire microplastics (TMPs) represent a major contributor to microplastic pollution, posing threats to aquatic ecosystems. As carbon-rich substrates, TMPs influence microbial colonization and ecological functions. This study investigates the impacts of pristine (P-TMPs) and scrap (S-TMPs) TMPs from the same brand on microbial communities within the tire-plastisphere.

Modulatory effects of transcranial direct current stimulation on sensory gating in Fibromyalgia Syndrome.

Introduction: Several studies have demonstrated a reduced habituation to redundant somatosensory stimulation (sensory gating) in Fibromyalgia Syndrome. Furthermore, anodal transcranial direct current stimulation has been shown to modulate somatosensory processing. The aim of this study was to examine the modulatory effects of anodal transcranial direct current stimulation applied over the left primary somatosensory cortex on sensory gating in Fibromyalgia Syndrome.

Cognitive discrepancy patterns and their association with psychosocial functioning across affective disorders.

Introduction: Individuals with major depressive disorder (MDD) and bipolar disorder (BD) frequently exhibit a disagreement between self-reported and objectively measured cognitive performance. Research suggests that these cognitive discrepancies may vary across disorders and are not exclusive to a specific diagnosis, potentially being influenced by clinical and sociodemographic factors. Overestimating cognitive abilities is associated with better psychosocial functioning in depression, whereas heightened sensitivity to cognitive deficits correlates with worse functioning.

Spray Drying of Double-Layer Emulsion Stabilised with an Orange Residue: Effect of Process Parameters and Collection Position.

This study investigated the impact of spray-drying conditions, specifically inlet air temperature (Tin: 131-159 °C) and feed rate (FR: 4.9-8.4 g/min), on the microencapsulation of oil in a double-layer emulsion stabilised with orange residue flour (ORF) and soy protein.

Thermodynamic and Kinetic Aspects of Calcium Oxalate Crystallization and Renal Lithiasis.

Thermodynamic factors (supersaturation of substances that form crystals) and kinetic factors (heterogeneous nucleants and crystallization inhibitors) affect the formation of crystals and stones in the urinary tract. We studied the effect of five different polyhydroxycarboxylic acids and phytate on the formation of calcium oxalate crystals in artificial urine. All tested molecules are known to inhibit the crystallization of this calcium salt, and to also form complexes with calcium ions.

Age and moral disgust: An experimental priming effects vignette study.

Disgust influences how people perceive and judge moral violations. Individuals who are more sensitive to disgust often judge such violations more harshly. This sensitivity may change depending on the context, like the age of the person committing the act.

A Multiomic Study of Platelet-Derived Extracellular Vesicles and Impact of Platelet Concentrate Sources.

Platelet-derived extracellular vesicles (pEVs) are a potent fraction of platelet concentrates, enhancing their therapeutic potential in regenerative medicine. This study evaluates pEV from three platelet sources: platelet lysate (PL), fresh platelets (fPs), and aged platelets (aPs), to determine how activation and storage conditions affect pEV characteristics, functionality, and molecular content. pEV are isolated using size exclusion chromatography (SEC) and characterized by transmission electron microscopy (TEM), western blot, and nanoparticle tracking analysis (NTA).

A response-threshold method for early cancer diagnosis and monitoring via swarms of nanorobots.

Most human pathologies are reflected in the blood content, in the form of so-called molecular biomarkers. These are biochemical species whose size is measured on the nanometric scale. Technological development on this scale is currently the subject of great research efforts.

Comparison of Anthropometric and Metabolic Indexes in the Diagnosis of Metabolic Syndrome: A Large-Scale Analysis of Spanish Workers.

Background: Metabolic syndrome (MS) is a major public health concern linked to an elevated risk of type 2 diabetes and cardiovascular disease. Simple, reliable screening tools are needed for early identification, especially in working populations.

Objective: To compare the diagnostic accuracy of body mass index (BMI), waist-to-height ratio (WtHR), triglyceride-glucose index (TyG), and waist-triglyceride index (WTI) for detecting MS based on NCEP ATP III and IDF criteria in a large cohort of Spanish workers.

Sociodemographic Factors, Healthy Habits, and Quality of Life in Relation to Insulin Resistance Risk in a Large Cohort of Spanish Workers.

Insulin resistance (IR) is a key pathogenic mechanism underlying numerous cardiometabolic disorders. While sociodemographic and lifestyle determinants of IR are well-established, their association with health-related quality of life (HRQoL) remains understudied. This study explores the relationship between IR risk, as measured by TyG, METS-IR, and SPISE-IR indices, and HRQoL in a large cohort of Spanish workers.

Is bisphenol A sorbed onto microplastics less bioavailable than freely dissolved bisphenol A? Implications for the gut health in a murine model.

There is a paucity of in vivo assays to investigate the potential deleterious effects of plastic-laden compounds in the gastrointestinal tract of mammals, compared to in vitro testing and ecotoxicity assays in marine organisms. This work aims to fill this gap through a comprehensive evaluation of the acute toxicokinetics and bioavailability of bisphenol A (BPA)-adsorbed medium-density polyethylene (PE) microplastics (MPs) (ca. 3000 μg BPA/g), with a mean particle size of 136 μm, which were administered via oral gavage at a mere 0.

Targeted mass spectrometry method for the determination of multiple gut-microbiota metabolites in human plasma.

The gut microbiota profoundly impacts human health by producing metabolites that can act as biomarkers for disease diagnosis and therapy. However, accurately measuring these metabolites in biomatrices is challenging due to their low concentrations, high molecular diversity, and interference from matrix components, demanding advanced and precise analytical methodologies. Hence, an ultra-high-performance liquid chromatography method coupled to triple quadrupole-tandem mass spectrometry detection, combined with a chemical derivatization procedure, was developed and validated to quantify seven gut metabolites, namely acetic acid, propionic acid, butyric acid, p-cresol sulfate, 3-indoxyl sulfate, indole-3-acetic acid, and L-tryptophan, in human plasma.

Neurotoxic biomarkers of ethanol exposure: from adolescent vulnerability to adult voluntary intake in rats of both sexes.

Background: Ethanol use is frequently initiated during adolescence, a vulnerable developmental period with a great deal of neuro-remodeling, specially affecting hippocampal integrity, and with a unique sensitivity to drug abuse. Previous data evaluated the neurochemical effects exerted by either ethanol or cocaine alone in the adolescent brain, but few studies measured the combined negative impact of both drugs immediate during adolescence and later following withdrawal and drug re-exposure in adulthood and therefore will be the aim of this study.

Methods: Male and female Sprague-Dawley rats were treated in adolescence with non-contingent paradigms of ethanol, cocaine, their combination or vehicle.

Diaphragmatic breathing for referred pain after total laparoscopic hysterectomy: a randomized clinical trial.

Background: Referred cervicoscapular pain is common after laparoscopic surgery. This pain has different characteristics from incisional pain and requires a different approach.

Method: A blinded, randomized, controlled trial was conducted.

Perceived Mental Workload and Psychological Variables in Elite Individual and Team Bulgarian Athletes: An Exploratory Study.

Background: The concept of mental workload (MW) is a conceptual framework for evaluating the balance between the cognitive resources allocated to a task and those available to an individual. MW is influenced by the effort expended, the complexity of the task, and the individuals total processing capacity and resources.

Objective: This paper aims to explore MW in the field of sport and its relationship with other psychological variables, such as anxiety and burnout.

Depression and anxiety: A 3-year follow-up study of associated risk and protective factors among university students.

Background: Longitudinal research on anxiety and depression and associated factors in university students can guide public health policies.

Methods: Prevalence and incidence of probable Major Depressive Episode-MDE and Generalized Anxiety Disorder-GAD were estimated in a multicenter cohort study of first-year students from five Spanish universities. Web-based surveys were conducted at baseline, 12, 24, and 36 months using an adapted Composite International Diagnostic Interview-CIDI.

Guilt as a Structural Symptom: Ethical Challenges in Contemporary Nursing Care.

Guilt in nursing is not just an individual emotion but an ethical experience rooted in the tension between care values and the conditions that constrain their practice. This systematic literature review analyzes guilt as a multidimensional phenomenon shaped by institutional, relational, and subjective factors. Eight key categories emerged: moral distress, institutional constraints, emotional and physical effects, end-of-life care, ethical conflicts with families, spirituality, informed consent, and coping strategies.

Identifying the key components of a diet and lifestyle screener for people living with and beyond cancer: an e-Delphi study.

Objectives: There are currently no validated screeners that evaluate diet and lifestyle of people living with and beyond cancer (PLWBC). The purpose of this study was to reach a consensus among an international expert panel on the essential items to include in this type of instrument.

Design: A scientific committee developed the initial list of items, which were presented to an expert panel in a two-round-modified electronic Delphi.

US-CoastEX: Observation-based probabilistic reanalysis of storm surge and sea level extremes for the United States.

Reliable estimates of storm surge and sea level extremes with proper uncertainty quantification are key for cost-effective risk/adaptation planning. However, observational estimates are often unavailable or uncertain along most coastlines owing to data scarcity. Here, we provide a fully observational-driven probabilistic dataset (US-CoastEX) of storm surge and sea level extremes for the U.

Potential mechanisms for the rapid post-drought reversal of ABA-induced stomatal closure by melatonin, 5-aminolevulinic acid, and brassinosteroids.

The regulation of stomatal movements is crucial for plants to optimize gas exchange and water balance. The plant hormone abscisic acid (ABA) triggers stomatal closure in response to drought, effectively minimizing water loss to prevent hydraulic failure. However, it significantly constrains photosynthesis, restricting plant growth and productivity.

Investigating the role of stable flies (Stomoxys calcitrans) and biting midges of the genus Culicoides as potential mechanical vectors of African swine fever virus in Lithuania, Poland and Romania.

Background: Since its emergence in Georgia in 2007, the seasonal pattern of African swine fever virus (ASFV) genotype II outbreaks in European pig populations has been evident. It is hypothesized that summer-related farming practices, along with the increased activity and abundance of arthropod vectors during warmer months, contribute to the increased incidence of these outbreaks during this period. This study investigated the potential role of stable flies (Stomoxys calcitrans) and biting midges of the genus Culicoides as mechanical vectors of ASFV.