[The transversal specialized formation in oncology for medical gynecology residents: A five-year review].

Introduction: The transversal specialized formation (TSF) in oncology has been enabling non-oncologist physicians to acquire oncology skills for five years. This study aims to assess the TSF for medical gynecology residents.

Materials And Methods: A 23-item questionnaire was sent to physicians from the specialized medical degree (SMD) in medical gynecology who completed the TSF between 2020 and 2023.

Endocrine disrupting effects of contaminants on communication and behaviors of insects: from molecular effect to ecological consequences.

An increasing number of studies have highlighted the insidious effects of endocrine disruptors on insect endocrinology, development, and behavior, prompting concerns regarding the ecological consequences of these pollutants. This review explores the effects of endocrine-disrupting chemicals (EDCs) on insect communication and behavior, focusing on the molecular mechanisms and ecological consequences. This study underscores the importance of addressing EDC risks in maintaining biodiversity and ecosystem functions.

Investigating circadian patterns in electrochemical skin Conductance: A year-long retrospective analysis using home-based devices.

Objective: This study presents a comprehensive analysis of electrochemical skin conductance (ESC) values collected from over 1.9 million measurements using Withings Body Scan and Body Comp scales. It aimed at establishing descriptive values for ESC while correcting for the influence of age, sex, and circadian and seasonal variations on sudomotor function.

Proposition of a new, minimally-invasive, software smartphone device to predict sleep apnea and its severity.

Purpose: obstructive sleep apnea is underdiagnosed due to limited access to polysomnography (PSG). We aimed to assess the performances of Apneal, an application recording sound and movements thanks to a smartphone's microphone, accelerometer and gyroscope, to estimate patients' apnea-hypopnea index (AHI).

Methods: monocentric proof-of-concept study with a first manual scoring step, then automatic detection of respiratory events from recorded signals using a sequential deep-learning model (version 0.

Generation and characterization of three human induced pluripotent stem cell lines from patients with glycogen storage disease type II.

Glycogen storage disease type II (GSDII), or Pompe disease, is a rare autosomal recessive metabolic disorder characterized by the deficiency of the lysosomal enzyme acid alpha-glucosidase (GAA). GAA deficiency results in the progressive accumulation of glycogen in cardiac and skeletal muscle tissues, leading to cellular dysfunction and clinical manifestations, including muscle weakness, respiratory difficulties, and cardiomyopathy. In this study, we report the derivation of three induced pluripotent stem cell (iPSC) lines from peripheral blood mononuclear cells of GSDII patients.

A new staging system for hereditary transthyretin amyloidosis in the era of specific amyloidosis therapies.

Objectives: Currently, there are two prognosis staging systems validated for transthyretin amyloidosis (ATTR). We sought to develop a new staging system dedicated to hereditary transthyretin amyloidosis (ATTRv) patients on specific treatments.

Methods And Results: A total of 258 patients diagnosed with ATTRv from two cardiac amyloidosis reference centres in France and Romania were stratified into three disease stages based on NT-proBNP, estimated glomerular filtration rate (eGFR) and global longitudinal strain (GLS).

Exploring the risks of over-reliance on AI in diagnostic pathology. What lessons can be learned to support the training of young pathologists?

The integration of Artificial Intelligence (AI) algorithms into pathology practice presents both opportunities and challenges. Although it can improve accuracy and inter-rater reliability, it is not infallible and can produce erroneous diagnoses, hence the need for pathologists to always check predictions. This critical judgment is particularly important when algorithm errors could lead to high-impact negative clinical outcomes, such as missing an invasive carcinoma.

Follicular helper T-cell lymphomas with EBV-positive neoplastic cells: a rare scenario with diagnostic implications.

Follicular helper T-cell lymphomas (TFHL) of the angioimmunoblastic type (AITL) and other TFHL variants often contain EBV-positive B-blasts, but EBV infection of the neoplastic T-cells has rarely been documented. Here, we report 10 cases of TFHL (9 AITLs and 1 TFHL NOS) associated with EBV infection in neoplastic T cells. The patients (5 males, 5 females), 56-81 years old, presented with polyadenopathy (8/8), B symptoms (7/7), and skin lesions (4/7).

Emotional speech markers of psychiatric disturbance in Huntington's disease.

Introduction: Psychiatric disorders and difficulties in emotional expression represent a major problem in the management of Huntington's Disease (HD). To improve patient follow-up, we propose to investigate the link between emotional expression and psychiatric symptoms, measured by the Problem Behaviors Assessment (PBA) scale. To this aim we developed the first emotional/psychiatric speech corpus, emoHD.

Chronic skin conditions and life trajectories: development and validation of "Dermatology Long-Term Life Impact Measure (DLLIM)".

Background: To date, tools evaluating the impact of skin diseases on quality of life have investigated short-term impact, overlooking the long-term effects on important life decisions.

Objective: to create and validate the "Dermatology Long-Term Life Impact Measure (DLLIM)" questionnaire, that assesses the impact of six chronic inflammatory skin diseases on an individual's life decisions METHODS: Following COSMIN guidelines, we developed and validated DLLIM through item refinement and psychometric testing in a sample of 16,727 patients with chronic skin diseases. Factorial and construct validity were assessed, alongside internal consistency using Cronbach's alpha.

Structural basis of poxvirus fusion regulation and anti-A16/G9 antibody-mediated neutralization and protection.

Monkeypox virus (MPXV) is a poxvirus endemic to Central and West Africa with high epidemic potential. Poxviruses enter host cells via a conserved entry-fusion complex (EFC), which mediates viral fusion to the cell membrane. The EFC is a promising therapeutic target, but the absence of structural data has limited the development of fusion-inhibiting treatments.

Compromised minds: cognitive decline in a social insect correlates with parasitism status.

Parasites can influence host physiology and behavior, often impairing cognition. We investigated how infection and parasite load affect olfactory learning and memory in the paper wasp Polistes dominula workers parasitized by the insect parasite Xenos vesparum (Strepsiptera). We adapted a Pavlovian conditioning assay based on the proboscis extension reflex protocol.

Determinants and Prediction of Transport Ventilators' Oxygen Consumption.

This study investigates the determinants of oxygen consumption in transport ventilators, a critical factor for patient safety, especially during long-distance transfers and in resource-limited settings. A bench study was conducted on 4 ventilators to measure oxygen consumption under various ventilation settings. The main factor influencing oxygen consumption was the bias flow, a specific flow not contributing to patient ventilation.

Association of Single Nucleotide Polymorphisms with Infection Susceptibility in Patients with Severe Alcoholic Hepatitis.

Background And Aims: Severe alcoholic hepatitis is characterized by an increased risk of infections. Polymorphisms in immune response-related genes may influence susceptibility to infections in alcoholic hepatitis. This study aimed to investigate the association between two clusters of differentiation 14's (CD14) single nucleotide polymorphisms (SNPs), rs2569190 and rs5744455, and the occurrence of infections in severe alcoholic hepatitis, the response to corticotherapy and the mortality rates at one and three months.

Contribution of ambient airborne particles on the susceptibility to respiratory viral infections.

The respiratory tract is the primary entry point for inhaled particles from anthropogenic or biological origin such as respiratory viruses. Ambient particulate matter (PM) has adverse effects on the respiratory tract through mechanisms eliciting inflammatory responses, oxidative stress, and other pathophysiological effects. At the same time, respiratory viruses cause a range of infections.

Does hemiparetic dorsiflexion in swing phase depend on spasticity?

Objective: This study quantified dorsiflexor and plantar flexor (PF) spasticity, and agonist and antagonist recruitment (cocontractions) during the swing phase of gait in individuals with hemiparesis with and without prior tibial neurotomy, investigating the role of spastic cocontraction versus spasticity in limiting dorsiflexion (DF).

Methods: Eleven hemiparetic subjects and 11 controls walking at comfortable and slow velocities underwent kinematic and electromyographic (EMG) analysis of PF and DF muscles. Five of the hemiparetic subjects had undergone tibial nerve neurotomy, which eliminates PF spasticity.

Efficacy and Safety of SGLT2 Inhibitors in Heart Failure: Observational Evidence in Geriatric Patients AGING-HF.

Background: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have shown beneficial effects in heart failure (HF) management, but data on their use in geriatric populations with high comorbidity remain limited. This observational study aimed to assess the real-world efficacy and safety of SGLT2i in elderly patients with HF.

Methods: This prospective multicenter study included 496 patients hospitalized for acute heart failure across 3 geriatric units.