Digital Cueing With Laser Shoes Does Not Improve Walking in Parkinson's Disease: Evidence Across Disease Severity and Freezing Status.

Background: Gait impairment in Parkinson's disease (PD) occurs early and pharmaceutical interventions do not fully restore this function. Visual cueing has been shown to improve gait and alleviate freezing of gait (FOG) in PD. Technological development of digital laser shoe visual cues now allows for visual cues to be used continuously when walking.

Access to Cyclic Aliphatic Sulfonyl Fluorides via Diels-Alder Cycloaddition.

Sulfur(VI) fluoride exchange (SuFEx) compounds are gaining increasing attention due to their various applications. We present the Diels-Alder reaction of ethenesulfonyl fluoride and analogues to rapidly access cyclic and bicyclic SuFEx derivatives in moderate to good yields. These derivatives have been shown to be useful intermediates in a variety of synthetic transformations to expand the toolkit for the preparation of cyclic aliphatic sulfonyl fluorides.

Estimated Glucose Disposal Rate and Risk of Stroke and Dementia in Nondiabetics: A UK Biobank Prospective Cohort Study.

Background: The estimated glucose disposal rate (eGDR) is a validated surrogate marker of insulin resistance. However, its association with stroke and dementia in nondiabetic populations remains insufficiently investigated.

Methods: This prospective cohort study included nondiabetic participants from the UK Biobank.

Coordinating the Medical Division of Labour: The Travails of Electronic Patient Records in the United Kingdom and United States.

This paper explores the interrelations between medical specialisation, the changing division of medical labour and the technologies that have emerged to coordinate and integrate patient care. Drawing on the examples of the United Kingdom and the United States, countries whose health systems provide important points of commonality and distinction, I explore the intersections between the rise of medical specialisation and the creation of new medical and paramedical roles. These roles have often emerged as a palliative to the increasing fragmentation and atomisation of medical labour, to 'assist' overburdened clinicians and provide better coordinated and integrated patient care.

Geometric Aging of the Thoracic Aorta: Insights From 2 Large Cohorts.

Background: Aortic structural degeneration occurs with aging; however, 3-dimensional geometric remodeling has not been well characterized in large populations.

Methods: We segmented the thoracic aorta from magnetic resonance images of 56 164 UKB (UK Biobank) participants and computed tomography images of 9417 PMBB (Penn Medicine Biobank) participants. We quantified structural measurements of elongation, dilation, tortuosity, and curvature across the thoracic aorta.

Observational and Experimental Evidence on the Interaction Between Fine Particulate Matter and Shared Genetic Variants Across Atherosclerotic Cardiovascular Disease Subtypes.

Background: Previous studies have suggested that the associations between ambient air pollution and atherosclerotic cardiovascular diseases (ASCVD) differ by genotype. A genome-wide approach provides a more comprehensive understanding of this relationship on a genomic scale.

Methods: Using data from ≈300 000 UK Biobank participants, we conducted a genome-wide interaction analysis on 10 745 802 variants.

Large-Scale Proteomics-Based Risk Score for the Prediction of Incident Cardio-Kidney-Metabolic Disease Risk.

Background: Cardio-kidney-metabolic (CKM) disease represents a significant public health challenge. While proteomics-based risk scores (ProtRS) enhance cardiovascular risk prediction, their utility in improving risk prediction for a composite CKM outcome beyond traditional risk factors remains unknown.

Methods: We analyzed 23 815 UK Biobank participants without baseline CKM disease, defined by -Tenth Revision codes as cardiovascular disease (coronary artery disease, heart failure, stroke, peripheral arterial disease, atrial fibrillation/flutter), kidney disease (chronic kidney disease or end-stage renal disease), or metabolic disease (type 2 diabetes or obesity).

Comparative Effectiveness of TAVI Platforms and Surgical Aortic Valve Replacement: A Network Meta-Analysis of Randomized Controlled Trials.

Background: Evidence informing clinical guidelines assumes that all transcatheter aortic valve implantation (TAVI) devices have similar effectiveness, in other words, displaying a class effect across TAVI valves. We aimed to assess the comparative effectiveness of different TAVI platforms relative to other TAVI counterparts or surgical aortic valve replacement (SAVR).

Methods: MEDLINE/Embase/CENTRAL were searched from inception until April 2025, for randomized controlled trials comparing outcomes with different commercially available TAVI devices relative to other TAVI counterparts or SAVR.

Perceptions of patients and health care professionals on postoperative pain management: Key factors influencing persistent opioid use.

Objective: This study applied the Theoretical Domains Framework (TDF) to explore the barriers and enablers to optimizing post-operative pain management and supporting safe opioid use from the perspectives of both patients and health care professionals, applying the Theoretical Domains Framework (TDF).

Design: Experience-based co-design (EBCD) qualitative study.

Methods: In the initial phase of the EBCD approach, focus groups were conducted comprising 20 participants, including 8 patients and 12 health care professionals involved in post-operative care.

Relationships of Circulating Plasma Metabolites With the QT Interval in a Large Population Cohort.

Background: There is a higher prevalence of heart rate corrected QT (QTc) prolongation in patients with diabetes and metabolic syndrome. QT interval genome-wide association studies have identified candidate genes for cardiac energy metabolism, and experimental studies suggest that polyunsaturated fatty acids have direct effects on ion channel function. Despite this, there has been limited study of metabolite concentration relationships with QT intervals.

Helicopter Rescue at Very High Altitude: Recommendations of the International Commission for Mountain Emergency Medicine (ICAR MedCom) 2025.

McLaughlin, Kyle, Charley Shimanski, Ken Zafren, Ian Jackson, Gerold Biner, Maurizio Folini, Andreas Hermansky, Eric Ridington, Peter Hicks, Giacomo Strapazzon, Marika Falla, Alastair Hopper, Dave Weber, Ryan Jackson, and Hermann Brugger. Helicopter rescue at very high altitude: Recommendations of the International Commission for Mountain Emergency Medicine (ICAR MedCom) 2025. 00:00-00, 2025.

Empowering Patients with Congenital Heart Disease: Development of a Digital Question Prompt List for Shared Decision-Making: A Pilot Study.

Background: Advancements in healthcare have significantly improved the prospect of patients with CHD, with over 97% now surviving adulthood. This growing population requires lifelong care and support to manage their condition. Digital health innovations, such as the "Ask Me Anything" (AMA) tool, aim to empower patients and improve collaboration with clinicians.

Post-traumatic growth following the death of a parent from homicide: A reflective perspective from adulthood.

Although there is considerable research into the impact of homicide on surviving family members, research is limited on subjective experiences of those who lost a parent due to homicide during childhood. Through interpretative phenomenological analysis, we conducted and analyzed in-depth semi-structured interviews, to explore lived experiences and perspectives of post-traumatic growth with adults who lost a parent due to homicide as a child. We developed five group experiential themes: 1.

Are Narrative CVs contributing towards shifting research culture? Workshop Report from the 2023 Recognition and Rewards Festival.

Background: Over the past decade, calls for research assessment reform have grown, led by initiatives such as the Declaration on Research Assessment (DORA) and the Leiden Manifesto, and, more recently, the Coalition for Advancing Research Assessment (CoARA). A key element being discussed as part of research assessment reform is a shift towards more qualitative assessments, focussed on the content of research and the broad skills and competencies of researchers, and the array of contributions they make to knowledge creation and innovation. Narrative CV formats have emerged as a good practice example for enabling qualitative assessments of research projects and researchers, and are becoming more widely piloted and implemented.

An updated Bioconductor workflow for correlation profiling subcellular proteomics.

Background: Subcellular localisation is a determining factor of protein function. Mass spectrometry-based correlation profiling experiments facilitate the classification of protein subcellular localisation on a proteome-wide scale. In turn, static localisations can be compared across conditions to identify differential protein localisation events.

Occupational Therapists' perspectives of implementing a new rehabilitation intervention for visual field loss due to stroke.

Background: This study aimed to explore the barriers and facilitators of implementing rehabilitation interventions for visual field loss due to stroke.

Methods: The study was a qualitative exploration using one-to-one interviews coded using template analysis and the COM-B a-priori framework. Participants were five occupational therapists from hospital (n=4) and community (n=1) National Health Service (NHS) stroke care settings in England.

The genome sequence of (Scopoli, 1763) (Lepidoptera: Geometridae).

We present a genome assembly from a male specimen of (Arthropoda; Insecta; Lepidoptera; Geometridae). The assembly contains two haplotypes with total lengths of 575.96 megabases and 573.

The genome sequence of the Black Hairstreak, (Linnaeus, 1758) (Lepidoptera: Lycaenidae).

We present a genome assembly from a male specimen of (Black Hairstreak; Arthropoda; Insecta; Lepidoptera; Lycaenidae). The assembly contains two haplotypes with total lengths of 869.86 megabases and 870.

The genome sequence of a flea beetle, Aubé, 1843.

We present a genome assembly from a female specimen of (flea beetle; Arthropoda; Insecta; Coleoptera; Chrysomelidae). This was a triploid specimen and one subgenome was assembled. The genome sequence has a total length of 1,003.

Cannabis and psychosis: minimising harm while maximising therapeutic potential.

Cannabis use increases the risk of psychosis, but cannabis-based medicinal products may provide additional therapeutic opportunities. Decriminalisation of cannabis has led to wider availability in certain jurisdictions, while in the UK regulated medicinal preparations are not readily accessible. A more balanced approach could reduce harms while maximising potential therapeutic benefits.

Risk factors and trajectories for self-harm, neurodevelopmental disorders and mental health conditions in pupils in alternative education provision in Wales: population-based electronic cohort study.

Background: Pupils in alternative education provision, known as 'Educated in Other Than At School' (EOTAS) in Wales, UK, are among the most vulnerable learners and who, for reasons such as mental health or behavioural challenges, do not attend a mainstream or special school.

Aims: We compared self-harm, neurodevelopmental disorders and mental health conditions between EOTAS pupils and controls with similar characteristics, before and after being in EOTAS provision.

Method: This population-based electronic cohort study included pupils in Wales aged 7-18 years, from the academic years 2010-11 to 2018-19.

Viscoelastic time responses of polymeric cell substrates measured continuously from 0.1-5000 Hz in liquid by photothermal AFM nanorheology.

The mechanical properties of the polymeric substrate or matrix where a cell grows affect cell behavior. Most studies have focused on relating elastic properties of polymeric substrates, which are time-independent, to cell behaviors. However, polymeric substrates and biological systems exhibit a time-dependent, often viscoelastic, mechanical response.

Variation in the Commissioning of Semaglutide for the Treatment of Obesity and Overweight Across England: Results of Three Freedom of Information-Based Mapping Exercises Across the 42 Integrated Care Boards of England.

Obesity medications are recommended in England with legislation necessitating their availability. However, given the number of people who meet clinically approved eligibility criteria, funding these medications and associated support services may limit efficacy at a population health level. This study aimed to assess the commissioning and availability of services and obesity medications across England.

Etripamil Nasal Spray for Recurrent Paroxysmal Supraventricular Tachycardia Conversion: Results From the NODE-303 Open-Label Study.

Introduction: Etripamil is a fast-acting intranasally self-administered calcium-channel blocker developed for termination of paroxysmal supraventricular tachycardia (PSVT). Prior studies have demonstrated safety and efficacy of etripamil for PSVT termination following an initial medically supervised test dose during sinus rhythm. NODE-303 is an open-label, single-arm study that evaluated etripamil for multiple, at-home PSVT episodes, without test dose before first use.

Load-dependent resistive-force theory for helical filaments.

The passive rotation of rigid helical filaments is the propulsion strategy used by flagellated bacteria and some artificial microswimmers to navigate at low Reynolds numbers. In a classical 1976 paper, Lighthill calculated the 'optimal' resistance coefficients in a local (logarithmically accurate) resistive-force theory that best approximates predictions from the non-local (algebraically accurate) slender-body theory for force-free swimming of a rotating helix without an attached load (e.g.