Bottom-up computational design of shape-selective organic macrocycles for humid CO capture.

The capture of CO emissions using porous solids is challenging because polar water molecules bind more strongly in most materials than non-polar CO molecules. This is a challenge for both flue gas capture and for direct air capture alike. Here we develop a bottom-up computational screening workflow to calculate the binding energy of 27,446 diverse molecular fragments with both CO and water.

Selective CO Adsorption in Ultrahydrophobic Molecular Pyrene Frameworks by Computational Design.

The separation of carbon dioxide from industrial flue gas streams using porous materials is often thwarted by humidity. Most porous sorbents adsorb water more effectively than CO. Hence, water can out-compete CO for adsorption sites, lowering the working CO sorption capacity and increasing sorbent regeneration costs.

The Perceived Effectiveness of the Clinical Nurse Specialist in Supporting Self-Management of Patients With Cancer: A Systematic Review of Qualitative Data.

Aim: As cancer care and outcomes improve, self-management becomes a critical aspect of care. Clinical Nurse Specialists roles empower, educate and support individuals with cancer to manage their health confidently.

Design: A systematic review following Joanna Briggs Institute guidance and reported in accordance with the PRISMA statement.

Self-management interventions for adults with chronic lumbar radicular pain: A scoping review.

Background: Several studies have evaluated physiotherapy treatment and/or post-operative care for chronic lumbar radicular pain (CLRP). The extent, range, and nature of research addressing self-management for CLRP is not clear. This scoping review explores existing research evaluating self-management interventions for CLRP.

Learning to read FAST MRI: Qualitative interviews with groups experienced reading mammograms.

Objectives: Abbreviated breast MRI (abMRI) is being introduced into breast screening practice worldwide. Increased provision of abMRI will require mammogram readers to learn abMRI-interpretation and the implementation of abMRI-reading into clinical practice. The present study explores the acceptability of the implementation of developed reader training, and the barriers and facilitators to training programme participation and subsequently to reading the training programme assessment task of abMRI images in a work/NHS context familiar to the individual participants.

Towards an Agreed Labelling System and Protocol for the Diagnosis of Speech Sound Disorder Subtypes in the United Kingdom.

Background: There is no single classification system or diagnostic protocol for speech sound disorder (SSD). This makes it difficult to collect large-scale outcome data and determine which interventions work best for which subtypes of SSD. The United Kingdom is unique in that its publicly funded healthcare system allows the collection of such outcome data across large numbers of children; however, a necessary first step towards this is to agree on a consistent diagnostic protocol and classification system for SSD that is feasible for use in the UK healthcare system.

Developing a core outcome set for interventions in people with mild cognitive impairment: study protocol.

Introduction: There is no standardised national guidance on clinical management for people living with mild cognitive impairment (MCI), and therapeutic interventions are limited. Understanding what outcomes are important and meaningful to people living with MCI and developing a core outcome set (COS) for research and clinical practice will improve the impact of clinical research and contribute towards developing effective care pathways for MCI. This study aims to develop a COS for adults living with MCI intended for use in interventional and clinical settings.

Exploring the Needs of Young People Born With Cleft Lip and/or Palate Approaching End of Routine Care, in the UK.

Objective: The aim of this study was to understand the needs of young people, aged 16 to 20 years, born with cleft lip and/or palate (CL/P) approaching end of routine care, in the United Kingdom (UK).

Design: Nominal group technique was used during 2 online focus groups to identify priorities for cleft care at transition to adult care. Focus group discussions were recorded, transcribed, and analyzed using reflexive thematic analysis.

Shared characteristics of intervention techniques for oral vocabulary and speech comprehensibility in preschool children with co-occurring features of developmental language disorder and speech sound disorder: a systematic review with narrative synthesis.

Objectives: To descriptively compare and contrast intervention techniques for preschool children with features of developmental language disorder (outcome: oral vocabulary) and speech sound disorder (outcome: speech comprehensibility) and analyse them in relation to effectiveness and theory.

Design: This is a systematic review with narrative synthesis. The process was supported by an expert steering group consisting of relevant professionals and people with lived experience.

How and when post intensive care syndrome-family is measured: A scoping review.

Objectives: Family members of Intensive Care Unit (ICU) patients can experience mental health difficulties. These are collectively described as Post Intensive Care Syndrome-Family (PICS-F). There are no standardised outcome measures to benchmark the impact of PICS-F.

Patient and caregiver shared experiences of pulmonary fibrosis (PF): A systematic literature review.

Pulmonary Fibrosis (PF) describes a group of lung diseases characterised by progressive scarring (fibrosis). Symptoms worsen over time and include breathlessness, tiredness, and cough, giving rise to psychological distress. Significant morbidity accompanies PF, so ensuring patients' care needs are well defined and provided for, represents an important treatment strategy.

Outcome measures for children with speech sound disorder: an umbrella review.

Objective: Speech sound disorder (SSD) describes a 'persistent difficulty with speech sound production that interferes with speech intelligibility or prevents verbal communication'. There is a need to establish which care pathways are most effective and efficient for children with SSD. Comparison of care pathways requires clearly defined, evidence-based, interventions and agreement on how to measure the outcomes.

Cancer-related pain in head and neck cancer survivors: longitudinal findings from the Head and Neck 5000 clinical cohort.

Purpose: Reports suggest pain is common in head and neck cancer (HNC). However, past studies are limited by small sample sizes and design and measurement heterogeneity. Using data from the Head and Neck 5000 longitudinal cohort, we investigated pain over a year post-diagnosis.

Exposure to microplastics and human reproductive outcomes: A systematic review.

Background: Microplastics, produced through degradation of environmental plastic pollution, have been detected in human tissues including placenta and fetal meconium. Cell culture and animal studies have demonstrated potential reproductive toxicity of these particles; however, their association with adverse fertility or pregnancy outcomes in humans is not known.

Objectives: To synthesise evidence for the presence of microplastics in human reproductive tissue and their associations with environmental exposures and reproductive outcomes.

A randomised controlled trial of the effectiveness of parent-based models of language intervention for 2- to 3-year-old children with speech, language and communication needs (SLCN) in areas of social disadvantage.

Background: Early language delay is exacerbated by social disadvantage. Factors such as parents' low levels of literacy, confidence and self-perception can affect the capacity to act on advice received, critical to empowerment. Methods used to achieve successful health outcomes in socially disadvantaged clinical populations may need enhancing.

Factoring patients' beliefs and values into decisions around anticoagulation: a community-led multi-cycle quality improvement project.

Low-molecular-weight heparin (LMWH), prescribed for prophylaxis of venous thromboembolism, is derived from porcine animal products. An audit in our Trust showed that most healthcare professionals (95%, n=58/61) did not consider religious or dietary preferences when prescribing LMWH. Focus groups with local stakeholders helped develop project aims.

A systematic review on adherence to continuous positive airway pressure (CPAP) treatment for obstructive sleep apnoea (OSA) in individuals with mild cognitive impairment and Alzheimer's disease dementia.

Obstructive sleep apnoea (OSA) is highly prevalent in mild cognitive impairment (MCI) and Alzheimer's disease (AD). The gold standard treatment for OSA is continuous positive airway pressure (CPAP). Long-term, well-powered efficacy trials are required to understand whether CPAP could slow cognitive decline in individuals with MCI/AD, but its tolerability in this group remains uncertain.

The effectiveness of nurse-led care in supporting self-management in patients with cancer: A systematic review.

Aims And Objectives: To determine the impact of nurse-led follow-up care supporting self-management of people who have had or have cancer.

Background: Cancer care is evolving towards enabling people to self-manage the impact of cancer, treatment and overall care on their quality of life (QoL), self-efficacy and distress.

Design: A systematic review following Joanna Briggs Institution (JBI) guidance and reported in accordance with the PRISMA statement was undertaken.

Cancer-Related Fatigue in Head and Neck Cancer Survivors: Longitudinal Findings from the Head and Neck 5000 Prospective Clinical Cohort.

Cancer-related fatigue (CRF) is a common side-effect of cancer and its treatments. For head and neck cancer (HNC), CRF may exacerbate the symptom burden and poor quality-of-life. Using data from the Head and Neck 5000 prospective clinical cohort, we investigated clinically important CRF over a year post-diagnosis, assessing temporal trends, CRF by HNC site and treatment received, and subgroups at higher risk of CRF.

Women's and midwives' views on the optimum process for informed consent for research in a feasibility study involving an intrapartum intervention: a qualitative study.

Background: Recruitment to intrapartum research is complex. Women are expected to understand unfamiliar terminology and assess potential harm versus benefit to their baby and themselves, often when an urgent intervention is required. Time pressures of intrapartum interventions are a major challenge for recruitment discussions taking place during labour, with research midwives expected to present, discuss and answer questions whilst maintaining equipoise.

Shared characteristics of intervention techniques for oral vocabulary and speech comprehensibility in preschool children with co-occurring features of developmental language disorder and a phonological speech sound disorder: protocol for a systematic review with narrative synthesis.

Introduction: Evidence suggests that over one-third of young children with developmental language disorder (DLD) or speech sound disorder (SSD) have co-occurring features of both. A co-occurring DLD and SSD profile is associated with negative long-term outcomes relating to communication, literacy and emotional well-being. However, the best treatment approach for young children with this profile is not understood.

A survey of quality-of-life tools used in the routine care of patients with multiple myeloma.

Background: New treatment options have significantly improved the life expectancy of myeloma patients such that their cause of death is increasingly likely to be from something other than myeloma. Furthermore, the adverse effects of short- or long-term treatments as well as the disease are impacting on quality of life (QoL) for longer periods of time. Understanding people's QoL and what is important to them, is part of providing holistic care.