Water Adsorption in Metal-Organic Frameworks: Characteristics, Mechanisms, and Structure-Property Relationships.

To address the increasingly limited water availability, using metal-organic frameworks (MOFs) to capture atmospheric water vapor as usable resources has emerged as a promising strategy. The adsorption characteristics of MOFs as well as their step pressure (i.e.

Development and Validation of an Individualized Prediction Model for Postoperative Late Recurrence After Hepatectomy for Hepatocellular Carcinoma (POLAR-HCC): A Multicenter Study.

Background: Postoperative late recurrence (POLAR) after 2 years from the date of surgical resection of hepatocellular carcinoma (HCC) represents a unique surveillance and management challenge. Despite identified risk factors, individualized prediction tools to guide personalized surveillance strategies for recurrence remain scarce. The current study sought to develop a predictive model for late recurrence among patients undergoing HCC resection.

Updating the epidemiology of blastomycosis and histoplasmosis in the United States, using national electronic health record data, 2013-2023.

Introduction: Where surveillance data are limited, nationally-representative electronic health records allow for geographic, temporal, and demographic characterization of the fungal diseases blastomycosis and histoplasmosis.

Methods: We identified incident blastomycosis and histoplasmosis cases from 2013 to 2023 within Oracle EHR Real-World Data, which comprises 1.6 billion healthcare encounters nationally.

The American Cancer Society National Lung Cancer Roundtable strategic plan: Tobacco treatment in the context of lung cancer screening.

Tobacco use is the primary contributor to disease and death in the United States, and cigarette smoking is the leading risk factor for lung cancer. Safe and effective treatments for tobacco dependence exist; however, access to and use of tobacco treatment remains low. The most recent Centers for Medicare and Medicaid Services National Coverage Determination requires a shared decision-making visit for lung cancer screening that includes counseling on the importance of maintaining cigarette smoking abstinence if a person formerly smoked; or the importance of smoking cessation if a person currently smokes and, if appropriate, furnishing of information about tobacco-cessation interventions.

Anterior-posterior and medial-lateral balance metrics are unchanged when two-dimensional pseudorandom motion perturbations are provided in semicircular canal coordinates.

Introduction: External continuous perturbations using a motion platform have been developed by employing either sum-of-sines (SoS) or a pseudorandom ternary sequence (PRTS) of numbers to quantify body sway evoked in the medial-lateral (ML) or anterior-posterior (AP) directions, which ultimately helps understand the human postural control system. These stimuli have been provided via pitch tilts of the motion platform for evaluations of AP balance responses or roll tilts for ML balance responses. However, little is known about whether a healthy postural control system responds to 2-dimensional (2D) perturbations similarly when the perturbation stimuli are provided in semicircular canal coordinates (i.

Pathway-based genetic association analysis for overdispersed count data.

Overdispersion is a common phenomenon in genetic data, such as gene expression count data. In genetic association studies, it is important to investigate the association between a gene expression and a set of genetic variants from a pathway. However, existing approaches for pathway analysis are primarily designed for continuous and binary outcomes and are not applicable to overdispersed count data.

Recent Biomedical Applications of Carbon Quantum Dots in Cancer Treatment.

Carbon-based quantum dots (CQDs) have been around for a few decades. Low cell toxicity, good water solubility, excellent and tunable fluorescence properties, and the ability to dope and modify the surface of these CQDs make them an incredible choice for the visualization and treatment of various cancers. This perspective analyzes some recent progress on size-color correlation, modification, and cancer treatment applications of CQDs.

Prenatal environmental risk for adolescent attention, thought, and substance use problems: A mixtures approach to coexposure and psychiatric comorbidities.

Background: Prospective studies suggest that prenatal exposure to chemical neurotoxicants and maternal stress increase risk for psychiatric problems. However, most studies have focused on childhood outcomes, leaving adolescence-a critical period for the emergence or worsening of psychiatric symptoms-relatively understudied. The complexity of prenatal coexposures and adolescent psychiatric comorbidities, particularly among structurally marginalized populations with high exposure burdens, remains poorly understood.

A view of the sustainable computing landscape.

This article presents a holistic research agenda to address the significant environmental impact of information and communication technology (ICT), which accounts for 2.1%-3.9% of global greenhouse gas emissions.

Stability of microRNAs in serum and plasma reveal promise as a circulating biomarker.

Purpose: To verify the stability and reliability of circulating microRNA (miRNA) profiles in plasma and serum under different processing and storage conditions to inform future applications to circulating biomarker analyses.

Background: The development of blood-based methods for early disease detection has become increasingly desirable across various medical fields. RNA profiles have been investigated but have been a challenge due to rapid degradation of the analyte by ubiquitous RNases.

Understanding brain donation decisions: Predictors of indecision and change over time from the Cleveland Alzheimer's Disease Research Center.

Introduction: Little is known about factors influencing indecision or changes in brain donation program (BDP) enrollment status among Alzheimer's disease and related dementias research participants. This study examined demographic features associated with these decisions in participants from the Cleveland Alzheimer's Disease Research Center (CADRC).

Methods: Demographics and BDP status were extracted from the CADRC database and analyzed based on initial and current BDP enrollment status.

Randomized Clinical Trial on Caries Prevention of Silver Diamine Fluoride.

This 30-mo double-blind randomized clinical superiority trial aimed to assess the effectiveness of semiannual application of 38% silver diamine fluoride (SDF) solution in preventing early childhood caries in primary upper anterior teeth. The active comparator was 5% sodium fluoride varnish (FV). The primary outcome was the mean number of new carious tooth surfaces per child at the 30-mo follow-up.

A pilot study examining a ketogenic diet as an adjunct therapy in college students with major depressive disorder.

A ketogenic diet (KD) has shown promise as an adjunctive therapy for neurological and neuropsychiatric disorders, including bipolar disorder and major depressive disorder (MDD). We examined tolerance for a KD in young adults with MDD and assessed symptoms of depression and metabolic health. Students (n = 24) with a confirmed diagnosis of MDD at baseline receiving standard of care counseling and/or medication treatment were enrolled in a 10-12 week KD intervention that included partial provision of ketogenic-appropriate food items, frequent dietary counseling, and daily morning tracking of capillary R-beta-hydroxybutyrate (R-BHB).

Sphingosine-1-phosphate signaling through Müller glia regulates neuroprotection, accumulation of immune cells, and neuronal regeneration in the rodent retina.

The purpose of this study was to investigate how Sphingosine-1-phosphate (S1P) signaling regulates glial phenotype, neuroprotection, and reprogramming of Müller glia (MG) into neurogenic MG-derived progenitor cells (MGPCs) in the adult male and female mouse retina. We found that S1P-related genes were dynamically regulated following retinal damage. (S1P receptor 1) and (sphingosine kinase 1) are expressed at low levels by resting MG and are rapidly upregulated following acute damage.

Variations in Medical Clearance Testing for Mental Health Emergency Department Visits.

Background And Objectives: There are recommendations against routine medical clearance testing for children evaluated in the emergency department (ED) for mental health concerns. Our objective was to determine variation, factors, and costs associated with medical clearance testing during ED encounters for mental health concerns.

Methods: We conducted a cross-sectional study of ED encounters among children aged 5 to 18 years who presented to 35 US children's hospitals for mental health concerns (2016-2023).

Strategies for Tailoring Patient-Centered Technologies Across the Cancer Continuum: Protocol for a Scoping Review.

Background: In the United States, cancer is more prevalent in racial and ethnic minority groups and in rural-dwelling and low-income people. Compared with White people of non-Hispanic descent, Black and African American people have higher cancer mortality and Hispanic people are more likely to be diagnosed with infection-related cancers. In addition, people who live in persistent poverty areas are more vulnerable to cancer mortality.

Isatuximab for Relapsed and/or Refractory AL Amyloidosis: Results of a Prospective Phase 2 Trial (SWOG S1702).

Isatuximab is an IgG1k monoclonal antibody that binds with high affinity to CD38 expressed on plasma cells. Anti-CD38 antibodies have shown efficacy as monotherapy and in combination in a variety of settings for patients with multiple myeloma and light chain (AL) amyloidosis. This multi-center, cooperative group phase 2 trial was designed to evaluate hematologic response, organ response, and safety of isatuximab monotherapy for the treatment of relapsed AL amyloidosis.

Characterization of Cross-Linked Elastomer Networks by Thermal Desorption/Pyrolysis Direct Analysis in Real-Time Mass Spectrometry (TDPy-DART-MS).

Tires are complex polymeric materials composed of rubber elastomers (both natural and synthetic), fillers, steel wire, textiles, and a range of antioxidant and curing systems. These constituents are distributed differently among the various tire parts, which are classified based on their function and proximity to the rim. This study presents a rapid and sensitive approach for the characterization of tire components using mild thermal desorption/pyrolysis (TDPy) coupled to direct analysis in real-time mass spectrometry (DART-MS).

Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severity.

Tuberculosis (TB) outcomes vary widely, from asymptomatic infection to mortality, yet most animal models do not recapitulate human phenotypic and genotypic variation. The genetically diverse Collaborative Cross mouse panel models distinct facets of TB disease that occur in humans and allows identification of genomic loci underlying clinical outcomes. We previously mapped a TB susceptibility locus on mouse chromosome 2.

Navigating Hepatitis C care: Knowledge gaps and access barriers among young women who inject drugs in rural Appalachia.

Background: Hepatitis C virus (HCV) and injection drug use among young women are dramatically rising in the rural United States. From 2004 to 2017, heroin use among non-pregnant women increased 22.4% biennially, mirroring increases in HCV cases, especially among younger populations.