Storage stability of an antioxidant tea prepared from purple corn (Zea mays L.) cob and stevia (Stevia rebaudiana Bert.) and its effects on biomarkers of oxidative stress in healthy humans.

Tea is consumed worldwide, and it is highly appreciated by consumers as a functional, healthy, and natural drink. The objectives of this research were to evaluate (1) the storage stability and (2) the consumption effect on biomarkers of oxidative stress of an antioxidant tea prepared from purple corn cob and stevia (AOxTea). The AOxTea bags were subjected to storage environments of 75 or 85 % of relative humidity at 30, 40 and 50 °C for up to 19 days.

Developing Potent Therapeutics for Liver Cancer Chemoresistance via an RNA Nanotech and Series-Circuit-Christmas-Bulb Mechanism Targeting ABC Transporters.

Liver cancer, particularly hepatocellular carcinoma (HCC), poses significant treatment challenges due to chemoresistance and cancer recurrence. Similar to customs at the border, the liver detoxifies incoming chemicals via efflux pumps and overexpresses ATP-binding cassette (ABC) drug exporters, leading to chemoresistance. ABC contains a multihomosubunit structure and a revolving transport mechanism, actively effluxing drugs from cancer cells, thereby reducing intracellular drug accumulation and therapeutic efficacy.

Paclitaxel chemotherapy disrupts circadian gene transcription and function of the suprachiasmatic nuclei in female mice.

Cancer patients experience circadian rhythm disruptions during and after chemotherapy that can contribute to debilitating side effects. It is unknown how chemotherapy mediates circadian disruptions, and specifically the extent to which these disruptions occur at the level of the principal clock, the suprachiasmatic nuclei (SCN) of the hypothalamus. In the present study, we assessed how the commonly used chemotherapeutic, paclitaxel, impacts the SCN molecular clock and SCN-dependent behavioral adaptations to circadian challenges in female mice.

Management of claudication in older adults and the role of exercise therapy.

Claudication from peripheral artery disease is a common mobility-limiting condition in older adults. Exercise therapy, whether delivered through supervised programs or structured home-based programs, plays a central role in claudication care for older adults, offering substantial functional gains with minimal risk, and should be the cornerstone of management alongside optimized medical therapy. This review examines contemporary management of claudication in the aging population, with emphasis on exercise therapy.

Adverse Pregnancy Outcomes in Patients with Congenital Uterine Anomalies: Evaluation of a Population Dataset.

This study aimed to characterize the risk of adverse pregnancy outcomes among patients with congenital uterine anomalies (CUA) using electronic health record data.Retrospective cohort study utilizing the TriNetX analytics research network, including female patients aged 10 to 55 with a documented singleton and intrauterine pregnancy.A total of 561,440 patients met inclusion criteria, of whom 3,381 (0.

Randomized Sham Controlled Trial of Targeted Lung Denervation in Patients with COPD (AIRFLOW-3).

Rationale: AIRFLOW-3 was a 1:1 randomized, double blind, sham controlled trial of the d'Nerva Targeted Lung Denervation (TLD) System in patients with COPD.

Objective: Evaluate the impact of TLD on COPD exacerbations compared to optimal medical treatment.

Methods: AIRFLOW-3 patients were symptomatic (CAT ≥10) with moderate to very severe airflow obstruction (25% ≤ FEV ≤ 80% predicted) and GOLD E status (≥2 moderate or ≥1 severe exacerbation over prior 12 months).

Neutrophil-to-Lymphocyte Ratio (NLR) as a Biomarker in Clinically Stable Chronic Obstructive Pulmonary Disease: SPIROMICS cohort.

Rationale: Inflammation is central to chronic obstructive pulmonary disease (COPD) pathogenesis but incompletely represented in COPD prognostic models. Neutrophil to lymphocyte ratio (NLR) is a readily available inflammatory biomarker.

Objectives: To explore the associations of NLR with smoking status, clinical features of COPD, and future adverse outcomes.

Evaluating Long-Term Effectiveness of Cystic Fibrosis Modulator Therapies After Rapid Adoption: A Dual-Approach Study.

Rationale: Modulator therapies like ivacaftor have revolutionized clinical management of cystic fibrosis (CF), showing marked short-term benefits in trials but heterogeneous findings in long-term observational studies. Since newer modulators have become the standard of care for the majority living with CF in the U.S.

Understanding the role of Shroom3 in the developing mouse myocardium.

Loss of actin cytoskeleton control can hinder integral developmental and physiological processes and can be the basis for a subset of developmental defects. SHROOM3 is an actin binding protein, best characterized as being essential for neural tube closure in vertebrates. Shroom3 expression has also been identified in the developing heart, with some associated congenital heart defects.

"Colorectal Cancer Care Quality in a Developing Country: Insights from a Comparison of Teaching and Non-teaching Hospitals in Iran".

Background: Our study represents the first effort in the Eastern Mediterranean Region to identify disparities in the quality of colorectal cancer (CRC) care in Iran.

Methods: We established a collaborative registry program for non-metastatic CRC patients to evaluate survival rates between teaching cancer centers (TCCs) and a high-volume, non-teaching, non-cancer center (NTNC). The study included a diverse patient population and considered various factors such as cancer stage, margin involvement, adherence to guidelines for adjuvant and neoadjuvant treatments, emergency surgeries, socioeconomic status, and risk of surgery.

Differences in Outcomes for Patients Receiving Labetalol and Nicardipine for Hypertension After Craniotomy.

Background: Acute postoperative hypertension (APH) is encountered in patients following craniotomy and is associated with major complications. This retrospective cohort study evaluates 30-day survival for patients who received labetalol, nicardipine, or both drugs.

Methods: Patients 18 and older who underwent craniotomy between January 1, 2010 and January 1, 2023 were included in the study.

Vaginal Lasers for Treating Stress Urinary Incontinence in Women: An Abridged Cochrane Systematic Review and Meta-Analysis.

Purpose: We assessed the effects of vaginal lasers for treating stress urinary incontinence (SUI) in women.

Materials And Methods: This systematic review and meta-analysis included randomized trials of women with SUI and assessed therapy with vaginal laser vs sham, control, or topical treatments.

Results: Nine studies of 689 women with SUI were included.

The influence of surgical technique and surgical skill on outcomes of cleft palate repair.

Background: There remains significant uncertainty about the fistula rate following palate repair with the Furlow double opposing Z-plasty (Furlow) technique compared to a straight-line mucosal incision with intravelar veloplasty (straight-line/IVVP) technique. Moreover, the relative impact of technique and surgical skill on fistula incidence remains unclear.

Methods: A prospective, observational study of cleft palate repair was conducted.

Gonorrhea and Chlamydia Screening for Adolescents and Young Adults in Emergency Departments.

Importance: Adolescents account for almost half of the 2.5 million diagnosed sexually transmitted infections in the US annually, and the emergency department functions as the primary source of health care for many adolescents. No recommendations exist for emergency department gonorrhea and chlamydia screening.

The International Association for the Study of Lung Cancer Staging Project: The Impact of Common Molecular Alterations on Overall Survival in NSCLC in Initial Analyses of the IASLC Ninth Edition Staging Database.

Introduction: TNM staging systems create prognostic categories by anatomic extent of disease. Whether therapeutically important molecular alterations in NSCLC augment the prognostic information of TNM staging is unclear. To study this, we analyzed molecular data from the ninth edition of the lung cancer staging system.

Effect of material, prosthesis height, and aging on the fracture strength of additively and subtractively manufactured implant-supported cantilevered prostheses.

Purpose: This study aimed to evaluate the inherent and after cyclic loading fracture strength of implant-supported cantilevered fixed prostheses fabricated from recently introduced additively manufactured (AM) and subtractively manufactured (SM) materials, considering variations in prosthesis height.

Materials And Methods: Three cylinder-shaped master files (20 mm long and 11 mm wide) with varying heights (7, 11, and 15 mm) and a titanium-base (Ti-base) abutment space were designed. These designs were used to fabricate a total of 144 specimens with two AM resins indicated for definitive use (Crowntec; AM-CT and Flexcera Smile Ultra+; AM-FS), one high-impact polymer composite (breCAM.

Are bio-based resins suitable alternatives for additively manufactured removable dies? An in vitro study on dimensional and positional trueness and stability.

Purpose: This study aimed to compare the dimensional and positional deviations of additively manufactured removable dies fabricated using two bio-based resins and one conventional dental cast resin, while also evaluating these outcomes over a 4-week period.

Materials And Methods: A right mandibular first molar preparation on a typodont was scanned to digitally design removable dies and hollow partial arch casts. Based on a priori power analysis, a total of 30 dies (n = 10) and three hollow casts (n = 1) were fabricated using additive manufacturing (AM) from three different dental cast resins: DentaMODEL (DM), FotoDent bio-based model (CB), and soy-based resin (SB).

An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole-Rat.

There is growing interest in understanding the mechanisms underlying differences in cancer incidence among species (comparative oncology). The naked mole-rat (NMR) is often referenced as "cancer-resistant" and prior studies focused on identifying mechanisms explaining this. However, efforts to assess this in vivo have been limited.

Mapping carbon utilization pathways in through C-metabolic flux analysis.

is a human fungal pathogen that survives and proliferates within phagocytic immune cells. To sustain growth in the nutrient-limited phagosome environment, the pathogenic yeast scavenges available carbon sources, which must be metabolized through central carbon metabolism for respiration and biomass synthesis. However, carbon metabolic pathways operating in the pathogenic yeast phase have not been extensively mapped.

Metabolic biochemical models of N fixation for sulfide oxidizers, methanogens, and methanotrophs.

Dinitrogen (N) fixation provides bioavailable nitrogen to the biosphere. However, in some habitats (e.g.

Serum Proteomic Profile Based on the TGF-β Pathway Stratifies Risk of Hepatocellular Carcinoma.

Background: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths, primarily due to late-stage diagnosis. In this multicenter study, our goal is to identify functional biomarkers that stratify the risk of HCC in patients with cirrhosis (CP) for early diagnosis.

Methods: Five thousand and eight serum proteins (Somascan) were analysed in Cohort A (477 CP, including 125 HCC).

Tracing priming effects in palsa peat carbon dynamics using a stable isotope-assisted metabolomics approach.

Introduction: Peatlands store up to a third of global soil carbon, and in high latitudes their litter inputs are increasing and changing in composition under climate change. Although litter significantly influences peatland carbon and nutrient dynamics by changing the overall lability of peatland organic matter, the physicochemical mechanisms of this impact-and thus its full scope-remain poorly understood.

Methods: We applied multimodal metabolomics (UPLC-HRMS, H NMR) paired with C Stable Isotope-Assisted Metabolomics (SIAM) to track litter carbon and its potential priming effects on both existing soil organic matter and carbon gas emissions.

An Educational Initiative Describing Clinician Teachers' Experiences Following Serious Illness Communication Skills Faculty Development Training.

Background: Serious illness communication skills (SICS) are essential competencies for clinicians to possess. Unfortunately, SICS teaching is not routinely taught and many clinician teachers (CTs) never received training on how to teach them. We funded two cohorts of CTs to learn an evidence-based approach to SICS teaching to scale a unified approach to such training.

Tagraxofusp, a CD123-targeted therapy, for chronic myelomonocytic leukemia: final results of a phase 1/2 study.

Chronic myelomonocytic leukemia (CMML) is an aggressive hematologic neoplasm characterized by an expansion of CD123 monocytes and plasmacytoid dendritic cells (pDCs). pDC bone marrow clusters in CMML have been associated with higher rates of acute myeloid leukemia transformation. We evaluated tagraxofusp, a CD123-targeted therapy, in a phase 1/2 trial for patients with CMML.