Anacyphrethines A and B as potent analgesics: Multiple ion channel inhibitors with an unprecedented chemical architecture.

Multi-target analgesics with minimal side effects and high efficacy are a key research focus in addressing the global pain crisis. Using a molecular networking approach, five pairs of potent analgesic alkaloid enantiomers were isolated from the roots of (. ).

Ultraviolet-Guided Isolation of Coumarins and Benzofuran Derivatives From Fig (Ficus carica L.) Leaves and Their Bioactivities.

Although fig leaves are widely used for dermatological treatment in traditional medicine, research on the bioactivity of their components is limited. In this study, an ultraviolet-guided approach was employed to isolate 2 novel benzofurans (1-2), 12 known benzofurans (3-14), and 13 known coumarins (15-26a/26b). Compounds 4-10, 13-14, 17, 20, 24, and 26a/26b were detected in fig leaves for the first time.

Reactive oxygen species-responsive hydrogel loaded with melatonin as a minimally invasive treatment for myocardial I/R injury.

Myocardial infarction (MI) poses a severe threat to human life, and timely reperfusion of ischemic myocardium stands as the most effective treatment approach. However, myocardial ischemia-reperfusion (I/R) could lead to the excessive generation of reactive oxygen species (ROS), worsening myocardial injury. In this investigation, an ROS-responsive injectable hydrogel encapsulating melatonin (MLT) was synthesized.

Advances in Nature-Inspired Particles for Bioanalytical Applications.

Nature has evolved sophisticated prototypes to achieve functions from efficient separation to selective capture, targeted interaction, and interactive communication. These biological blueprints provide transformative inspiration for engineering advanced particle materials tailored for bioanalytical challenges. This review comprehensively examines recent advances in nature-inspired particles from natural prototypes to preparation methods and various bioanalytical applications.

A transparent and waterproof cellulose composite film with carbon quantum dots: A greener agricultural film capable of light management.

Biodegradable agriculture films with the function of light conversion to better match the spectrum of plant photosynthesis are critical for achieving sustainable development and boosting plant production. In this work, transparent light conversion cellulose composite films were prepared by incorporating blue and red emitting carbon dots (B&R-CDs) into a regenerated cellulose (RC) film, followed by covering with a silicone acrylic emulsion (SAE) layer to enhance water resistance. SEM observations showed that the surface of the cellulose composite film was smooth.

Lectin-affinity glycosylation pattern analysis of plasma extracellular vesicles: An all-in-one clinical assessment for gastric cancer diagnosis and treatment.

Extracellular vesicles (EVs) exhibit extensive glycosylation modifications, which are promising biomarkers for gastric cancer (GC). However, EV glycomics and the potential application of EV glycosylation patterns in liquid biopsy remain largely unexplored. This study aims to elucidate the heterogeneity of EV glycosylation in the initiation and progression of GC and to identify specific EV glycosylation markers for clinical assessment.

Pressure-Activated Efficient Near-Infrared Luminescence in Atomically Precise Gold Nanoclusters.

Achieving efficient near-infrared (NIR) luminescence in atomically precise gold nanoclusters is challenging due to the strong vibrational freedom of the gold core. Herein, we synthesized two gold nanoclusters, [Au(PPh)Cl]Cl () and Au(PPh)Cl (), with comparable initial NIR photoluminescence quantum yields (PLQY, 0.3% and 0.

Photoactivated Ion Transport: Role of Intrinsic Defects and Plasmonics for Efficient Ionic Power Harvesting.

The process of photosynthesis in green plants and energy conversion in certain archaea are inseparable from photoregulated ion pumping. Two-dimensional (2D) nanofluidic membranes, emerging as competitive candidates for constructing ion pumps, present intriguing prospects for harvesting light energy. However, the inevitable presence of defects during the synthesis of 2D materials underscores the critical need to understand their impact on ion transport dynamics within nanofluidic systems.

Light-induced CoO surface reconstruction in hollow heterostructure for durable photocatalytic seawater splitting.

Photocorrosion triggered by the unconsumed photogenerated holes severely deteriorates the photocatalytic efficiency and stability of semiconductor photocatalysts, especially in seawater with complex ions. Here, we report a hierarchical hollow ZnInS heterostructure integrating an inner CoO nanocage and atomically dispersed Pt anchoring at surface S vacancies for hydrogen evolution from natural seawater (23.88 mmol g h) and pure water (48.

NHBO(OH) and CsRbBO(OH)·HO: Two Hydroxyborates Feature Significant Optical Anisotropy and Contain [BO(OH)] Chains.

Two hydroxyborates, NHBO(OH) and CsRbBO(OH)·HO, featuring hydroxylated fundamental building blocks (FBBs) [BO(OH)], were synthesized via the high-temperature melting method and hydrothermal synthesis method. Both compounds contain [BO(OH)] chains that assemble into pseudo-2D layers via O-H···O/N-H···O hydrogen bonds and further interconnect into 3D frameworks. Despite slight structural differences between the BO rings in the [BO(OH)] FBB of the two compounds, they exhibit comparable band gaps (6.

Low-Bandgap Organic Conjugated Copolymers with Ultra-Broadband Optical Limiting Properties Extending to Near-Infrared-II.

Developing organic conjugated copolymers with an intramolecular charge transfer (ICT) system is an efficient strategy for expanding their applications but is still a challenge for broadband optical limiting (OL). Herein, three thiadiazoloquinoxaline (TQ)-based donor-acceptor (D-A) type copolymers , , and with different electron-donating groups of thiophene, bithiophene, and di(thiophen-2-yl)ethene, respectively, were reported. Copolymers exhibit low bandgaps of 0.

A NIR light activated self-reporting carbon dots assembly as phototheranostics for tumor photodynamic therapy.

Photodynamic therapy (PDT) has emerged as a promising protocol for cancer therapy. However, real-time monitoring of PDT progress and accurate determination of the optimal treatment timing remain challenges. In this work, we selected carbon dots (CDs) and new indocyanine green (IR820) as building units to fabricate a smart nanotheranostics (CDs-IR820 assembly) with the characteristics of controlled release and real-time imaging to solve the time gap between diagnosis and treatment.

Highly flexible and multifunctional lyocell-basalt fiber filter media for high-performance air filtration.

Cellulose-based functionalized fabrics are emerging as promising air purification filter materials. However, limitations such as poor moisture resistance, low strength, and heat sensitivity are challenging in the practical application of fine particulate matter filtration. Here, we developed a flexible and multifunctional lyocell/basalt fiber (LC/BF) filter fabric using a wet-laid process, avoiding the need for additional binders.

Cryogen-free low-temperature photoemission electron microscopy for high-resolution nondestructive imaging of electronic phases.

Quantum materials exhibit phases such as superconductivity at low temperatures, yet imaging their phase transition dynamics with high spatial resolution remains challenging due to conventional tools' limitations-scanning tunneling microscopy offers static snapshots, while transmission electron microscopy lacks band sensitivity. Photoemission electron microscopy (PEEM) can resolve band structures in real/reciprocal spaces rapidly, but suffering from insufficient resolution for (near)atomic-scale quantum physics due to the unstable cooling designs. Here, we developed cryogen-free low-temperature PEEM (CFLT-PEEM) achieving 21.

Driving Pesticide Application Efficiency through Nanoscale Interfacial Control.

Pesticide spraying is a cornerstone of modern agriculture, significantly boosting the food yield per unit area. However, inefficiencies in the spraying process─due to droplet loss─result in substantial environmental pollution and economic waste. A timely review and perspective are thus greatly needed, especially to guide future research.

Strategies for Continuous Responsive Motion in a Constant Environment.

Continuous responsive motion gains significant attention due to its widespread applications in autonomous braking systems, low-power generation, human-computer interaction, and other fields. Continuous responsive motion in a constant environment is particularly important because it enables self-sustained actuation in unmanned settings. In this review, four strategies are summarized for continuous responsive motion in a constant environment and elaborate on the mechanisms, including the Belousov-Zhabotinsky reaction strategy, the self-shadowing effect strategy, the gradient stimulus field strategy, and the complex device-based strategy.

CO hydrogenation to HCOOH catalyzed by aqueous Pd needle assembly.

Carbon dioxide (CO) conversion to liquid fuels has attracted great attention due to the current environmental concerns and energy crisis. However, the selective conversion of CO to target liquids is formidably challenging due to the chemical inertness of CO. We theoretically and experimentally confirm that the bending of Pd-Pd bond can breaks the asymmetric potential well and facilitate CO adsorption.

Synthesis of Novel 7-Phenyl-2,3-Dihydropyrrolo[2,1-]Quinazolin-9(1)-ones as Cholinesterase Inhibitors Targeting Alzheimer's Disease Through Suzuki-Miyaura Cross-Coupling Reaction.

An important field of research in medicinal and organic chemistry involves halogen-containing heterocyclic synthones, which form the backbone of more complex organic compounds. This study aimed to design and synthesize 28 novel derivatives of 7-aryl-2,3-dihydropyrrolo[2,1-]quinazolin-9(1)-one. The derivatives were created from 7-bromoquinoline intermediates to evaluate their potential as cholinesterase inhibitors for treating neurodegenerative diseases such as Alzheimer's disease.

Bionic Bovine Achilles Tendon Collagen Composite Membrane Loaded with Anti-Inflammatory Kukoamine B Promotes Skin Wound Healing.

Skin is the first line of defence between the human body and the outside world, and it is constantly exposed to external injuries and wounds for a variety of reasons. Collagen is a structural protein of the extracellular matrix and an important component of the dermis. As a wound dressing, collagen not only provides nutrients to wounds but also enhances the immune response in the pre-healing phase, making it an excellent biomaterial for healing.

Achieving 500-GHz communication over 1.2 km using an astronomical telescope with a quantum-limited superconducting receiver.

500 GHz video transmission over 1.2 km is achieved using an astronomical telescope equipped with a quantum-limited superconducting SIS receiver.

Fast and highly selective proton transport through Ca-regularized laminar membrane for spontaneous acid recovery and energy generation.

Realizing highly selective and fast proton transport is central to many applications. This work demonstrates that by simply intercalating MXene layered membranes with Ca, the proton selectivity against heavy metal ions, crucial for acidic wastewater treatment and acid recovery, can be enhanced by nearly 2 orders of magnitude, and the proton permeation rate can be enhanced by nearly 1 order of magnitude. We reveal that after intercalation, the interlayer spacings of the membrane become smaller and highly uniform, mitigating ion leakage through large spacings.

Synthesis and Characterization of (HCN)(VO)·2HO with Edge-Sharing VO Octahedra Exhibiting Large Birefringence.

In recent years, planar π-conjugated systems have emerged as a pivotal platform for designing birefringent materials due to their intrinsic structural anisotropy. Among the documented π-conjugated motifs, pyridinium-derived cations exhibit exceptional anisotropic first-order polarizabilities, demonstrating remarkable potential for birefringence modulation. Herein, single crystals of (HCN)VO·2HO () were successfully synthesized via an aqueous solution method.

Spatially programmed regioisomeric conjugated microporous polymers modulating zinc sites for selective CO photoreduction to CH.

Conjugated microporous polymers show great potential for photocatalytic CO reduction into value-added products. However, their catalytic activity and selectivity remain significantly limited due to poor charge separation efficiency and the lack of suitable active sites. Herein, we propose a topology-driven dipole programming strategy that synergistically decouples atomic-level electronic configuration control from spatially resolved active site engineering.

A transparent hybrid metal halide glassy scintillation screen for high-resolution fast neutron radiography.

Fast neutron radiography offers exceptional penetration for high-density and bulky objects, yet its resolution is hindered by light scattering in conventional scintillators and screen fabrication techniques. To address this, here, we develop a transparent glassy Mn-based hybrid metal halide scintillation screen, (BTPP)(HTPP)MnBr (BTPP = butyltriphenylphosphonium, HTPP = heptyltriphenylphosphonium), leveraging temperature-dependent ordered-disordered transitions. The large-area screen boasts >70% visible light transmittance (500-800 nm), a high photoluminescence quantum yield (~85.

Crystal structure of cyclohexylamine oxidase from Acinetobacter sp. YT-02 reveals key residues for catalytic activity and substrate specificity.

Cyclohexylamine oxidase is a member of amine oxidases that catalyzes the conversion of cyclohexylamine to cyclohexanone. In our previous work, the enzymatic activity assay of cyclohexylamine oxidase CHAO indicated that its specific activity towards cyclohexylamine of CHAO was ten times higher than that of its homolog CHAO. In this study, the crystal structure of CHAO was determined by the molecular replacement method at a resolution of 1.