How does it affect the willingness to continue rehabilitation training? A usability evaluation of a multi-sensory rehabilitation interactive game system (MRIGS) for older adults with mild dementia.

The prevalence of dementia is increasing every year, with one person developing dementia every 3 s. Therefore, this study proposes a novel multi-sensory rehabilitation interactive game system (MRIGS), which uses grip assistive devices combined with different colors and tactile stimulation to achieve multi-sensory training effects of vision, hearing, and touch. This study involved 17 older adults (72.

Short occipital circulation time derived from quantitative digital subtraction angiography is associated with headache risk in patients with unruptured brain arteriovenous malformations.

Purpose: To explored key angiographic markers associated with headache risk in patients with unruptured brain arteriovenous malformations (BAVMs).

Methods: This retrospective study included patients with unruptured, supratentorial BAVMs without prior interventions who underwent digital subtraction angiography between January 2011 and January 2024. The patients were stratified into headache and nonheadache groups on the basis of symptoms at initial presentation.

Hanging drop culture reprograms mesenchymal stem cell transcriptome to enhance cell delivery efficiency via attenuated pulmonary entrapment.

The three-dimensional (3D) culture system has emerged as an indispensable platform for modulating stem cell function in biomedicine, drug screening, and cell therapy. Despite a few studies confirming the functionality of 3D culture, the molecular factors underlying this process remain obscure. Here, we have utilized a hanging drop method to generate 3D spheroid-derived mesenchymal stem cells (3D MSCs) and compared them to conventionally 2D-cultured MSCs.

Virtual reality-enhanced exergames for weight control: a systematic review and meta-analysis of randomized controlled trials.

Background: Obesity is an important public health issue. Virtual reality provides an opportunity to increase benefits of traditional exercise programs with more immersive, interactive, and enjoyable experiences for weight control.

Objectives: This study aimed to explore the efficacy of virtual reality-enhanced exergames for obesity-related outcomes, including body weight, body mass index, body fat, and waist circumference.

Association between haemoglobin levels and the risk of diabetic retinopathy in adults with type 2 diabetes: a retrospective cohort study using the TriNetX network.

Background: Diabetic retinopathy (DR) is the leading cause of preventable blindness. Although hyperglycaemia is the primary driver, other modifiable risk factors may contribute to DR development. This study investigated the association between haemoglobin levels and DR risk in adults with type 2 diabetes.

Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis.

Background: Studies examining the association of chronic kidney disease (CKD) with cancer risk have demonstrated conflicting results.

Methods: This was an individual participant data meta-analysis including 54 international cohorts contributing to the CKD Prognosis Consortium. Included cohorts had data on albuminuria [urine albumin-to-creatinine ratio (ACR)], estimated glomerular filtration rate (eGFR), overall and site-specific cancer incidence, and established risk factors for cancer.

Linezolid versus daptomycin for VRE bloodstream infections in patients with malignancy: The impact of neutropenia on outcomes.

Objectives: Vancomycin-resistant enterococcal bloodstream infections (VRE-BSIs) carry high mortality in patients with malignancy. While neutropenia is a known risk factor for mortality in patients with malignancy and BSI, its impact on the effectiveness of daptomycin and linezolid in VRE-BSI is not well defined.

Methods: We conducted a multicenter cohort study of hospitalized patients aged ≥18 years with malignancy and VRE-BSI between 2010 and 2021.

Functional dysconnectivity in triple and reward networks among adolescents with borderline personality disorder.

Background: In adolescents, the role of functional dysconnectivity in the default mode network (DMN), salience network (SAN), frontoparietal network (FPN), and reward network as markers of borderline personality disorder (BPD) remains uncertain.

Methods: A total of 45 adolescents with BPD comorbid with a mood disorder (bipolar disorder or major depressive disorder), 31 adolescents without BPD but with a mood disorder, and 47 healthy adolescents were enrolled in the study. All participants underwent resting-state functional connectivity magnetic resonance imaging.

ctDNA detects residual disease after neoadjuvant chemoradiotherapy and guides adjuvant therapy in esophageal squamous cell carcinoma.

The diagnostic accuracy of circulating tumor DNA (ctDNA) for detecting molecular residual disease (MRD) after multimodal treatment remains unclear. In a prospective cohort of 132 patients with locally advanced esophageal squamous cell carcinoma (ESCC) undergoing neoadjuvant chemoradiotherapy (nCRT) followed by clinical response evaluation and surgery, tumor-informed personalized-panel and fixed-panel ctDNA assays are applied to serial blood samples. Personalized ctDNA assay demonstrates a superior baseline detection rate (99.

Near and far transfer effects of working memory training: A preregistered, double-blind, randomized-controlled study.

Background: Previous research indicates near transfer effects of working memory (WM) training on updating, shifting, and inhibition tasks, although findings vary. Regarding fluid intelligence (Gf), studies yield conflicting results on the far transfer effects of WM training. The current study investigates whether different styles of adaptive visuospatial N-back WM training produce near and far transfer effects and whether individual differences moderate these effects.

Effect of brand love on brand defense mediated by customer brand engagement: The moderated mediation role of regulatory focus.

In an era where negative word-of-mouth escalates and spreads rapidly on social media, understanding the psychological mechanisms of brand defense is of critical importance. Expanding on literature that establishes brand love as a strong predictor of pro-brand behaviors in offline settings, this study investigates the psychological process that transforms this emotion into defensive behaviors in the high-visibility and high-risk environment of social media. This study advances and tests a moderated mediation model, specifying that customer brand engagement (CBE) mediates the brand love-brand defense relationship.

Chemical alteration of UO micro-particles in model lung systems.

Uranium dioxide (UO) particles can be released from mines, nuclear fuel manufacturing, reactor accidents, and weapons use. They pose inhalation risks, yet their behavior in the human lung remains poorly understood. This study investigates the long-term chemical alteration and dissolution of µm-sized UO particles in two model lung fluids: Simulated Lung Fluid (SLF) and Artificial Lysosomal Fluid (ALF), representing extracellular and intracellular lung environments, respectively.

Serological surveillance of Leucocytozoon spp. in Taiwan.

Chicken Leucocytozoonosis is a protozoan disease that affects the blood and tissues of chickens. High summer temperatures create optimal conditions for reproducing biting midges, the primary vectors for transmitting Leucocytozoon to chickens. In Taiwan, a subtropical region, the disease remains prevalent throughout the year, except in winter, leading to significant economic losses due to increased mortality and reduced egg production.

Development of carbon black-percolated GaInSn liquid metal networks for high-sensitive electrochemical detection of diuron in environmental samples.

Diuron (DU), a widely used herbicide, is persistent and toxic, posing serious environmental and health risks. Therefore, the development of advanced sensor materials for the sensitive detection of DU is urgently needed. Here, we present a simple, cost-effective ultrasonic-assisted method to fabricate a high-performance nanocomposite of carbon black (CB) and Ga-liquid metal (GaInSn), which is utilized to modify a carbon electrode (CB/GaInSn/SPCE) for developing an electrochemical sensor for DU detection.

Elucidating cooking-driven flavor dynamics of paddy field carp (Cyprinus carpio) using a combination of E-nose, E-tongue, GC-MS and GC-IMS.

The cooking process exerts a notable influence on the flavor characteristics of fish. E-nose, GC-MS, and GC-IMS technologies were utilized to investigate how three thermal processing methods (steaming, frying, and roasting) alter the volatile odors of paddy field carp (PFC). GC-MS and GC-IMS analyses indicated that the volatile compound compositions of steaming and raw samples were relatively similar.

Targeting KCNN4 channels modulates microglial activation and apoptosis in a PD-relevant inflammatory model.

Parkinson's disease (PD) is characterized by chronic neuroinflammation and progressive dopaminergic neurodegeneration, driven primarily by the activation of microglia and associated apoptotic pathways. The intermediate-conductance calcium-activated potassium channel KCNN4 has recently emerged as a potential therapeutic target, yet its role in chronic neurodegenerative conditions remains underexplored. In this study, we investigated whether pharmacological inhibition of KCNN4 using TRAM-34 can modulate both inflammatory and apoptotic responses in an LPS-induced mouse model of PD.

Effectiveness of a multimodal information technology-based hand hygiene strategies on reducing healthcare-associated infections in nursing homes: A cluster-randomized controlled trial.

Aim: To assess the effectiveness of a multimodal information technology-based hand hygiene strategy in improving knowledge, compliance, accuracy, and healthcare-associated infections density in Taiwan's nursing homes.

Background: Hand hygiene is the most effective and cost-efficient method for preventing healthcare-associated infections. However, compliance rates among healthcare workers in Taiwan remain low (3.

Intercostal nerve block is superior than erector spinae plane block after uniportal video-assisted thoracoscopic surgery: randomized controlled trial.

In this double-blinded, randomized controlled trial, sixty patients undergoing elective uniportal video-assisted thoracoscopic surgery (VATS) lobectomy were randomly assigned to receive thoracoscopic intercostal nerve block (ICNB, n ​= ​30) or ultrasound-guided erector spinae plane block (ESPB, n ​= ​30). No block-related adverse events occurred. The ICNB group showed significantly lower resting and coughing visual analog scale scores, than the ESPB group, 4 (4.

Minor resection for primary hepatocellular carcinoma promotes curative recurrent treatments.

Background: The extent of primary hepatectomy for hepatocellular carcinoma (HCC) may influence long-term outcomes, especially at recurrence. We investigated whether initial minor or major hepatectomy impacts retreatment options and survival following recurrence.

Methods: We retrospectively reviewed patients with primary HCC who underwent either initial major or minor hepatectomy.

Comparative analysis of real and virtual greenspaces: Perceived restorativeness and psychological health effects.

Objectives: This study aimed to compare the psychological effects of real and virtual greenspaces and identify key environmental features that contribute to perceived restorativeness and mood changes in university students.

Study Design: A mixed-methods crossover experimental design was used to evaluate psychological responses to three types of greenspaces: real campus greenspaces, virtual campus greenspaces, and virtual forest greenspaces.

Methods: Thirty-five college students participated in three 20-min greenspace exposures, spaced one week apart in randomized order.