Brain activation for language and its relationship to cognitive and linguistic measures.

Language learning and use relies on domain-specific, domain-general cognitive and sensory-motor functions. Using fMRI during story listening and behavioral tests, we investigated brain-behavior associations between linguistic and non-linguistic measures in individuals with varied multilingual experience and reading skills, including typical reading participants (TRs) and dyslexic readers (DRs). Partial Least Square Correlation revealed a main component linking cognitive, linguistic, and phonological measures to amodal/associative brain areas.

Acute Effect of the Bounce Squat on Ground Reaction Force at the Turning Point and Barbell Kinematics.

Achermann, BB, Drewek, A, and Lorenzetti, SR. Acute effect of the bounce squat on ground reaction force at the turning point and barbell kinematics. J Strength Cond Res XX(X): 000-000, 2025-The free-weight back squat is a key exercise for developing lower-body strength, with variations that influence muscle activation and performance.

Essentials of the System of Radiological Protection.

The System of Radiological Protection (the "System") developed by the International Commission on Radiological Protection (ICRP) is built on nearly a century of efforts of numerous scientists and practitioners working together internationally. It rests on three enduring pillars: science, ethics, and experience. These pillars support the three fundamental principles that shape radiological protection strategies: justification, optimisation, and application of dose limits.

Targeting the Epigenetic Remodeler GCN5 Prevents Vascular Oxidative Stress and Endothelial Dysfunction in Obesity: Insights in Patients with Cardiometabolic Disease.

Introduction: Epigenetic changes are important modulators of gene expression. The histone acetyltransferase gene non-derepressible 5 (Gcn5) is emerging as a pivotal epigenetic player in metabolism and cancer, yet its role in obesity and cardiovascular disease remains elusive.

Aims: To investigate Gcn5 role in obesity-related endothelial dysfunction.

Coping Profiles and Functioning During Emerging Adulthood: A Comparative Person-Centered Longitudinal Approach.

Young adults use a combination of coping strategies to deal with challenges. Yet, limited research has focused on these combinations, as they differ across different profiles of youth and their implications during the major life transitions of emerging adulthood. Addressing this gap, the present longitudinal person-centered study assesses the nature, stability, predictors (stressful life events, sex), and outcomes (affect, attitude toward life, physical symptoms) of coping profiles during this period.

Machine learning for myocarditis diagnosis using cardiovascular magnetic resonance: a systematic review, diagnostic test accuracy meta-analysis, and comparison with human physicians.

Myocarditis is an inflammation of heart tissue. Cardiovascular magnetic resonance imaging (CMR) has emerged as an important non-invasive imaging tool for diagnosing myocarditis, however, interpretation remains a challenge for novice physicians. Advancements in machine learning (ML) models have further improved diagnostic accuracy, demonstrating good performance.

Target controlled infusion in the intensive care unit: a scoping review.

Target-controlled infusion (TCI) systems, originally developed for intravenous drug administration of anesthetic drugs, enable precise drug delivery based on pharmacokinetic-pharmacodynamic (PKPD) models. While widely used in the operating room, their application in the intensive care unit (ICU) remains limited despite the complexity of drug dosing in critically ill patients. This scoping review evaluates existing evidence on the use of TCI systems in ICU settings, focusing on sedation, analgesia, and antibiotic administration.

Consensus on clinical outcome measures for lumbar spinal stenosis: recommendations from the ISSLS lumbar spinal stenosis taskforce.

Purpose: The purpose of this study was to determine through a Delphi process a list of outcomes measures for clinicians to use when assessing individuals with Lumbar Spinal Stenosis (LSS).

Methods: A three-phase Delphi process was conducted by the International Society for the Study of the Lumbar Spine (ISSLS) Lumbar Spinal Stenosis Taskforce, including two online surveys, two virtual meetings, and three in-person consensus meetings at the ISSLS annual conferences (2023-2025). Participants evaluated and ranked outcome measures for LSS, with final endorsement requiring > 66% agreement.

Estimation of cup orientation on intraoperative fluoroscopy in total hip arthroplasty: how safe is the safe zone-an experimental study.

Background: Accurate acetabular cup orientation in total hip arthroplasty (THA) is crucial for successful outcomes. Intraoperative fluoroscopy may be used to evaluate acetabular cup placement. This study aimed to evaluate the accuracy of purely visual estimation of cup inclination and anteversion using intraoperative fluoroscopy, considering different surgeon experience levels and cup designs.

Modern approaches to radiotherapy in primary cutaneous lymphomas: insights and recommendations from the DEGRO dermato-oncology working group.

The growing use of reduced-dose radiotherapy in patients with primary cutaneous lymphoma is a promising development. Nevertheless, the absence of controlled clinical trials to ascertain standardized doses for each specific type constitutes a significant impediment to the advancement of this field. This expert opinion strongly advocates for advancements in radiation oncology practice that address the unique complexities of primary cutaneous lymphoma.

Intracranial Rescue Stenting in Pediatric Focal Cerebral Arteriopathy.

Background: Pediatric acute ischemic stroke is a rare yet severe condition with multifactorial etiology, often associated with vasculopathies. Endovascular intervention in children with focal cerebral arteriopathy is seldom reported.

Purpose: Our aim was to report feasibility of intracranial rescue stenting for the management of pediatric focal cerebral arteriopathy with flow-limiting stenosis.

Diagnostic tips for multi-phase post-mortem computed tomography angiography interpretation in upper gastro-intestinal bleeding.

In the past 10 years, the Multi-phase Post-mortem Computed Tomography Angiography (MPMCTA) has considerably improved the quality and precision of postmortem diagnoses, particularly in cases with vascular implication. MPMCTA is known to have higher sensitivity for detecting the source of a hemorrhage than autopsy. Death by upper gastro-intestinal (GI) bleeding is not so uncommon in forensic practice.

Changes in problem-solving style when pain does not resolve. A longitudinal analysis of adults with chronic pain after total knee replacement.

One-fifth of adults who receive a total knee replacement (TKR) go on to develop chronic pain. The behavioural approach taken to find a solution to pain may vary from assimilative (pursuit of analgesia) to accommodative (acceptance of pain insolubility and adoption of alternative goals). A total of 313 patients participated in a trial of an enhanced care pathway for TKR reported pain at 3 months after surgery.

Great debate: the universal definition of myocardial infarction is flawed and should be put to rest.

Myocardial infarction (MI) is defined pathologically as myocardial cell death resulting from prolonged ischaemia. The clinical definition of this pathological process relies on clinical evidence of myocardial ischaemia and biomarker evidence of myocardial cell death. Cardiac troponins are the standard clinical biomarker for assessing cardiac cell death.

CD4 T Cells Acquire Innate Capability Upon Classical T Cell Activation.

Memory T cells, a sizable compartment of the mature immune system, enable enhanced responses upon re-infection with the same pathogen. We have recently shown that virus-experienced innate acting T (T) cells can modulate infectious or autoimmune diseases through TCR-independent IFN-γ production. However, how these cells arise remains unclear.

Association Between Oral Health and Physical Frailty in an Adult Community-Dwelling Caucasian Population.

Background: Although oral diseases and frailty can be met earlier in life, there is limited information on their association across the lifespan.

Objectives: To scope for the association of oral factors with physical frailty in Greek community-dwelling adults.

Methods: Participants were over 18 years of age with ≥ 20 natural teeth, ≥ 10 occlusal contacts, and no removable dentures.

Minimum Area Confidence Set Optimality for Simultaneous Confidence Bands for Percentiles With Applications to Drug Shelf-Life Estimation.

One important property of any drug product is its stability over time. A key objective in drug stability studies is to estimate the shelf-life of a drug, involving a suitable definition of the true shelf-life and the construction of an appropriate estimate of the true shelf-life. Simultaneous confidence bands (SCBs) for percentiles in linear regression are valuable tools for determining the shelf-life in drug stability studies.

Structure-Function Associations of Choroidal Thickness With Retinal Sensitivity in Myopia.

Purpose: The purpose of this study was to investigate the focal relationship between choroidal thickness and retinal sensitivity in myopic eyes.

Methods: Participants underwent swept-source optical coherence tomography (SS-OCT) imaging and microperimetry testing. Choroidal thicknesses were obtained by segmenting the SS-OCT scans using a deep-learning approach.

A H Background-Free 3D Printing Digital Light Processing Resin for Applications in NMR Spectroscopy.

Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful analytical technique with a wide range of applications. To support the analysis of diverse and complex samples, various NMR tools and accessories have been created. Three-dimensional (3D) printing is an underutilized production method for NMR hardware, mainly due to the lack of H NMR background-free resins.

Preclinical Investigations Toward Gd-free Molecularly Targeted Dual-Modal, MRI Dynamic (DCE-MRI)/Optical Imaging Contrast Agent for Cardiac Angiosarcoma.

Aims: Cardiac tumors are aggressive and asymptomatic in early stages, causing late diagnosis and locoregional metastasis. Currently, the standard of care uses gadolinium-based contrast agents for MRI, and the associated hypersensitivity reactions are a significant concern, such as gadolinium deposition disease. In addition, the proximity of cardiac lesions closer to vital structures complicates surgical interventions.

Nail toxicities associated with cancer therapies: Insights and recommendations from the EADV task force dermatology for cancer patients.

Nail toxicities are a frequent yet underreported adverse effect of cancer therapies. These toxicities can significantly impact patients' quality of life and may lead to treatment modifications or interruptions. This narrative review aims to analyse the types, severity and underlying mechanisms of nail toxicities associated with cancer treatments as well as their management.

Expert consensus for prevention, diagnosis and management of persistent chemotherapy-induced alopecia.

Background: Persistent chemotherapy-induced alopecia (pCIA) is a distressing side effect of antineoplastic agents, imposing significant psychological burdens on cancer survivors. Despite its impact, there are no standardized guidelines for diagnosis, prevention or management.

Objective: To establish consensus-based definitions, diagnostic criteria, grading systems and management recommendations for pCIA.