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http://dx.doi.org/10.1097/ALN.0000000000005641 | DOI Listing |
Anesthesiology
October 2025
Department of Anesthesiology, Pharmacology, Intensive Care and Emergency Medicine, University Hospital of Geneva, Geneva, Switzerland; Geneva Neuroscience Center, University of Geneva, Geneva, Switzerland.
Insects
August 2025
Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, Silwood Park Campus, Ascot, Berkshire SL5 7PY, UK.
The rise of RNAi-based biopesticides marks a turning point in pest control, prompting reflection on the future role of (Bt). Far from being outdated, Bt remains a cornerstone of sustainable agriculture, with proven efficacy, safety, and public trust. This opinion piece advocates for Bt's continued relevance in an RNAi-driven future, urging a complementary, not competitive, view of both technologies within integrated pest management frameworks.
View Article and Find Full Text PDFHu Li Za Zhi
August 2025
Post-Baccalaureate Program in Nursing, Fu Jen Catholic University, Taiwan, ROC.
The World Health Organization has projected a global shortage of 5.7 million nurses by 2030 (World Health Organization, 2024). However, the International Council of Nurses warns that, in light of the COVID-19 pandemic and ongoing workforce shortages, this gap could escalate to as many as 13 million over the same timeframe (International Council of Nurses, 2021).
View Article and Find Full Text PDFJ Int AIDS Soc
June 2025
Wits Ezintsha, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Introduction: The REPRIEVE study demonstrated significant reductions in major adverse cardiovascular events (MACE) with pitavastatin among people living with HIV (PWH) with low to moderate cardiovascular risk. Most MACE events occurred in higher-income countries, raising important considerations for similar primary prevention interventions within HIV programmes in low- and middle-income countries (LMICs) as antiretrovirals become safer and as PWH age.
Discussion: Limited data from Africa and within REPRIEVE suggests that MACE may not be as prevalent among PWH as within other geographies.
Genes Dis
May 2025
Department of Pharmacy, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan 450008, China.
The ubiquitin (Ub) system, a ubiquitous presence across eukaryotes, plays a crucial role in the precise orchestration of diverse cellular protein processes. From steering cellular signaling pathways and orchestrating cell cycle progression to guiding receptor trafficking and modulating immune responses, this process plays a crucial role in regulating various biological functions. The dysregulation of Ub-mediated signaling pathways in prevalent cancers ushers in a spectrum of clinical outcomes ranging from tumorigenesis and metastasis to recurrence and drug resistance.
View Article and Find Full Text PDF