Recent Developments in Catalytic Asymmetric Aziridination.

Aziridines, structurally related to epoxides, are among the most challenging and fascinating heterocycles in organic chemistry due to their increasing applications in asymmetric synthesis, medicinal chemistry, and materials science. These three-membered nitrogen-containing rings serve as key intermediates in the synthesis of chiral amines, complex molecules, and pharmaceutically relevant compounds. This review provides an overview of recent progress in catalytic asymmetric aziridination, focusing on novel methodologies, an analysis of the scope and limitations of each approach, and mechanistic insights.

The Key Role of Public Forests in Restoring Connectivity: an Application to Castilla y León Region, Spain.

Forests have been increasingly affected by natural disturbances and human activities. These impacts have caused habitat fragmentation and a loss of ecological connectivity. This study examines potential restoration pathways that reconnect the five largest forest cores in the Castilla y León region of Spain.

Emerging strategies, applications and challenges of targeting NAD in the clinic.

Beyond their classical functions as redox cofactors, recent fundamental and clinical research has expanded our understanding of the diverse roles of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) in signaling pathways, epigenetic regulation and energy homeostasis. Moreover, NAD and NADP influence numerous diseases as well as the processes of aging, and are emerging as targets for clinical intervention. Here, we summarize safety, bioavailability and efficacy data from NAD-related clinical trials, focusing on aging and neurodegenerative diseases.

The Solve-RD Solvathons as a pan-European interdisciplinary collaboration to diagnose patients with rare disease.

Despite advances in genomic diagnostics, the majority of individuals with rare diseases remain without a confirmed genetic diagnosis. The rapid emergence of advanced omics technologies, such as long-read genome sequencing, optical genome mapping and multiomic profiling, has improved diagnostic yield but also substantially increased analytical and interpretational complexity. Addressing this complexity requires systematic multidisciplinary collaboration, as recently demonstrated by targeted diagnostic workshops.

Postpartum depression in Ecuadorian women: does the quality of health care during childbirth matter?

Poor quality obstetric care can harm women's mental health, especially after childbirth. This study examines how the perceived quality of health services during childbirth is related to postpartum depression in Ecuador. Using data from 16,451 women in the 2018 National Health and Nutrition Survey, we applied probit and latent class probit models.

Indications for haematopoietic cell transplantation and CAR-T for haematological diseases, solid tumours and immune disorders: 2025 EBMT practice recommendations.

For over two decades, the EBMT has updated recommendations on indications for haematopoietic cell transplantation (HCT) practice based on clinical and scientific developments in the field. This is the ninth special EBMT report on indications for HCT for haematological diseases, solid tumours and immune disorders. Our aim is to provide guidance on HCT indications according to prevailing clinical practice in EBMT countries and centres.

Serum progesterone variability on embryo transfer day in hormone replacement therapy cycles using intramuscular injections during frozen embryo transfers.

Purpose: To assess the intra-individual variability of serum progesterone (P) levels on embryo transfer (ET) day, when the same dose of intramuscular progesterone (IM-P) was used in two consecutive hormone replacement therapy (HRT) frozen embryo transfer (FET) cycles.

Methods: A total of 75 patients undergoing two consecutive HRT-FET cycles in one year performed at Bahceci Ankara IVF Center between November 2019 and February 2022 were retrospectively analyzed. Serum P levels were measured at the 117th-119th hours of support by a single laboratory.

Personalised genomic strategies improve diagnostic yield in inherited retinal dystrophies: a stepwise, patient-centred approach.

Background: Inherited retinal dystrophies (IRDs) are a genetically heterogeneous group of conditions, with approximately 40% of cases remaining unresolved after initial genetic testing. This study aimed to assess the impact of a personalised genomic approach integrating whole-exome sequencing (WES) reanalysis, whole-genome sequencing (WGS), customised gene panels and functional assays to improve diagnostic yield in unresolved cases.

Subjects/methods: We retrospectively reviewed a cohort of 597 individuals with IRDs, including 525 probands and 72 affected relatives.

Highly protected areas buffer against aridity thresholds in global drylands.

Drylands are highly vulnerable to global-scale aridity thresholds that cause drastic reductions in their productivity. While protected areas may help buffer against the impact of aridification, their effectiveness in mitigating the aridity thresholds across global drylands remains virtually unknown. Here we assembled a global dataset of drylands and found that highly protected areas, which include national parks and wilderness areas, can buffer the emergence of aridity thresholds in ecosystem productivity by up to 0.

Air-test for assessing gas exchange and the potential benefit of alveolar recruitment manoeuvre in anaesthetized dogs.

Objective: To determine the use of Air-Test in ventilated, anaesthetized dogs for evaluating oxygen uptake and to determine its potential utility in guiding the decision to perform an alveolar recruitment manoeuvre (ARM).

Study Design: Retrospective cohort study.

Animals: A total of 25 client-owned dogs undergoing general anaesthesia.

The effects of positive end-expiratory pressure and end-inspiratory pause on dead space and alveolar ventilation in mechanically ventilated dogs.

Objective: To evaluate the effect of 5 cmHO positive end-expiratory pressure (PEEP) and end-inspiratory pause (EIP) on airway dead space (V) and its resultant effects on alveolar tidal volume (V) and physiological dead space-to-tidal volume ratio (V/V) in dorsally recumbent anesthetized dogs.

Study Design: Prospective, controlled clinical study.

Animals: Healthy adult dogs (n = 20, > 20 kg) undergoing elective surgery.

The lifespan trajectories of brain activities related to conflict-driven cognitive control.

Cognitive control is fundamental to human goal-directed behavior. Understanding its trajectory across the lifespan is crucial for optimizing cognitive function throughout life, particularly during periods of rapid development and decline. While existing studies have revealed an inverted U-shaped trajectory of cognitive control in both behavioral and anatomical domains, the age-related changes in functional brain activities remain poorly understood.

Adherence trends to the Mediterranean Diet in Spanish youth: A systematic review and meta-analysis.

Aims: Young people are consuming less healthy diets such as Mediterranean diet (MedDiet), which is associated with an increased risk of chronic diseases, including obesity. This systematic review aimed to synthesize the literature concerning the prevalence and trends of adherence to the (MedDiet) in a young Spanish population (aged 2-24 years) from 2004 to 2023.

Data Synthesis: The present review included observational studies and final assessments of longitudinal studies to assess the prevalence or trend in adherence to the MedDiet using the Mediterranean Diet Quality Index for Children and Adolescents (KIDMED) in three categories (low (≤3), medium (4-7), and high (≥8)).

Tailoring Antioxidant Activities: Metal-Type Dependent, Highly Active SOD or Catalase Mimetics.

The failure of the therapeutic administration of superoxide dismutase (SOD) and catalase (CAT) enzymes to prevent oxidative stress has fostered the development of metal complexes that are capable of mimicking their activity. In the present work, two new pyridine azacyclophane ligands capable of coordinating Cu and Fe to give rise to mimetics with high activities toward disproportionation of the superoxide anion or hydrogen peroxide, depending on the metal ion, have been prepared. Although the Cu complexes have some of the highest SOD activities reported to date, they are completely inactive toward HO disproportionation.

Exploring the epic of older women's lives: Alexander Zeldin's The Confessions and Jan Vilanova's The Most Beautiful Thing We Can Do as intergenerational dramaturgies of the female life course.

Five decades after the term 'herstory' (Morgan 1970) was proposed, stories which have vindicated the social and historical role of anonymous women have proliferated in different biographical genres. More recently, the devastating effect of the COVID-19 pandemic on older people has also generated the need to generate or examine narratives of ageing (Jewusiak 2023) and to strengthen generational relationships (Ayalon et al. 2020).

Mapping female ageing in the twenty-first century in Deborah Moggach's last novels.

Despite having published seventeen novels, a good number of short stories, and scripts since she started her writing career at the end of the 1970s, academic work on Moggach's literary career has mainly dealt with her novel These Foolish Things (2004) and its film version The Best Exotic Marigold Hotel (2011). This paper will focus on Moggach's last three novels in which the reader is guided by the voice of three women in their late sixties and seventies, namely Something to Hide (2015), The Carer (2019), and The Black Dress (2021). Following an already well-established body of criticism on representations of female ageing in fiction, this paper will argue that Moggach's last novels add nuance and richness to the representation of female ageing in the twenty-first century.

Sexual pleasure in older age: haptic visuality and female eroticism in three contemporary Spanish films.

This article explores the representation of female sexuality in later life through the lens of three contemporary Spanish films: La vida era eso (2020), Destello bravío (2021), and Mamacruz (2023). Drawing from feminist aging studies, film theory, and concepts such as haptic visuality and clitoral sexuality, the study challenges the patriarchal, ageist, and phallocentric narratives that have long shaped cultural understandings of older women's erotic lives. Through close readings of these films, the article demonstrates how they subvert the dominant heteronormative gaze by foregrounding sensory pleasure, autoeroticism, and the reawakening of desire in older women.

Spiritual Support for People Affected by Dementia: A Scoping Review.

As a life-limiting illness, dementia requires a holistic approach to care, where spiritual support plays a crucial role in helping individuals and their caregivers find meaning and solace. Our aim was to systematically map the research conducted on psychosocial interventions developed to provide spiritual support for people living with dementia and their caregivers from diagnosis and across the disease trajectory. A scoping review was conducted to explore the breadth of research on 'spiritual support' in dementia care, encompassing interventions, service delivery models, programs, toolkits, approaches, and activities.

Nutrition for Mountain Biking and Cyclocross.

The Union Cycliste Internationale recognizes several mountain biking (MTB) disciplines, including downhill, enduro, cross-country short track, cross-country Olympic, cross-country marathon, and multiday stage racing. Cyclocross is recognized as a separate cycling discipline. Both MTB and cyclocross include cycling on off-road surfaces of varying technicality on specialized bicycles purposed for the respective disciplines.

Uncovering new lineages in the Sunda pangolin () with museum mitogenomics.

Accurately identifying evolutionarily significant units (ESUs) is crucial for conservation planning, especially for species like pangolins threatened by overhunting and habitat loss. ESUs help categorize different pangolin populations, aiding in understanding their genetic diversity and distribution, which is vital for targeted conservation efforts. This research generated mitochondrial genomes from historical museum specimens of Sunda pangolins () from underrepresented locations, uncovering a new evolutionary lineage from the Mentawai Islands that diverged from Indochina and west Sundaland populations around 760 000 years ago.