Implant Stability in Narrow Posterior Alveolar Ridges: A Randomized Controlled Trial Comparing Conventional Ridge Split and Osseodensification.

Introduction: Successful implant placement in the posterior mandible often requires augmentation of narrow ridges. This study aimed to compare the primary stability of dental implants placed using the conventional ridge split technique and the osseodensification method in narrow posterior mandibular ridges.

Methods: A randomized controlled trial was conducted involving 14 patients, with a total of 28 implants divided equally between two groups.

Two-Step Hybrid Method for the Energetics of Individual Noncovalent Interactions in Molecular Crystals.

We present a two-step method for the direct estimation of the energy of individual non-covalent interactions (NCIs) such as hydrogen bond (HB), CH…π or π…π interactions in any given molecular crystal. The first step of this method is to calculate the energy of a NCI by a molecular tailoring approach based (MTA-based) method utilizing a sufficiently large molecular crystal structure. This calculation is performed at the low Hartree-Fock (HF) level.

The burden of cardiovascular events according to cardiovascular risk profile in adults from high-income, middle-income, and low-income countries (PURE): a cohort study.

Background: Current strategies to prevent adverse cardiovascular outcomes focus primary prevention in high-risk groups and secondary prevention in people with known cardiovascular disease. We aimed to determine the proportion of events occurring in lower-risk groups globally.

Methods: We included people aged 40 years to younger than 75 years who were enrolled in the Prospective Urban Rural Epidemiology (PURE) study, which is an ongoing, international, prospective, population-based cohort study that started recruiting adults from households selected to be broadly representative of the sociodemographic composition of their communities.

Isolation and characterization of from a mangrove habitat: identification of dual-function antimicrobial and anticancer peptides.

Actinomycetes were isolated from mangrove soil samples and cultivated on starch casein nitrate (SCN) medium. The isolate was identified as through 16S rRNA gene sequencing and phylogenetic analysis using MEGA X. Microscopic examination revealed filamentous mycelia with spirally coiled spore chains bearing cylindrical, hairy spores with curved edges, consistent with the genus morphology.

Utilization of natural and waste sources for synthesis of cellulose, chitin, and chitosan for a suitable environment.

The growing need for sustainable materials has sparked interest in natural polymers such as cellulose, chitin, and chitosan. This review explored the synthesis routes and various natural and waste-derived sources of these biopolymers. Chitin and chitosan, obtained primarily from crustaceans, insects, and microorganisms, are economically valuable due to their biodegradability and biocompatibility.

PEGylated PLGA nanoparticles: unlocking advanced strategies for cancer therapy.

Poly(lactic-co-glycolic acid) (PLGA) is a widely utilized biodegradable and biocompatible polymer in drug delivery systems, particularly for encapsulating drug molecules with poor solubility and permeability. PLGA nanoparticles, composed of polylactic acid (PLA) and polyglycolic acid (PGA), offer tunable properties such as controlled degradation rates and drug release kinetics. The PEGylation of PLGA nanoparticles results in the formation of a polyethylene glycol (PEG) corona on their surface, which enhances systemic circulation by reducing opsonization and immune system recognition.

Unveiling the power of polymeric nanoparticles: Pioneering advances in breast cancer treatment.

Breast cancer has become the most common type of cancer worldwide. Chemotherapy is a prevalent and efficacious treatment for breast cancer; yet, it presents several problems that might impact both the treatment's effectiveness and the patient's quality of life. Certain breast cancer cells exhibit inherent resistance to chemotherapeutic agents from the outset.

Role of Artificial Intelligence in Nanomedicine and Organ-specific Therapy: An Updated Review.

Background: In organ-specific therapy, artificial intelligence (AI) is primarily used to improve surgical planning through image analysis, predict post-transplant outcomes, personalize treatment plans based on patient data, optimize organ allocation logistics, and donor-recipient precision mapping for organs to improve transplants. Furthermore, all these applications ultimately lead to better patient outcomes and enhanced organ therapy.

Objective: This review aims to examine the revolutionary effects of AI in some key healthcare fields, such as nanomedicine, cancer treatment, clinical applications, and organ-specific delivery.

Intraoperative fluorescence angiography with indocyanine green to prevent anastomotic leak in rectal cancer surgery (IntAct): an unblinded randomised controlled trial.

Background: Data are mixed on whether indocyanine green (ICG) fluorescence angiography can reduce the high rate of anastomotic leaks in patients undergoing surgery for rectal cancer. Therefore, we aimed to investigate the safety and efficacy of ICG fluorescence angiography in reducing the rate of clinical anastomotic leaks in these patients.

Methods: IntAct was an unblinded randomised controlled trial conducted at 28 specialist rectal cancer centres across eight European countries.

The Intersection of Psychology and Gynecology: A Comprehensive Review of Pain Management Strategies in Women's Health.

Chronic gynecological pain conditions, including dysmenorrhea, endometriosis, vulvodynia, and chronic pelvic pain syndrome (CPPS), present significant challenges in women's health. These conditions result in significant physical discomfort and are closely associated with psychological comorbidities such as anxiety, depression, and increased central pain sensitization. Traditional pharmacological and surgical interventions often provide limited relief, as they fail to address the complex interplay between biological, neurological, and psychological factors underlying pain perception.

Psychosocial Problems in the Siblings of Multitransfused Thalassemia Patients.

Background: Thalassemia significantly affects the psychosocial health of patients, their families, and siblings. Recognizing and addressing psychosocial challenges within the family system and among siblings is crucial to enhance their well-being and the overall family functioning.

Objectives: To assess the psychosocial stress in siblings of multiple-transfused thalassemia patients, utilizing two distinct scales specifically designed to evaluate psychological distress in children.

Non-canonical role of Yorkie in the development of Malpighian tubules of Drosophilamelanogaster.

Tissue morphogenesis is a highly coordinated process necessary for correct morphology and function. The Hippo pathway plays a crucial role in regulating the size of organs, and mutation in this pathway can lead to the development of several diseases including tumor. Our study shows that transcriptional coactivator Yorkie, the downstream target of the Hippo pathway, plays a critical role in developing Malpighian tubules in Drosophila.

A pilot study comparing conventional and digital impression techniques for speech analysis using Hindi vowels in maxillectomy patients rehabilitated with an obturator.

Aim: Maxillectomy patients frequently have speech impairments resulting from the loss of the oral-nasal partition. Prosthodontic rehabilitation with an obturator helps restore speech intelligibility, with its success largely dependent on accurate impression recording of maxillary defects. This investigation evaluated the effectiveness of conventional versus digital impression techniques in the context of speech analysis, specifically using Hindi vowels, in maxillectomy patients rehabilitated with obturators.

Investigating structural and dynamic changes in cellulose due to nanocrystallization.

Cellulose nanocrystals (CNCs) is synthesized from alpha-cellulose by acid hydrolysis method, and formation of nanocrystallization is comprised by using various microscopic and spectroscopic techniques like PXRD, XPS, Raman, FTIR, PL, UV-Vis, DSC, TGA, DLS, SEM, TEM. Nanocrystalline cellulose shows a notably higher photoluminescence (PL) intensity than cellulose, which enhances its ability to absorb and emit visible light. This increase in PL intensity is attributed to a smaller particle size of CNCs, greater surface area, and quantum confinement effects.

A Comparative Evaluation of the Effect of Photobiomodulation on the Depth of Anaesthesia During Endodontic Treatment of Teeth with Symptomatic Irreversible Pulpitis-A Prospective Clinical Trial.

Background: Effective pulpal anesthesia is crucial in endodontic practice, particularly in treating symptomatic irreversible pulpitis. This study explores photobiomodulation therapy (PBMT) as a non-invasive adjunct to traditional anesthesia.

Aim: To compare the efficiency of diode laser and Er, Cr: YSGG laser in enhancing anesthesia depth during endodontic treatment of teeth with symptomatic irreversible pulpitis.

Enhanced Cleaning, Enhanced Healing: A Systematic Review of Advances in Endodontic Irrigation.

Background: Effective irrigation is crucial for successful endodontic treatment, ensuring debris removal, disinfection, and biofilm elimination. This systematic review analyzes recent advances in endodontic irrigants and activation systems.

Materials And Methods: A comprehensive search of PubMed, Scopus, Web of Science, and Google Scholar was conducted to identify relevant studies published between 2015 and 2025.

An insight into molecular targets and nanotherapeutics for diabetic wound healing.

Objective: This article reviewed the recent research findings of diabetic wound healing including molecular targets, signaling pathways, and nanotherapeutics for diabetic wound healing.

Significance: The prevalence of diabetes (DI) is rising daily throughout the world, and one of the main issues for diabetic patients is poor wound healing. Therefore, new molecular target identification and advanced drug delivery systems development are necessary for the effective treatment of diabetic wounds.

Intramolecular Versus Intermolecular Bonding in Drug Gemcitabine and Nucleobases: A Computational Study.

The adsorption of the drug gemcitabine on nucleobases was investigated using a dispersion-corrected density functional theory (DFT) study. The planar structure of complexes is more stable than those with stacked and buckle-angled configurations. The complexes were found to possess at least two intermolecular hydrogen bonds.

Investigation into PVDF-HFP and PVP Polymer Blend Electrolytes with Lithium Ions for Energy Storage Application.

To improve solid-state lithium batteries, solution casting has been employed to create lithium ion-conducting copolymer electrolytes involving poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP)/polyvinylpyrrolidone (PVP) blend polymers with various compositions. Following X-ray diffraction and Fourier transformation (FTIR), the structural characterisation and identification of molecular bonding in polymer electrolytes were confirmed. Through AC impedance analysis, the electrical characteristics of the solid-state polymer films were investigated.

Diagnostic accuracy of 18F-FDG and 68 Ga-FAPi PET/CT for patients with gastric carcinoma: a systematic review and meta-analysis.

Objective: This systematic review aims to assess the diagnostic performance of FDG PET/CT and FAPi PET/CT in patients with gastric carcinoma, specifically for the evaluation of primary tumors, metastatic lymph nodes, and metastatic lesions.

Methods: Following PRISMA guidelines, relevant databases were searched until January 20, 2023. Studies reporting histopathology or surgical outcomes as the reference standard were included.

Spatio-temporal analysis of air quality in high traffic density zones of Haridwar City, India.

Urban air pollution poses a significant threat to human health and environmental quality, especially in rapidly urbanizing areas. This study aimed to analyze the spatio-temporal variations of air quality in Haridwar City, India, identifying critical pollution hotspots. A systematic air quality monitoring approach was adopted to assess the air quality at the high traffic density zones of Haridwar City.

Penetration depth of different irrigants in simulated lateral canalsPenetration depth of different irrigants in simulated lateral canals.

Proper root canal disinfection needs lateral canals to receive irrigant penetration so that microbial biofilms can be eliminated. Therefore, it is of interest to investigate using confocal laser scanning microscopy how deep NaOCl (5.25%) and CHX (2%) and EDTA (17%) solution penetrated into 60 extracted teeth.

Sleep Disturbances in Survivors of Childhood Acute Lymphoblastic Leukemia: A Cross-Sectional Study.

Objectives: Survivors of childhood cancer are at risk of sleep disturbances, an often, neglected aspect of holistic health. This study was carried out to determine the prevalence of sleep disturbances in survivors of pediatric acute lymphoblastic leukemia (ALL) and to identify any risk factors for the same.

Methods: Survivors of ALL aged 6-18 years, who had completed their treatment, at least two or more years ago, were enrolled.