Comprehensive genomic assessment of available probiotics in India: A framework for safety and functionality evaluation.

Probiotic strains, defined as live microorganisms that confer health benefits to the host when administered in adequate amounts, are widely incorporated into commercial products. Therefore, assessing the safety and functional attributes of 20 commercially available probiotic strains using complete genome sequencing is of immediate importance. Our analysis revealed that 15% of the products were mislabeled, containing species different from those declared on the label.

Delayed Sternal Closure Following Complex Cardiac Surgery in Neonates.

BackgroundDelayed sternal closure (DSC) is a well-established management strategy following complex congenital cardiac surgery that is used to mitigate postoperative hemodynamic and respiratory instability. It is mostly used in neonates requiring prolonged cardiopulmonary bypass (CPB), long aortic cross-clamp times, or deep hypothermic circulatory arrest who are predisposed to myocardial edema or bleeding. Our study evaluates morbidity and mortality after DSC in neonates including superficial and deep sternal wound infections, along with requirement for surgical debridement.

Enhanced Cleaning, Enhanced Healing: A Systematic Review of Advances in Endodontic Irrigation.

Background: Effective irrigation is crucial for successful endodontic treatment, ensuring debris removal, disinfection, and biofilm elimination. This systematic review analyzes recent advances in endodontic irrigants and activation systems.

Materials And Methods: A comprehensive search of PubMed, Scopus, Web of Science, and Google Scholar was conducted to identify relevant studies published between 2015 and 2025.

Endodontic Treatment of Maxillary Molars with Canal Variations: A Case Report of Two Cases.

The clinician must be familiar with the morphology of the roots of all teeth and the associated intricate root canal anatomy to achieve proper access to the canals, effective debridement, and obturation for successful endodontic treatment. These case reports intensify the complexity of maxillary molar morphologic variation and represent successful endodontic treatment of maxillary 1 molars with six canals and maxillary 2 molar with two palatal canals, which is rarely discussed in literature.

Prevalence of the Histological Characteristics in Various Teeth of Different Age-groups: An Observational Study.

Aim: To assess the prevalence and distribution of enamel lamellae, enamel tufts, and incremental lines in different tooth types (incisors, canines, premolars, and molars) across various age-groups (≤20, 21-40, 41-60, and 60 and above) using histological analysis.

Materials And Methods: A total of 200 extracted human permanent teeth from individuals were collected and categorized into four groups, based on age-group I (≤20 years), group II (21-40 years), group III (41-60 years) and group IV (>60 years) including various tooth types such as incisor, canine, premolar and molars, respectively. Teeth were manually sectioned longitudinally using a carborundum disk and examined under a light microscope (10× magnification) to assess enamel lamellae, enamel tufts, enamel spindles, interglobular dentin, the cementoenamel junction (CEJ), and incremental lines in cementum.

Comparative Evaluation of Cytotoxicity, Anti-inflammatory, and Drug Release Profiles of Allicin-incorporated GO-AgNP Hydrogel: An Study.

Aim: This study evaluates the cytotoxicity, anti-inflammatory effects, and drug release profiles of an allicin-incorporated graphene oxide-silver nanoparticle (GO-AgNP) hydrogel as an intracanal medicament.

Materials And Methods: The allicin-incorporated GO-AgNP hydrogel was synthesized and characterized using transmission electron microscopy. Human periodontal ligament (PDL) fibroblasts were used for 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide cytotoxicity assays, assessing cell viability at 10, 25, 50, and 100 µg/mL concentrations over 24, 48, and 72 hours.

Retention in Care Among People Living with HIV in Nigeria: A Systematic Review and Meta-analysis.

Background: In 2021, Nigeria had an estimated 1.9 million people living with the human immunodeficiency virus (PLHIV) and 1.7 million (90%) on antiretroviral therapy (ART).

Statins as antiepileptogenic drugs: Analyzing the evidence and identifying the most promising statin.

Many brain insults and injuries are "epileptogenic": they increase the risk of developing epilepsy. It is desirable to identify treatments that are "antiepileptogenic": treatments that prevent the development of epilepsy, if administered after the occurrence of an epileptogenic insult. Current antiepileptic drugs are not antiepileptogenic, but evidence of antiepileptogenic efficacy is accumulating for a growing number of other compounds.

Optimized hybrid machine learning approach for smartphone based diabetic retinopathy detection.

Diabetic Retinopathy (DR) is defined as the Diabetes Mellitus difficulty that harms the blood vessels in the retina. It is also known as a silent disease and cause mild vision issues or no symptoms. In order to enhance the chances of effective treatment, yearly eye tests are vital for premature discovery.

Enhancement of hydrocarbons and phenols in catalytic pyrolysis bio-oil by employing aluminum hydroxide nanoparticle based spent adsorbent derived catalysts.

The present study investigated the effects of metal loaded spent adsorbent as catalyst for the catalytic pyrolysis of pine needle biomass. Metal active sites (Ni, Fe, Cu, Zn and Mo) were introduced in alumina matrix by wet impregnation process. Non-catalytic and catalytic semi-batch pyrolysis study was carried out at conditions: 550 °C temperature, 50 °C min heating rate and 200 mL min N flow rate.

Pregnancy and cardiac interventions: What are the optimal management options?

Cardiac disease is the leading cause of maternal mortality in the United Kingdom. Major causes of cardiac death in pregnant women include cardiomyopathies, myocardial infarction, ischemic heart disease, and aortic dissection. Uncorrected congenital heart disease and women who have had corrective or palliative surgery may have complicated pregnancies as well.

Acute Kidney Injury Associated with Cardiac Surgery: a Comprehensive Literature Review.

Objective: To comprehensively understand cardiac surgeryassociated acute kidney injury (CSA-AKI) and methods of prevention of such complication in cardiac surgery patients.

Methods: A comprehensive literature search was performed using the electronic database to identify articles describing acute kidney injury (AKI) in patients that undergone cardiac surgery. There was neither time limit nor language limit on the search.

Maternal and Neonatal Outcomes in Patients of Gestational Diabetes Mellitus on Metformin Therapy.

Background: Present study carried out in a tertiary referral hospital in North India attempts to determine the maternal and neonatal outcomes of metformin therapy in patients of gestational diabetes mellitus.

Objectives: To evaluate maternal and neonatal outcomes in patients of GDM on metformin therapy and to study its adverse effects.

Method: In this prospective observational study, all women diagnosed with GDM not controlled by medical nutrition therapy were started on metformin therapy and the maternal and neonatal outcomes were studied.

Predicting likelihood of psychological disorders in PlayerUnknown's Battlegrounds (PUBG) players from Asian countries using supervised machine learning.

Multiplayer Online Battle Arena (MOBA) has become one of the most popular genre of online video games played by gamers worldwide. Previous studies have exhibited that excessive engagement in games can lead to Internet Gaming Disorder (IGD). Internet Gaming Disorder has been associated with psychological disorders like impulsivity, anxiety and Attention Deficit Hyperactivity Disorder (ADHD).

Oral Health Knowledge, Attitude, and Practice among Nursing Students in the North-Eastern Part of Rajasthan, India.

Background: Professional and paramedical students have a key role in oral health promotion. The aim of this study was to assess oral health-related Knowledge, Attitude, and Practice (KAP) among the nursing students in Rajasthan.

Materials And Methods: A cross-sectional, questionnaire-based study was carried out among 409 nursing students from five different institutes who were selected by simple random sampling.

Proximal arterial cannulation in thoracic aortic surgery-Literature review.

Surgery on thoracic aorta is complex with a number of approaches being required depending on the pathology and anatomy that is specific to each patient and therefore, careful planning is required to ensure successful outcomes. Among the key factors that determine a satisfactory and safe operation is the choice of arterial cannulation site to establish cardiopulmonary bypass and deliver brain protection adequately. Direct proximal aortic cannulation is the gold-standard method for elective aortic root surgery and traditionally femoral arterial cannulation has been used in complex aortic surgeries such as redo or acute pathologies; however, axillary and innominate artery (IA) cannulation has evolved dramatically and several centers are currently using proximal cannulation sites as the default cannulation choice in elective and emergency settings of complex thoracic aortic surgeries.