Clathrin-Mediated Endocytosis for Enhanced Apoptosis Induction and Cellular Imaging in Triple-Negative Breast Cancer by Casein-Protected Blue-Emissive Carbon Dots.

The development of multifunctional nanoplatforms capable of drug delivery and real-time cellular imaging remains a key challenge in cancer theranostics. Herein, we report the development of a casein-protected maleic acid-derived nitrogen-doped carbon dot-based luminescent nanoplatform (MNCD@Cas NPs) for efficient delivery of the anticancer drug doxorubicin hydrochloride (DOX) to triple-negative breast cancer cells. Synthesized via a facile two-step method, the MNCD@Cas NPs exhibit bright blue fluorescence (λ = 390 nm), high water dispersibility, excellent colloidal stability, and substantial DOX loading capacity (∼84%) driven by electrostatic interactions.

Advancing Accuracy in Non-invasive Hemoglobin Estimation: A Comparative Clinical Study of the Performance of the Non-invasive Anemia Detection App (NiADA).

Background: Anemia remains a significant global health burden, particularly in low- and middle-income countries. Traditional hemoglobin screening methods are invasive, resource-intensive, and often impractical for large-scale or repeated population-level screening. The Non-invasive Anemia Detection App (NiADA, Monere AI Private Limited, Kolkata, West Bengal, India) provides a smartphone-based, artificial intelligence (AI)-powered alternative for estimating hemoglobin levels using images of the lower palpebral conjunctiva.

A framework for biosafety assessment of microbial strains in Biotechnology applications.

Biosafety refers to the principles and practices that prevent unintentional exposure to biological agents and limit their potential harm to humans and the environment. Therefore, we developed a comprehensive biosafety assessment framework for 40 microbial strains used in biotechnology, evaluating five key parameters: pathogenicity, immunogenicity, environmental persistence, genetic stability, and taxonomy. Principal component analysis showed that 84% of the risk variation was unrelated to taxonomy, emphasizing the need for strain-specific evaluations.

Comprehensive genomic assessment of available probiotics in India: A framework for safety and functionality evaluation.

Probiotic strains, defined as live microorganisms that confer health benefits to the host when administered in adequate amounts, are widely incorporated into commercial products. Therefore, assessing the safety and functional attributes of 20 commercially available probiotic strains using complete genome sequencing is of immediate importance. Our analysis revealed that 15% of the products were mislabeled, containing species different from those declared on the label.

Ever-Increasing Role of Computational Tools in Solid-State Pharmaceutics: Advancing Drug Development with Enhanced Molecular Understanding and Risk Assessment.

The field of solid-state pharmaceutics comprises a broad range of investigations into various structural aspects of pharmaceutical solids, establishing a rational structure-property correlation. These solid systems allow the tunability of the physicochemical properties, such as solubility and dissolution, which in turn influence the pharmacokinetic and pharmacodynamic parameters of the active pharmaceutical ingredient (API). Hence, the study of physical characteristics of an API, e.

Plasmid prevalence is independent of antibiotic resistance in environmental .

The rapid rise of antibiotic-resistant pathogens poses a critical threat to the treatment of infectious diseases. While the spread of antibiotic resistance genes (ARGs) via plasmid conjugation has been extensively studied both in the lab and the clinic, the prevalence and diversity of plasmids in drug-susceptible isolates (e.g.

Unlocking the full potential of piperine-loaded nanocarriers for cancer treatment.

In the twenty-first century, cancer continues to be a significant worldwide health concern that requires immediate and ongoing attention. Currently, chemotherapeutic treatments are constrained by various limitations, including drug resistance, nonspecific distribution, and organ toxicity. These difficulties highlight the need for safer and more efficient substitutes, like Piperine (PPN), a bioactive alkaloid obtained from and , as a viable option for cancer therapy.

Nailing the Outcome: A Comparative Study of Proximal Femoral Nail Anti-Rotation-II and Trochanteric Fixation Nail in Unstable Intertrochanteric Femur Fractures.

Introduction: Intertrochanteric femur fractures are among the most common injuries in the elderly population and represent a major public health issue. Treatment aims to achieve stable fixation that allows early mobilization and minimizes complications. The choice of implant plays a critical role in clinical outcomes, particularly in unstable fracture patterns.

Surgical Management of Chronic Locked Posterior Dislocation of Shoulder using the Modified McLaughlin Procedure.

Introduction: Chronic locked posterior dislocation (CLPD) of the shoulder presents a big challenge to the orthopedic surgeon due to the progressive damage to the glenohumeral articulation and increase in size of the reverse Hill-Sachs lesion (RHSL). Multiple treatment strategies have been postulated depending upon the size of the humeral head defect and the RHSL.

Case Report: A 35-year-old Indian male patient presented to our Outpatient Department with complaints of pain and restriction in the range of motion over the right shoulder since suffering an injury over the shoulder 6 months back.

Comparative Analysis of Dorsal Distraction Plating Versus External Fixation in the Management of Intra-Articular Distal Radius Fractures.

Introduction: Fractures located in close proximity to the lower end of the radius bone, which make up around 16% of fractures requiring emergency treatment require careful treatment to regain mobility in the wrist joint and the fingers. Although classic external fixation (ExFix) methods are widely used, newer procedures such as dorsal distraction plating are showing potential . This study investigates the concepts, debates, and results of several methods so that to determine the most effective fracture treatment.

Multivariate and predictive modelling of arsenic and cadmium in rice: Influence of origin, grain type, and processing.

Rice is a global dietary staple and understanding the accumulation of toxic and essential elements in rice grains is vital for public health, particularly in high-consumption regions. While prior studies have assessed elemental contamination, applying advanced machine learning (ML) to predict and analyze geographic patterns remains limited. This study analyzed arsenic (As), cadmium (Cd), and six essential elements (Zn, Fe, Cu, Mn, Se, and Mo) in 46 rice samples sold in Sydney, Australia, using ICP-MS.

SCAI/HRS technical review on transcatheter left atrial appendage occlusion.

Background: Nonvalvular atrial fibrillation (NVAF) is associated with an increased risk of stroke due to thrombus formation in the left atrial appendage, where over 90% of thrombi originate. While oral anticoagulation (OAC) is the standard therapy for stroke prevention, many patients cannot tolerate long-term OAC due to bleeding risks. Percutaneous left atrial appendage occlusion (LAAO) has emerged as an alternative strategy.

Optimization of steel anchor pile configurations for enhanced pullout resistance in expansive soil foundations.

This study aims to predict the pullout behavior of steel anchor piles in saturated expansive soil using finite element method-based PLAXIS 3D CONNECT Edition V22 software. It inspects the effects of varying pile parameters and spacings for a displacement of 10% of the pile diameter. The study evaluates the performance of single and group anchor piles by comparing square configurations (2 × 2, 3 × 3, and 4 × 4) at varying centre-to-centre (c/c) spacings of 2.

Exploring the Interplay Between Physical Activity and Idiopathic Tinnitus Management: A Scoping Review on Severity Modulation and Perceptual Outcomes.

Unlabelled: Tinnitus, a condition characterized by the perception of ringing or buzzing in the ears, affects millions of individuals worldwide, often leading to significant distress, impaired quality of life, and mental health concerns. Despite the widespread nature of tinnitus, effective treatment strategies remain limited, with few established guidelines for management. Recent studies suggest that Physical Activity may play a role in modulating tinnitus severity and perception, providing potential relief for sufferers.

Precision control of microstructure variation and tensile properties in dissimilar friction stir lap welding joints using an adjustable tool.

Friction-assisted plastic deformation at the joint interface is essential for achieving the desired joint properties in dissimilar friction stir lap welding (FSLW) of aluminum alloy (Al) with steel (Fe). This plastic deformation can be precisely controlled by using an adjustable tool, where shoulder and probe rotation speeds are independently controlled. This study explores the effect of microstructure evolution and probe rotation speed on the weld's interface morphology and tensile properties of FSLW joints between an aluminum alloy and steel using an adjustable tool.

Beyond virus: Systematic review and meta-analysis on Impact of physical exercises on chikungunya sequelae of pain to functional restoration.

Background Objectives: Chikungunya virus (CHIKV) infection often results in persistent sequelae, including chronic pain and functional limitations, significantly impacting quality of life. Physical exercise is a potential intervention, but its efficacy remains unclear. This systematic review and meta-analysis aimed to evaluate the impact of physical exercises on chikungunya sequelae, focusing on pain reduction and functional restoration.

Finite size effect in Kuramoto oscillators with inertia on simplicial complex.

We investigate the finite-size effects of the dynamical evolution on the Kuramoto model with inertia coupled through triadic interactions. Our findings reveal that fluctuations resulting from the finite size drive the system toward a synchronized state at finite coupling, which contrasts with the analytical predictions in thermodynamic limit made for the same system. Building on the analytical calculations performed at the thermodynamic limit, we identify the origin of the synchronization transition that arises because of the finite size.

Association between prescriber practices and major depression treatment outcomes.

Practice variability may represent an opportunity to improve care by identifying the differences in outcomes associated with differences in practice. To characterize differences in depression treatment outcomes among individual providers in outpatient psychiatry practices and primary care practices, we examined a longitudinal cohort derived from outpatient electronic health records from two academic medical centers and six community hospitals in Eastern Massachusetts. This cohort included antidepressant-treated individuals with an ICD-9/10 diagnosis of major depressive disorder, and deidentified health care providers treating at least 10 such patients per year between 2008 and 2022.

The impact of haemostatic agent used during robot-assisted radical prostatectomy on post-op infection and anastomotic leak.

Objective: Despite the widespread use of robotic-assisted radical prostatectomy (RARP), considerable variation exists in practice with regard to postoperative cystograms prior to trial without catheter (TWOC).Our practice was to undertake a cystogram at 7-14-day post-op and proceed with TWOC if the leak was small or absent.In this study, we evaluate the risk factors for anastomotic leak and post-op urinary tract infection (UTI), while assessing the impact of using powdered haemostat Arista AH on post-op UTIs and cystographic leaks to rationalise the use of cystograms.

Residual learning based convolution neural network for improved channel estimation for VehA channel.

Accurate channel estimation is crucial for reliable communication in orthogonal frequency division multiplexing (OFDM) systems, especially in high-mobility scenarios. Traditional channel estimation techniques, such as least squares (LS) and linear minimum mean square error (LMMSE), face limitations in terms of estimation accuracy and computational complexity. To address these challenges, this paper proposes a novel convolutional neural network (CNN)-based channel estimation framework utilizing residual learning and iterative refinement.

Developing interpretable machine learning models to predict length of stay and disposition decision for adult patients in emergency departments.

Objective: Machine learning (ML) models have emerged as tools to predict length of stay (LOS) and disposition decision (DD) in emergency departments (EDs) to combat overcrowding. However, site-specific ML models are not transferable to different sites. Our objective was to develop interpretable ML models to predict LOS and DD at specific time points, all while establishing a transparent data analysis framework.

A motile rod in an active nematic medium: caging, orientational trapping, and anomalous diffusion.

We study the dynamical and statistical properties of a motile polar rod embedded in a vibrated granular medium composed of fore-aft symmetric rods using particle-based numerical simulations. Our study reveals phase-dependent memory effects and transport behaviors of the polar rod governed by the structural phase of the medium. In the isotropic phase, the rod behaves as an active Brownian particle, experiencing a noisy environment with increasing medium concentration that leads to short-lived directional memory, resulting in enhanced rotational diffusion and reduced translational diffusivity.

Removal of fluoride from aqueous solution using high surface area activated carbon derived from fish scale solid waste.

Fluoride contamination in drinking water is a widespread environmental issue that poses a significant threat to human health. In this regard, there is a need to explore low-cost and effective adsorbents for the removal of fluoride from aqueous solution. The low-cost activated carbon (AC) was synthesized via KOH activation using fish scale followed by carbonization at 800 °C under a N atmosphere.

Conidiobolus spp.: A Rare Pathogen Causing Rhino-Facial Entomophthoramycosis: A Case Series.

Rhinofacial entomophthoramycosis is a rare chronic fungal infection caused by ., primarily affecting the nasal and facial regions of immunocompetent individuals in tropical and subtropical areas. This case series describes five patients diagnosed with this condition over three years at a district hospital.

Postmortem Testing for HIV, HBV, and HCV: Insights from Autopsy Findings.

Introduction: A body brought for autopsy is full of information, which is visible only to those who are willing to see it carefully The cause of death can be natural or unnatural or it can be unnatural complicated by a natural cause i.e. disease complicating the trauma.